Androgen Receptor Signaling

Jia, Li; Choong, Catherine S-Y.; Ricciardelli, Carmela; Kim, Joshua; Tilley, Wayne D.; Coetzee, Gerhard A

doi:10.1158/0008-5472.can-03-3486

Cited by 81Prostate Cancer Treatment and ResearchEstrogen and related hormone effectsCytokine Signaling Pathways and Interactions

Androgen Receptor Signaling

Jia, Li, Choong, Catherine S-Y., Ricciardelli, Carmela, Kim, Joshua, Tilley, Wayne D., Coetzee, Gerhard A·2004·Cancer Research

DOI 10.1158/0008-5472.can-03-3486

Open this paper in CoChat — free account

Abstract

Nonsteroidal signaling via the androgen receptor (AR) plays an im-portant role in hormone-refractory prostate cancer. Previously, we have reported that the pleiotropic cytokine, interleukin (IL)-6, inhibited dihydrotestosterone-mediated expression of prostate-specific antigen in LNCaP cells (Jia et al., Mol Can Res 2003;1:385-92). In the present study, we explored the mechanisms involved in this inhibition and considered possible effects on AR nuclear translocation, recruitment of transcription cofactors, and the signaling pathways that may mediate this inhibitory effect. IL-6 neither induced nuclear localization of the AR nor inhibited dihydrotestosterone-induced nuclear translocation of the receptor. IL-6 did not affect AR or p160 coactivator recruitment to the transcription initiation complex on the prostate-specific antigen enhancer and promoter. Moreover, it did not lead to the recruitment of the corepressor silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) or histone deacetylase 1 (HDAC1) at the same sites. IL-6 did, however, prevent the recruitment of the secondary coactivator, p300, to the complex and partially inhibited histone H3 acetylation at the same loci. Furthermore, inhibition by IL-6 was not mediated by the mitogen-activated protein kinase or the Akt pathways and was partially abrogated by signal transducers and activators of transcription-3 knock-down using small interfering RNA. Our results show that IL-6 modulates androgen action through the differential recruitment of cofactors to target genes. These findings may account for the pleiotropic actions of IL-6 in malignant prostate cells.

Integrity signals

Registry

Crossref · 10.1158/0008-5472.can-03-3486

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

In the presence of androgen, IL-6 treatment of LNCaP cells impairs transcription of prostate-specific antigen (PSA) via a mechanism that prevents recruitment of the histone acetyltransferase coactivator p300 to the PSA promoter.
“In the presence of androgen, IL-6 treatment of LNCaP cells impairs transcription of prostate-specific antigen (PSA), via a mechanism that prevents recruitment of the histone acetyltransferase coactivator p300 to the PSA promoter (21).”
From Minireview: Alternative Activation Pathways for the Androgen Receptor in Prostate Cancer (2011) · cites this paper as [21]

The development of androgen-independent prostate cancer.
Feldman, B. J., & Feldman, D. (2001) · Nature reviews. Cancer · doi:10.1038/35094009 · Cited by 2,326 · see citing works
Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription
Shang, Y., Hu, X., DiRenzo, J., Lazar, M. A., & Brown, M. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00188-4 · Cited by 1,647 · see citing works
Activation of the interferon system by short-interfering RNAs
Sledz, C. A., Holko, M., de Veer, M. J., Silverman, R. H., & Williams, B. R. G. (2003) · Nature Cell Biology · doi:10.1038/ncb1038 · Cited by 1,401 · see citing works
A Road Map for Those Who Don't Know JAK-STAT
Aaronson, D. S., & Horvath, C. M. (2002) · Science · doi:10.1126/science.1071545 · Cited by 1,339 · see citing works
Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor.
Čulig, Z., Hobisch, A., Cronauer, M. V., Radmayr, C., Trapman, J., Hittmair, A., Bartsch, G., & Klocker, H. (1994) · PubMed · Cited by 938 · see citing works
CREB-binding Protein and p300 in Transcriptional Regulation
Vo, N., & Goodman, R. H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r000025200 · Cited by 868 · see citing works
Formation of the Androgen Receptor Transcription Complex
Shang, Y., Myers, M., & Brown, M. A. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00471-9 · Cited by 673 · see citing works
Coregulator codes of transcriptional regulation by nuclear receptors
Rosenfeld, M. G., & Glass, C. K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100041200 · Cited by 509 · see citing works
Review of the in Vivo Functions of the p160 Steroid Receptor Coactivator Family
Xu, J., & Li, Q. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0116 · Cited by 493 · see citing works
Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor.
Lin, H.-K., Yeh, S., Kang, H.-Y., & Chang, C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121173298 · Cited by 401 · see citing works
ELEVATED LEVELS OF CIRCULATING INTERLEUKIN-6 AND TRANSFORMING GROWTH FACTOR-beta 1 IN PATIENTS WITH METASTATIC PROSTATIC CARCINOMA
Adler, H. L., McCURDY, M. A., Kattan, M. W., Timme, T. L., Scardino, P. T., & Thompson, T. C. (1999) · The Journal of Urology · doi:10.1016/s0022-5347(01)62092-5 · Cited by 387 · see citing works
The Current State of Hormonal Therapy for Prostate Cancer
Hellerstedt, B. A., & Pienta, K. J. (2002) · CA: A Cancer Journal for Clinicians · doi:10.3322/canjclin.52.3.154 · Cited by 386 · see citing works
Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways.
Ueda, T., Bruchovsky, N., & Sadar, M. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108255200 · Cited by 381 · see citing works
Serum interleukin 6 as a prognostic factor in patients with prostate cancer.
Nakashima, J., Tachibana, M., Horiguchi, Y., Oya, M., Ohigashi, T., Asakura, H., & Murai, M. (2000) · PubMed · Cited by 351 · see citing works
Interleukin-6 Is an Autocrine Growth Factor in Human Prostate Cancer
Giri, D., Özen, M., & Ittmann, M. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63067-2 · Cited by 331 · see citing works
Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells.
Ueda, T., Mawji, N. R., Bruchovsky, N., & Sadar, M. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203313200 · Cited by 311 · see citing works
Interleukin-6 as a paracrine and autocrine growth factor in human prostatic carcinoma cells in vitro.
Okamoto, M., Lee, C., & Oyasu, R. (1997) · PubMed · Cited by 307 · see citing works
Interleukin-6: A candidate mediator of human prostate cancer morbidity
Twillie, D. A., Eisenberger, M. A., Carducci, M. A., Hseih, W.-S., Kim, W. Y., & Simons, J. W. (1995) · Urology · doi:10.1016/s0090-4295(99)80034-x · Cited by 286 · see citing works
Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells
Qiu, Y., Ravi, L., & Kung, H.-J. (1998) · Nature · doi:10.1038/30012 · Cited by 280 · see citing works
Interleukin-6 and prostate cancer progression
SMITH, P., Hobisch, A., Lin, D. C., CULIG, Z., & KELLER, E. (2001) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00021-6 · Cited by 264 · see citing works
Androgen receptor as a target in androgen-independent prostate cancer
Balk, S. P. (2002) · Urology · doi:10.1016/s0090-4295(02)01593-5 · Cited by 264 · see citing works
Multiple Signal Input and Output Domains of the 160-Kilodalton Nuclear Receptor Coactivator Proteins
Ma, H., Hong, H., Huang, S.-M., Irvine, R. A., Webb, P., Kushner, P. J., Coetzee, G. A., & Stallcup, M. R. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.9.6164 · Cited by 256 · see citing works
Self-citation
Characterization of the role of IL‐6 in the progression of prostate cancer
Chung, T., Yu, J.-Q., Spiotto, M., Bartkowski, M., & Simons, J. (1999) · The Prostate · doi:10.1002/(sici)1097-0045(19990215)38:3 · Cited by 253 · see citing works
Bicalutamide Functions as an Androgen Receptor Antagonist by Assembly of a Transcriptionally Inactive Receptor
Masiello, D., Cheng, S., Bubley, G. J., Lu, M. L., & Balk, S. P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203310200 · Cited by 240 · see citing works
Involvement of Proteasome in the Dynamic Assembly of the Androgen Receptor Transcription Complex*
Kang, Z., Pirskanen, A., Jänne, O., & Palvimo, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209074200 · Cited by 204 · see citing works
Constitutive activation of the Ras/mitogen-activated protein kinase signaling pathway promotes androgen hypersensitivity in LNCaP prostate cancer cells.
Bakin, R. E., Gioeli, D. G., Sikes, R. A., Bissonette, E. A., & Weber, M. J. (2003) · PubMed · Cited by 201 · see citing works
STAT3 mediates IL‐6‐induced neuroendocrine differentiation in prostate cancer cells
Spiotto, M., & Chung, T. (2000) · The Prostate · doi:10.1002/(sici)1097-0045(20000215)42:3 · Cited by 191 · see citing works
Cyclin D1 Binds the Androgen Receptor and Regulates Hormone-Dependent Signaling in a p300/CBP-Associated Factor (P/CAF)-Dependent Manner
Reutens, A. T., Fu, M., Wang, C., Albanese, C., McPhaul, M. J., Sun, Z., Balk, S. P., Jänne, O. A., Palvimo, J. J., & Pestell, R. G. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.5.0641 · Cited by 189 · see citing works
Food groups and risk of colorectal cancer in Italy
Franceschi, S., Favero, A., Vecchia, C. L., Negri, E., Conti, E., Montella, M., Giacosa, A., Nanni, O., & Decarli, A. (1997) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19970703)72:1 · Cited by 187 · see citing works
p300 mediates androgen-independent transactivation of the androgen receptor by interleukin 6.
Debes, J. D., Schmidt, L. J., Huang, H., & Tindall, D. J. (2002) · PubMed · Cited by 172 · see citing works
Interleukin-6 induces androgen responsiveness in prostate cancer cells through up-regulation of androgen receptor expression.
Lin, D., Whitney, M. C., Yao, Z., & Keller, E. T. (2001) · PubMed · Cited by 169 · see citing works
Interleukin-6 differentially regulates androgen receptor transactivation via PI3K-Akt, STAT3, and MAPK, three distinct signal pathways in prostate cancer cells
Yang, L., Wang, L., Lin, H., Kan, P., Xie, S., Tsai, M.-Y., Wang, P., Chen, Y.-T., & Chang, C. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00792-7 · Cited by 168 · see citing works
Contribution of the Androgen Receptor to Prostate Cancer Predisposition and Progression
Buchanan, G., Irvine, R. A., Coetzee, G. A., & Tilley, W. D. (2001) · Cancer and Metastasis Reviews · doi:10.1023/a:1015531326689 · Cited by 165 · see citing works
Self-citation
Cyclin D1: Mechanism and Consequence of Androgen Receptor Co-repressor Activity
Petre, C. E., Wetherill, Y. B., Danielsen, M., & Knudsen, K. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m106399200 · Cited by 144 · see citing works
STAT3 mediates IL-6-induced growth inhibition in the human prostate cancer cell line LNCaP
Spiotto, M. T., & Chung, T. D. (2000) · The Prostate · doi:10.1002/(sici)1097-0045(20000201)42:2 · Cited by 132 · see citing works
Interleukin-6 Induces G1Arrest through Induction of p27Kip1, a Cyclin-Dependent Kinase Inhibitor, and Neuron-like Morphology in LNCaP Prostate Tumor Cells
Mori, S., Murakami-Mori, K., & Bonavida, B. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0515 · Cited by 103 · see citing works
Cross‐talk between signal transducer and activator of transcription 3 and estrogen receptor signaling
Yamamoto, T., Matsuda, T., Junicho, A., Kishi, H., Saatcioglu, F., & Atsushi, M. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)02296-1 · Cited by 91 · see citing works
Interleukin 6 Receptor mRNA in Prostate Carcinomas and Benign Prostate Hyperplasia
Siegsmund, M. J., Yamazaki, H., & Pastan, I. H. (1994) · The Journal of Urology · doi:10.1016/s0022-5347(17)35267-9 · Cited by 91 · see citing works
Attenuation of Ras signaling restores androgen sensitivity to hormone-refractory C4-2 prostate cancer cells.
Bakin, R. E., Gioeli, D. G., Bissonette, E. A., & Weber, M. J. (2003) · PubMed · Cited by 83 · see citing works
Protein Inhibitor of Activated STAT3 Regulates Androgen Receptor Signaling in Prostate Carcinoma Cells
Junicho, A., Matsuda, T., Yamamoto, T., Kishi, H., Korkmaz, K., Saatcioglu, F., Fuse, H., & Muraguchi, A. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3753 · Cited by 81 · see citing works
Androgen receptor activity at the prostate specific antigen locus: steroidal and non-steroidal mechanisms.
Li, J., Kim, J. P., Shen, H. C., Clark, P. E., Tilley, W. D., & Coetzee, G. A. (2003) · PubMed · Cited by 68 · see citing works
Self-citation
Human prostatic cell line PNT1A, a useful tool for studying androgen receptor transcriptional activity and its differential subnuclear localization in the presence of androgens and antiandrogens
Avancès, C., Georget, V., Térouanne, B., Orio, F., Cussenot, O., Mottet, N. A., Costa, P., & Sultan, C. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00669-4 · Cited by 37 · see citing works
Mitogen‐activated protein kinase pathway is involved in androgen‐independent PSA gene expression in LNCaP cells
Franco, O. E., Onishi, T., Yamakawa, K., Arima, K., Yanagawa, M., Sugimura, Y., & Kawamura, J. (2003) · The Prostate · doi:10.1002/pros.10258 · Cited by 29 · see citing works
Androgen and retinoic acid interaction in LNCaP cells, effects on cell proliferation and expression of retinoic acid receptors and epidermal growth factor receptor
Li, M., Richter, F., Chang, C., Irwin, R. J., & Huang, H. F. S. (2002) · BMC Cancer · doi:10.1186/1471-2407-2-16 · Cited by 22 · see citing works
Modulation of cellular proliferation and production of prostate-specific antigen and matrix adhesion molecules in human prostate carcinoma cells by polypeptide growth factors: comparative analyses of MDA PCa2a with established cell lines.
Rajagopal, S., Navone, N. M., Troncoso, P., Fritsche, H. A., & Chakrabarty, S. (1998) · International Journal of Oncology · doi:10.3892/ijo.12.3.589 · Cited by 11 · see citing works

Flagged first, then by citations

Sorted by citations

A Hierarchical Network of Transcription Factors Governs Androgen Receptor-Dependent Prostate Cancer Growth
Wang, Q., Li, W., Liu, X. S., Carroll, J. S., Jänne, O. A., Keeton, E. K., Chinnaiyan, A. M., Pienta, K. J., & Brown, M. A. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.041 · Cited by 689 · see citing works
Androgen receptor signaling in prostate cancer development and progression
Tindall, D. J., & Lonergan, P. E. (2011) · Journal of Carcinogenesis · doi:10.4103/1477-3163.83937 · Cited by 544 · see citing works
Spatial and Temporal Recruitment of Androgen Receptor and Its Coactivators Involves Chromosomal Looping and Polymerase Tracking
Wang, Q., Carroll, J. S., & Brown, M. A. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.07.018 · Cited by 450 · see citing works
Interleukin-6 regulation of prostate cancer cell growth.
Culig, Z., Steiner, H., Bartsch, G., & Hobisch, A. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20477 · Cited by 269 · see citing works
Increased Hsp27 after Androgen Ablation Facilitates Androgen-Independent Progression in Prostate Cancer via Signal Transducers and Activators of Transcription 3–Mediated Suppression of Apoptosis
Rocchi, P., Beraldi, E., Ettinger, S., Fazli, L., Vessella, R. L., Nelson, C. C., & Gleave, M. E. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1840 · Cited by 225 · see citing works
Prostate specific antigen gene regulation by androgen receptor
Kim, J. P., & Coetzee, G. A. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20228 · Cited by 197 · see citing works
Self-citation
Molecular markers of prostate cancer outcome
Quinn, D. I., Henshall, S. M., & Sutherland, R. L. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2004.12.035 · Cited by 191 · see citing works
Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator
Zhu, M., Bakhru, P., Conley, B. E., Nelson, J. S., Free, M. E., Martin, A. J., Starmer, J., Wilson, E. M., & Su, M. A. (2016) · Nature Communications · doi:10.1038/ncomms11350 · Cited by 171 · see citing works
Genes Associated with Prostate Cancer Are Differentially Expressed in African American and European American Men
Powell, I. J., Dyson, G. E., Land, S. J., Ruterbusch, J. J., Bock, C. H., Lenk, S., Herawi, M., Everson, R., Giroux, C. N., Schwartz, A. G., et al. (2013) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-12-1238 · Cited by 162 · see citing works
Recent advances on multiple tumorigenic cascades involved in prostatic cancer progression and targeting therapies
Mimeault, M., & Batra, S. K. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi229 · Cited by 153 · see citing works
Minireview: Alternative Activation Pathways for the Androgen Receptor in Prostate Cancer
Lamont, K. R., & Tindall, D. J. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0469 · Cited by 150 · see citing works
Genomic Androgen Receptor-Occupied Regions with Different Functions, Defined by Histone Acetylation, Coregulators and Transcriptional Capacity
Li, J., Berman, B. P., Jariwala, U., Yan, X., Cogan, J. P., Walters, A., Chen, T., Buchanan, G., Frenkel, B., & Coetzee, G. A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003645 · Cited by 147 · see citing works
Self-citation
Heregulin-Induced Activation of HER2 and HER3 Increases Androgen Receptor Transactivation and CWR-R1 Human Recurrent Prostate Cancer Cell Growth
Gregory, C. W., Whang, Y. E., McCall, W., Fei, X., Liu, Y., Ponguta, L. A., French, F. S., Wilson, E. M., & Earp, H. S. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1158 · Cited by 140 · see citing works
Soy isoflavone phyto-pharmaceuticals in interleukin-6 affections
Dijsselbloem, N., Berghe, W. V., Naeyer, A. D., & Haegeman, G. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.05.036 · Cited by 136 · see citing works
Expression levels of the JAK/STAT pathway in the transition from hormone-sensitive to hormone-refractory prostate cancer
Tam, L., McGlynn, L. M., Traynor, P., Mukherjee, R., Bartlett, J. M. S., & Edwards, J. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603871 · Cited by 131 · see citing works
Short Hairpin RNA Knockdown of the Androgen Receptor Attenuates Ligand-Independent Activation and Delays Tumor Progression
Cheng, H., Snoek, R., Ghaidi, F., Cox, M., & Rennie, P. S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0028 · Cited by 127 · see citing works
Exercise-induced myokines and their effect on prostate cancer
Kim, J., Galvao, D. A., Newton, R. U., Gray, E. S., & Taaffe, D. R. (2021) · Nature Reviews Urology · doi:10.1038/s41585-021-00476-y · Cited by 126 · see citing works
Self-citation
Persistent androgen receptor-mediated transcription in castration-resistant prostate cancer under androgen-deprived conditions
Decker, K. F., Zheng, D., He, Y., Bowman, T. A., Edwards, J. R., & Li, J. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks888 · Cited by 104 · see citing works
Cx3Cr1-Cre induction leads to microglial activation and IFN-1 signaling caused by DNA damage in early postnatal brain
Sahasrabuddhe, V., & Ghosh, H. S. (2022) · Cell Reports · doi:10.1016/j.celrep.2021.110252 · Cited by 91 · see citing works
Inhibition of HER-2/neu Kinase Impairs Androgen Receptor Recruitment to the Androgen Responsive Enhancer
Liu, Y., Majumder, S., McCall, W., Sartor, C. I., Mohler, J. L., Gregory, C. W., Earp, H. S., & Whang, Y. E. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4292 · Cited by 99 · see citing works
Andrographolide, an Herbal Medicine, Inhibits Interleukin-6 Expression and Suppresses Prostate Cancer Cell Growth
Chun, J. Y., Tummala, R., Nadiminty, N., Lou, W., Liu, C., Yang, J., Evans, C. P., Zhou, Q., & Gao, A. C. (2010) · Genes & Cancer · doi:10.1177/1947601910383416 · Cited by 100 · see citing works
Control of Androgen Receptor Signaling in Prostate Cancer by the Cochaperone Small Glutamine–Rich Tetratricopeptide Repeat Containing Protein α
Buchanan, G., Ricciardelli, C., Harris, J. M., Prescott, J., Yu, Z. C.-L., Li, J., Butler, L. M., Marshall, V. R., Scher, H. I., Gerald, W. L., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1646 · Cited by 86 · see citing works
Self-citation
Interleukin‐6 undergoes transition from growth inhibitor associated with neuroendocrine differentiation to stimulator accompanied by androgen receptor activation during LNCaP prostate cancer cell progression
Lee, S. O., Chun, J. Y., Nadiminty, N., Lou, W., & Gao, A. C. (2007) · The Prostate · doi:10.1002/pros.20553 · Cited by 85 · see citing works
The NF-κB/IL-6 pathway in metastatic androgen-independent prostate cancer: new therapeutic approaches?
Paule, B., Terry, S., Kheuang, L., Soyeux, P., Vacherot, F., & TAILLE, A. D. L. (2007) · World Journal of Urology · doi:10.1007/s00345-007-0175-6 · Cited by 75 · see citing works
Dynamic Nucleosome-Depleted Regions at Androgen Receptor Enhancers in the Absence of Ligand in Prostate Cancer Cells
Andreu‐Vieyra, C., Lai, J., Berman, B. P., Frenkel, B., Li, J., Jones, P. A., & Coetzee, G. A. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05934-11 · Cited by 71 · see citing works
Self-citation
Effects and mechanisms of pyrethroids on male reproductive system
Wang, Q., Shen, J., Zhang, R., Hong, J., Li, Z., Ding, Z., Wang, H.-X., Zhang, J., Zhang, M., & Xu, L. (2020) · Toxicology · doi:10.1016/j.tox.2020.152460 · Cited by 70 · see citing works
Androgen receptor‐related diseases: what do we know?
Shukla, G. C., Plaga, A. R., Shankar, E., & Gupta, S. (2016) · Andrology · doi:10.1111/andr.12167 · Cited by 72 · see citing works
A transcription-independent function of FOXO1 in inhibition of androgen-independent activation of the androgen receptor in prostate cancer cells.
Liu, P., Li, S., Gan, L., Kao, T. P., & Huang, H. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2038 · Cited by 67 · see citing works
Locus-Wide Chromatin Remodeling and Enhanced Androgen Receptor-Mediated Transcription in Recurrent Prostate Tumor Cells
Li, J., Shen, H. C., Wantroba, M., Khalid, O. S., Liang, G., Wang, Q., Gentzschein, E., Pinski, J., Stanczyk, F. Z., Jones, P. A., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00581-06 · Cited by 66 · see citing works
Self-citation
Inhibition of the Akt, cyclooxygenase‐2, and matrix metalloproteinase‐9 pathways in combination with androgen deprivation therapy: Potential therapeutic approaches for prostate cancer
Miyamoto, H., Altuwaijri, S., Cai, Y., Messing, E. M., & Chang, C. (2005) · Molecular Carcinogenesis · doi:10.1002/mc.20121 · Cited by 65 · see citing works
Stromal Androgen Receptor in Prostate Cancer Development and Progression
Leach, D. A., & Buchanan, G. (2017) · Cancers · doi:10.3390/cancers9010010 · Cited by 63 · see citing works
The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at the prostate-specific antigen locus
Kim, J. Y., Jia, L., Stallcup, M. R., & Coetzee, G. A. (2004) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01701 · Cited by 59 · see citing works
Self-citation
Curcumin Blocks the Activation of Androgen and Interlukin‐6 on Prostate‐Specific Antigen Expression in Human Prostatic Carcinoma Cells
Tsui, K., Feng, T., Lin, C., Chang, P., & Juang, H. (2008) · Journal of Andrology · doi:10.2164/jandrol.108.004911 · Cited by 57 · see citing works
IL-6, IL-10 and HSP-90 expression in tissue microarrays from human prostate cancer assessed by computer-assisted image analysis.
Cardillo, M. R., & Ippoliti, F. (2006) · PubMed · Cited by 57 · see citing works
Identification of Putative Androgen Receptor Interaction Protein Modules
Jasavala, R. J., Martinez, H. D., Thumar, J. R., Andaya, A., Gingras, A., Eng, J. K., Aebersold, R. H., Han, D. K. M., & Wright, M. E. (2006) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m600169-mcp200 · Cited by 56 · see citing works
Celastrol Blocks Interleukin-6 Gene Expression via Downregulation of NF-κB in Prostate Carcinoma Cells
Chiang, K., Tsui, K., Chung, L., Yeh, C., Chen, W., Chang, P., & Juang, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093151 · Cited by 51 · see citing works
Therapeutic Strategies to Target the Androgen Receptor
Xiang, W., & Wang, S. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00716 · Cited by 49 · see citing works
Androgen Receptor–Dependent PSA Expression in Androgen-Independent Prostate Cancer Cells Does Not Involve Androgen Receptor Occupancy of the PSA Locus
Li, J., & Coetzee, G. A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3679 · Cited by 49 · see citing works
Self-citation
An androgen-IL-6-Stat3 autocrine loop re-routes EGF signal in prostate cancer cells.
Aaronson, D. S., Muller, M., Neves, S. R., Chung, W.-C., Jayaram, G., Iyengar, R., & Ram, P. T. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.02.006 · Cited by 47 · see citing works
The Androgen Receptor: Unlocking the Secrets of Its Unique Transactivation Domain
Shen, H. C., & Coetzee, G. A. (2005) · Vitamins and hormones · doi:10.1016/s0083-6729(05)71010-4 · Cited by 44 · see citing works
Self-citation
Modulation of Androgen Receptor Transactivation by FoxH1
Chen, G., Nomura, M., Morinaga, H., Matsubara, E., Okabe, T., Goto, K., Yanase, T., Zheng, H., Lu, J., & Nawata, H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506147200 · Cited by 43 · see citing works
GLI1, a crucial mediator of sonic hedgehog signaling in prostate cancer, functions as a negative modulator for androgen receptor
Chen, G., Goto, Y., Sakamoto, R., Tanaka, K., Matsubara, E., Nakamura, M., Zheng, H., Lu, J., Takayanagi, R., & Nomura, M. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.12.065 · Cited by 42 · see citing works
The orphan receptor ERRα interferes with steroid signaling
Teyssier, C., Bianco, S., Lanvin, O., & Vanacker, J.-M. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn520 · Cited by 37 · see citing works
Vitamin D, intermediary metabolism and prostate cancer tumor progression
Wang, W.-L. W., & Tenniswood, M. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00183 · Cited by 29 · see citing works
Rapid, non‐destructive, cell‐based screening assays for agents that modulate growth, death, and androgen receptor activation in prostate cancer cells
Tavassoli, P., Snoek, R., Ray, M. R., Rao, L. G., & Rennie, P. S. (2007) · The Prostate · doi:10.1002/pros.20532 · Cited by 29 · see citing works
Heterogeneity in hormone-dependent breast cancer and therapy: Steroid hormones, HER2, melanoma antigens, and cannabinoid receptors
Kunstič, T. T., Debeljak, N., & Tacer, K. F. (2023) · Advances in Cancer Biology - Metastasis · doi:10.1016/j.adcanc.2022.100086 · Cited by 33 · see citing works
Interleukin-1β Attenuates Renin Gene Expression Via a Mitogen-Activated Protein Kinase Kinase-Extracellular Signal-Regulated Kinase and Signal Transducer and Activator of Transcription 3-Dependent Mechanism in As4.1 Cells
Liu, X., Shi, Q., & Sigmund, C. D. (2006) · Endocrinology · doi:10.1210/en.2006-0129 · Cited by 27 · see citing works
Racial disparity in prostate cancer in the African American population with actionable ideas and novel immunotherapies
Dovey, Z. S., Nair, S. S., Chakravarty, D., & Tewari, A. K. (2021) · Cancer Reports · doi:10.1002/cnr2.1340 · Cited by 26 · see citing works
A Competitive Inhibitor That Reduces Recruitment of Androgen Receptor to Androgen-responsive Genes
Cherian, M. T., Wilson, E. M., & Shapiro, D. J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.344671 · Cited by 25 · see citing works
Drug Insight: lycopene in the prevention and treatment of prostate cancer
Guns, E. S. T., & Cowell, S. P. (2005) · Nature Clinical Practice Urology · doi:10.1038/ncpuro0073 · Cited by 24 · see citing works
Molecular markers in the diagnosis of prostate cancer
van der Poel, H. G. (2006) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2006.07.003 · Cited by 23 · see citing works
Transcription Factors Involved in Prostate Gland Adaptation to Androgen Deprivation
Rosa‐Ribeiro, R., Nishan, U., Vidal, R. O., Barbosa, G. O., Reis, L. O., Cesar, C. L., & Carvalho, H. F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097080 · Cited by 23 · see citing works
Interleukin-10 Induces Expression of Neuroendocrine Markers and PDL1 in Prostate Cancer Cells
Samiea, A., Yoon, J. S. J., Ong, C. J., Zoubeidi, A., Chamberlain, T. C., & Mui, A. (2020) · Prostate Cancer · doi:10.1155/2020/5305306 · Cited by 22 · see citing works
Enantioselective effects of alpha-hexachlorocyclohexane (HCH) isomers on androgen receptor activity in vitro
Pavlíková, N., Bláhová, L., Petr Klán, A., Bathula, S. R., Sklenář, V., Giesy, J. P., & Bláha, L. (2011) · Chemosphere · doi:10.1016/j.chemosphere.2011.08.052 · Cited by 20 · see citing works
Inhibition of tumor growth and sensitization to chemotherapy by RNA interference targeting interleukin‐6 in the androgen‐independent human prostate cancer PC3 model
Sakai, I., Miyake, H., Terakawa, T., & Fujisawa, M. (2011) · Cancer Science · doi:10.1111/j.1349-7006.2011.01854.x · Cited by 17 · see citing works
Bayesian Hierarchical Varying-Sparsity Regression Models with Application to Cancer Proteogenomics
Ni, Y., Stingo, F. C., Ha, M. J., Akbani, R., & Baladandayuthapani, V. (2018) · Journal of the American Statistical Association · doi:10.1080/01621459.2018.1434529 · Cited by 17 · see citing works
Structure–Activity Relationship (SAR) Studies of Novel Monovalent AR/AR-V7 Dual Degraders with Potent Efficacy against Advanced Prostate Cancer
Xiao, M., Ha, S., Zhu, J., Tao, W., Fu, Z., Wei, H., Hou, Q., Luo, G., & Xiang, H. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c02177 · Cited by 16 · see citing works
Enhanced sensitivity to androgen withdrawal due to overexpression of interleukin-6 in androgen-dependent human prostate cancer LNCaP cells
Terakawa, T., Miyake, H., Furukawa, J., Ettinger, S., Gleave, M. E., & Fujisawa, M. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6605358 · Cited by 16 · see citing works
Mechanisms by Which Interleukin-6 Regulates Prostate-Specific Antigen Gene Expression in Prostate LNCaP Carcinoma Cells
Tsui, K., Lin, Y.-F., Chen, Y.-H., Chang, P. L., & Juang, H. (2010) · Journal of Andrology · doi:10.2164/jandrol.109.009878 · Cited by 14 · see citing works
Systematic multi-omics investigation of androgen receptor driven gene expression and epigenetics changes in prostate cancer
Li, L., Cho, K. H., Yu, X., & Cheng, S. (2025) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2025.110000 · Cited by 13 · see citing works
Enzalutamide-Resistant Progression of Castration-Resistant Prostate Cancer Is Driven via the JAK2/STAT1-Dependent Pathway
Luo, Y., Yang, X., Basourakos, S. P., Zuo, X., Wei, D., Zhao, J., Li, M., Li, Q., Feng, T., Guo, P., et al. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.652443 · Cited by 13 · see citing works
Expression of interleukin-6 is downregulated by 17-(allylamino)-17-demethoxygeldanamycin in human prostatic carcinoma cells
Tsui, K., Feng, T., Hsieh, W., Chang, P., & Juang, H. (2008) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2008.00887.x · Cited by 12 · see citing works
Cytokine profiling identifies an interaction of IL-6 and IL-1α to drive PSMA-PSA prostate clones
Jemaa, A. B., Bouraoui, Y., Rais, N. B., Nouira, Y., & Oueslati, R. (2016) · Immunobiology · doi:10.1016/j.imbio.2016.07.002 · Cited by 11 · see citing works
Bergamottin a CYP3A inhibitor found in grapefruit juice inhibits prostate cancer cell growth by downregulating androgen receptor signaling and promoting G0/G1 cell cycle block and apoptosis
Vetrichelvan, O., Gorjala, P., Goodman, O. B., & Mitra, R. (2021) · PLoS ONE · doi:10.1371/journal.pone.0257984 · Cited by 10 · see citing works
Ginsenoside compound K suppresses tumour growth in the 22Rv1 xenograft model and inhibits androgenic responses via the transcriptional mechanism in human prostate cancer cells
Jiang, M., Sun, Y., & Song, K. (2022) · FEBS Journal · doi:10.1111/febs.16676 · Cited by 8 · see citing works
Psychosocial Stress, Glucocorticoid Signaling, and Prostate Cancer Health Disparities in African American Men.
Woods‐Burnham, L., Stiel, L., Martinez, S. R., Sanchez-Hernández, E. S., Ruckle, H. C., Almaguel, F. G., Stern, M. C., Roberts, L. R., Williams, D. R., Montgomery, S., et al. (2020) · PubMed · Cited by 8 · see citing works
The co-regulators SRC-1 and SMRT are involved in interleukin-6-induced androgen receptor activation
Wang, Q., Wang, H., Ju, Q., Ding, Z., Ge, X., Shi, Q.-M., Zhou, J., Zhou, X.-L., Zhang, J.-P., Zhang, M., et al. (2016) · European Cytokine Network · doi:10.1684/ecn.2016.0380 · Cited by 6 · see citing works
Involvement of interleukin‐1β mediated nuclear factor κB signalling pathways to down‐regulate prostate‐specific antigen and cell proliferation in LNCaP prostate cancer cells
Bouraoui, Y., Rais, N. B., Čulig, Z., & Oueslati, R. (2011) · Cell Biology International · doi:10.1042/cbi20100922 · Cited by 5 · see citing works
Role of IL-6 in Regulating the Androgen Receptor
Čulig, Z., & Hobisch, A. (2009) · Springer eBooks · doi:10.1007/978-0-387-69179-4_20 · Cited by 2 · see citing works
Transcription Factors STAT5 and STAT3
Čulig, Z., Pestell, R. G., & Nevalainen, M. T. (2008) · Humana Press eBooks · doi:10.1007/978-1-60327-079-3_12 · Cited by 1 · see citing works
Novel Approaches to Androgen Receptor Blockade
Mellinghoff, I. K. (2006) · Translational medicine series · doi:10.3109/9781420019858.010 · Cited by 1 · see citing works
WOMEN IN CANCER PROFILE: My pathway to understanding the role of the tumour microenvironment in cancer progression
Ricciardelli, C. (2016) · Endocrine Related Cancer · doi:10.1530/erc-16-0335 · Cited by 1 · see citing works
Self-citation
Mapping the Androgen Receptor Cistrome
Wang, Q., & Brown, M. A. (2009) · Springer eBooks · doi:10.1007/978-0-387-69179-4_28 · Cited by 1 · see citing works
New directions in endocrine therapy: renewed interest in the androgen receptor
Čulig, Z., & Hobisch, A. (2008) · Therapy · doi:10.2217/14750708.5.1.47 · Cited by 1 · see citing works
Évolution des formes moléculaires de l'antigène spécifique de la prostate chez des groupes sérologiques de patients atteints de pathologies prostatiques
Bouraoui, Y., Raïs, N. B., Elouni, Z., Mezigh, C., Machghoul, S., & Oueslati, R. (2006) · Immuno-analyse & Biologie Spécialisée · doi:10.1016/j.immbio.2006.07.006
INTERLEUKIN-6, ITS SUBUNIT gp 130 AND THE POTENTIAL RISK OF PROSTATE CANCER IN A POPULATION OF MEN FROM TOBAGO
Roman, L. N. (2006) · D-Scholarship@Pitt (University of Pittsburgh)
Absence of Ligand in Prostate Cancer Cells Androgen Receptor Enhancers in the Dynamic Nucleosome-Depleted Regions at
Frenkel, B., Li, J., Jones, P. A., Lai, J., & Berman, B. P. (2014)
TGF-β1/TRAF-6 and IL-6/STAT-3 pathways in PSA-PSMA phenotypes of hormone-sensitive and hormone-refractory prostate Cancer
Jemaa, A. B., Azaiez, M. B., Sallami, S., Nouira, Y., Ghazouani, E., & Oueslati, R. (2026) · Clinical Immunology · doi:10.1016/j.clim.2026.110679
La Neuropiline-1, un nouveau biomarqueur de résistance thérapeutique du cancer de la prostate
Blanc, C. (2016) · theses.fr (ABES) · doi:10.70675/b45322c5z1cbdz42c4zba0azdb401927d53c
BindingDB Entry 50016950: Therapeutic Strategies to Target the Androgen Receptor.
BindingDB (2023) · UC San Diego · doi:10.7270/q2j1076h
Rol de HO-1 en la regulación de la inflamación asociada al cáncer de próstata. Compartimentalización subcelular y función
Elguero, M. B. (2013) · Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)

Role of IL-6 in Regulating the Androgen Receptor
Čulig, Z., & Hobisch, A. (2009) · Springer eBooks · doi:10.1007/978-0-387-69179-4_20 · Cited by 2 · see citing works
Interleukin-6 regulates prostate-specific protein expression in prostate carcinoma cells by activation of the androgen receptor.
Hobisch, A., Eder, I. E., Putz, T., Horninger, W., Bartsch, G. C., Klocker, H., & Čulig, Z. (1998) · PubMed · Cited by 437 · see citing works
Androgen-Independent Induction of Androgen-Responsive Genes by Interleukin-6 Regulation
Čulig, Z. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6182-1_11
Androgen receptor signaling: Mechanism of interleukin-6 inhibition. Jia L, Choong CS, Ricciardelli C, Kim J, Tilley WD, Coetzee GA, Department of Urology and Preventive Medicine, Norris Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA.Cancer Res 2004;64:2619-26
Bosland, M. (2004) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/s1078-1439(04)00154-1
Role of the androgen receptor axis in prostate cancer
Čulig, Z. (2003) · Urology · doi:10.1016/s0090-4295(03)00698-8 · Cited by 60 · see citing works

Authors: Jia, L., Choong, C. S.-Y., Ricciardelli, C., Kim, J., Tilley, W. D., & Coetzee, G. A.
Affiliations: 1Department of Urology and Preventive Medicine, Norris Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, and
Hanson Institute (AU)
University of Southern California (US)
ORCID: Choong, Catherine S-Y.
Ricciardelli, Carmela
Kim, Joshua
Tilley, Wayne D.
Coetzee, Gerhard A
Venue: Cancer Research
Publisher: American Association for Cancer Research (AACR)
Published: 2004-04-01
Volume: 64
Issue: 7
Pages: 2619-2626
ISSN: 0008-5472 (ISSN-L)
1538-7445
DOI: 10.1158/0008-5472.can-03-3486
OpenAlex: W1966572152
Cited by: 80
References: 45
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 3 · 2018: 1 · 2017: 1 · 2016: 6 · 2014: 4 · 2013: 2 · 2012: 2
FWCI: 8.58
Type: journal article
Language: en
Open access: closed
Locations: Cancer Research (publishedVersion)
PubMed (publishedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Funders: National Cancer Institute (R01CA84890, T32CA009320, R01CA084890)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Keywords: androgen receptor, interleukin-6, prostate-specific antigen, castration-resistant prostate cancer, dihydrotestosterone, nuclear translocation, transcriptional coactivator, P300, SMRT, HDAC1, histone H3 acetylation, corepressors, STAT3, MAPK signaling, Akt signaling, LNCaP cells
MeSH terms: Cell Nucleus, DNA-Binding Proteins, Histone Deacetylases, Humans, Male, Nuclear Proteins, Prostatic Neoplasms, Proto-Oncogene Proteins, Receptors, Androgen, Repressor Proteins, Dihydrotestosterone, Signal Transduction, Transcriptional Activation, Trans-Activators, Interleukin-6, Gene Expression, Protein Serine-Threonine Kinases, Prostate-Specific Antigen, Cell Line, Tumor, STAT3 Transcription Factor, Proto-Oncogene Proteins c-akt, Histone Deacetylase 1, Nuclear Receptor Co-Repressor 2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Androgen Receptor Signaling

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks