The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Induction of Sonic Hedgehog Mediators by Transforming Growth Factor-β: Smad3-Dependent Activation of Gli2 and Gli1 Expression In vitro and In vivo
Open accessAbstract
Hedgehog (Hh) and transforming growth factor-β (TGF-β) family members are involved in numerous overlapping processes during embryonic development, hair cycle, and cancer. Herein, we show that TGF-β induces the expression of the Hh signaling molecules Gli1 and Gli2 in various human cell types, including normal fibroblasts and keratinocytes, as well as various cancer cell lines. Gli2 induction by TGF-β is rapid, independent from Hh receptor signaling, and requires a functional Smad pathway. Gli1 expression is subsequently activated in a Gli2-dependent manner. In transgenic mice overexpressing TGF-β1 in the skin, Gli1 and Gli2 expression is also elevated and depends on Smad3. In pancreatic adenocarcinoma cell lines resistant to Hh inhibition, pharmacologic blockade of TGF-β signaling leads to repression of cell proliferation accompanied with a reduction in Gli2 expression. We thus identify TGF-β as a potent transcriptional inducer of Gli transcription factors. Targeting the cooperation of Hh and TGF-β signaling may provide new therapeutic opportunities for cancer treatment. [Cancer Res 2007;67(14):6981–6]
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Cites
Hedgehog signaling in animal development: paradigms and principles
Ingham, P. W., & McMahon, A. P. (2001) · Genes & Development · doi:10.1101/gad.938601 · Cited by 2,985
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TGF-β Signaling in Tumor Suppression and Cancer Progression
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Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome
Hahn, H., Wicking, C., Zaphiropoulos, P. G., Gailani, M. R., Shanley, S., Chidambaram, A., Vorechovsky, I., Holmberg, E., Unden, A. B., Gillies, S., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81268-4 · Cited by 2,022
Dennler, S. (1998) · The EMBO Journal · doi:10.1093/emboj/17.11.3091 · Cited by 1,793
Self-citationCytostatic and apoptotic actions of TGF-β in homeostasis and cancer
Siegel, P. M., & Massagué, J. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1208 · Cited by 1,604
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
Thayer, S. P., di Magliano, M. P., Heiser, P. W., Nielsen, C. M., Roberts, D. J., Lauwers, G. Y., Qi, Y. P., Gysin, S., Castillo, C. F.-D., Yajnik, V., et al. (2003) · Nature · doi:10.1038/nature02009 · Cited by 1,480
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
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Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
Berman, D. M., Karhadkar, S. S., Maitra, A., Montes de Oca, R., Gerstenblith, M. R., Briggs, K., Parker, A. R., Shimada, Y., Eshleman, J. R., Watkins, D. N., et al. (2003) · Nature · doi:10.1038/nature01972 · Cited by 1,251
New insights into TGF-β–Smad signalling
Dijke, P. T., & Hill, C. S. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.03.008 · Cited by 1,180
Cited by
Signaling cross-talk between TGF-β/BMP and other pathways
Guo, X., & Wang, X.-F. (2009) · Cell Research · doi:10.1038/cr.2008.302 · Cited by 1,015
Self-citationBasal cell carcinomas: attack of the hedgehog
Epstein, E. H. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2503 · Cited by 834
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma
Morris, J. P., Wang, S. C., & Hebrok, M. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2899 · Cited by 567
Syed, V. (2016) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25496 · Cited by 482
A highlight on Sonic hedgehog pathway
Carballo, G. B., Honorato, J. R., de Lopes, G. P. F., & Spohr, T. C. L. D. S. E. (2018) · Cell Communication and Signaling · doi:10.1186/s12964-018-0220-7 · Cited by 460
Metadata
- Authors
- Dennler, S., André, J., Alexaki, I., Li, A., Magnaldo, T., ten Dijke, P., Wang, X.-J., Verrecchia, F., & Mauviel, A.
- Venue
- Cancer Research
- Published
- 2007-07-15
- Volume
- 67
- Issue
- 14
- Pages
- 6981-6986
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W1987860480
- Cited by
- 342
- References
- 43
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Dennler, S., André, J., Alexaki, I., Li, A., Magnaldo, T., ten Dijke, P., Wang, X.-J., Verrecchia, F., & Mauviel, A. (2007). Induction of Sonic Hedgehog Mediators by Transforming Growth Factor-β: Smad3-Dependent Activation of Gli2 and Gli1 Expression In vitro and In vivo. Cancer Research. https://doi.org/10.1158/0008-5472.can-07-0491
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