The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Fatty Acid Synthase and Cancer: New Application of an Old Pathway
Abstract
Fatty acid synthase (FAS), the sole mammalian enzyme capable of de novo fatty acid synthesis, is highly expressed in most human carcinomas. FAS is associated with poor prognosis in breast and prostate cancer, is elaborated into the blood of cancer patients, and its inhibition is selectively cytotoxic to human cancer cells. Thus, FAS and fatty acid metabolism in cancer has become a focus for the potential diagnosis and treatment of cancer. (Cancer Res 2006; 66(12): 5977-80)
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Citations
Cites
The Mitochondrial Carnitine Palmitoyltransferase System — From Concept to Molecular Analysis
McGarry, J. D., & Brown, N. F. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00001.x · Cited by 1,616 · cited 1×
“Importantly, the high steady-state levels of malonyl-CoA during lipogenesis inhibit carnitine palmitoyltransferase-1 (CPT-1), the rate-limiting enzyme of mitochondrial fatty acid oxidation, shunting fatty acids away from oxidation and toward storage as triglycerides (4).”
BackgroundFatty acid synthesis: a potential selective target for antineoplastic therapy
Kuhajda, F. P., Jenner, K., Wood, F. D., Hennigar, R. A., Jacobs, L. B., Dick, J. D., & Pasternack, G. R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.14.6379 · Cited by 705 · cited 1×
“Endogenously synthesized fatty acids in cancer cells are esterified predominantly to phospholipids, not triglyceride (5).”
BackgroundSelf-citation�ber den Stoffwechsel der Carcinomzelle
Warburg, O. (1924) · Die Naturwissenschaften · doi:10.1007/bf01504608 · Cited by 631
Cited by
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Menendez, J. A., & Lupu, R. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2222 · Cited by 2,941
Rysman, E., Brusselmans, K., Scheys, K., Timmermans, L., Derua, R., Munck, S., Van Veldhoven, P. P., Waltregny, D., Daniëls, V. W., Machiels, J., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3871 · Cited by 721
De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy
Mashima, T., Seimiya, H., & Tsuruo, T. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6605007 · Cited by 555
Hilvo, M., Denkert, C., Lehtinen, L., Müller, B., Brockmöller, S., Seppänen-Laakso, T., Budczies, J., Bucher, E., Yetukuri, L., Castillo, S., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3894 · Cited by 532
Adipocyte and lipid metabolism in cancer drug resistance
Cao, Y. (2019) · Journal of Clinical Investigation · doi:10.1172/jci127201 · Cited by 522
Metadata
- Authors
- Kuhajda, F. P.
- Venue
- Cancer Research
- Published
- 2006-06-15
- Volume
- 66
- Issue
- 12
- Pages
- 5977-5980
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W1967482096
- Cited by
- 647
- References
- 3
- FWCI
- 12.82
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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