The DOI matches its Crossref record; 191 of the 191 references it cites were found in a registry or an index.
Adipocyte and lipid metabolism in cancer drug resistance
Open accessAbstract
Development of novel and effective therapeutics for treating various cancers is probably the most congested and challenging enterprise of pharmaceutical companies. Diverse drugs targeting malignant and nonmalignant cells receive clinical approval each year from the FDA. Targeting cancer cells and nonmalignant cells unavoidably changes the tumor microenvironment, and cellular and molecular components relentlessly alter in response to drugs. Cancer cells often reprogram their metabolic pathways to adapt to environmental challenges and facilitate survival, proliferation, and metastasis. While cancer cells' dependence on glycolysis for energy production is well studied, the roles of adipocytes and lipid metabolic reprogramming in supporting cancer growth, metastasis, and drug responses are less understood. This Review focuses on emerging mechanisms involving adipocytes and lipid metabolism in altering the response to cancer treatment. In particular, we discuss mechanisms underlying cancer-associated adipocytes and lipid metabolic reprogramming in cancer drug resistance.
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Cites
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Cited by
Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics
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Metadata
- Authors
- Cao, Y.
- Venue
- Journal of Clinical Investigation
- Published
- 2019-07-02
- Volume
- 129
- Issue
- 8
- Pages
- 3006-3017
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- OpenAlex
- W2954493501
- Cited by
- 522
- References
- 191
- FWCI
- 13.62
- Type
- journal article
- Language
- en
- Open access
- bronze
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