The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Kaiso Contributes to DNA Methylation-Dependent Silencing of Tumor Suppressor Genes in Colon Cancer Cell Lines
Published version of a preprint
Abstract
Aberrant CpG methylation of tumor suppressor gene regulatory elements is associated with transcriptional silencing and contributes to malignant transformation of different tissues. It is presumed that methylated DNA sequences recruit repressor machinery to actively shutdown gene expression. The Kaiso protein is a transcriptional repressor expressed in human and murine colorectal tumors that can bind to methylated clusters of CpG dinucleotides. We show here that Kaiso represses methylated tumor suppressor genes and can bind in a methylation-dependent manner to the CDKN2A in human colon cancer cell lines. The contribution of Kaiso to epigenetic silencing was underlined by the fact that Kaiso depletion induced tumor suppressor gene expression without affecting DNA methylation levels. As a consequence, colon cancer cells became susceptible to cell cycle arrest and cell death mediated by chemotherapy. The data suggest that Kaiso is a methylation-dependent “opportunistic” oncogene that silences tumor suppressor genes when they become hypermethylated. Because Kaiso inactivation sensitized colon cancer cell lines to chemotherapy, it is possible that therapeutic targeting of Kaiso could improve the efficacy of current treatment regimens. [Cancer Res 2008;68(18):7258–63]
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“Kaiso binds to the methylated promoters of CDKN2A, MGMT and HIC1 in both HCT116 and Colo320 human colon cancer cell lines62.”
From Transcription factors as readers and effectors of DNA methylation (2016) · cites this paper as [62]
Citations
Cites
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BackgroundCpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future
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The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor
Prokhortchouk, A., Hendrich, B., Jørgensen, H., Ruzov, A., Wilm, M., Georgiev, G., Bird, A., & Prokhortchouk, E. (2001) · Genes & Development · doi:10.1101/gad.198501 · Cited by 533
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Items 101–119 of 119
RETRACTED: Kaiso is expressed in lung cancer: Its expression and localization is affected by p120ctn
Dai, S., Wang, Y., Jiang, G., Zhang, P., Dong, X.-J., Wei, Q., Xu, H., Li, Q., Zhao, C., & Wang, E. (2016) · Lung Cancer · doi:10.1016/j.lungcan.2016.11.015
RetractedFunctional characterization of KAISO and Kaiso knockout mice : apoptosis and testis atropy
고동인 (2014) · YUHSpace (Yonsei University Medical Library)
El papel de EZH2 en el cáncer colorrectal = The role of EZH2 in colorectal cancer
Vilorio-Marqués, L. (2017) · doi:10.18002/10612/6936
ZBTB33 (zinc finger and BTB domain containing
Dohn, R., & Reynolds, A. B. (2011)
The impact of sex and species of cells in herpes simplex virus infection
Tseng, Y. (2019) · ANU Open Research (Australian National University) · doi:10.25911/5d77831416351
Role of Epigenetics in Colorectal Cancer
Miao, B., Gupta, S., Mathur, M., Suravajhala, P., & Bandapalli, O. R. (2021) · Springer eBooks · doi:10.1007/978-3-030-63369-1_6
Molecular Interactions of Zinc Finger Protein Kaiso with Hemimethylated DNA
Thapa, B., & Adhikari, N. P. (2023) · Journal of Nepal Physical Society · doi:10.3126/jnphyssoc.v9i1.57551
Thapa, B., & Adhikari, N. P. (2024) · AIP Advances · doi:10.1063/5.0211323
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Matsuzaki, H., Kimura, M., Morihashi, M., & Tanimoto, K. (2024) · Figshare · doi:10.6084/m9.figshare.26729818
Matsuzaki, H., Kimura, M., Morihashi, M., & Tanimoto, K. (2024) · Figshare · doi:10.6084/m9.figshare.26729809
Matsuzaki, H., Kimura, M., Morihashi, M., & Tanimoto, K. (2024) · Figshare · doi:10.6084/m9.figshare.26729812
Matsuzaki, H., Kimura, M., Morihashi, M., & Tanimoto, K. (2024) · Figshare · doi:10.6084/m9.figshare.26729815
Wang, Y., Hu, T., Jia, J., Chen, W., & Zhang, C. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-11789-9
Kaiso reads methylated CpGs at the nucleosome entry/exit site and displaces the histone H3 tailPreprint
Gadea, F. C. M., & Nikolova, E. N. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.7525044
The interplay between genetics and epigenetics in colorectal cancer
Derks, S. (2009) · Research Publications (Maastricht University) · doi:10.26481/dis.20091002sd
Metadata
- Authors
- Lopes, E. C., Valls, E., Figueroa, M. E., Mazur, A., Meng, F.-G., Chiosis, G., Laird, P. W., Schreiber-Agus, N., Greally, J. M., Prokhortchouk, E., & Melnick, A.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Yeshiva University (US)
- 2Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, New York; Departments of
- Bioengineering Center (RU)
- USC Norris Comprehensive Cancer Center (US)
- 4Medicine and Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York;
- Albert Einstein College of Medicine (US)
- Venue
- Cancer Research
- Published
- 2008-09-14
- Volume
- 68
- Issue
- 18
- Pages
- 7258-7263
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2089255658
- Cited by
- 119
- References
- 30
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 11 · 2018: 4 · 2017: 7 · 2016: 11 · 2015: 6 · 2014: 8 · 2013: 5 · 2012: 14
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ca075090-09)
- National Cancer Institute (R01-CA-075090, R01CA118699)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- Kaiso, DNA methylation, CpG methylation, tumor suppressor, transcriptional silencing, CDKN2A, colon cancer, epigenetic silencing, transcriptional repressor, cell cycle arrest, chemosensitivity, colorectal neoplasia
- MeSH terms
- Cell Cycle, Colonic Neoplasms, Humans, Promoter Regions, Genetic, Protein Binding, Transcription Factors, Transfection, Genes, Tumor Suppressor, Cell Death, DNA Methylation, Cyclin-Dependent Kinase Inhibitor p16, Genes, p16, Gene Silencing, RNA, Small Interfering, HCT116 Cells, Cell Line, Tumor
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