The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy
Open accessAbstract
Enhanced lipid biosynthesis is a characteristic feature of cancer. Deregulated lipogenesis plays an important role in tumour cell survival. These observations suggest that enzymes in the lipid synthesis pathway would be rational therapeutic targets for cancer. To this end, we review the enzymes in de novo fatty-acid synthesis and related pathways.
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Cites
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Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Menendez, J. A., & Lupu, R. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2222 · Cited by 2,941 · cited 1×
“In cancer cells, transcriptional regulation of FASN gene is one of the important mechanisms of FASN overexpression (Kuhajda, 2006; Menendez and Lupu, 2007).”
BackgroundATP citrate lyase inhibition can suppress tumor cell growth
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Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology
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Fatty Acid Synthase and Cancer: New Application of an Old Pathway
Kuhajda, F. P. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4673 · Cited by 647
ATP citrate lyase is an important component of cell growth and transformation
Bauer, D. E., Hatzivassiliou, G., Zhao, F., Andreadis, C., & Thompson, C. B. (2005) · Oncogene · doi:10.1038/sj.onc.1208773 · Cited by 537
The Crystal Structure of a Mammalian Fatty Acid Synthase
Maier, T., Leibundgut, M., & Ban, N. (2008) · Science · doi:10.1126/science.1161269 · Cited by 505
Intracellular unesterified arachidonic acid signals apoptosis
Cao, Y., Pearman, A. T., Zimmerman, G. A., McIntyre, T. M., & Prescott, S. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.200367597 · Cited by 437
ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer
Migita, T., Narita, T., Nomura, K., Miyagi, E., Inazuka, F., Matsuura, M., Ushijima, M., Mashima, T., Seimiya, H., Satoh, Y., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1235 · Cited by 403
Self-citationFuruta, E., Pai, S. K., Zhan, R., Bandyopadhyay, S., Watabe, M., Mo, Y.-Y., Hirota, S., Hosobe, S., Tsukada, T., Miura, K., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2489 · Cited by 392
Cited by
Aspects of the Tumor Microenvironment Involved in Immune Resistance and Drug Resistance
Khalaf, K., Hana, D., Chou, J. T.-T., Singh, C., Mackiewicz, A., & Kaczmarek, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.656364 · Cited by 513
Regulation and Metabolic Significance of De Novo Lipogenesis in Adipose Tissues
Song, Z., Xiaoli, A. M., & Yang, F. (2018) · Nutrients · doi:10.3390/nu10101383 · Cited by 435
UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis
Moon, J.-S., Lee, S., Park, M.-A., Siempos, I. I., Haslip, M., Lee, P. J., Yun, M., Kim, C. K., Howrylak, J., Ryter, S. W., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78253 · Cited by 238
RetractedZaytseva, Y. Y., Rychahou, P. G., Gulhati, P., Elliott, V. A., Mustain, W. C., O'Connor, K., Morris, A. J., Sunkara, M., Weiss, H. L., Lee, E. Y., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-4057 · Cited by 208
Glucose-dependent de Novo Lipogenesis in B Lymphocytes
Dufort, F. J., Gumina, M. R., Ta, N. L., Tao, Y., Heyse, S. A., Scott, D. A., Richardson, A. D., Seyfried, T. N., & Chiles, T. C. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.551051 · Cited by 160
Metadata
- Authors
- Mashima, T., Seimiya, H., & Tsuruo, T.
- Venue
- British Journal of Cancer
- Published
- 2009-04-07
- Volume
- 100
- Issue
- 9
- Pages
- 1369-1372
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2088545470
- Cited by
- 555
- References
- 35
- FWCI
- 6.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Mashima, T., Seimiya, H., & Tsuruo, T. (2009). De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy. British Journal of Cancer. https://doi.org/10.1038/sj.bjc.6605007
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
