The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Receptor for activated C kinase 1 (RACK1) and Src regulate the tyrosine phosphorylation and function of the androgen receptor.
Open accessAbstract
The androgen receptor (AR) remains functionally important in the development and progression of prostate cancer even when the disease seems androgen "independent." Because signal transduction by growth factor receptors increases in advanced prostate cancer and is capable of sensitizing the AR to androgen, there is considerable interest in determining the mechanisms by which signaling systems can modulate AR function. We show herein that the adaptor/scaffolding protein receptor for activated C kinase 1 (RACK1), which was previously reported to interact with the AR, modulates the tyrosine phosphorylation of AR and its interaction with the Src tyrosine kinase. We also show that down-regulation of RACK1 by short interfering RNA inhibits growth and stimulates prostate-specific antigen transcription in androgen-treated prostate cancer cells. Our results suggest that RACK1 mediates the cross-talk of AR with additional binding partners, such as Src, and facilitates the tyrosine phosphorylation and transcriptional activity of the AR.
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“The activity of Src on AR transactivation is modulated, at least in part, through its binding partner and associated scaffolding protein receptor for activated C kinase 1 (RACK1) (43).”
From Minireview: Alternative Activation Pathways for the Androgen Receptor in Prostate Cancer (2011) · cites this paper as [43]
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1 retracted
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RetractedSequence and structure-based prediction of eukaryotic protein phosphorylation sites
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Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor.
Lin, H.-K., Yeh, S., Kang, H.-Y., & Chang, C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121173298 · Cited by 401
The RACK1 Scaffold Protein: A Dynamic Cog in Cell Response Mechanisms
McCahill, A., Warwicker, J., Bolger, G. B., Houslay, M. D., & Yarwood, S. J. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.6.1261 · Cited by 386
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Buoso, E., Serafini, M., Galasso, M., Ronfani, M., Poloni, L. M., Lanni, C., Corsini, E., & Racchi, M. (2018) · Springer eBooks · doi:10.1007/978-3-319-64597-1_116-1
Src kinase and Androgen Receptor in Prostate Cancer
Saxena, P. (2010) · Digital WPI
Das, S., & Ghosh, A. (2024) · Springer eBooks · doi:10.1007/978-981-96-0301-5_1
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Metadata
- Authors
- Kraus, S., Gioeli, D., Vomastek, T., Gordon, V., & Weber, M. J.
- Affiliations
- University of Virginia Health System (US)
- Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, Virginia
- Venue
- Cancer Research
- Published
- 2006-11-15
- Volume
- 66
- Issue
- 22
- Pages
- 11047-11054
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2142284564
- Cited by
- 118
- References
- 42
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 12 · 2013: 5 · 2012: 5
- FWCI
- 7.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Defense (W81XWH)
- Prostate Cancer Foundation
- National Institutes of Health (W81XWH)
- National Cancer Institute (R01CA105402, P01CA104106)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- androgen receptor, RACK1, Src kinase, tyrosine phosphorylation, prostate cancer, castration-resistant prostate cancer, adaptor proteins, signal transduction, growth factor receptor signaling, transcriptional activity
- MeSH terms
- Receptors for Activated C Kinase, Androgens, Animals, Chlorocebus aethiops, Humans, Male, Phosphorylation, Prostatic Neoplasms, Receptors, Androgen, Receptors, Cell Surface, Substrate Specificity, Signal Transduction, Disease Progression, src-Family Kinases, COS Cells
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