The DOI matches its Crossref record; 57 of the 58 references it cites were found in a registry or an index.
Heparanase, Hyaluronan, and CD44 in Cancers: A Breast Carcinoma Perspective
Open accessAbstract
Glycosaminoglycans are major constituents of the cancer cell surface and the tumor stroma. The heparan sulfate degrading enzyme heparanase, hyaluronan, and its receptor CD44 are up-regulated in breast cancer, generating a microenvironment that promotes tumor progression and metastasis. Recent experimental and clinical evidence shows that heparanase, hyaluronan, and CD44 regulate cancer cell proliferation, migration, and invasion, as well as tumor-associated angiogenesis and are correlated with patient survival. These findings suggest that they may be used as prognostic factors and targets for breast cancer treatment. (Cancer Res 2006; 66(21): 10233-7)
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“HA is known to target the overly expressed CD44 receptors in several tumors including MDA-MB-231 human breast cancer 41 and A549 lung cancer.42,43”
From Catalase-Integrated Hyaluronic Acid as Nanocarriers for Enhanced Photodynamic Therapy in Solid Tumor (2019) · cites this paper as [41]
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High Interstitial Fluid Pressure - an Obstacle in Cancer Therapy
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Hyaluronan: from extracellular glue to pericellular cue
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Mammalian heparanase: Gene cloning, expression and function in tumor progression and metastasis
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Yang, Z. F., Ho, D. W., Ng, M. N., Lau, C. K., Yu, W. C., Ngai, P., Chu, P., Lam, C. T., Poon, R. T. P., & Fan, S. T. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.01.013 · Cited by 1,188
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Metadata
- Authors
- Götte, M., & Yip, G. W.
- Affiliations
- 1Department of Obstetrics and Gynecology, Münster University Hospital, Münster, Germany and
- National University of Singapore (SG)
- ORCID
- Yip, George W.
- Venue
- Cancer Research
- Published
- 2006-11-01
- Volume
- 66
- Issue
- 21
- Pages
- 10233-10237
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2134709252
- Cited by
- 340
- References
- 58
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 6 · 2023: 11 · 2022: 12 · 2021: 20 · 2020: 14 · 2019: 9 · 2018: 16 · 2017: 22 · 2016: 22 · 2015: 19 · 2014: 25 · 2013: 28 · 2012: 24
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Medical Research Council
- National Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- heparanase, hyaluronic acid, CD44, breast cancer, glycosaminoglycans, tumor microenvironment, tumor stroma, metastasis, tumor progression, angiogenesis, tumor cell proliferation, cell migration and invasion, prognostic factors, therapeutic target
- MeSH terms
- Heparanase, Breast Neoplasms, Female, Glucuronidase, Humans, Hyaluronic Acid, Neoplasm Invasiveness, Hyaluronan Receptors, Cell Proliferation
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