The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Hyperpolarized 13C Lactate, Pyruvate, and Alanine: Noninvasive Biomarkers for Prostate Cancer Detection and Grading
Open accessAbstract
An extraordinary new technique using hyperpolarized 13C-labeled pyruvate and taking advantage of increased glycolysis in cancer has the potential to improve the way magnetic resonance imaging is used for detection and characterization of prostate cancer. The aim of this study was to quantify, for the first time, differences in hyperpolarized [1-13C] pyruvate and its metabolic products between the various histologic grades of prostate cancer using the transgenic adenocarcinoma of mouse prostate (TRAMP) model. Fast spectroscopic imaging techniques were used to image lactate, alanine, and total hyperpolarized carbon (THC = lactate + pyruvate + alanine) from the entire abdomen of normal mice and TRAMP mice with low- and high-grade prostate tumors in 14 s. Within 1 week, the mice were dissected and the tumors were histologically analyzed. Hyperpolarized lactate SNR levels significantly increased (P < 0.05) with cancer development and progression (41 ± 11, 74 ± 17, and 154 ± 24 in normal prostates, low-grade primary tumors, and high-grade primary tumors, respectively) and had a correlation coefficient of 0.95 with the histologic grade. In addition, there was minimal overlap in the lactate levels between the three groups with only one of the seven normal prostates overlapping with the low-grade primary tumors. The amount of THC, a possible measure of substrate uptake, and hyperpolarized alanine also increased with tumor grade but showed more overlap between the groups. In summary, elevated hyperpolarized lactate and potentially THC and alanine are noninvasive biomarkers of prostate cancer presence and histologic grade that could be used in future three-dimensional 13C spectroscopic imaging studies of prostate cancer patients. [Cancer Res 2008;68(20):8607–15]
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Cites
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Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR
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Cited by
Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized [1- 13 C]Pyruvate
Nelson, S. J., Kurhanewicz, J., Vigneron, D. B., Larson, P. E. Z., Harzstark, A. L., Ferrone, M., van Criekinge, M., Chang, J. W., Bok, R., Park, I., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006070 · Cited by 1,286
Self-citationKurhanewicz, J., Vigneron, D. B., Brindle, K., Chekmenev, E. Y., Comment, A., Cunningham, C. H., DeBerardinis, R. J., Green, G. G., Leach, M. O., Rajan, S. S., et al. (2011) · Neoplasia · doi:10.1593/neo.101102 · Cited by 681
Self-citationKeshari, K. R., & Wilson, D. M. (2014) · Chem. Soc. Rev. · doi:10.1039/c3cs60124b · Cited by 358
Gallagher, F. A., Kettunen, M. I., Hu, D.-E., Jensen, P. R., Zandt, R. I. ‘., Karlsson, M., Gisselsson, A., Nelson, S. K., Witney, T. H., Bohndiek, S. E., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911447106 · Cited by 301
Self-citationHu, S., Balakrishnan, A., Bok, R. A., Anderton, B., Larson, P. E. Z., Nelson, S. J., Kurhanewicz, J., Vigneron, D. B., & Goga, A. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.04.012 · Cited by 245
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Metadata
- Authors
- Albers, M. J., Bok, R., Chen, A. P., Cunningham, C. H., Zierhut, M. L., Zhang, V. Y., Kohler, S. J., Tropp, J., Hurd, R. E., Yen, Y.-F., Nelson, S. J., Vigneron, D. B., & Kurhanewicz, J.
- Venue
- Cancer Research
- Published
- 2008-10-15
- Volume
- 68
- Issue
- 20
- Pages
- 8607-8615
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W1986007087
- Cited by
- 520
- References
- 25
- FWCI
- 11.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Albers, M. J., Bok, R., Chen, A. P., Cunningham, C. H., Zierhut, M. L., Zhang, V. Y., Kohler, S. J., Tropp, J., Hurd, R. E., Yen, Y.-F., Nelson, S. J., Vigneron, D. B., & Kurhanewicz, J. (2008). Hyperpolarized 13C Lactate, Pyruvate, and Alanine: Noninvasive Biomarkers for Prostate Cancer Detection and Grading. Cancer Research. https://doi.org/10.1158/0008-5472.can-08-0749
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