Cited by 2,222Cancer Cells and MetastasisCellular Mechanics and InteractionsLymphatic System and Diseases

High Interstitial Fluid Pressure - an Obstacle in Cancer Therapy

Heldin, Carl-Henrik, Rubin, Kristofer, Pietras, Kristian, Östman, Arne·2004·Nature reviews. Cancer

Abstract

Many solid tumours show an increased interstitial fluid pressure (IFP), which forms a barrier to transcapillary transport. This barrier is an obstacle in tumour treatment, as it results in inefficient uptake of therapeutic agents. There are a number of factors that contribute to increased IFP in the tumour, such as vessel abnormalities, fibrosis and contraction of the interstitial matrix. Lowering the tumour IFP with specific signal-transduction antagonists might be a useful approach to improving anticancer drug efficacy.

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Crossref · 10.1038/nrc1456

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79 of 79 references verified0 citation errors · 0 not checkable

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  • Hypoxic tumor tissue and hypoxic tumor cells are major drivers of tumor progression.

    “Necrotic tumor tissue does not present much harm to the host organism, but the hypoxic part of the tumor tissue and the hypoxic tumor cells are usually the major drivers of tumor progression [1–3].”
  • Cancer hypoxia and the induced adaptation mechanisms are major causes of therapy resistance.

    “Cancer hypoxia and the induced adaptation mechanisms are two of the major causes of therapy resistance.”

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Authors
Heldin, C.-H., Rubin, K., Pietras, K., & Östman, A.
Affiliations
  • Ludwig Cancer Research (SE)
  • Uppsala University (SE)
  • University of California, San Francisco (US)
  • Karolinska Institutet (SE)
Corresponding author
Heldin, Carl-Henrik
Venue
Nature reviews. Cancer
Published
2004-10
Volume
4
Issue
10
Pages
806-813
ISSN
  • 1474-175X (ISSN-L)
  • 1474-1768
OpenAlex
W2028156849
Cited by
2,222
References
78
Citations by year
2026: 121 · 2025: 110 · 2024: 118 · 2023: 119 · 2022: 163 · 2021: 158 · 2020: 158 · 2019: 123 · 2018: 123 · 2017: 135 · 2016: 133 · 2015: 110 · 2014: 117 · 2013: 124 · 2012: 87
FWCI
3.19
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Cancer (publishedVersion)
  • PubMed (publishedVersion)
Funders
Cancerfonden
Topics
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
Keywords
interstitial fluid pressure, solid tumors, tumor microenvironment, tumor fibrosis, anticancer drug delivery, tumor hypoxia
MeSH terms
Alprostadil, Animals, Antineoplastic Agents, Biological Transport, Bradykinin, Humans, Hyaluronoglucosaminidase, Hydrostatic Pressure, Neoplasms, Niacinamide, Platelet-Derived Growth Factor, Tumor Necrosis Factor-alpha, Signal Transduction, Transforming Growth Factor beta, Vascular Endothelial Growth Factor A, Extracellular Fluid, Mice

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