Cited by 71Immunotherapy and Immune ResponsesCancer Immunotherapy and BiomarkersCancer Research and Treatments

Mutation-selective tumor remission with Ras-targeted, whole yeast-based immunotherapy

Lu, Yingnian, Bellgrau, Donald, Dwyer-Nield, Lori D., Malkinson, Alvin M., Duke, Richard C., Rodell, Timothy C., Franzusoff, Alex·2004·Cancer Research

Abstract

Activating mutations in Ras oncoproteins represent attractive targets for cancer immunotherapy, but few vectors capable of generating immune responses required for tumor killing without vector neutralization have been described. Whole recombinant yeast heterologously expressing mammalian mutant Ras proteins were used to immunize mice in a carcinogen-induced lung tumor model. Therapeutic immunization with the whole recombinant yeast caused complete regression of established Ras mutation-bearing lung tumors in a dose-dependent, antigen-specific manner. In combination with the genomic sequencing of tumors in patients, the yeast-based immunotherapeutic approach could be applied to treat Ras mutation-bearing human cancers.

Integrity signals

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Crossref · 10.1158/0008-5472.can-04-1487

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23 of 23 references verified0 citation errors · 0 not checkable

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Authors
Lu, Y., Bellgrau, D., Dwyer-Nield, L. D., Malkinson, A. M., Duke, R. C., Rodell, T. C., & Franzusoff, A.
Affiliations
  • GlobeImmune (United States) (US)
  • University of Colorado Health (US)
  • 3School of Pharmacy, and
  • University of Colorado Cancer Center (US)
Venue
Cancer Research
Published
2004-08-01
Volume
64
Issue
15
Pages
5084-5088
ISSN
  • 0008-5472 (ISSN-L)
  • 1538-7445
OpenAlex
W2124601689
Cited by
71
References
23
Citations by year
2025: 2 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 4 · 2014: 5 · 2013: 2 · 2012: 3
FWCI
1.56
Type
journal article
Language
en
Open access
closed
Locations
  • Cancer Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Cancer Center, University of Colorado
  • National Cancer Institute (R01CA033497, CA-33497, R01CA096133, CA96133)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK058722, DK58722)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Cancer Research and Treatments
Keywords
tumor remission, cancer immunotherapy, antigen-specific immune response, lung cancer, carcinogen-induced tumors
MeSH terms
Adenoma, Animals, DNA, Neoplasm, Humans, Immunotherapy, Lung Neoplasms, Male, Mice, Inbred Strains, Mutation, Neoplasms, Experimental, Recombinant Proteins, Saccharomyces cerevisiae, Urethane, Gene Expression Regulation, Neoplastic, Proto-Oncogene Proteins p21(ras), Mice

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