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Research Progress on Therapeutic Effect and Mechanism of Propolis on Wound Healing

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Yang, Juan, Pi, Anjuan, Yan, Lele, Li, Juan, Nan, Sha, Zhang, Jing, Hao, Yuhui·2022·Evidence-Based Complementary and Alternative Medicine
DOI 10.1155/2022/5798941PMC PMC9334088
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Abstract

Propolis is a kind of reduct collected by bees from various plant sources. Because propolis is a mixture, it has a variety of biological activities, excellent anti-inflammatory and bactericidal effects. Especially in the treatment of infectious wounds, acute wounds, burns, and scalds and promoting wound healing, more and more scientists began to apply it to the research field of wound healing. The standard preparation of propolis combined with other compound components has a safer and less toxic effect in the treatment of trauma. In order to more effectively use propolis products in wound treatment. This paper reviews the effect and treatment mechanism of propolis on different types of wound healing, as well as the synergistic effect of propolis and other compounds, in order to provide ideas for the further exploration of the biological activity and pharmacological function of propolis in the future, as well as its in-depth development in the field of wound healing. It will also provide a theoretical reference for the further development and utilization of propolis.

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  1. [1]Farstvedt E. Stashak T. S. Othic A. Update on topical wound medications Clinical Techniques in Equine Practice 2004 3 2 164 172 10.1053/j.ctep.2004.08.003 2-s2.0-14644440505 · DOI
  2. [2]Chen J. Han C. M. Lin X. W. Tang Z. J. Su S. J. Effect of silver nanoparticle dressing on second degree burn wound Zhonghua Wai Ke Za Zhi 2006 44 1 50 52 16620649
  3. [3]Olczyk P. Wisowski G. Komosinska-Vassev K. Propolis modifies collagen types I and III accumulation in the matrix of burnt tissue Evidence-Based Complementary and Alternative Medicine 2013 2013 10 423809 10.1155/2013/423809 2-s2.0-84879295582 PMC3679764 23781260 · DOI · Paper page
  4. [4]Sandri G. Bonferoni M. C. D’Autilia F. Wound dressings based on silver sulfadiazine solid lipid nanoparticles for tissue repairing European Journal of Pharmaceutics and Biopharmaceutics 2013 84 1 84 90 10.1016/j.ejpb.2012.11.022 2-s2.0-84876942241 23207329 · DOI
  5. [5]Leitch I. O. W. Kucukcelebi A. Robson M. C. Inhibition of wound contraction by topical antimicrobials ANZ Journal of Surgery 1993 63 4 289 293 10.1111/j.1445-2197.1993.tb00385.x 2-s2.0-0027270262 8311815 · DOI
  6. [6]Muller M. J. Hollyoak M. A. Moaveni Z. Brown T. L. H. Herndon D. Heggers J. Retardation of wound healing by silver sulfadiazine is reversed by aloe vera and nystatin Burns 2003 29 8 834 836 10.1016/s0305-4179(03)00198-0 2-s2.0-0242636267 14636760 · DOI
  7. [7]Wasef L. G. Shaheen H. M. El-Sayed Y. S. Effects of silver nanoparticles on burn wound healing in a mouse model Biological Trace Element Research 2020 193 2 456 465 10.1007/s12011-019-01729-z 2-s2.0-85066148536 31111309 · DOI
  8. [8]Iyyam Pillai S. Palsamy P. Subramanian S. Kandaswamy M. Wound healing properties of Indian propolis studied on excision wound-induced rats Pharmaceutical Biology 2010 48 11 1198 1206 10.3109/13880200903578754 2-s2.0-78049454632 20819020 · DOI
  9. [9]Khalil M. L. Biological activity of bee propolis in health and disease Asian Pacific Journal of Cancer Prevention 2006 7 1 22 31 16629510
  10. [10]Tolba M. F. El-Serafi A. T. Omar H. A. Caffeic acid phenethyl ester protects against glucocorticoid-induced osteoporosis in vivo: impact on oxidative stress and RANKL/OPG signals Toxicology and Applied Pharmacology 2017 324 26 35 10.1016/j.taap.2017.03.021 2-s2.0-85016620129 28363435 · DOI
  11. [11]Romana-Souza B. Dos Santos J. S. Monte-Alto-Costa A. Caffeic acid phenethyl ester promotes wound healing of mice pressure ulcers affecting NF-κB, NOS2 and NRF2 expression Life Sciences 2018 207 158 165 10.1016/j.lfs.2018.05.057 2-s2.0-85048139439 29864436 · DOI
  12. [12]Nichitoi M. M. Josceanu A. M. Isopescu R. D. Polyphenolics profile effects upon the antioxidant and antimicrobial activity of propolis extracts Scientific Reports 2021 11 1 20113 10.1038/s41598-021-97130-9 PMC8505647 34635677 · DOI
  13. [13]Koc F. Tekeli M. Y. Kanbur M. Karayigit M. Ö Liman B. C. The effects of chrysin on lipopolysaccharide-induced sepsis in rats Journal of Food Biochemistry 2020 44 9 e13359 10.1111/jfbc.13359 32614079 · DOI
  14. [14]Arjun H. Banskota and Yasuhiro Tezuka and Shigetoshi Kadota recent progress in pharmacological research of propolis Phytotherapy Research 2001 15 7 561 571 11746834
  15. [15]Daleprane J. B. da Silva Freitas V. Pacheco A. Anti-atherogenic and anti-angiogenic activities of polyphenols from propolis The Journal of Nutritional Biochemistry 2012 23 6 557 566 10.1016/j.jnutbio.2011.02.012 2-s2.0-84860881700 21764281 · DOI
  16. [16]El Adaouia Taleb R. Djebli N. Chenini H. Sahin H. Kolayli S. In vivo and in vitro anti-diabetic activity of ethanolic propolis extract Journal of Food Biochemistry 2020 44 7 e13267 10.1111/jfbc.13267 32378224 · DOI
  17. [17]Skaba D. Morawiec T. Tanasiewicz M. Influence of the toothpaste with Brazilian ethanol extract propolis on the oral cavity health Evidence-Based Complementary and Alternative Medicine 2013 2013 12 215391 10.1155/2013/215391 2-s2.0-84879340719 PMC3687592 23861699 · DOI
  18. [18]Anjaly K. Tiku A. B. Caffeic acid phenethyl ester induces radiosensitization via inhibition of DNA damage repair in androgen-independent prostate cancer cells Environmental Toxicology 2022 37 5 995 1006 10.1002/tox.23459 35006630 · DOI
  19. [19]Paulino N. Coutinho L. A. Coutinho J. R. Vilela G. C. Silva Leandro V. P. D. Paulino A. S. Antiulcerogenic effect of Brazilian propolis formulation in mice Pharmacology & Pharmacy 2015 6 12 580 588 10.4236/pp.2015.612060 · DOI
  20. [20]Sabir A. Sumidarti A. Interleukin-6 expression on inflamed rat dental pulp tissue after capped with Trigona sp. propolis from south Sulawesi, Indonesia Saudi Journal of Biological Sciences 2017 24 5 1034 1037 10.1016/j.sjbs.2016.12.019 2-s2.0-85009736755 28663700 PMC5478294 · DOI
  21. [21]Meneghelli C. Joaquim L. S. D. Félix G. L. Q. Southern Brazilian autumnal propolis shows anti-angiogenic activity: an in vitro and in vivo study Microvascular Research 2013 88 1 11 10.1016/j.mvr.2013.03.003 2-s2.0-84878604056 23538317 · DOI
  22. [22]Alsherbiny M. A. Bhuyan D. J. Radwan I. Chang D. Li C. G. Metabolomic identification of anticancer metabolites of Australian propolis and proteomic elucidation of its synergistic mechanisms with doxorubicin in the MCF7 cells International Journal of Molecular Sciences 2021 22 15 p. 7840 10.3390/ijms22157840 34360606 PMC8346082 · DOI
  23. [23]Badr G. Sayed E. A. Waly H. Hassan K. A. H. Mahmoud M. H. Selamoglu Z. The therapeutic mechanisms of propolis against CCl4 -mediated liver injury by mediating apoptosis of activated hepatic Stellate cells and improving the hepatic architecture through PI3K/AKT/mTOR, TGF-β/Smad2, Bcl2/BAX/P53 and iNOS signaling pathways Cellular Physiology and Biochemistry 2019 53 2 301 322 10.33594/000000140 2-s2.0-85070522073 31343125 · DOI
  24. [24]Bonfim A. P. Sakita K. M. Faria D. R. Preclinical approaches in vulvovaginal candidiasis treatment with mucoadhesive thermoresponsive systems containing propolis PLoS One 2020 15 12 e0243197 10.1371/journal.pone.0243197 PMC7732059 33306677 · DOI
  25. [25]Coskun Z. M. Ersoz M. Gecili M. Ozden A. Acar A. Cytotoxic and apoptotic effects of ethanolic propolis extract on C6 glioma cells Environmental Toxicology 2020 35 7 768 773 10.1002/tox.22911 32061154 · DOI
  26. [26]Rivera-Yañez N. Rodriguez-Canales M. Nieto-Yañez O. Hypoglycaemic and antioxidant effects of propolis of chihuahua in a model of experimental diabetes Evidence-Based Complementary and Alternative Medicine 2018 2018 10 4360356 10.1155/2018/4360356 2-s2.0-85045035787 PMC5866899 29713363 · DOI · Paper page
  27. [27]Ji C. Pan Y. Xu S. Propolis ameliorates restenosis in hypercholesterolemia rabbits with carotid balloon injury by inhibiting lipid accumulation, oxidative stress, and TLR4/NF-κB pathway Journal of Food Biochemistry 2021 45 4 e13577 10.1111/jfbc.13577 33729587 · DOI
  28. [28]Barary M. Hosseinzadeh R. Kazemi S. The effect of propolis on 5-fluorouracil-induced cardiac toxicity in rats Scientific Reports 2022 12 1 p. 8661 10.1038/s41598-022-12735-y PMC9127097 35606482 · DOI
  29. [29]Song M. Y. Lee D. Y. Kim E. H. Anti-inflammatory and anti-oxidative effect of Korean propolis on helicobacter pylori-induced gastric damage in vitro Journal of Microbiology 2020 58 10 878 885 10.1007/s12275-020-0277-z 32876916 · DOI
  30. [30]Sehn E. Hernandes L. Franco S. L. Goncalves C. Baesso M. Dynamics of reepithelialisation and penetration rate of a bee propolis formulation during cutaneous wounds healing Analytica Chimica Acta 2009 635 1 115 120 10.1016/j.aca.2009.01.019 2-s2.0-59049096655 19200487 · DOI
  31. [31]Afkhamizadeh M. Aboutorabi R. Ravari H. Topical propolis improves wound healing in patients with diabetic foot ulcer: a randomized controlled trial Natural Product Research 2018 32 17 2096 2099 10.1080/14786419.2017.1363755 2-s2.0-85028525980 28826262 · DOI
  32. [32]Bretz W. A. Chiego D. J. Jr. Marcucci M. C. Cunha I. Custodio A. Schneider L. G. Preliminary report on the effects of propolis on wound healing in the dental pulp Zeitschrift Für Naturforschung C 1998 53 11-12 1045 1048 10.1515/znc-1998-11-1217 9933969 · DOI
  33. [34]Kwiecińska-Piróg J. Skowron K. Śniegowska A. The impact of ethanol extract of propolis on biofilm forming by proteus mirabilis strains isolated from chronic wounds infections Natural Product Research 2019 33 22 3293 3297 10.1080/14786419.2018.1470513 2-s2.0-85046496542 29726711 · DOI
  34. [35]Jacob A. Parolia A. Pau A. Davamani Amalraj F. The effects of Malaysian propolis and Brazilian red propolis on connective tissue fibroblasts in the wound healing process BMC Complementary and Alternative Medicine 2015 15 1 p. 294 10.1186/s12906-015-0814-1 2-s2.0-84939785541 26303848 PMC4549008 · DOI
  35. [37]Likitpongpipat N. Sangmaneedet S. Klanrit P. Noisombut R. Krisanaprakornkit S. Chailertvanitkul P. Promotion of dental pulp wound healing in New Zealand white rabbits’ teeth by Thai propolis product Journal of Veterinary Dentistry 2019 36 1 17 24 10.1177/0898756418818891 2-s2.0-85059322120 30587093 · DOI
  36. [38]Huanbutta K. Sittikijyothin W. Sangnim T. Development of topical natural based film forming system loaded propolis from stingless bees for wound healing application Journal of Pharmaceutical Investigation 2020 50
  37. [39]Berretta A. A. Nascimento A. P. Bueno P. C. P. de Oliveira Lima Leite Vaz M. M. Marchetti J. M. Propolis standardized extract (EPP-AF®), an innovative chemically and biologically reproducible pharmaceutical compound for treating wounds International Journal of Biological Sciences 2012 8 4 512 521 10.7150/ijbs.3641 2-s2.0-84859522503 22457606 PMC3314192 · DOI · Paper page
  38. [40]Eskandarinia A. Kefayat A. Gharakhloo M. A propolis enriched polyurethane-hyaluronic acid nanofibrous wound dressing with remarkable antibacterial and wound healing activities International Journal of Biological Macromolecules 2020 149 467 476 10.1016/j.ijbiomac.2020.01.255 32001284 · DOI
  39. [41]Stojko M. Włodarczyk J. Sobota M. Biodegradable electrospun nonwovens releasing propolis as a promising dressing material for burn wound treatment Pharmaceutics 2020 12 9 p. 883 10.3390/pharmaceutics12090883 PMC7558515 32957509 · DOI
  40. [42]Eskandarinia A. Kefayat A. Rafienia M. Agheb M. Navid S. Ebrahimpour K. Cornstarch-based wound dressing incorporated with hyaluronic acid and propolis: in vitro and in vivo studies Carbohydrate Polymers 2019 216 25 35 10.1016/j.carbpol.2019.03.091 2-s2.0-85063780245 31047065 · DOI
  41. [43]Marquele-Oliveira F. da Silva Barud H. Torres E. C. Development, characterization and pre-clinical trials of an innovative wound healing dressing based on propolis (EPP-AF®)-containing self-microemulsifying formulation incorporated in biocellulose membranes International Journal of Biological Macromolecules 2019 136 570 578 10.1016/j.ijbiomac.2019.05.135 2-s2.0-85067519489 31226369 · DOI
  42. [44]Barud H. D. S. de Araújo Júnior A. M. Saska S. Antimicrobial Brazilian propolis (EPP-AF) containing biocellulose membranes as promising biomaterial for skin wound healing Evidence-Based Complementary and Alternative Medicine 2013 2013 10 703024 10.1155/2013/703024 2-s2.0-84880178217 PMC3690832 23840264 · DOI
  43. [45]Baygar T. Characterization of silk sutures coated with propolis and biogenic silver nanoparticles (AgNPs); an eco-friendly solution with wound healing potential against surgical site infections (SSIs) Turkish Journal of Medical Sciences 2020 50 1 258 266 10.3906/sag-1906-48 31655520 PMC7080367 · DOI
  44. [47]Bruno S. Grange C. C. Collino F. Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury PLoS One 2012 7 3 e33115 10.1371/journal.pone.0033115 2-s2.0-84858185865 PMC3303802 22431999 · DOI
  45. [48]Gatti S. Bruno S. Deregibus M. C. Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury Nephrology Dialysis Transplantation 2011 26 5 1474 1483 10.1093/ndt/gfr015 2-s2.0-79955571241 21324974 · DOI
  46. [49]Pessolato A. G. T. Martins D. D. S. Ambrósio C. E. Mancanares C. A. F. de Carvalho A. F. Propolis and amnion reepithelialise second-degree burns in rats Burns 2011 37 7 1192 1201 10.1016/j.burns.2011.05.016 2-s2.0-80052961645 21741176 · DOI
  47. [50]de Almeida E. B. Cordeiro Cardoso J. Karla de Lima A. The incorporation of Brazilian propolis into collagen-based dressing films improves dermal burn healing Journal of Ethnopharmacology 2013 147 2 419 425 10.1016/j.jep.2013.03.031 2-s2.0-84876948041 23542143 · DOI · Paper page
  48. [52]Bayrami M. Bayrami A. Habibi-Yangjeh A. Biologically-synthesised ZnO/CuO/Ag nanocomposite using propolis extract and coated on the gauze for wound healing applications IET Nanobiotechnology 2020 14 7 548 554 10.1049/iet-nbt.2020.0024 33010129 PMC8676286 · DOI
  49. [53]Eyarefe O. D. Ozota C. A. Jarikre T. A. Emikpe B. O. Pathological and immunohistochemical evaluation of wound healing potential of Nigerian bee propolis in albino rats Comparative Clinical Pathology 2019 28 2 455 466 10.1007/s00580-018-2873-4 2-s2.0-85058855516 · DOI
  50. [54]Nani M. Leone A. Bom V. P. Evaluation and comparison of wound healing properties of an ointment (alpaWash) containing Brazilian micronized propolis and peucedanum ostruthium leaf extract in skin ulcer in rats International Journal of Pharmaceutical Compounding 2018 22 2 154 163 29877862
  51. [55]Gheib N. Farzam A. Habibian Z. Samiee-Rad F. The effect of oral consumption of propolis alone and in combination with silver nanoparticles on wound healing in male wistar rats Wound Management & Prevention 2020 66 4 38 46 10.25270/wmp.2020.4.3846 32294058 · DOI
  52. [56]Ernawati D. S. Puspa A. Expression of vascular endothelial growth factor and matrix metalloproteinase-9 in Apis mellifera Lawang propolis extract gel-treated traumatic ulcers in diabetic rats Veterinary World 2018 11 3 304 309 10.14202/vetworld.2018.304-309 2-s2.0-85044039370 29657421 PMC5891844 · DOI
  53. [57]Kiderman A. Torten R. Furst A. L. Reinus K. Bilateral eosinophilic ulcers in an infant treated with propolis Journal of Dermatological Treatment 2001 12 1 29 31 10.1080/095466301750163554 2-s2.0-0035040585 12171685 · DOI
  54. [58]Samet N. Laurent C. Susarla S. M. Samet-Rubinsteen N. The effect of bee propolis on recurrent aphthous stomatitis: a pilot study Clinical Oral Investigations 2007 11 2 143 147 10.1007/s00784-006-0090-z 2-s2.0-34249714761 17285269 · DOI
  55. [59]Santos V. R. Gomes R. T. Mesquita R. A. D. Efficacy of Brazilian propolis gel for the management of denture stomatitis: a pilot study Phytotherapy Research 2008 22 11 1544 1547 10.1002/ptr.2541 2-s2.0-57349168699 18696746 · DOI
  56. [60]Kucharzewski M. Kozka M. Urbanek T. Topical treatment of nonhealing venous leg ulcer wit h propolis ointment Evidence-Based Complementary and Alternative Medicine 2013 2013 5 254017 10.1155/2013/254017 2-s2.0-84877276610 PMC3639626 23662121 · DOI
  57. [61]Bergin S. M. Wraight P. Silver based wound dressings and topical agents for treating diabetic foot ulcers Cochrane Database of Systematic Reviews 2006 2006 1 CD005082 10.1002/14651858.CD005082.pub2 16437516 · DOI
  58. [62]Henshaw F. R. Bolton T. Nube V. Topical application of the bee hive protectant propolis is well tolerated and improves human diabetic foot ulcer healing in a prospective feasibility study Journal of Diabetes and Its Complications 2014 28 6 850 857 10.1016/j.jdiacomp.2014.07.012 2-s2.0-84908300106 25239451 · DOI
  59. [63]Hozzein W. N. Badr G. Al Ghamdi A. A. Sayed A. Al-Waili N. S. Garraud O. Topical application of propolis enhances cutaneous wound healing by promoting TGF-beta/Smad-mediated collagen production in a streptozotocin-induced type I diabetic mouse model Cellular Physiology and Biochemistry 2015 37 3 940 954 10.1159/000430221 2-s2.0-84942279422 26381245 · DOI
  60. [64]Mujica V. Orrego R. Fuentealba R. Leiva E. Zuniga-Hernandez J. Propolis as an adjuvant in the healing of human diabetic foot wounds receiving care in the diagnostic and treatment centre from the regional hospital of Talca Journal of Diabetes Research 2019 2019 10 2507578 10.1155/2019/2507578 2-s2.0-85072738660 PMC6757282 31612147 · DOI
  61. [65]Peng D. Z. The pathogenetic factors, molecular mechanism and the management strategies of postburn inflammatory reaction Chinese Journal of Burns 2005 21 6 405 409 16480612
  62. [66]Guimarães N. S. Mello J. C. Paiva J. S. Baccharis dracunculifolia, the main source of green propolis, exhibits potent antioxidant activity and prevents oxidative mitochondrial damage Food and Chemical Toxicology 2012 50 3-4 1091 1097 10.1016/j.fct.2011.11.014 2-s2.0-84856478927 22119782 · DOI
  63. [67]Oztürk F. Kurt E. Cerçi M. The effect of propolis extract in experimental chemical corneal injury Ophthalmic Research 2000 32 1 13 18 10.1159/000055581 2-s2.0-0342545470 10657750 · DOI
  64. [68]McLennan S. V. Bonner J. Milne S. The anti-inflammatory agent propolis improves wound healing in a rodent model of experimental diabetes Wound Repair and Regeneration 2008 16 5 706 713 10.1111/j.1524-475x.2008.00421.x 2-s2.0-51349114196 19128266 · DOI
  65. [69]Gregory S. R. Piccolo N. Piccolo M. T. Piccolo M. S. Heggers J. P. Comparison of propolis skin cream to silver sulfadiazine:a naturopathic alternative to antibiotics in treatment of minor burns Journal of Alternative & Complementary Medicine 2002 8 1 77 83 10.1089/107555302753507203 2-s2.0-0036182686 11890438 · DOI
  66. [70]Picolotto A. Pergher D. Pereira G. P. Bacterial cellulose membrane associated with red propolis as phytomodulator: improved healing effects in experimental models of diabetes mellitus Biomedicine & Pharmacotherapy 2019 112 108640 10.1016/j.biopha.2019.108640 2-s2.0-85061804098 30784929 · DOI
  67. [71]Ashcroft G. S. Yang X. Glick A. B. Mice lacking smad3 show accelerated wound healing and an impaired local inflammatory response Nature Cell Biology 1999 1 5 260 266 10.1038/12971 2-s2.0-0033195998 10559937 · DOI · Paper page
  68. [72]Mirzoeva O. K. Calder P. C. The effect of propolis and its components on eicosanoid production during the inflammatory response Prostaglandins, Leukotrienes and Essential Fatty Acids 1996 55 6 441 449 10.1016/s0952-3278(96)90129-5 2-s2.0-0030457644 9014224 · DOI
  69. [73]Song Y. S. Park E. H. Hur G. M. Ryu Y. S. Kim Y. M. Jin C. Ethanol extract of propolis inhibits nitric oxide synthase gene expression and enzyme activity Journal of Ethnopharmacology 2002 80 2-3 155 161 10.1016/s0378-8741(02)00023-5 2-s2.0-0036240197 12007705 · DOI
  70. [74]Tan-No K. Nakajima T. Shoji T. Anti-inflammatory effect of propolis through inhibition of nitric oxide production on carrageenin-induced mouse paw edema Biological and Pharmaceutical Bulletin 2006 29 1 96 99 10.1248/bpb.29.96 2-s2.0-29844449645 16394518 · DOI
  71. [75]Cao X. P. Chen Y. F. Zhang J. L. You M. M. Wang K. Hu F. L. Mechanisms underlying the wound healing potential of propolis based on its in vitro antioxidant activity Phytomedicine 2017 34 76 84 10.1016/j.phymed.2017.06.001 2-s2.0-85028000961 28899513 · DOI
  72. [76]Veloz J. J. Alvear M. Salazar L. A. Antimicrobial and antibiofilm activity against streptococcus mutans of individual and mixtures of the main polyphenolic compounds found in chilean propolis BioMed Research International 2019 2019 7 7602343 10.1155/2019/7602343 2-s2.0-85060155259 PMC6334332 30719447 · DOI
  73. [77]Lupatini N. R. J. Danopoulos P. Swikidisa R. Alves P. V. Evaluation of the antibacterial activity of green propolis extract and meadowsweet extract against Staphylococcus aureus bacteria: importance in would care compounding preparations International Journal of Pharmaceutical Compounding 2016 20 4 333 337 28333678
  74. [78]Khodabakhshi D. Eskandarinia A. Kefayat A. In vitro and in vivo performance of a propolis-coated polyurethane wound dressing with high porosity and antibacterial efficacy Colloids and Surfaces B: Biointerfaces 2019 178 177 184 10.1016/j.colsurfb.2019.03.010 2-s2.0-85062478410 30856587 · DOI
  75. [79]Zancanela D. C. Funari C. S. Herculano R. D. Natural rubber latex membranes incorporated with three different types of propolis: physical-chemistry and antimicrobial behaviours Materials Science and Engineering: C 2019 97 576 582 10.1016/j.msec.2018.12.042 2-s2.0-85059080534 30678944 · DOI
  76. [80]Tosi E. A. Ré E. Ortega M. E. Cazzoli A. F. Food preservative based on propolis: bacteriostatic activity of propolis polyphenols and flavonoids upon Escherichia coli Food Chemistry 2007 104 3 1025 1029 10.1016/j.foodchem.2007.01.011 2-s2.0-34248660811 · DOI
  77. [81]Guo F. B. The antibacterial activity of propolis Journal of Biochemistry 2004 36 3 10 12
  78. [83]Parihar A. Parihar M. S. Milner S. Bhat S. Oxidative stress and anti-oxidative mobilization in burn injury Burns 2008 34 1 6 17 10.1016/j.burns.2007.04.009 2-s2.0-38049185351 17905515 · DOI
  79. [84]Costa P. Somensi L. B. da Silva R. C. M. V. A. F. Role of the antioxidant properties in the gastroprotective and gastric healing activity promoted by Brazilian green propolis and the healing efficacy of artepillin C Inflammopharmacology 2020 28 4 1009 1025 10.1007/s10787-019-00649-7 31745698 · DOI
  80. [85]Ocakci A. Kanter M. Cabuk M. Buyukbas S. Role of caffeic acid phenethyl ester, an active component of propolis, against NAOH-induced esophageal burns in rats International Journal of Pediatric Otorhinolaryngology 2006 70 10 1731 1739 10.1016/j.ijporl.2006.05.018 2-s2.0-33747893741 16828884 · DOI
  81. [86]Wang Y. Y. Huang Y. Y. Juan D. U. Effects of honey and propolis on wound healing in rats with second-degree scald Journal of Tianjin University of Traditional Chinese Medicine 2006 31 03 154 156
  82. [87]Zhang J. L. Wang K. Hu F. L. Advance in studies on antioxidant activity of propolis and its molecular mechanism China Journal of Chinese Materia Medica 2013 38 16 2645 2652 24228580
  83. [88]Olczyk P. Ramos P. Komosinska-Vassev K. Stojko J. Pilawa B. Positive effect of propolis on free radicals in burn wounds Evidence-Based Complementary and Alternative Medicine 2013 2013 12 356737 10.1155/2013/356737 2-s2.0-84878693200 PMC3676959 23762125 · DOI
  84. [89]Aytekin A. A. Tuncay Tanrıverdi S. Aydın Köse F. Kart D. Eroğlu İ Özer Ö Propolis loaded liposomes: evaluation of antimicrobial and antioxidant activities Journal of Liposome Research 2020 30 2 107 116 10.1080/08982104.2019.1599012 30913939 · DOI
  85. [90]Touzani S. Imtara H. Katekhaye S. Determination of phenolic compounds in various propolis samples collected from an African and an asian region and their impact on antioxidant and antibacterial activities Molecules 2021 26 15 p. 4589 10.3390/molecules26154589 34361742 PMC8347760 · DOI
  86. [91]Boufadi M. Y. Soubhye J. Van Antwerpen P. Anti-inflammatory, antioxidant effects, and bioaccessibility of Tigzirt propolis Journal of Food Biochemistry 2021 45 4 e13663 10.1111/jfbc.13663 33605470 · DOI
  87. [92]Martinotti S. Pellavio G. Laforenza U. Ranzato E. Propolis induces AQP3 expression: a possible way of action in wound healing Molecules 2019 24 8 p. 1544 10.3390/molecules24081544 2-s2.0-85064878730 PMC6515181 31010117 · DOI
  88. [93]Sforcin J. M. Propolis and the immune system: a review Journal of Ethnopharmacology 2007 113 1 1 14 10.1016/j.jep.2007.05.012 2-s2.0-34447581120 17580109 · DOI
  89. [94]Dimov V. Ivanovska N. Bankova V. Popov S. Immunomodulatory action of propolis: IV prophylactic activity against gram-negative infections and adjuvant effect of the water-soluble derivative Vaccine 1992 10 12 817 823 10.1016/0264-410x(92)90043-j 2-s2.0-0026700938 1455907 · DOI
  90. [95]Tatefuji T. Izumi N. Ohta T. Arai S. Ikeda M. Kurimoto M. Isolation and identification of compounds from Brazilian propolis which enhance macrophage spreading and mobility Biological & Pharmaceutical Bulletin 1996 19 7 966 970 8839971
  91. [96]Ansorge S. Reinhold D. Lendeckel U. Propolis and some of its constituents down-regulate DNA synthesis and inflammatory cytokine production but induce TGF-β1 production of human immune cells Zeitschrift Für Naturforschung C 2003 58 7-8 580 589 10.1515/znc-2003-7-823 12939048 · DOI
  92. [97]Baum C. L. Arpey C. J. Normal cutaneous wound healing: clinical correlation with cellular and molecular events Dermatologic Surgery 2006 31 6 674 686 10.1111/j.1524-4725.2005.31612 15996419 · DOI
  93. [98]Hiromatsu Y. Toda S. Mast cells and angiogenesis Microscopy Research and Technique 2003 60 1 64 69 10.1002/jemt.10244 2-s2.0-0037221692 12500262 · DOI
  94. [99]Walsh L. J. Mast cells and oral inflammation Critical Reviews in Oral Biology & Medicine 2003 14 3 188 198 10.1177/154411130301400304 2-s2.0-0038544209 12799322 · DOI
  95. [102]Komi D. E. A. Khomtchouk K. Santa Maria P. L. A review of the contribution of mast cells in wound healing: involved molecular and cellular mechanisms Clinical Reviews in Allergy and Immunology 2020 58 3 298 312 10.1007/s12016-019-08729-w 2-s2.0-85061261975 30729428 · DOI
  96. [103]Cho M. S. Park W. S. Jung W. K. Caffeic acid phenethyl ester promotes anti-inflammatory effects by inhibiting MAPK and NF-κB signaling in activated HMC-1 human mast cells Pharmaceutical Biology 2014 52 7 926 932 10.3109/13880209.2013.865243 2-s2.0-84902458209 24920235 · DOI
  97. [104]Nader M. A. Caffeic acid phenethyl ester attenuates IgE-induced immediate allergic reaction Inflammopharmacology 2013 21 2 169 176 10.1007/s10787-012-0138-4 2-s2.0-84879502433 22610380 · DOI
  98. [105]Kanda T. Akiyama H. Yanagida A. Inhibitory effects of apple polyphenol on induced histamine release from RBL-2H3 cells and rat mast cells Bioscience, Biotechnology, and Biochemistry 1998 62 7 1284 1289 10.1271/bbb.62.1284 2-s2.0-0032113292 9720210 · DOI
  99. [106]Kawai M. Hirano T. Higa S. Flavonoids and related compounds as anti-allergic substances Allergology International 2007 56 2 113 123 10.2332/allergolint.r-06-135 2-s2.0-34250795661 17384531 · DOI
  100. [107]Yano S. Umeda D. Yamashita T. Dietary flavones suppresses IgE and Th2 cytokines in OVA-immunized BALB/c mice European Journal of Nutrition 2007 46 5 257 263 10.1007/s00394-007-0658-7 2-s2.0-34547173554 17497073 · DOI
  101. [108]Nakamura R. Nakamura R. Watanabe K. Effects of propolis from different areas on mast cell degranulation and identification of the effective components in propolis International Immunopharmacology 2010 10 9 1107 1112 10.1016/j.intimp.2010.06.013 2-s2.0-77955921601 20601180 · DOI
  102. [109]Bae Y. Lee S. Kim S. H. Chrysin suppresses mast cell-mediated allergic inflammation: involvement of calcium, caspase-1 and nuclear factor-κB Toxicology and Applied Pharmacology 2011 254 1 56 64 10.1016/j.taap.2011.04.008 2-s2.0-79957982285 21515303 · DOI
  103. [110]Barroso P. R. Lopes-Rocha R. Pereira E. M. F. Effect of propolis on mast cells in wound healing Inflammopharmacology 2012 20 5 289 294 10.1007/s10787-011-0105-5 2-s2.0-84866979638 22179947 · DOI
  104. [111]Pippi B. Lana A. J. Moraes R. C. In vitro evaluation of the acquisition of resistance, antifungal activity and synergism of Brazilian red propolis with antifungal drugs on Candida spp Journal of Applied Microbiology 2015 118 4 839 850 10.1111/jam.12746 2-s2.0-84924914555 25565139 · DOI
  105. [112]Stepanović S. Antić N. Dakić I. Svabic-Vlahovic M. In vitro antimicrobial activity of propolis and synergism between propolis and antimicrobial drugs Microbiological Research 2003 158 4 353 357 10.1078/0944-5013-00215 2-s2.0-0347724110 14717457 · DOI
  106. [113]Krol W. Scheller S. Shani J. Pietsz G. Czuba Z. Synergistic effect of ethanolic extract of propolis and antibiotics on the growth of staphylococcus aureus Arzneimittelforschung 1993 43 5 607 609 8329008
  107. [114]Ahn J. C. Biswas R. Chung P. S. Synergistic effect of radachlorin mediated photodynamic therapy on propolis induced apoptosis in AMC-HN-4 cell lines via caspase dependent pathway Photodiagnosis and Photodynamic Therapy 2013 10 3 236 243 10.1016/j.pdpdt.2013.01.005 2-s2.0-84883462094 23993849 · DOI

Cited by

Sorted by citations

Authors
Yang, J., Pi, A., Yan, L., Li, J., Nan, S., Zhang, J., & Hao, Y.
Affiliations
  • Chongqing Normal University (CN)
  • Army Medical University (CN)
Corresponding author
Hao, Yuhui
ORCID
Venue
Evidence-Based Complementary and Alternative Medicine
Publisher
Wiley
Published
2022-07-21
Volume
2022
Pages
1-15
ISSN
  • 1741-427X (ISSN-L)
  • 1741-4288
DOI
10.1155/2022/5798941
PMC
PMC9334088
OpenAlex
W4286492030
Cited by
48
References
5
Citations by year
2026: 3 · 2025: 22 · 2024: 9 · 2023: 9 · 2022: 5
FWCI
1.13
Type
journal article
Language
en
Open access
Licence
Locations
  • Evidence-based Complementary and Alternative Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (18CXZ004, BLJ20J005)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Insect Science › Bee Products Chemical Analysis
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Health Sciences › Medicine › Pharmacology › Healthcare and Venom Research
Keywords
propolis, wound healing, anti-inflammatory activity, antibacterial activity, wound infection, burns, acute wounds, synergistic effect, wound healing mechanisms, bee products

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