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Cited by 19Reproductive Biology and FertilityOvarian function and disordersReproductive biology and impacts on aquatic species

The Key Role of Peroxisomes in Follicular Growth, Oocyte Maturation, Ovulation, and Steroid Biosynthesis

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Wang, Shan, Yang, HaoXuan, Fu, YongLun, Teng, XiaoMing, Wang, ChiChiu, Xu, WenMing·2022·Oxidative Medicine and Cellular Longevity
DOI 10.1155/2022/7982344PMC PMC8831076
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Abstract

The absence of peroxisomes can cause disease in the human reproductive system, including the ovaries. The available peroxisomal gene‐knockout female mouse models, which exhibit pathological changes in the ovary and reduced fertility, are listed in this review. Our review article provides the first systematic presentation of peroxisomal regulation and its possible functions in the ovary. Our immunofluorescence results reveal that peroxisomes are present in all cell types in the ovary; however, peroxisomes exhibit different numerical abundances and strong heterogeneity in their protein composition among distinct ovarian cell types. The peroxisomal compartment is strongly altered during follicular development and during oocyte maturation, which suggests that peroxisomes play protective roles in oocytes against oxidative stress and lipotoxicity during ovulation and in the survival of oocytes before conception. In addition, the peroxisomal compartment is involved in steroid synthesis, and peroxisomal dysfunction leads to disorder in the sexual hormone production process. However, an understanding of the cellular and molecular mechanisms underlying these physiological and pathological processes is lacking. To date, no effective treatment for peroxisome‐related disease has been developed, and only supportive methods are available. Thus, further investigation is needed to resolve peroxisome deficiency in the ovary and eventually promote female fertility.

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  1. [1]McGee E. A. Hsueh A. J. Initial and cyclic recruitment of ovarian follicles Endocrine Reviews 2000 21 2 200 214 10782364
  2. [2]Sharma R. Biedenharn K. R. Fedor J. M. Agarwal A. Lifestyle factors and reproductive health: taking control of your fertility Reproductive Biology and Endocrinology 2013 11 1 10.1186/1477-7827-11-66 2-s2.0-84880085926 PMC3717046 23870423 · DOI
  3. [3]Novikoff A. B. Novikoff P. M. Microperoxisomes The Journal of Histochemistry and Cytochemistry 1973 21 11 963 966 10.1177/21.11.963 2-s2.0-0015807905 4587528 · DOI
  4. [4]Singh D. Pandey R. S. Changes in catalase activity and hydrogen peroxide level in rat ovary during estrous cycle and induction of catalase in rat ovary by estradiol-17 beta Indian Journal of Experimental Biology 1998 36 4 421 423 9717456
  5. [5]Gould S. J. Valle D. Peroxisome biogenesis disorders: genetics and cell biology Trends in Genetics 2000 16 8 340 345 10.1016/S0168-9525(00)02056-4 2-s2.0-0034255179 10904262 · DOI
  6. [6]Moser H. W. Genotype-phenotype correlations in disorders of peroxisome biogenesis Molecular Genetics and Metabolism 1999 68 2 316 327 10.1006/mgme.1999.2926 2-s2.0-0032729864 10527683 · DOI
  7. [7]Wanders R. J. Peroxisomes, lipid metabolism, and peroxisomal disorders Molecular Genetics and Metabolism 2004 83 1-2 16 27 10.1016/j.ymgme.2004.08.016 2-s2.0-4744371532 15464416 · DOI
  8. [8]Wanders R. J. Tager J. M. Lipid metabolism in peroxisomes in relation to human disease Molecular Aspects of Medicine 1998 19 2 69 154 9827430
  9. [9]Lazarow P. B. Peroxisome Structure, Function, and Biogenesis—Human Patients and Yeast Mutants Show Strikingly Similar Defects in Peroxisome Biogenesis Journal of Neuropathology and Experimental Neurology 1995 54 10.1097/00005072-199509000-00015 2-s2.0-0029026096 7666062 · DOI
  10. [10]Moser H. W. Powers J. M. Smith K. D. Adrenoleukodystrophy: molecular genetics, pathology, and Lorenzo’s oil Brain Pathology 1995 5 3 259 266 10.1111/j.1750-3639.1995.tb00602.x 2-s2.0-0029088558 8520725 · DOI
  11. [11]Powers J. M. Adreno-leukodystrophy (adreno-testiculo-leukomyelo-neuropathic-complex) Clinical Neuropathology 1985 4 5 181 199 2998664
  12. [12]Powers J. M. Schaumburg H. H. The testis in adreno-leukodystrophy The American Journal of Pathology 1981 102 1 90 98 7468762 PMC1903430
  13. [13]Distel B. Erdmann R. Gould S. J. A unified nomenclature for peroxisome biogenesis factors The Journal of Cell Biology 1996 135 1 1 3 10.1083/jcb.135.1.1 2-s2.0-10144261887 8858157 PMC2121017 · DOI
  14. [14]Smith J. J. Aitchison J. D. Regulation of peroxisome dynamics Current Opinion in Cell Biology 2009 21 1 119 126 10.1016/j.ceb.2009.01.009 2-s2.0-60749125720 19188056 PMC2681484 · DOI
  15. [15]Hashimoto T. Peroxisomal ?-Oxidation: enzymology and molecular biology Annals of the New York Academy of Sciences 1996 804 1 Peroxisomes 86 98 10.1111/j.1749-6632.1996.tb18610.x 2-s2.0-0030462488 8993538 · DOI
  16. [16]Hashimoto T. Peroxisomal beta-oxidation enzymes Neurochemical Research 1999 24 4 551 563 10.1023/A:1022540030918 2-s2.0-0032918215 10227687 · DOI
  17. [17]Lazarow P. B. De Duve C. A fatty acyl-CoA oxidizing system in rat liver peroxisomes; enhancement by clofibrate, a hypolipidemic drug Proceedings of the National Academy of Sciences of the United States of America 1976 73 6 2043 2046 10.1073/pnas.73.6.2043 2-s2.0-0342528190 180535 PMC430444 · DOI
  18. [18]Kroetz D. L. Yook P. Costet P. Bianchi P. Pineau T. Peroxisome Proliferator-activated Receptor α Controls the Hepatic CYP4A Induction Adaptive Response to Starvation and Diabetes The Journal of Biological Chemistry 1998 273 47 31581 31589 10.1074/jbc.273.47.31581 2-s2.0-0032553545 9813074 · DOI
  19. [20]Elliott B. M. Dodd N. J. Elcombe C. R. Increased hydroxyl radical production in liver peroxisomal fractions from rats treated with peroxisome proliferators Carcinogenesis 1986 7 5 10.1093/carcin/7.5.795 2-s2.0-0022965484 3009047 · DOI
  20. [21]Zwacka R. M. Reuter A. Pfaff E. The glomerulosclerosis gene Mpv17 encodes a peroxisomal protein producing reactive oxygen species The EMBO Journal 1994 13 21 5129 5134 10.1002/j.1460-2075.1994.tb06842.x 7957077 PMC395460 · DOI
  21. [22]Stolz D. B. Zamora R. Vodovotz Y. Peroxisomal localization of inducible nitric oxide synthase in hepatocytes Hepatology 2002 36 1 81 93 10.1053/jhep.2002.33716 2-s2.0-0036288639 12085352 · DOI
  22. [23]Fransen M. Nordgren M. Wang B. Apanasets O. Role of peroxisomes in ROS/RNS-metabolism: implications for human disease Biochimica et Biophysica Acta 2012 1822 9 1363 1373 10.1016/j.bbadis.2011.12.001 2-s2.0-84864050485 22178243 · DOI · Paper page
  23. [24]Droge W. Oxidative stress and aging Advances in Experimental Medicine and Biology 2003 543 191 200 10.1007/978-1-4419-8997-0_14 14713123 · DOI
  24. [25]Saran M. Review Free Radical Research 2003 37 10 1045 1059 10.1080/10715760310001594631 2-s2.0-0142030521 14703794 · DOI
  25. [26]Oshino N. Oshino R. Chance B. The characteristics of the “peroxidatic” reaction of catalase in ethanol oxidation The Biochemical Journal 1973 131 3 555 563 10.1042/bj1310555 2-s2.0-0015592696 4720713 PMC1177502 · DOI
  26. [27]Siraki A. G. Pourahmad J. Chan T. S. Khan S. O’Brien P. J. Endogenous and endobiotic induced reactive oxygen species formation by isolated hepatocytes Free Radical Biology & Medicine 2002 32 1 2 10 10.1016/S0891-5849(01)00764-X 2-s2.0-0036138662 11755311 · DOI
  27. [28]Chance B. Sies H. Boveris A. Hydroperoxide metabolism in mammalian organs Physiological Reviews 1979 59 3 527 605 10.1152/physrev.1979.59.3.527 2-s2.0-0018776894 37532 · DOI · Paper page
  28. [29]McCord J. M. Keele B. B. Jr. Fridovich I. An enzyme-based theory of obligate anaerobiosis: the physiological function of superoxide dismutase Proceedings of the National Academy of Sciences of the United States of America 1971 68 5 1024 1027 10.1073/pnas.68.5.1024 2-s2.0-0015056379 4995818 PMC389105 · DOI
  29. [30]Schriner S. E. Linford N. J. Martin G. M. Extension of murine life span by overexpression of catalase targeted to mitochondria Science 2005 308 5730 1909 1911 10.1126/science.1106653 2-s2.0-21144434217 15879174 · DOI · Paper page
  30. [31]Fumie H. Hidenori H. Significance of catalase in peroxisomal fatty acyl-CoA β-oxidation Biochimica et Biophysica Acta 1987 921 1 142 150 10.1016/0005-2760(87)90180-9 2-s2.0-0023644049 2887206 · DOI
  31. [32]Litwin J. A. Beier K. Volkl A. Hofmann W. J. Fahimi H. D. Immunocytochemical investigation of catalase and peroxisomal lipid β-oxidation enzymes in human hepatocellular tumors and liver cirrhosis Virchows Archiv 1999 435 5 486 495 10.1007/s004280050432 2-s2.0-0032754922 10592052 · DOI
  32. [33]Lauer C. Volkl A. Riedl S. Fahimi H. D. Beier K. Impairment of peroxisomal biogenesis in human colon carcinoma Carcinogenesis 1999 20 6 985 989 10.1093/carcin/20.6.985 2-s2.0-0345211519 10357777 · DOI
  33. [34]Antonenkov V. D. Grunau S. Ohlmeier S. Hiltunen J. K. Peroxisomes are oxidative organelles Antioxidants & Redox Signaling 2010 13 4 525 537 10.1089/ars.2009.2996 2-s2.0-77954484645 19958170 · DOI
  34. [35]Brites P. Waterham H. R. Wanders R. J. Functions and biosynthesis of plasmalogens in health and disease Biochimica et Biophysica Acta 2004 1636 2-3 219 231 10.1016/j.bbalip.2003.12.010 2-s2.0-2942633430 15164770 · DOI
  35. [36]Keller G. A. Barton M. C. Shapiro D. J. Singer S. J. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase is present in peroxisomes in normal rat liver cells Proceedings of the National Academy of Sciences of the United States of America 1985 82 3 770 774 10.1073/pnas.82.3.770 2-s2.0-0021961770 3883347 PMC397128 · DOI
  36. [37]Kovacs W. J. Olivier L. M. Krisans S. K. Central role of peroxisomes in isoprenoid biosynthesis Progress in Lipid Research 2002 41 5 369 391 10.1016/S0163-7827(02)00002-4 2-s2.0-0036018142 12121718 · DOI
  37. [38]Kovacs W. J. Tape K. N. Shackelford J. E. Localization of the pre-squalene segment of the isoprenoid biosynthetic pathway in mammalian peroxisomes Histochemistry and Cell Biology 2007 127 3 273 290 10.1007/s00418-006-0254-6 2-s2.0-33846991643 17180682 · DOI
  38. [39]Kovacs W. J. Shackelford J. E. Tape K. N. Disturbed cholesterol homeostasis in a Peroxisome-DeficientPEX2Knockout mouse model Molecular and Cellular Biology 2004 24 1 1 13 10.1128/MCB.24.1.1-13.2004 2-s2.0-0346993671 14673138 PMC303355 · DOI
  39. [40]Grant P. Ahlemeyer B. Karnati S. The biogenesis protein PEX14 is an optimal marker for the identification and localization of peroxisomes in different cell types, tissues, and species in morphological studies Histochemistry and Cell Biology 2013 140 4 423 442 10.1007/s00418-013-1133-6 2-s2.0-84885421198 23959168 · DOI
  40. [41]Bock P. Peroxisomes in the mouse ovary Zeitschrift für Zellforschung und Mikroskopische Anatomie 1972 133 1 131 140 10.1007/BF00307072 2-s2.0-0015475615 4117132 · DOI
  41. [42]El Mouatassim S. Guerin P. Menezo Y. Expression of genes encoding antioxidant enzymes in human and mouse oocytes during the final stages of maturation Molecular Human Reproduction 1999 5 8 720 725 10.1093/molehr/5.8.720 2-s2.0-0344035676 10421798 · DOI
  42. [43]Roels F. Tytgat T. Beken S. Peroxisome mosaics in the liver of patients and the regulation of peroxisome expression in rat hepatocyte cultures Annals of the New York Academy of Sciences 1996 804 1 Peroxisomes 502 515 10.1111/j.1749-6632.1996.tb18640.x 2-s2.0-0030481713 8993568 · DOI
  43. [44]Harvey M. B. Arcellana-Panlilio M. Y. Zhang X. Schultz G. A. Watson A. J. Expression of genes encoding antioxidant enzymes in preimplantation mouse and cow embryos and primary bovine oviduct cultures employed for embryo Coculture1 Biology of Reproduction 1995 53 3 532 540 10.1095/biolreprod53.3.532 2-s2.0-0029082406 7578676 · DOI
  44. [45]Figueroa C. Kawada M. E. Véliz L. P. Peroxisomal proteins in rat gametes Cell Biochemistry and Biophysics 2000 32 1-3 259 268 10.1385/CBB:32:1-3:259 2-s2.0-0034577989 11330055 · DOI
  45. [46]Eppig J. J. Intercommunication between mammalian oocytes and companion somatic cells BioEssays 1991 13 11 569 574 10.1002/bies.950131105 2-s2.0-0026251723 1772412 · DOI
  46. [47]Beyer E. C. Gap junctions International Review of Cytology 1993 137C 1 37 8387468
  47. [48]Kumar N. M. Gilula N. B. The gap junction communication channel Cell 1996 84 3 381 388 10.1016/S0092-8674(00)81282-9 2-s2.0-0030028301 8608591 · DOI
  48. [49]Taniguchi Ishikawa E. Gonzalez-Nieto D. Ghiaur G. Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells Proceedings of the National Academy of Sciences of the United States of America 2012 109 23 9071 9076 10.1073/pnas.1120358109 2-s2.0-84861872402 22611193 PMC3384185 · DOI
  49. [50]Al-Gubory K. H. Fowler P. A. Garrel C. The roles of cellular reactive oxygen species, oxidative stress and antioxidants in pregnancy outcomes The International Journal of Biochemistry & Cell Biology 2010 42 10 1634 1650 10.1016/j.biocel.2010.06.001 2-s2.0-77956185722 20601089 · DOI
  50. [51]Wang S. He G. Chen M. Zuo T. Xu W. Liu X. The role of antioxidant enzymes in the ovaries Oxidative Medicine and Cellular Longevity 2017 2017 14 4371714 10.1155/2017/4371714 2-s2.0-85031896489 PMC5632900 29147461 · DOI
  51. [52]Guerin P. El Mouatassim S. Menezo Y. Oxidative stress and protection against reactive oxygen species in the pre-implantation embryo and its surroundings Human Reproduction Update 2001 7 2 175 189 10.1093/humupd/7.2.175 2-s2.0-0035102208 11284661 · DOI
  52. [53]Tatemoto H. Sakurai N. Muto N. Protection of porcine oocytes against apoptotic cell death caused by oxidative stress during in vitro maturation: role of cumulus Cells1 Biology of Reproduction 2000 63 3 805 810 10.1095/biolreprod63.3.805 2-s2.0-0033846209 10952924 · DOI
  53. [54]Liu L. Trimarchi J. R. Keefe D. L. Involvement of mitochondria in oxidative stress-induced cell death in mouse Zygotes1 Biology of Reproduction 2000 62 6 1745 1753 10.1095/biolreprod62.6.1745 2-s2.0-0034076245 10819779 · DOI
  54. [55]Agarwal A. Aponte-Mellado A. Premkumar B. J. Shaman A. Gupta S. The effects of oxidative stress on female reproduction: a review Reproductive Biology and Endocrinology 2012 10 1 p. 49 10.1186/1477-7827-10-49 2-s2.0-84862986432 PMC3527168 22748101 · DOI
  55. [56]Devine P. J. Perreault S. D. Luderer U. Roles of reactive oxygen species and antioxidants in ovarian Toxicity1 Biology of Reproduction 2012 86 2 p. 27 10.1095/biolreprod.111.095224 2-s2.0-84860231131 PMC3290661 22034525 · DOI
  56. [57]Fujii J. Iuchi Y. Okada F. Fundamental roles of reactive oxygen species and protective mechanisms in the female reproductive system Reproductive Biology and Endocrinology 2005 3 1 10.1186/1477-7827-3-43 2-s2.0-27344460746 PMC1224869 16137335 · DOI
  57. [59]Peterson S. L. Stevenson P. M. Changes in catalase activity and concentration during ovarian development and differentiation Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1992 1135 2 207 214 10.1016/0167-4889(92)90138-2 2-s2.0-0026766935 1616939 · DOI
  58. [60]Basini G. Simona B. Santini S. E. Grasselli F. Reactive oxygen species and anti-oxidant defences in swine follicular fluids Reproduction, Fertility, and Development 2008 20 2 269 274 10.1071/RD07147 2-s2.0-38549092056 18255016 · DOI
  59. [61]El-Shahat K. H. Kandil M. Antioxidant capacity of follicular fluid in relation to follicular size and stage of estrous cycle in buffaloes Theriogenology 2012 77 8 10.1016/j.theriogenology.2011.11.018 2-s2.0-84859423448 22341505 · DOI
  60. [62]Behl R. Pandey R. S. FSH induced stimulation of catalase activity in goat granulosa cells in vitro Animal Reproduction Science 2002 70 3-4 215 221 10.1016/S0378-4320(02)00006-4 2-s2.0-0037089002 11943491 · DOI
  61. [63]Parshad R. K. Guraya S. S. Changes in catalase activity during follicular growth, atresia and luteinization in rat ovary Indian Journal of Experimental Biology 1993 31 2 109 111 8500825
  62. [64]Angelucci S. Ciavardelli D. di Giuseppe F. Proteome analysis of human follicular fluid Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 2006 1764 11 10.1016/j.bbapap.2006.09.001 2-s2.0-33846014267 17067859 · DOI
  63. [65]Combelles C. M. Holick E. A. Paolella L. J. Walker D. C. Wu Q. Profiling of superoxide dismutase isoenzymes in compartments of the developing bovine antral follicles Reproduction 2010 139 5 871 881 10.1530/REP-09-0390 2-s2.0-77951570818 20197373 PMC3244472 · DOI
  64. [66]Hozyen H. F. Ahmed H. H. Essawy G. E. Shalaby S. I. Seasonal changes in some oxidant and antioxidant parameters during folliculogenesis in Egyptian buffalo Animal Reproduction Science 2014 151 3-4 10.1016/j.anireprosci.2014.10.005 2-s2.0-84922746732 25458317 · DOI
  65. [67]Du B. Takahashi K. Ishida G. M. Nakahara K. Saito H. Kurachi H. Usefulness of intraovarian artery pulsatility and resistance indices measurement on the day of follicle aspiration for the assessment of oocyte quality Fertility and Sterility 2006 85 2 366 370 10.1016/j.fertnstert.2005.07.1316 2-s2.0-31644442045 16595213 · DOI
  66. [68]Espey L. L. Current status of the hypothesis that mammalian ovulation is comparable to an inflammatory reaction Biology of Reproduction 1994 50 2 233 238 10.1095/biolreprod50.2.233 2-s2.0-0028127924 8142541 · DOI
  67. [69]Stouffer R. L. Xu F. Duffy D. M. Molecular control of ovulation and luteinization in the primate follicle Frontiers in Bioscience 2007 12 1 297 307 10.2741/2065 2-s2.0-34249799914 17127300 · DOI
  68. [70]Rizzo A. Roscino M. T. Binetti F. Sciorsci R. L. Roles of reactive oxygen species in female reproduction Reproduction in Domestic Animals 2012 47 2 344 352 10.1111/j.1439-0531.2011.01891.x 2-s2.0-84858438063 22022825 · DOI
  69. [71]Park Y. S. You S. Y. Cho S. Eccentric localization of catalase to protect chromosomes from oxidative damages during meiotic maturation in mouse oocytes Histochemistry and Cell Biology 2016 146 3 281 288 10.1007/s00418-016-1446-3 2-s2.0-84966642549 27160095 · DOI
  70. [72]Tilly J. L. Tilly K. I. Inhibitors of oxidative stress mimic the ability of follicle-stimulating hormone to suppress apoptosis in cultured rat ovarian follicles Endocrinology 1995 136 1 242 252 10.1210/endo.136.1.7828537 2-s2.0-0028836515 7828537 · DOI
  71. [73]Rueda B. R. Tilly K. I. Hansen T. R. Hoyer P. B. Tilly J. L. Expression of superoxide dismutase, catalase and glutathione peroxidase in the bovine corpus luteum: evidence supporting a role for oxidative stress in luteolysis Endocrine 1995 3 3 227 232 10.1007/BF02994448 2-s2.0-0028893398 21153199 · DOI
  72. [74]Sim C. Denlinger D. L. Catalase and superoxide dismutase-2 enhance survival and protect ovaries during overwintering diapause in the mosquito Culex pipiens Journal of Insect Physiology 2011 57 5 628 634 10.1016/j.jinsphys.2011.01.012 2-s2.0-79957494806 21277308 PMC3104096 · DOI
  73. [75]Nagan N. Zoeller R. A. Plasmalogens: biosynthesis and functions Progress in Lipid Research 2001 40 3 199 229 10.1016/S0163-7827(01)00003-0 2-s2.0-0035102918 11275267 · DOI
  74. [76]Prates E. G. Alves S. P. Marques C. C. Fatty acid composition of porcine cumulus oocyte complexes (COC) during maturation: effect of the lipid modulators trans-10, cis-12 conjugated linoleic acid (t10,c12 CLA) and forskolin In Vitro Cellular & Developmental Biology. Animal 2013 49 5 335 345 10.1007/s11626-013-9624-2 2-s2.0-84878012849 23645468 · DOI
  75. [77]Karnati S. Baumgart-Vogt E. Peroxisomes in mouse and human lung: their involvement in pulmonary lipid metabolism Histochemistry and Cell Biology 2008 130 4 719 740 10.1007/s00418-008-0462-3 2-s2.0-51249112758 18665385 · DOI
  76. [78]Wang S. Role of peroxisomes in granulosa cells, follicular development and steroidogenesis in the mouse ovary, [Ph. D. thesis] 2018 Justus Liebig University Giessen
  77. [79]Wu L. L. Dunning K. R. Yang X. High-fat diet causes lipotoxicity responses in cumulus-oocyte complexes and decreased fertilization rates Endocrinology 2010 151 11 5438 5445 10.1210/en.2010-0551 2-s2.0-77957727931 20861227 · DOI
  78. [80]Yang X. Dunning K. R. Wu L. L. Identification of perilipin-2 as a lipid droplet protein regulated in oocytes during maturation Reproduction, Fertility, and Development 2010 22 8 1262 1271 10.1071/RD10091 2-s2.0-77957736605 20883652 · DOI
  79. [81]Hajra A. K. Larkins L. K. Das A. K. Hemati N. Erickson R. L. MacDougald O. A. Induction of the Peroxisomal Glycerolipid-synthesizing Enzymes during Differentiation of 3T3-L1 Adipocytes: The Journal of Biological Chemistry 2000 275 13 9441 9446 10.1074/jbc.275.13.9441 2-s2.0-0034737640 10734090 · DOI
  80. [82]Dieuaide-Noubhani M. Asselberghs S. Mannaerts G. P. Veldhoven V. Evidence that multifunctional protein 2, and not multifunctional protein 1, is involved in the peroxisomal β-oxidation of pristanic acid The Biochemical Journal 1997 325 2 367 373 10.1042/bj3250367 2-s2.0-0030851630 9230115 PMC1218569 · DOI
  81. [83]Reddy J. K. Mannaerts G. P. Peroxisomal lipid metabolism Annual Review of Nutrition 1994 14 1 343 370 10.1146/annurev.nu.14.070194.002015 7946524 · DOI
  82. [84]Sturmey R. G. O'Toole P. J. Leese H. J. Fluorescence resonance energy transfer analysis of mitochondrial:lipid association in the porcine oocyte Reproduction 2006 132 6 829 837 10.1530/REP-06-0073 2-s2.0-33845967794 17127743 · DOI
  83. [85]Dunning K. R. Cashman K. Russell D. L. Thompson J. G. Norman R. J. Robker R. L. Beta-oxidation is essential for mouse oocyte developmental competence and early embryo Development1 Biology of Reproduction 2010 83 6 909 918 10.1095/biolreprod.110.084145 2-s2.0-77957729516 20686180 · DOI
  84. [86]Downs S. M. Mosey J. L. Klinger J. Fatty acid oxidation and meiotic resumption in mouse oocytes Molecular Reproduction and Development 2009 76 9 844 853 10.1002/mrd.21047 2-s2.0-67650854463 19455666 PMC3995453 · DOI
  85. [87]Paczkowski M. Silva E. Schoolcraft W. B. Krisher R. L. Comparative importance of fatty acid beta-oxidation to nuclear maturation, gene expression, and glucose metabolism in mouse, bovine, and porcine cumulus oocyte Complexes1 Biology of Reproduction 2013 88 5 p. 111 10.1095/biolreprod.113.108548 23536372 · DOI
  86. [88]Marei W. F. Wathes D. C. Fouladi-Nashta A. A. Impact of linoleic acid on bovine oocyte maturation and embryo development Reproduction 2010 139 6 979 988 10.1530/REP-09-0503 2-s2.0-77952632194 20215338 · DOI
  87. [89]Sugino N. Karube-Harada A. Taketani T. Sakata A. Nakamura Y. Withdrawal of ovarian steroids stimulates prostaglandin F2.ALPHA. production through nuclear Factor-.KAPPA.B activation via oxygen radicals in human endometrial stromal cells: potential relevance to menstruation The Journal of Reproduction and Development 2004 50 2 215 225 10.1262/jrd.50.215 2-s2.0-4544235840 15118249 · DOI
  88. [90]Buhimschi I. A. Kramer W. B. Buhimschi C. S. Thompson L. P. Weiner C. P. Reduction-oxidation (redox) state regulation of matrix metalloproteinase activity in human fetal membranes American Journal of Obstetrics and Gynecology 2000 182 2 458 464 10.1016/S0002-9378(00)70239-0 2-s2.0-0034049020 10694352 · DOI
  89. [91]Diczfalusy U. Kase B. F. Alexson S. E. Bjorkhem I. Metabolism of prostaglandin F2 alpha in Zellweger syndrome. Peroxisomal beta-oxidation is a major importance for in vivo degradation of prostaglandins in humans The Journal of Clinical Investigation 1991 88 3 978 984 10.1172/JCI115401 2-s2.0-0025925185 1885782 PMC295499 · DOI
  90. [92]Stocco C. Aromatase expression in the ovary: hormonal and molecular regulation Steroids 2008 73 5 473 487 10.1016/j.steroids.2008.01.017 2-s2.0-40649127468 18321551 PMC2365984 · DOI
  91. [93]Sanders S. L. Stouffer R. L. Localization of steroidogenic enzymes in macaque luteal tissue during the menstrual cycle and simulated early pregnancy: immunohistochemical evidence supporting the two-cell model for estrogen production in the primate corpus Luteum1 Biology of Reproduction 1997 56 5 1077 1087 10.1095/biolreprod56.5.1077 2-s2.0-0030978581 9160704 · DOI
  92. [94]Vitti M. di Emidio G. di Carlo M. Peroxisome proliferator-activated receptors in female reproduction and fertility PPAR Research 2016 2016 12 4612306 10.1155/2016/4612306 2-s2.0-84986188742 PMC4983391 27559343 · DOI
  93. [95]Berger J. Moller D. E. The mechanisms of action of PPARs Annual Review of Medicine 2002 53 1 409 435 10.1146/annurev.med.53.082901.104018 2-s2.0-0036183630 11818483 · DOI · Paper page
  94. [96]Huang J. C. The role of peroxisome proliferator-activated receptors in the development and physiology of gametes and preimplantation embryos PPAR Research 2008 2008 7 732303 10.1155/2008/732303 2-s2.0-41149122069 PMC2266973 18354728 · DOI
  95. [97]Barlaka E. Gorbe A. Gaspar R. Paloczi J. Ferdinandy P. Lazou A. Activation of PPARβ/δ protects cardiac myocytes from oxidative stress-induced apoptosis by suppressing generation of reactive oxygen/nitrogen species and expression of matrix metalloproteinases Pharmacological Research 2015 95-96 102 110 10.1016/j.phrs.2015.03.008 2-s2.0-84927155494 25828396 · DOI
  96. [98]Gervois P. Torra I. P. Fruchart J. C. Staels B. Regulation of lipid and lipoprotein metabolism by PPAR activators Clinical Chemistry and Laboratory Medicine 2000 38 1 3 11 10.1515/CCLM.2000.002 2-s2.0-0034106942 10774955 · DOI
  97. [99]Komar C. M. Braissant O. Wahli W. Curry T. E. Jr. Expression and localization of PPARs in the rat ovary during follicular development and the periovulatory period Endocrinology 2001 142 11 4831 4838 10.1210/endo.142.11.8429 2-s2.0-0034751344 11606451 · DOI
  98. [100]Komar C. M. Curry T. E. Jr. Localization and expression of messenger RNAs for the peroxisome proliferator-activated receptors in ovarian tissue from naturally cycling and pseudopregnant Rats1 Biology of Reproduction 2002 66 5 1531 1539 10.1095/biolreprod66.5.1531 2-s2.0-0036234471 11967220 · DOI
  99. [101]Froment P. Fabre S. Dupont J. Expression and functional role of peroxisome proliferator-activated Receptor-γ in ovarian folliculogenesis in the Sheep1 Biology of Reproduction 2003 69 5 1665 1674 10.1095/biolreprod.103.017244 2-s2.0-0242361748 12890736 · DOI
  100. [102]Komar C. M. Peroxisome proliferator-activated receptors (PPARs) and ovarian function – implications for regulating steroidogenesis, differentiation, and tissue remodeling Reproductive Biology and Endocrinology 2005 3 1 p. 41 10.1186/1477-7827-3-41 2-s2.0-27544433196 PMC1266036 16131403 · DOI
  101. [103]Viergutz T. Loehrke B. Poehland R. Becker F. Kanitz W. Relationship between different stages of the corpus luteum and the expression of the peroxisome proliferator-activated receptor gamma protein in bovine large lutein cells Journal of Reproduction and Fertility 2000 118 1 153 161 10.1530/jrf.0.1180153 10793637 · DOI
  102. [104]Cui Y. Miyoshi K. Claudio E. Loss of the Peroxisome Proliferation-activated Receptor gamma (PPARγ) Does Not Affect Mammary Development and Propensity for Tumor Formation but Leads to Reduced Fertility The Journal of Biological Chemistry 2002 277 20 17830 17835 10.1074/jbc.M200186200 2-s2.0-0037124098 11884400 · DOI
  103. [105]Kurzynska A. Bogacki M. Chojnowska K. Bogacka I. Peroxisome proliferator activated receptor ligands affect progesterone and 17beta-estradiol secretion by porcine corpus luteum during early pregnancy Journal of Physiology and Pharmacology 2014 65 5 709 717 25371531
  104. [107]Hogenboom S. Tuyp J. J. Espeel M. Koster J. Wanders R. J. Waterham H. R. Phosphomevalonate kinase is a cytosolic protein in humans Journal of Lipid Research 2004 45 4 697 705 10.1194/jlr.M300373-JLR200 2-s2.0-1642547058 14729858 · DOI
  105. [108]Hogenboom S. Tuyp J. J. Espeel M. Koster J. Wanders R. J. Waterham H. R. Mevalonate kinase is a cytosolic enzyme in humans Journal of Cell Science 2004 117 4 631 639 10.1242/jcs.00910 2-s2.0-1242329391 14730012 · DOI
  106. [109]Faust P. L. Kovacs W. J. Cholesterol biosynthesis and ER stress in peroxisome deficiency Biochimie 2014 98 75 85 10.1016/j.biochi.2013.10.019 2-s2.0-84895182182 24211592 · DOI · Paper page
  107. [110]Magalhaes M. M. Magalhaes M. C. Peroxisomes in adrenal steroidogenesis Microscopy Research and Technique 1997 36 6 493 502 10.1002/(SICI)1097-0029(19970315)36:6<493::AID-JEMT6>3.0.CO;2-J 9142695 · DOI
  108. [111]Suzuki Y. Orii T. Takiguchi M. Mori M. Hijikata M. Hashimoto T. Biosynthesis of membrane polypeptides of rat liver Peroxisomes1 Journal of Biochemistry 1987 101 2 491 496 10.1093/oxfordjournals.jbchem.a121935 2-s2.0-0023098280 3584097 · DOI
  109. [113]Keller G. A. Scallen T. J. Clarke D. Maher P. A. Krisans S. K. Singer S. J. Subcellular localization of sterol carrier protein-2 in rat hepatocytes: its primary localization to peroxisomes The Journal of Cell Biology 1989 108 4 1353 1361 10.1083/jcb.108.4.1353 2-s2.0-0024596796 2925789 PMC2115497 · DOI
  110. [114]van Amerongen A. van Noort M. van Beckhoven J. R. Rommerts F. F. Orly J. Wirtz K. W. The subcellular distribution of the nonspecific lipid transfer protein (sterol carrier protein 2) in rat liver and adrenal gland Biochimica et Biophysica Acta 1989 1001 3 243 248 10.1016/0005-2760(89)90106-9 2-s2.0-0024534996 2917149 · DOI
  111. [115]Mendis-Handagama S. Chamindrani M. L. Watkins P. A. Luteinizing hormone causes rapid and transient changes in rat Leydig cell peroxisome volume and intraperoxisomal sterol carrier protein-2 content Endocrinology 1990 127 6 2947 2954 10.1210/endo-127-6-2947 2-s2.0-0025695327 2249635 · DOI
  112. [116]Vahouny G. V. Chanderbhan R. Noland B. J. Sterol carrier protein2. Identification of adrenal sterol carrier protein2 and site of action for mitochondrial cholesterol utilization. The Journal of Biological Chemistry 1983 258 19 11731 11737 10.1016/S0021-9258(17)44290-6 6311823 · DOI
  113. [117]Mendis-Handagama S. M. Aten R. F. Watkins P. A. Scallen T. J. Berhman H. R. Peroxisomes and sterol carrier protein-2 in luteal cell steroidogenesis: a possible role in cholesterol transport from lipid droplets to mitochondria Tissue & Cell 1995 27 5 483 490 10.1016/S0040-8166(05)80056-4 2-s2.0-0028823706 7491620 · DOI
  114. [118]Chanderbhan R. Noland B. J. Scallen T. J. Vahouny G. V. Sterol carrier protein2. Delivery of cholesterol from adrenal lipid droplets to mitochondria for pregnenolone synthesis. The Journal of Biological Chemistry 1982 257 15 8928 8934 10.1016/S0021-9258(18)34222-4 7096342 · DOI
  115. [119]Reinhart M. P. Intracellular sterol trafficking Experientia 1990 46 6 599 611 10.1007/BF01939699 2-s2.0-0025337728 2193824 · DOI
  116. [120]Vahouny G. V. Chanderbhan R. Kharroubi A. Noland B. J. Pastuszyn A. Scallen T. J. Sterol carrier and lipid transfer proteins Advances in Lipid Research 1987 22 83 113 10.1016/B978-0-12-024922-0.50007-2 3328490 · DOI
  117. [121]Wirtz K. W. Snoek G. T. Gadella T. W. van Paridon P. A. Somerharju P. J. Properties and possible function of phosphatidylinositol-transfer proteins Biotechnology and Applied Biochemistry 1990 12 5 485 488 2288701
  118. [122]Rennert H. Amsterdam A. Billheimer J. T. Strauss J. F. 3rd. Regulated expression of sterol carrier protein 2 in the ovary: a key role for cyclic AMP Biochemistry 1991 30 47 11280 11285 10.1021/bi00111a013 2-s2.0-0026347930 1659897 · DOI
  119. [123]Trzeciak W. H. Simpson E. R. Scallen T. J. Vahouny G. V. Waterman M. R. Studies on the synthesis of sterol carrier protein-2 in rat adrenocortical cells in monolayer culture. Regulation by ACTH and dibutyryl cyclic 3',5'-AMP. The Journal of Biological Chemistry 1987 262 8 3713 3717 10.1016/S0021-9258(18)61413-9 3029121 · DOI
  120. [124]Moeller G. Adamski J. Multifunctionality of human 17β-hydroxysteroid dehydrogenases Molecular and Cellular Endocrinology 2006 248 1-2 47 55 10.1016/j.mce.2005.11.031 2-s2.0-33644894458 16413960 · DOI
  121. [126]Magalhaes M. C. Magalhaes M. M. Ultrastructural alterations produced in rat adrenal by aminoglutethimide A stereologic and cytochemical study. Endocrinology 1972 90 2 444 452 10.1210/endo-90-2-444 2-s2.0-0015292010 5009329 · DOI
  122. [127]Mazzocchi G. Robba C. Rebuffat P. Belloni A. S. Nussdorfer G. G. Effects of the hypolipidemic drug nafenopin on the zona fasciculata of the rat adrenal cortex: a correlated biochemical and stereological study The Anatomical Record 1982 204 3 245 254 10.1002/ar.1092040309 2-s2.0-0020466585 7158828 · DOI
  123. [128]Mazzocchi G. Rebuffat P. Belloni A. S. Gottardo G. Meneghelli V. Nussdorfer G. G. Effects of mevinolin, an inhibitor of cholesterol synthesis, on the morphological and functional responses of rat adrenal zona fasciculata to a prolonged treatment with 4-aminopyrazolo-pyrimidine The Anatomical Record 1988 221 3 700 706 10.1002/ar.1092210304 2-s2.0-0023747447 3189865 · DOI
  124. [129]Mendis-Handagama S. M. Zirkin B. R. Ewing L. L. Comparison of components of the testis interstitium with testosterone secretion in hamster, rat, and guinea pig testes perfused in vitro The American Journal of Anatomy 1988 181 1 12 22 10.1002/aja.1001810103 2-s2.0-0023856581 3348144 · DOI
  125. [130]Klinken S. P. Stevenson P. M. Changes in enzyme activities during the artificially stimulated transition from follicular to luteal cell types in rat ovary European Journal of Biochemistry 1977 81 2 327 332 10.1111/j.1432-1033.1977.tb11955.x 2-s2.0-0017703594 202454 · DOI
  126. [131]Black V. H. Russo J. J. Stereological analysis of the guinea pig adrenal: effects of dexamethasone and ACTH treatment with emphasis on the inner cortex The American Journal of Anatomy 1980 159 1 85 120 10.1002/aja.1001590108 2-s2.0-0019137049 6255789 · DOI
  127. [132]Russo J. J. Black V. H. Hormone-dependent changes in peroxisomal enzyme activity in guinea pig adrenal. The Journal of Biological Chemistry 1982 257 7 3883 3889 10.1016/S0021-9258(18)34865-8 6277951 · DOI
  128. [133]Fortune J. E. Ovarian follicular growth and development in Mammals1 Biology of Reproduction 1994 50 2 225 232 10.1095/biolreprod50.2.225 2-s2.0-0028098141 8142540 · DOI · Paper page
  129. [134]Tuckey R. C. Kostadinovic Z. Stevenson P. M. Ferredoxin and cytochrome P-450scc concentrations in granulosa cells of porcine ovaries during follicular cell growth and luteinization Journal of Steroid Biochemistry 1988 31 2 201 205 10.1016/0022-4731(88)90055-6 2-s2.0-0023693235 3404990 · DOI
  130. [135]Sligar S. G. Lipscomb J. D. Debrunner P. G. Gunsalus I. C. Superoxide anion production by the autoxidation of cytochrome P450cam Biochemical and Biophysical Research Communications 1974 61 1 290 296 10.1016/0006-291X(74)90565-8 2-s2.0-0016281530 4441397 · DOI
  131. [136]Tuckey R. C. Kamin H. The oxyferro complex of adrenal cytochrome P-450scc. Effect of cholesterol and intermediates on its stability and optical characteristics. The Journal of Biological Chemistry 1982 257 16 9309 9314 10.1016/S0021-9258(18)34070-5 7107571 · DOI
  132. [137]Goda K. Chu J. Kimura T. Schaap A. P. Cytochrome c enhancement of singlet molecular oxygen production by the NADPH- dependent adrenodoxin reductase-adrenodoxin system: The role of singlet oxygen in damaging adrenal mitochondrial membranes Biochemical and Biophysical Research Communications 1973 52 4 1300 1306 10.1016/0006-291X(73)90642-6 2-s2.0-0015930014 4146221 · DOI
  133. [138]Behrman H. R. Aten R. F. Evidence that hydrogen peroxide blocks hormone-sensitive cholesterol transport into mitochondria of rat luteal cells Endocrinology 1991 128 6 2958 2966 10.1210/endo-128-6-2958 2-s2.0-0025744225 2036971 · DOI
  134. [139]Sugino N. Takiguchi S. Kashida S. Karube A. Nakamura Y. Kato H. Superoxide dismutase expression in the human corpus luteum during the menstrual cycle and in early pregnancy Molecular Human Reproduction 2000 6 1 19 25 10.1093/molehr/6.1.19 10611256 · DOI
  135. [140]Keller G. A. Warner T. G. Steimer K. S. Hallewell R. A. Cu,Zn superoxide dismutase is a peroxisomal enzyme in human fibroblasts and hepatoma cells Proceedings of the National Academy of Sciences 1991 88 16 7381 7385 10.1073/pnas.88.16.7381 2-s2.0-0025915727 PMC52299 1651504 · DOI
  136. [141]Kananen K. Markkula M. Rainio E. Su J. G. Hsueh A. J. Huhtaniemi I. T. Gonadal tumorigenesis in transgenic mice bearing the mouse inhibin alpha-subunit promoter/simian virus T-antigen fusion gene: characterization of ovarian tumors and establishment of gonadotropin-responsive granulosa cell lines Molecular Endocrinology 1995 9 5 616 627 10.1210/mend.9.5.7565808 2-s2.0-0029016076 7565808 · DOI
  137. [142]Brigelius-Flohe R. Muller C. Menard J. Florian S. Schmehl K. Wingler K. Functions of GI-GPx: lessons from selenium-dependent expression and intracellular localization BioFactors 2001 14 1-4 101 106 10.1002/biof.5520140114 2-s2.0-0034856806 11568446 · DOI
  138. [144]Li Q. Sanlioglu S. Li S. Ritchie T. Oberley L. Engelhardt J. F. GPx-1 gene delivery modulates NFκB activation following diverse environmental injuries through a specific subunit of the IKK complex Antioxidants & Redox Signaling 2001 3 3 415 432 10.1089/15230860152409068 2-s2.0-0034936463 11491654 · DOI
  139. [145]Agarwal A. Allamaneni S. S. Role of free radicals in female reproductive diseases and assisted reproduction Reproductive Biomedicine Online 2004 9 3 338 347 10.1016/S1472-6483(10)62151-7 2-s2.0-4544300285 15353087 · DOI
  140. [146]Fridovich I. Superoxide radical and superoxide dismutases Annual Review of Biochemistry 1995 64 1 97 112 10.1146/annurev.bi.64.070195.000525 2-s2.0-0029053451 7574505 · DOI · Paper page
  141. [148]Stocco D. M. Wells J. Clark B. J. The effects of hydrogen peroxide on steroidogenesis in mouse Leydig tumor cells Endocrinology 1993 133 6 2827 2832 10.1210/endo.133.6.8243310 2-s2.0-0027132475 8243310 · DOI
  142. [149]Behrman H. R. Preston S. L. Luteolytic actions of peroxide in rat ovarian cells Endocrinology 1989 124 6 2895 2900 10.1210/endo-124-6-2895 2-s2.0-0024315397 2470582 · DOI
  143. [150]Endo T. Aten R. F. Leykin L. Behrman H. R. Hydrogen peroxide evokes antisteroidogenic and antigonadotropic actions in human granulosa luteal cells The Journal of Clinical Endocrinology and Metabolism 1993 76 2 337 342 10.1210/jcem.76.2.7679398 2-s2.0-0027480951 7679398 · DOI
  144. [151]Diemer T. Allen J. A. Hales K. H. Hales D. B. Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis Endocrinology 2003 144 7 2882 2891 10.1210/en.2002-0090 2-s2.0-0037661090 12810543 · DOI
  145. [154]Barth P. G. Gootjes J. Bode H. Vreken P. Majoie C. B. Wanders R. J. Late onset white matter disease in peroxisome biogenesis disorder Neurology 2001 57 11 1949 1955 10.1212/WNL.57.11.1949 2-s2.0-0035846634 11769739 · DOI
  146. [155]Moser A. B. Rasmussen M. Naidu S. Phenotype of patients with peroxisomal disorders subdivided into sixteen complementation groups The Journal of Pediatrics 1995 127 1 13 22 10.1016/S0022-3476(95)70250-4 2-s2.0-0029153135 7541833 · DOI
  147. [156]Baes M. Van Veldhoven P. P. Generalised and conditional inactivation of Pex genes in mice Biochimica et Biophysica Acta 2006 1763 12 1785 1793 10.1016/j.bbamcr.2006.08.018 2-s2.0-33845462129 17007945 · DOI
  148. [157]Rodemer C. Thai T. P. Brugger B. Inactivation of ether lipid biosynthesis causes male infertility, defects in eye development and optic nerve hypoplasia in mice Human Molecular Genetics 2003 12 15 1881 1895 10.1093/hmg/ddg191 2-s2.0-0042131525 12874108 · DOI
  149. [158]Huyghe S. Schmalbruch H. de Gendt K. Peroxisomal multifunctional protein 2 is essential for lipid homeostasis in Sertoli cells and male fertility in mice Endocrinology 2006 147 5 2228 2236 10.1210/en.2005-1571 2-s2.0-33645877112 16484321 · DOI
  150. [159]Fan C. Y. Pan J. Chu R. Hepatocellular and Hepatic Peroxisomal Alterations in Mice with a Disrupted Peroxisomal Fatty Acyl-coenzyme A Oxidase Gene The Journal of Biological Chemistry 1996 271 40 24698 24710 10.1074/jbc.271.40.24698 2-s2.0-10144234128 8798738 · DOI · Paper page
  151. [160]Horrocks L. A. Yeo Y. K. Health benefits of docosahexaenoic acid (DHA) Pharmacological Research 1999 40 3 211 225 10.1006/phrs.1999.0495 2-s2.0-0344329878 10479465 · DOI
  152. [161]Birch E. E. Hoffman D. R. Uauy R. Birch D. G. Prestidge C. Visual acuity and the essentiality of docosahexaenoic acid and arachidonic acid in the diet of term infants Pediatric Research 1998 44 2 201 209 10.1203/00006450-199808000-00011 2-s2.0-0031871394 9702915 · DOI
  153. [162]Martínez M. Vázquez E. García-Silva M. T. Therapeutic effects of docosahexaenoic acid ethyl ester in patients with generalized peroxisomal disorders The American Journal of Clinical Nutrition 2000 71 1 376S 385S 10.1093/ajcn/71.1.376s 10618001 · DOI
  154. [163]Noguer M. T. Martinez M. Visual follow-up in peroxisomal-disorder patients treated with docosahexaenoic acid ethyl ester Investigative Ophthalmology & Visual Science 2010 51 4 2277 2285 10.1167/iovs.09-4020 2-s2.0-77951248337 19933185 · DOI
  155. [164]Paker A. M. Sunness J. S. Brereton N. H. Docosahexaenoic acid therapy in peroxisomal diseases: results of a double-blind, randomized trial Neurology 2010 75 9 826 830 10.1212/WNL.0b013e3181f07061 2-s2.0-77956366856 20805528 PMC3013498 · DOI
  156. [165]Moser A. B. Borel J. Odone A. A new dietary therapy for adrenoleukodystrophy: biochemical and preliminary clinical results in 36 patients Annals of Neurology 1987 21 3 240 249 10.1002/ana.410210305 2-s2.0-0023158322 2440378 · DOI
  157. [166]Tanaka K. Shimizu T. Ohtsuka Y. Yamashiro Y. Oshida K. Early dietary treatments with Lorenzo's oil and docosahexaenoic acid for neurological development in a case with Zellweger syndrome Brain & Development 2007 29 9 586 589 10.1016/j.braindev.2007.02.005 2-s2.0-34548289424 17418516 · DOI
  158. [167]Arai Y. Kitamura Y. Hayashi M. Oshida K. Shimizu T. Yamashiro Y. Effect of dietary Lorenzo’s oil and docosahexaenoic acid treatment for Zellweger syndrome Congenital Anomalies 2008 48 4 180 182 10.1111/j.1741-4520.2008.00201.x 2-s2.0-55349110332 18983586 · DOI
  159. [169]van Geel B. M. Assies J. Haverkort E. B. Progression of abnormalities in adrenomyeloneuropathy and neurologically asymptomatic X-linked adrenoleukodystrophy despite treatment with “Lorenzo’s oil” Journal of Neurology, Neurosurgery, and Psychiatry 1999 67 3 290 299 10.1136/jnnp.67.3.290 2-s2.0-0032790614 PMC1736534 10449548 · DOI · Paper page
  160. [170]de Vet E. C. van den Bosch H. Alkyl-dihydroxyacetonephosphate synthase Cell Biochemistry and Biophysics 2000 32 1-3 117 121 10.1385/CBB:32:1-3:117 2-s2.0-0034569735 11330037 · DOI
  161. [171]Braverman N. E. Moser A. B. Functions of plasmalogen lipids in health and disease Biochimica et Biophysica Acta 2012 1822 9 1442 1452 10.1016/j.bbadis.2012.05.008 2-s2.0-84864046701 22627108 · DOI · Paper page
  162. [172]Holmes R. D. Wilson G. N. Hajra A. K. Peroxisomal enzyme deficiency in the Conradi-Hunerman form of chondrodysplasia punctata The New England Journal of Medicine 1987 316 25 p. 1608 10.1056/NEJM198706183162517 2-s2.0-0023268452 3587298 · DOI
  163. [173]Das A. K. Holmes R. D. Wilson G. N. Hajra A. K. Dietary ether lipid incorporation into tissue plasmalogens of humans and rodents Lipids 1992 27 6 401 405 10.1007/BF02536379 2-s2.0-0026764672 1630273 · DOI
  164. [174]Wilson G. N. Holmes R. G. Custer J. Zellweger syndrome: diagnostic assays, syndrome delineation, and potential therapy American Journal of Medical Genetics 1986 24 1 69 82 10.1002/ajmg.1320240109 2-s2.0-0022531459 3706414 · DOI
  165. [175]Zhang R. Chen L. Jiralerspong S. Snowden A. Steinberg S. Braverman N. Recovery of PEX1-Gly843Asp peroxisome dysfunction by small-molecule compounds Proceedings of the National Academy of Sciences of the United States of America 2010 107 12 5569 5574 10.1073/pnas.0914960107 2-s2.0-77950409779 20212125 PMC2851769 · DOI
  166. [176]Berendse K. Ebberink M. S. IJlst L. Poll-The B. T. Wanders R. J. Waterham H. R. Arginine improves peroxisome functioning in cells from patients with a mild peroxisome biogenesis disorder Orphanet Journal of Rare Diseases 2013 8 1 p. 138 10.1186/1750-1172-8-138 2-s2.0-84883867896 PMC3844471 24016303 · DOI
  167. [177]Wei H. Kemp S. McGuinness M. C. Moser A. B. Smith K. D. Pharmacological induction of peroxisomes in peroxisome biogenesis disorders Annals of Neurology 2000 47 3 286 296 10.1002/1531-8249(200003)47:3<286::AID-ANA3>3.0.CO;2-B 10716247 · DOI
  168. [178]Imamura A. Tsukamoto T. Shimozawa N. Temperature-sensitive phenotypes of peroxisome-assembly processes represent the milder forms of human peroxisome-biogenesis disorders American Journal of Human Genetics 1998 62 6 1539 1543 10.1086/301881 2-s2.0-17544402925 9585609 PMC1377160 · DOI
  169. [179]Shimozawa N. Suzuki Y. Zhang Z. Nonsense and temperature-sensitive mutations in PEX13 are the cause of complementation group H of peroxisome biogenesis disorders Human Molecular Genetics 1999 8 6 1077 1083 10.1093/hmg/8.6.1077 2-s2.0-0033014751 10332040 · DOI
  170. [180]Cartier N. Hacein-Bey-Abina S. Bartholomae C. C. Lentiviral hematopoietic cell gene therapy for X-linked adrenoleukodystrophy Methods in Enzymology 2012 507 187 198 10.1016/B978-0-12-386509-0.00010-7 2-s2.0-84857579405 22365775 · DOI · Paper page
  171. [181]Toscano M. G. Romero Z. Munoz P. Cobo M. Benabdellah K. Martin F. Physiological and tissue-specific vectors for treatment of inherited diseases Gene Therapy 2011 18 2 117 127 10.1038/gt.2010.138 2-s2.0-79951517169 20962871 · DOI
  172. [182]Sokal E. M. Smets F. Bourgois A. Hepatocyte transplantation in a 4-year-old girl with peroxisomal biogenesis disease: technique, safety, and metabolic follow-up1 Transplantation 2003 76 4 735 738 10.1097/01.TP.0000077420.81365.53 2-s2.0-0041335271 12973120 · DOI
  173. [183]Van Maldergem L. Moser A. B. Vincent M. F. Orthotopic liver transplantation from a living-related donor in an infant with a peroxisome biogenesis defect of the infantile Refsum disease type Journal of Inherited Metabolic Disease 2005 28 4 593 600 10.1007/s10545-005-0593-9 2-s2.0-19944416601 15902563 · DOI
  174. [184]Lian H. Y. Gao Y. Jiao G. Z. Antioxidant supplementation overcomes the deleterious effects of maternal restraint stress-induced oxidative stress on mouse oocytes Reproduction 2013 146 6 559 568 10.1530/REP-13-0268 2-s2.0-84886801471 24043846 · DOI
  175. [185]Tripathi A. PremKumar K. V. Pandey A. N. Melatonin protects against clomiphene citrate-induced generation of hydrogen peroxide and morphological apoptotic changes in rat eggs European Journal of Pharmacology 2011 667 1-3 419 424 10.1016/j.ejphar.2011.06.005 2-s2.0-80052022904 21693115 · DOI
  176. [186]Tamura H. Takasaki A. Miwa I. Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate Journal of Pineal Research 2008 44 3 280 287 10.1111/j.1600-079X.2007.00524.x 2-s2.0-40849139435 18339123 · DOI
  177. [187]Eryilmaz O. G. Devran A. Sarikaya E. Aksakal F. N. Mollamahmutoglu L. Cicek N. Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems Journal of Assisted Reproduction and Genetics 2011 28 9 815 820 10.1007/s10815-011-9604-y 2-s2.0-85027921954 21748445 PMC3169684 · DOI
  178. [188]Batioglu A. S. Sahin U. Gurlek B. Ozturk N. Unsal E. The efficacy of melatonin administration on oocyte quality Gynecological Endocrinology 2012 28 2 91 93 10.3109/09513590.2011.589925 2-s2.0-84856090849 21770829 · DOI
  179. [189]Liu M. Yin Y. Ye X. Resveratrol protects against age-associated infertility in mice Human Reproduction 2013 28 3 707 717 10.1093/humrep/des437 2-s2.0-84874399872 23293221 · DOI
  180. [190]Jiang Y. Zhang Z. Cha L. Resveratrol plays a protective role against premature ovarian failure and prompts female germline stem cell survival International Journal of Molecular Sciences 2019 20 14 p. 3605 10.3390/ijms20143605 2-s2.0-85070506240 PMC6678805 31340581 · DOI
  181. [191]Jiang H. L. Cao L. Q. Chen H. Y. Protective effects ROS up-regulation on premature ovarian failure by suppressing ROS-TERT signal pathway European Review for Medical and Pharmacological Sciences 2018 22 19 6198 6204 30338789
  182. [192]Mier-Cabrera J. Aburto-Soto T. Burrola-Méndez S. Women with endometriosis improved their peripheral antioxidant markers after the application of a high antioxidant diet Reproductive Biology and Endocrinology 2009 7 1 p. 54 10.1186/1477-7827-7-54 2-s2.0-67651250055 19476631 PMC2693127 · DOI
  183. [193]Mier-Cabrera J. Genera-Garcia M. De la Jara-Diaz J. Perichart-Perera O. Vadillo-Ortega F. Hernandez-Guerrero C. Effect of vitamins C and E supplementation on peripheral oxidative stress markers and pregnancy rate in women with endometriosis International Journal of Gynaecology and Obstetrics 2008 100 3 252 256 10.1016/j.ijgo.2007.08.018 2-s2.0-39149126401 18005966 · DOI
  184. [194]Cotgreave I. A. N-acetylcysteine: pharmacological considerations and experimental and clinical applications Advances in Pharmacology 1996 38 205 227 10.1016/S1054-3589(08)60985-0 2-s2.0-0345018815 8895810 · DOI
  185. [195]Kelly G. S. Clinical applications of N-acetylcysteine Alternative Medicine Review 1998 3 2 114 127 10.1016/S1054-3589(08)60985-0 2-s2.0-0345018815 9577247 · DOI
  186. [196]Amin A. F. Shaaban O. M. Bediawy M. A. N -acetyl cysteine for treatment of recurrent unexplained pregnancy loss Reproductive Biomedicine Online 2008 17 5 722 726 10.1016/S1472-6483(10)60322-7 2-s2.0-56749144149 18983759 · DOI
  187. [197]Aseervatham G. S. Sivasudha T. Jeyadevi R. Arul Ananth D. Environmental factors and unhealthy lifestyle influence oxidative stress in humans--an overview Environmental Science and Pollution Research International 2013 20 7 4356 4369 10.1007/s11356-013-1748-0 2-s2.0-84883586337 23636598 · DOI

Cited by

Sorted by citations

Authors
Wang, S., Yang, H., Fu, Y., Teng, X., Wang, C., & Xu, W.
Affiliations
  • Tongji University (CN)
  • Chinese University of Hong Kong (HK)
Corresponding author
Xu, WenMing
ORCID
Venue
Oxidative Medicine and Cellular Longevity
Publisher
Wiley
Published
2022-01
Volume
2022
Issue
1
Pages
7982344-7982344
ISSN
  • 1942-0994 (ISSN-L)
  • 1942-0900
DOI
10.1155/2022/7982344
PMC
PMC8831076
OpenAlex
W4210661683
Cited by
19
References
9
Citations by year
2026: 4 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 1
FWCI
0.75
Type
journal article
Language
en
Open access
Licence
Locations
  • Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Natural Sciences Foundation of China (81901435, T13-602/21-N, C5045-20EF, 14122021)
  • Theme-based Research Scheme (81901435, T13-602/21-N, C5045-20EF, 14122021)
  • Collaborative Research Fund (81901435, T13-602/21-N, C5045-20EF, 14122021)
  • General Research Fund (81901435, T13-602/21-N, C5045-20EF, 14122021)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
Keywords
peroxisomes, ovary, folliculogenesis, oocyte maturation, ovulation, steroidogenesis, peroxisomal dysfunction, female fertility, oxidative stress, lipotoxicity, ovarian cell types
MeSH terms
Animals, Cell Differentiation, Female, Fertility, Ovarian Follicle, Humans, Oocytes, Ovulation, Steroids, Signal Transduction, Oxidative Stress, Peroxisomes, Cell Proliferation, Mice, Gene Knockout Techniques

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