Cited by 217Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryThyroid Cancer Diagnosis and Treatment

Hypothyroidism: etiology, diagnosis, and management

Almandoz, Jaime P., Gharib, Hossein·2012·Medical Clinics of North America

Abstract

Hypothyroidism is the result of inadequate production of thyroid hormone or inadequate action of thyroid hormone in target tissues. Primary hypothyroidism is the principal manifestation of hypothyroidism, but other causes include central deficiency of thyrotropin-releasing hormone or thyroid-stimulating hormone (TSH), or consumptive hypothyroidism from excessive inactivation of thyroid hormone. Subclinical hypothyroidism is present when there is elevated TSH but a normal free thyroxine level. Treatment involves oral administration of exogenous synthetic thyroid hormone. This review presents an update on the etiology and types of hypothyroidism, including subclinical disease; drugs and thyroid function; and diagnosis and treatment of hypothyroidism.

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Crossref · 10.1016/j.mcna.2012.01.005

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120 of 120 references verified0 citation errors · 0 not checkable

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  • More than 50% of hypothyroidism patients reportedly show with the presence of SIBO.

    “More than 50% of hypothyroidism patients reportedly show with the presence of SIBO (Almandoz and Gharib, 2012).”

    From Thyroid disorders and gastrointestinal dysmotility: an old association (2024) · cites this paper as Almandoz and Gharib, 2012

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Authors
Almandoz, J. P., & Gharib, H.
Affiliations
Mayo Clinic (US)
Corresponding author
Gharib, Hossein
Venue
Medical Clinics of North America
Publisher
Elsevier BV
Published
2012-03
Volume
96
Issue
2
Pages
203-221
ISSN
0025-7125 (ISSN-L)
OpenAlex
W2120806571
Cited by
216
References
123
Citations by year
2026: 4 · 2025: 10 · 2024: 51 · 2023: 17 · 2022: 21 · 2021: 17 · 2020: 13 · 2019: 9 · 2018: 13 · 2017: 10 · 2016: 9 · 2015: 11 · 2014: 7 · 2013: 16 · 2012: 6
FWCI
1.78
Type
journal article
Language
en
Open access
closed
Locations
  • Medical Clinics of North America (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Keywords
hypothyroidism, primary hypothyroidism, central hypothyroidism, subclinical hypothyroidism, thyroid hormone inactivation, thyroid-stimulating hormone deficiency, drug-induced hypothyroidism, thyroid function tests, thyroid hormone replacement
MeSH terms
Dose-Response Relationship, Drug, Drug Therapy, Combination, Humans, Hypothyroidism, Risk Factors, Thyroid Function Tests, Thyroid Hormones, Thyrotropin, Thyroxine, Triiodothyronine, Hormone Replacement Therapy

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