Human thyroid tumor cell lines derived from different tumor types present a common dedifferentiated phenotype
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Abstract
Cell lines are crucial to elucidate mechanisms of tumorigenesis and serve as tools for cancer treatment screenings. Therefore, careful validation of whether these models have conserved properties of in vivo tumors is highly important. Thyrocyte-derived tumors are very interesting for cancer biology studies because from one cell type, at least five histologically characterized different benign and malignant tumor types can arise. To investigate whether thyroid tumor–derived cell lines are representative in vitro models, characteristics of eight of those cell lines were investigated with microarrays, differentiation markers, and karyotyping. Our results indicate that these cell lines derived from differentiated and undifferentiated tumor types have evolved in vitro into similar phenotypes with gene expression profiles the closest to in vivo undifferentiated tumors. Accordingly, the absence of expression of most thyrocyte-specific genes, the nonresponsiveness to thyrotropin, as well as their large number of chromosomal abnormalities, suggest that these cell lines have acquired characteristics of fully dedifferentiated cells. They represent the outcome of an adaptation and evolution in vitro, which questions the reliability of these cell lines as models for differentiated tumors. However, they may represent useful models for undifferentiated cancers, and by their comparison with differentiated cells, can help to define the genes involved in the differentiation/dedifferentiation process. The use of any cell line as a model for a cancer therefore requires prior careful and thorough validation for the investigated property. [Cancer Res 2007;67(17):8113–20]
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Dedifferentiated thyroid cell lines usually overexpress genes involved in general metabolism, cell cycle, and proliferation.
“Dedifferentiated thyroid cell lines usually overexpress genes involved in general metabolism, cell cycle, and proliferation [36].”
From Restoration of p53 using the novel MDM2-p53 antagonist APG115 suppresses dedifferentiated papillary thyroid cancer cells (2017) · cites this paper as [36]
Dedifferentiation in thyroid carcinoma is characterized by loss of thyroid specific markers and gain of proliferative capacity.
“Furthermore, dedifferentiation in thyroid carcinoma is characterized by a loss of thyroid specific markers and a subsequent gain of proliferative capacity [36, 37].”
From Restoration of p53 using the novel MDM2-p53 antagonist APG115 suppresses dedifferentiated papillary thyroid cancer cells (2017) · cites this paper as [36]
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- Authors
- van Staveren, W. C. G., Solís, D. W., Delys, L., Duprez, L., Andry, G., Franc, B., Thomas, G., Libert, F., Dumont, J. E., Detours, V., & Maenhaut, C.
- Affiliations
- 1Institute of Interdisciplinary Research (IRIBHM);
- Erasmus Hospital (BE)
- Université Libre de Bruxelles (BE)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Singleton Hospital (GB)
- Venue
- Cancer Research
- Published
- 2007-09-01
- Volume
- 67
- Issue
- 17
- Pages
- 8113-8120
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2119644508
- Cited by
- 123
- References
- 54
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 13 · 2022: 2 · 2021: 6 · 2020: 3 · 2019: 7 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 10 · 2014: 6 · 2013: 9 · 2012: 9
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- dedifferentiation, gene expression profiles, chromosomal abnormalities, in vitro evolution, cell line validation
- MeSH terms
- Adenoma, Carcinoma, Papillary, Cell Differentiation, Humans, Karyotyping, Organ Specificity, Phenotype, Thyroid Gland, Thyroid Neoplasms, Thyrotropin, Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, Cluster Analysis, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Cell Line, Tumor
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