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Direct Transcriptional Up-regulation of Cyclooxygenase-2 by Hypoxia-Inducible Factor (HIF)-1 Promotes Colorectal Tumor Cell Survival and Enhances HIF-1 Transcriptional Activity during Hypoxia
Abstract
Cyclooxygenase (COX)-2, the inducible key enzyme for prostanoid biosynthesis, is overexpressed in most colorectal carcinomas and a subset of colorectal adenomas. Genetic, biochemical, and clinical evidence indicates an important role for COX-2 in colorectal tumorigenesis. Although COX-2 can be induced by aberrant growth factor signaling and oncogene activation during colorectal tumorigenesis, the role of microenvironmental factors such as hypoxia in COX-2 regulation remains to be elucidated. For the first time, we report that under hypoxic conditions COX-2 protein levels increase in colorectal adenoma and carcinoma cells. Rigorous analyses reveal that COX-2 up-regulation is transcriptional and is associated with hypoxia-inducible factor (HIF)-1alpha induction. Oligonucleotide pull-down and chromatin immunoprecipitation assays reveal that HIF-1alpha binds a hypoxia-responsive element on the COX-2 promoter. COX-2 up-regulation during hypoxia is accompanied by increased levels of prostaglandin E(2) (PGE(2)), which promote tumor cell survival under hypoxic conditions. In addition, elevated levels of PGE(2) in hypoxic colorectal tumor cells enhance vascular endothelial growth factor expression and HIF-1 transcriptional activity by activating the mitogen-activated protein kinase pathway, showing a potential positive feedback loop that contributes to COX-2 up-regulation during hypoxia. This study identifies COX-2 as a direct target for HIF-1 in colorectal tumor cells. In addition, COX-2 up-regulation represents a pivotal cellular adaptive response to hypoxia with implication for colorectal tumor cell survival and angiogenesis. We propose that using modified COX-2-selective inhibitors, which are only activated under hypoxic conditions, could potentially be a novel more selective strategy for colorectal cancer prevention and treatment.
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“In addition, hypoxia also induces COX-2 [86].”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [86]
Citations
Cites
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
Hanahan, D., & Folkman, J. (1996) · Cell · doi:10.1016/s0092-8674(00)80108-7 · Cited by 6,885
Targeting HIF-1 for cancer therapy
Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717
Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212
Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535
Hypoxia — a key regulatory factor in tumour growth
Harris, A. L. (2002) · Nature Reviews Cancer · doi:10.1038/nrc704 · Cited by 5,177
Lessons from hereditary colorectal cancer
Kinzler, K. W., & Vogelstein, B. (1996) · Cell · doi:10.1016/s0092-8674(00)81333-1 · Cited by 4,919
The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor, in Familial Adenomatous Polyposis
Steinbach, G., Lynch, P. M., Phillips, R. K. S., Wallace, M. H., Hawk, E. T., Gordon, G., Wakabayashi, N., Saunders, B. P., Shen, Y., Fujimura, T., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200006293422603 · Cited by 2,522
Regulation of angiogenesis by hypoxia: role of the HIF system
Pugh, C. W., & Ratcliffe, P. J. (2003) · Nature Medicine · doi:10.1038/nm0603-677 · Cited by 2,520
Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas
Eberhart, C. E., Coffey, R. J., Aramandla, R., Giardiello, F. M., Ferrenbach, S., & DuBois, R. N. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90246-1 · Cited by 2,512
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
Carmeliet, P., Dor, Y., Herbert, J.-M., Fukumura, D., Brusselmans, K., Dewerchin, M., Neeman, M., Bono, F., Abramovitch, R., Maxwell, P., et al. (1998) · Nature · doi:10.1038/28867 · Cited by 2,502
Research works printed but not linked: 1
- Oshima M, Dinchuk JE, Kargman SL, et al. Suppression of intestinal polyposis in Apc δ716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 1996; 87: 803–9. · DOI
Cited by
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Items 201–300 of 301
Hypoxia-induced HIF1α dependent COX2 promotes ovarian cancer progress
Ding, Y., Zhuang, S., Li, Y., Yu, X., Lü, M., & Ding, N. (2021) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-021-09900-9 · Cited by 17
Strillacci, A., Griffoni, C., Lazzarini, G., Valerii, M. C., Molfetta, S. D., Rizzello, F., Campieri, M., Moyer, M. P., Tomasi, V., & Spisni, E. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605859 · Cited by 17
Mohammadi, A., Yaghoobi, M. M., Gholamhoseinian, A., Kalantari-Khandani, B., Sharifi, H. P., & Saravani, M. (2016) · Inflammation · doi:10.1007/s10753-016-0343-1 · Cited by 17
Aliabad, R. A., Hassanpour, K., & Norooznezhad, A. H. (2024) · Immunity Inflammation and Disease · doi:10.1002/iid3.1370 · Cited by 16
The Role of Abnormal Uterine Junction Zone in the Occurrence and Development of Adenomyosis
Xie, T., Xu, X., Yang, Y. L., Wu, C., Liu, X., Zhou, L., & Song, Y. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00684-2 · Cited by 16
Grau, R., Díaz‐Muñoz, M. D., Cacheiro‐Llaguno, C., Fresno, M., & Iñiguez, M. A. (2008) · PPAR Research · doi:10.1155/2008/352437 · Cited by 16
Qi, Q.-M., Guo, S.-W., & Liu, X.-S. (2019) · Reproductive and Developmental Medicine · doi:10.4103/2096-2924.262390 · Cited by 15
“[29] For example, COX-2 expression is regulated by HIF-1α transcriptional activity.[30] HIF-1α-induced COX-2 expression leads to elevated prostaglandin E2 (PGE2) levels, which can induce PGE2-mediated vascularization.”
BackgroundMu, L., Jinshen, W., Yuezhi, C., Le-ping, L., Xiaobo, G., Sheng, Z., & Changqing, J. (2014) · Chinese Medical Journal · doi:10.3760/cma.j.issn.0366-6999.20141114 · Cited by 15
CRISPR/Cas9 Mediated Knockout of Cyclooxygenase-2 Gene Inhibits Invasiveness in A2058 Melanoma Cells
Haase‐Kohn, C., Laube, M., Donat, C. K., Belter, B., & Pietzsch, J. (2022) · Cells · doi:10.3390/cells11040749 · Cited by 15
Koo, J. S., & Kim, H. (2011) · Tumor Biology · doi:10.1007/s13277-011-0190-5 · Cited by 15
Oxygen regulates molecular mechanisms of cancer progression and metastasis
Gupta, K., Madan, E., Sayyid, M. M., Arias‐Pulido, H., Moreno, E., Kuppusamy, P., & Gogna, R. (2013) · Cancer and Metastasis Reviews · doi:10.1007/s10555-013-9464-2 · Cited by 16
Effective prediction of potential ferroptosis critical genes in clinical colorectal cancer
Huang, H., Dai, Y., Duan, Y., Yuan, Z., Li, Y., Zhang, M., Zhu, W., Yu, H. J., Zhong, W., & Feng, S. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1033044 · Cited by 13
Zhang, A., Cong, L., Nan, C., Zhao, Z., & Liu, L. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05735-1 · Cited by 14
Gao, F., Brant, K. A., Ward, R. M., Cattley, R. T., Barchowsky, A., & Fabisiak, J. P. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.06.007 · Cited by 14
Yang, H., Jiang, J., Yang, Y.-T., Yang, X.-D., Guo, Z., Qi, Y., Zeng, F.-H., Zhang, K., Chen, N.-Z., Xiang, B., et al. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i39.8798 · Cited by 14
Lim, W., & Kang, C. (2020) · Animal Cells and Systems · doi:10.1080/19768354.2020.1748108 · Cited by 14
Mihaljević, Z., Matić, A., Stupin, A., Frkanec, R., Tavčar, B., Kelava, V., Bujak, I. T., Kolobarić, N., Kibel, A., & Drenjančević, I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176353 · Cited by 14
Fu, J., Zou, Y. S., Huang, Z., Chang, Y. Z., Zhou, Q., Zhang, H., Lai, Y., Peng, S., & Zhang, Y. (2015) · RSC Advances · doi:10.1039/c5ra00270b · Cited by 13
Che, X., Liu, J., Huang, H., Mi, X., Xia, Q., Li, J., Zhang, D., Ke, Q., Gao, J., & Huang, C. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.04.012 · Cited by 13
Song, H., & Lee, Y. (2016) · Journal of Ginseng Research · doi:10.1016/j.jgr.2016.04.001 · Cited by 13
Liang, Y., Zhen, X., Wang, K., & Ma, J. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.06.079 · Cited by 13
Retracted Article: Oleuropein inhibits esophageal cancer through hypoxic suppression of BTG3 mRNA
Zhang, F., & Zhang, M. (2019) · Food & Function · doi:10.1039/c8fo02223b · Cited by 12
RetractedThe role of HIF-1α in nicotine-induced root and bone resorption during orthodontic tooth movement
Ullrich, N., Schröder, A., Bauer, M. L. M., Spanier, G., Jantsch, J., Deschner, J., Proff, P., & Kirschneck, C. (2020) · European Journal of Orthodontics · doi:10.1093/ejo/cjaa057 · Cited by 13
Zheng, Y., Zhao, Y., Jiang, J., Zou, B., & Dong, L. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.899385 · Cited by 12
The Role of Prostaglandins as Major Inflammatory Mediators in Colorectal Cancer
Macia-Guardado, M., Lutz, V., Hengstschläger, M., & Dolznig, H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262412191 · Cited by 17
Otake, S., Yoshida, K., Seira, N., Sanchez, C. M., Regan, J. W., Fujino, H., & Murayama, T. (2014) · Pharmacology Research & Perspectives · doi:10.1002/prp2.83 · Cited by 11
Red ginseng represses hypoxia-induced cyclooxygenase-2 through sirtuin1 activation
Lim, W., Shim, M. K., Kim, S., & Lee, Y. (2015) · Phytomedicine · doi:10.1016/j.phymed.2015.03.005 · Cited by 11
Pringels, S., Damme, N. V., Craene, B. D., Pattyn, P., Ceelen, W. P., Peeters, M., & Grooten, J. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-515 · Cited by 11
Yang, Y., Geng, Y., Cheng, X., Gao, J., Shi, Z., & Zhao, M. (2023) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2023.11822 · Cited by 10
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Wu, Y. (2023) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557523666230509122402 · Cited by 10
Intracellular prostaglandin E2 contributes to hypoxia-induced proximal tubular cell death
García-Pastor, C., Martínez, S. B., Bosch, R. J., Fernández‐Martínez, A. B., & Lucio-Cazaña, F. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-86219-w · Cited by 10
Arachidonic acid metabolism as a novel pathogenic factor in gastrointestinal cancers
Lu, W., Aihaiti, A., Abudukeranmu, P., Liu, Y., & Gao, H. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05057-2 · Cited by 9
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Compare, D., Nardone, O. M., & Nardone, G. (2010) · Pharmaceuticals · doi:10.3390/ph3082495 · Cited by 9
Combination of physical activity, nutrition, or other metabolic factors and vaccine response
Kenneth, W. H. (2007) · Frontiers in bioscience · doi:10.2741/2444 · Cited by 10
Targeting Cyclooxygenase-2 in Pheochromocytoma and Paraganglioma: Focus on Genetic Background
Ullrich, M., Richter, S., Seifert, V., Hauser, S., Calsina, B., Martínez‐Montes, Á. M., ter Laak, M., Ziegler, C. G., Timmers, H. J. L. M., Eisenhofer, G., et al. (2019) · Cancers · doi:10.3390/cancers11060743 · Cited by 8
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Lee, W., Chiu, C.-H., Chu, T., & Chien, Y.-S. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.876723 · Cited by 8
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Young, A. L., Chalmers, C. R., Hawcroft, G., Perry, S., Treanor, D. E., Toogood, G. J., Jones, P. F., & Hull, M. A. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-92 · Cited by 8
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Maturu, P. (2016) · Codon Publications eBooks · doi:10.15586/codon.wt.2016.ch12 · Cited by 8
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Terasaki, M., Ogawa, Y., Endo, T., Maeda, H., Hamada, J., Osada, K., Miyashita, K., & Mutoh, M. (2018) · Anticancer Research · doi:10.21873/anticanres.12458 · Cited by 7
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Boyle, A. J., Narvaez, A., Tong, J., Zoghbi, S. S., Pike, V. W., Innis, R. B., & Vasdev, N. (2021) · Molecular Imaging and Biology · doi:10.1007/s11307-021-01675-0 · Cited by 6
Tu, T., Peng, Z., Zhang, L., Yang, J., Guo, K., Tang, X., Ye, J., Zhang, F., Huang, A., Yu, J., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03442-2 · Cited by 7
Zhang, X., & Sun, L. (2024) · iScience · doi:10.1016/j.isci.2024.111484 · Cited by 6
Pascoal, V., Marchesini, R., Athié, M. C. P., de Matos, A. H. B., Conte, F. F., Pereira, T. C., Secolin, R., Gilioli, R., Malheiros, J. M., Polli, R. S., et al. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01190-y · Cited by 8
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Tamiya‐Koizumi, K., Otoki, Y., Nakagawa, K., Kannagi, R., Mizutani, N., Suzuki, M., Kyogashima, M., Iwaki, S., Aoyama, M., Murate, T., et al. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.04.061 · Cited by 6
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Mori, N., Mironchik, Y., Wildes, F. B., Wu, S. Y., Mori, K., Krishnamachary, B., & Bhujwalla, Z. M. (2020) · Current Cancer Reports · doi:10.25082/ccr.2020.01.005 · Cited by 6
Seeger, D. R., Golovko, S. A., Grove, B. D., & Golovko, M. Y. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15291 · Cited by 6
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Ene, C. D., & Nicolae, I. (2015) · InTech eBooks · doi:10.5772/59176 · Cited by 5
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Adams, J. L., Duffy, K. J., Moore, M. L., & Yang, J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.12400-x · Cited by 7
Expression of heregulin and ErbB receptors in mesenchymal stem cells
Gui, C., Wang, J., He, A., Chen, T., Liu, X., Luo, R., & Jiang, J. (2008) · Chinese Medical Journal · doi:10.1097/00029330-200801020-00012 · Cited by 5
Xiao, X., Zhen, W., Bai, D., Zheng, B., Wang, Y., Ma, X., Xie, X., Zhang, Y., Guo, F., Ito, K., et al. (2026) · Poultry Science · doi:10.1016/j.psj.2026.106909 · Cited by 6
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Roy, S., Shaw, R., Pandey, A., & Trigun, S. K. (2025) · Discover Oncology · doi:10.1007/s12672-025-03004-1 · Cited by 4
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Amjadi, O., Rafiei, A., Ajami, A., Hosseini, V., & Asgarian‐Omran, H. (2014) · Research in Molecular Medicine · doi:10.18869/acadpub.rmm.2.2.1 · Cited by 3
Reducing PMA-induced COX-2 expression using a herbal formulation in MCF-7 breast cancer cells
Nair, M. V., Umrao, A., Rao, G. A., & Rao, J. (2021) · Journal of Emerging Investigators · doi:10.59720/20-195 · Cited by 3
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Momin, S., & Nagaraju, G. P. (2020) · Diagnostics and therapeutic advances in GI malignancies · doi:10.1007/978-981-15-2017-4_4 · Cited by 2
Wang, M., Shi, Z., Liu, D., Zhang, G.-Y., Sha, J., & Jiang, B. (2010) · Frontiers in Biology · doi:10.1007/s11515-010-0033-6 · Cited by 2
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Gottfried, E., Peter, K., & Kreutz, M. P. (2010) · Springer eBooks · doi:10.1007/978-90-481-9531-2_7 · Cited by 2
Guan, N., Zhang, M., Gong, W.-Y., Mao, X., Yang, S., & Hao, C. (2022) · Hypertension Research · doi:10.1038/s41440-022-00889-1 · Cited by 2
Ilie, P. C., Stefanescu, S., & Veronese, N. (2020) · Atena Journal of Public Health · Cited by 2
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Lopez‐Ramirez, M. A., Soliman, S. I., Hale, P., Lai, C. C., Pham, A., Estrada, E. J., McCurdy, S., Girard, R., Verma, R., Moore, T., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.29.428891 · Cited by 2
Ruan, M., Xi, X., Guo, N., Wang, F., Ma, R., Ju, S., Lv, J., Hou, S., & Ju, S. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08148-4 · Cited by 1
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Dunn, L. (2012) · Scholarship@Western (Western University) · Cited by 1
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Ferremi, F. J., Moscoso, V. V., Montanaro, M. A., González-Baró, M. R., & Cattáneo, E. R. (2024) · Lipids in Health and Disease · doi:10.1186/s12944-024-02344-1 · Cited by 1
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Morales‐Ruiz, M., Tugues, S., & Jiménez, W. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-866-9_17 · Cited by 1
Syahrizal, D., Mustika, C. R., Renaldi, T. A., Suryokusumo, M. G., & Hendarto, H. (2020) · E3S Web of Conferences · doi:10.1051/e3sconf/202015101003 · Cited by 1
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Munro, S. K. (2013) · ResearchSpace (University of Auckland) · Cited by 1
Hif-1α stabilisation polarises macrophages via cyclooxygenase/prostaglandin E2 in vivoPreprint
Lewis, A., & Elks, P. M. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/536862 · Cited by 1
Pharmacological modulation and manipulation of cancer drug resistance
Devery, A. (2010) · Arrow@dit (Dublin Institute of Technology) · Cited by 1
Eicosanoid Regulation of Hematopoietic Stem and Progenitor Cell Function
Hoggatt, J. (2010) · IUScholarWorks (Indiana University) · doi:10.7912/c2/1697
Vázquez-Cedeira, M. (2012) · Gredos (University of Salamanca) · doi:10.14201/gredos.115614
Laflamme, C. (2009) · Archipel (Université du Québec à Montréal)
Hüsecken, Y. (2014) · DuEPublico (University of Duisburg-Essen)
The role of galanin in perineural invasion of head and neck cancer
Scanlon, C. S. (2014) · Deep Blue (University of Michigan)
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Delić, A. (2015) · Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam)
Mohideen, H., & Sahbi, A. M. (2013) · Memorial University Research Repository (Memorial University)
Telomerase in hematological and other malignancies : therapeutic implications
Li, B. (2015) · Figshare
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Martínez, A. M., Lucio-Cazaña, F. J., & Fernández‐Martínez, A. B. (2013) · Dialnet (Universidad de la Rioja)
Direktor, Ä., & Unertl, K. E. (2009)
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Allam, U. S., Kamatham, S., Adarsha, M., Jasmine, S. M., & Prasad, P. V. G. (2017) · Springer eBooks · doi:10.1007/978-981-10-6728-0_15
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Papamichali, R. (2018) · doi:10.12681/eadd/43492
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Yanni, S. E. (2010)
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Pafford, J. B. (2012)
chen, C., Tan, X., Kou, X., Qin, X., Li, Z., Li, J., & Li, Q. (2021) · Research Square · doi:10.21203/rs.3.rs-726985/v1
Tsai, Y.-T., Lo, W., Chen, P., Ko, C., Kao, T., Yang, W., Chang, K., Hung, C.-Y., Kikkawa, U., Chang, W., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-965026/v1
Smedh, U., Gustafsson, A., Axelsson, H., Cahlin, C., Lönnroth, C., & Lundholm, K. (2010) · Springer eBooks · doi:10.1007/978-90-481-9531-2_15
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(2017) · Journal of Chemical Biological and Physical Sciences · doi:10.24214/jcbps.b.7.4.132430
Kim, S., Park, Y., Kim, S., Lee, J., Wang, D., & DuBois, R. N. (2023) · doi:10.1158/0008-5472.c.6503078.v1
Kim, S., Park, Y., Kim, S., Lee, J., Wang, D., & DuBois, R. N. (2023) · doi:10.1158/0008-5472.22390835.v1
Daneau, G., Boidot, R., Martinive, P., & Féron, O. (2023) · doi:10.1158/1078-0432.c.6517821.v1
Wu, C. J., Xiao, R., Zhang, L., Chen, Z., Zhang, M., Li, J., Zhou, Y., Wang, S., Jiang, C. Q., Wang, H., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1617864
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Chisholm, J. D., & Kerr, W. G. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-29808-0.00039-x
Umezaki, N., Boku, S., Matsuo, Y., Yamamoto, T., Satake, H., Watanabe, M., Hirota, K., Sugie, T., & Sekimoto, M. (2026) · Scientific Reports · doi:10.1038/s41598-026-42753-z
Diabetes and colorectal cancer : epidemiological and physiopathological studies
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Fleurance, R. (2021) · theses.fr (ABES) · doi:10.70675/0a82ed6ez6595z4366z832fz70cbe839c7ff
Effects of Tumor Microenvironment on Immunity and Consequent Clinical Considerations
Baronzio, G., Freitas, I., Fiorentini, G., Crugnola, A. R., Hager, E. D., Ceppodomo, D., & Kiselevsky, M. V. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9576-4_9
Metadata
- Authors
- Kaidi, A., Qualtrough, D., Williams, A. C., & Paraskeva, C.
- Affiliations
- Cancer Research UK (GB)
- Venue
- Cancer Research
- Published
- 2006-07-01
- Volume
- 66
- Issue
- 13
- Pages
- 6683-6691
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2008854828
- Cited by
- 300
- References
- 49
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 10 · 2023: 6 · 2022: 13 · 2021: 17 · 2020: 24 · 2019: 18 · 2018: 13 · 2017: 16 · 2016: 17 · 2015: 23 · 2014: 16 · 2013: 19 · 2012: 22
- FWCI
- 7.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Bristol Research (University of Bristol) (publishedVersion)
- Explore Bristol Research (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- cyclooxygenase-2, hypoxia-inducible factor-1α, colorectal cancer, colorectal adenoma, hypoxia, prostaglandin E2, hypoxia response element, transcriptional regulation, vascular endothelial growth factor, MAPK signaling, tumor cell survival, angiogenesis, COX-2 selective inhibitors, tumor microenvironment
- MeSH terms
- Base Sequence, Cell Survival, Humans, Molecular Sequence Data, Promoter Regions, Genetic, Transcription, Genetic, Colorectal Neoplasms, Dinoprostone, Cell Hypoxia, Up-Regulation, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, HT29 Cells, MAP Kinase Signaling System, HCT116 Cells, Cell Growth Processes, Cyclooxygenase 2, Hypoxia-Inducible Factor 1, alpha Subunit
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