Hypothyroidism: etiology, diagnosis, and management
Abstract
Hypothyroidism is the result of inadequate production of thyroid hormone or inadequate action of thyroid hormone in target tissues. Primary hypothyroidism is the principal manifestation of hypothyroidism, but other causes include central deficiency of thyrotropin-releasing hormone or thyroid-stimulating hormone (TSH), or consumptive hypothyroidism from excessive inactivation of thyroid hormone. Subclinical hypothyroidism is present when there is elevated TSH but a normal free thyroxine level. Treatment involves oral administration of exogenous synthetic thyroid hormone. This review presents an update on the etiology and types of hypothyroidism, including subclinical disease; drugs and thyroid function; and diagnosis and treatment of hypothyroidism.
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More than 50% of hypothyroidism patients reportedly show with the presence of SIBO.
“More than 50% of hypothyroidism patients reportedly show with the presence of SIBO (Almandoz and Gharib, 2012).”
From Thyroid disorders and gastrointestinal dysmotility: an old association (2024) · cites this paper as Almandoz and Gharib, 2012
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- Authors
- Almandoz, J. P., & Gharib, H.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Gharib, Hossein
- ORCID
- Almandoz, Jaime P.
- Venue
- Medical Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 96
- Issue
- 2
- Pages
- 203-221
- ISSN
- 0025-7125 (ISSN-L)
- OpenAlex
- W2120806571
- Cited by
- 216
- References
- 123
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 51 · 2023: 17 · 2022: 21 · 2021: 17 · 2020: 13 · 2019: 9 · 2018: 13 · 2017: 10 · 2016: 9 · 2015: 11 · 2014: 7 · 2013: 16 · 2012: 6
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medical Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Keywords
- hypothyroidism, primary hypothyroidism, central hypothyroidism, subclinical hypothyroidism, thyroid hormone inactivation, thyroid-stimulating hormone deficiency, drug-induced hypothyroidism, thyroid function tests, thyroid hormone replacement
- MeSH terms
- Dose-Response Relationship, Drug, Drug Therapy, Combination, Humans, Hypothyroidism, Risk Factors, Thyroid Function Tests, Thyroid Hormones, Thyrotropin, Thyroxine, Triiodothyronine, Hormone Replacement Therapy
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