TMPRSS2:ETV4 Gene Fusions Define a Third Molecular Subtype of Prostate Cancer

Tomlins, Scott A.; Mehra, Rohit; Rhodes, Daniel R.; Smith, Lisa R.; Roulston, Diane; Helgeson, Beth E.; Cao, Xuhong; Wei, John T.; Rubin, Mark A.; Shah, Rajal B.; Chinnaiyan, Arul M.

doi:10.1158/0008-5472.can-06-0168

TMPRSS2:ETV4 Gene Fusions Define a Third Molecular Subtype of Prostate Cancer

Although common in hematologic and mesenchymal malignancies, recurrent gene fusions have not been well characterized in epithelial carcinomas. Recently, using a novel bioinformatic approach, we identified recurrent gene fusions between TMPRSS2 and the ETS family members ERG or ETV1 in the majorit…