Cited by 118Prostate Cancer Treatment and ResearchEstrogen and related hormone effectsSperm and Testicular Function

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Receptor for activated C kinase 1 (RACK1) and Src regulate the tyrosine phosphorylation and function of the androgen receptor.

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Kraus, Sarah, Gioeli, Daniel, Vomastek, Tomas, Gordon, Vicki, Weber, Michael J.·2006·Cancer Research

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Abstract

The androgen receptor (AR) remains functionally important in the development and progression of prostate cancer even when the disease seems androgen "independent." Because signal transduction by growth factor receptors increases in advanced prostate cancer and is capable of sensitizing the AR to androgen, there is considerable interest in determining the mechanisms by which signaling systems can modulate AR function. We show herein that the adaptor/scaffolding protein receptor for activated C kinase 1 (RACK1), which was previously reported to interact with the AR, modulates the tyrosine phosphorylation of AR and its interaction with the Src tyrosine kinase. We also show that down-regulation of RACK1 by short interfering RNA inhibits growth and stimulates prostate-specific antigen transcription in androgen-treated prostate cancer cells. Our results suggest that RACK1 mediates the cross-talk of AR with additional binding partners, such as Src, and facilitates the tyrosine phosphorylation and transcriptional activity of the AR.

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RETRACTED: Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade
Wong, C., McNally, C., Nickbarg, E., Komm, B. S., & Cheskis, B. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192569699 · Cited by 321
Retracted
Sequence and structure-based prediction of eukaryotic protein phosphorylation sites
Blom, N., Gammeltoft, S., & Brunak, S. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.3310 · Cited by 3,212
Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins.
Dorit Ron, A., Chen, C., Caldwell, J., Jamieson, L., Orr, E., & Mochly‐Rosen, D. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.3.839 · Cited by 723
Steroid‐induced androgen receptor–oestradiol receptor β–Src complex triggers prostate cancer cell proliferation
Migliaccio, A., Castoria, G., Domenico, M. D., de Falco, A., Bilancio, A., Lombardi, M., Barone, M. V., Ametrano, D., Zannini, M. S., Abbondanza, C., et al. (2000) · The EMBO Journal · doi:10.1093/emboj/19.20.5406 · Cited by 672
Activation of the Src/p21ras/Erk pathway by progesterone receptor via cross‐talk with estrogen receptor
Migliaccio, A., Piccolo, D., Castoria, G., Domenico, M. D., Bilancio, A., Lombardi, M., Gong, W., Beato, M., & Auricchio, F. (1998) · The EMBO Journal · doi:10.1093/emboj/17.7.2008 · Cited by 627
From HER2/Neu signal cascade to androgen receptor and its coactivators: A novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells
Yeh, S., Lin, H., Kang, H., Thin, T. H., Lin, M., & Chang, C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5458 · Cited by 594
Progesterone Receptor Contains a Proline-Rich Motif that Directly Interacts with SH3 Domains and Activates c-Src Family Tyrosine Kinases
Boonyaratanakornkit, V., Scott, M. P., Ribon, V., Sherman, L., Anderson, S. M., Maller, J. L., Miller, W. T., & Edwards, D. P. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00304-5 · Cited by 590
Androgen receptor phosphorylation, turnover, nuclear transport, and transcriptional activation. Specificity for steroids and antihormones.
Kemppainen, J., Lane, M. V., Sar, M., & Wilson, E. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48380-9 · Cited by 430
Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor.
Lin, H.-K., Yeh, S., Kang, H.-Y., & Chang, C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121173298 · Cited by 401
The RACK1 Scaffold Protein: A Dynamic Cog in Cell Response Mechanisms
McCahill, A., Warwicker, J., Bolger, G. B., Houslay, M. D., & Yarwood, S. J. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.6.1261 · Cited by 386

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Authors: Kraus, S., Gioeli, D., Vomastek, T., Gordon, V., & Weber, M. J.
Affiliations: University of Virginia Health System (US)
Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, Virginia
ORCID: Kraus, Sarah
Gioeli, Daniel
Weber, Michael J.
Venue: Cancer Research
Publisher: American Association for Cancer Research (AACR)
Published: 2006-11-15
Volume: 66
Issue: 22
Pages: 11047-11054
ISSN: 0008-5472 (ISSN-L)
1538-7445
DOI: 10.1158/0008-5472.can-06-0596
OpenAlex: W2142284564
Cited by: 118
References: 42
Citations by year: 2026: 1 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 12 · 2013: 5 · 2012: 5
FWCI: 7.95
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Cancer Research (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Defense (W81XWH)
Prostate Cancer Foundation
National Institutes of Health (W81XWH)
National Cancer Institute (R01CA105402, P01CA104106)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords: androgen receptor, RACK1, Src kinase, tyrosine phosphorylation, prostate cancer, castration-resistant prostate cancer, adaptor proteins, signal transduction, growth factor receptor signaling, transcriptional activity
MeSH terms: Receptors for Activated C Kinase, Androgens, Animals, Chlorocebus aethiops, Humans, Male, Phosphorylation, Prostatic Neoplasms, Receptors, Androgen, Receptors, Cell Surface, Substrate Specificity, Signal Transduction, Disease Progression, src-Family Kinases, COS Cells

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Receptor for activated C kinase 1 (RACK1) and Src regulate the tyrosine phosphorylation and function of the androgen receptor.

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