The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Homozygous Deletions and Chromosome Amplifications in Human Lung Carcinomas Revealed by Single Nucleotide Polymorphism Array Analysis
Open accessAbstract
Genome-wide copy number changes were analyzed in 70 primary human lung carcinoma specimens and 31 cell lines derived from human lung carcinomas, with high-density arrays representing ∼115,000 single nucleotide polymorphism loci. In addition to previously characterized loci, two regions of homozygous deletion were found, one near the PTPRD locus on chromosome segment 9p23 in four samples representing both small cell lung carcinoma (SCLC) and non–small cell lung carcinoma (NSCLC) and the second on chromosome segment 3q25 in one sample each of NSCLC and SCLC. High-level amplifications were identified within chromosome segment 8q12-13 in two SCLC specimens, 12p11 in two NSCLC specimens and 22q11 in four NSCLC specimens. Systematic copy number analysis of tyrosine kinase genes identified high-level amplification of EGFR in three NSCLC specimens, FGFR1 in two specimens and ERBB2 and MET in one specimen each. EGFR amplification was shown to be independent of kinase domain mutational status.
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Cites
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Self-citationEGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
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Self-citationA human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
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BackgroundA cell cycle regulator potentially involved in genesis of many tumor types
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BackgroundInfluentialCitric acid cycle intermediates as ligands for orphan G-protein-coupled receptors
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“Examples where identification of cancer-specific amplifications preceded the identification of cancer somatic mutations include PDGFRA (7, 8), EGFR (9–14), ERBB2 (15, 16), and PIK3CA (17–19).”
BackgroundInfluential
Cited by
Somatic mutations affect key pathways in lung adenocarcinoma
Ding, L., Getz, G., Wheeler, D. A., Mardis, E. R., McLellan, M. D., Cibulskis, K., Sougnez, C., Greulich, H., Muzny, D. M., Morgan, M. B., et al. (2008) · Nature · doi:10.1038/nature07423 · Cited by 2,681
Self-citationThe Diploid Genome Sequence of an Individual Human
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Characterizing the cancer genome in lung adenocarcinoma
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Self-citationA faster circular binary segmentation algorithm for the analysis of array CGH data
Venkatraman, E. S., & Olshen, A. B. (2007) · Bioinformatics · doi:10.1093/bioinformatics/btl646 · Cited by 961
Metadata
- Authors
- Zhao, X., Weir, B. A., LaFramboise, T., Lin, M., Beroukhim, R., Garraway, L., Beheshti, J., Lee, J. C., Naoki, K., Richards, W. G., Sugarbaker, D., Chen, F., Rubin, M. A., Jänne, P. A., Girard, L., Minna, J., Christiani, D., Li, C., Sellers, W. R., & Meyerson, M.
- Venue
- Cancer Research
- Published
- 2005-07-01
- Volume
- 65
- Issue
- 13
- Pages
- 5561-5570
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2118411662
- Cited by
- 337
- References
- 11
- FWCI
- 30.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhao, X., Weir, B. A., LaFramboise, T., Lin, M., Beroukhim, R., Garraway, L., Beheshti, J., Lee, J. C., Naoki, K., Richards, W. G., Sugarbaker, D., Chen, F., Rubin, M. A., Jänne, P. A., Girard, L., Minna, J., Christiani, D., Li, C., Sellers, W. R., & Meyerson, M. (2005). Homozygous Deletions and Chromosome Amplifications in Human Lung Carcinomas Revealed by Single Nucleotide Polymorphism Array Analysis. Cancer Research. https://doi.org/10.1158/0008-5472.can-04-4603
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