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Cited by 245

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Adipose-Derived Mesenchymal Stem Cells as Stable Source of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Delivery for Cancer Therapy

Grisendi, Giulia, Bussolari, Rita, Cafarelli, Luigi, Petak, Istvan, Rasini, Valeria, Veronesi, Elena, De Santis, Giorgio, Spano, Carlotta, Tagliazzucchi, Mara, Barti-Juhasz, Helga, Scarabelli, Laura, Bambi, Franco, Frassoldati, Antonio, Rossi, Giulio, Casali, Christian, Morandi, Uliano, Horwitz, Edwin M., Paolucci, Paolo, Conte, PierFranco, Dominici, Massimo·2010·Cancer Research
DOI 10.1158/0008-5472.can-09-1865
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Abstract

Adipose-derived mesenchymal stromal/stem cells (AD-MSC) may offer efficient tools for cell-based gene therapy approaches. In this study, we evaluated whether AD-MSC could deliver proapoptotic molecules for cancer treatment. Human AD-MSCs were isolated and transduced with a retroviral vector encoding full-length human tumor necrosis factor–related apoptosis-inducing ligand (TRAIL), a proapoptotic ligand that induces apoptosis in a variety of human cancers but not normal tissues. Although several studies have documented the antitumor activity of recombinant human TRAIL, its use in vivo is limited by a short half-life in plasma due to a rapid clearance by the kidney. We found that these limitations can be overcome using stably transduced AD-MSC, which could serve as a constant source of TRAIL production. AD-MSC armed with TRAIL targeted a variety of tumor cell lines in vitro, including human cervical carcinoma, pancreatic cancer, colon cancer, and, in combination with bortezomib, TRAIL-resistant breast cancer cells. Killing activity was associated with activation of caspase-8 as expected. When injected i.v. or s.c. into mice, AD-MSC armed with TRAIL localized into tumors and mediated apoptosis without significant apparent toxicities to normal tissues. Collectively, our results provide preclinical support for a model of TRAIL-based cancer therapy relying on the use of adipose-derived mesenchymal progenitors as cellular vectors. Cancer Res; 70(9); 3718–29. ©2010 AACR.

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Metadata

Authors
Grisendi, G., Bussolari, R., Cafarelli, L., Petak, I., Rasini, V., Veronesi, E., De Santis, G., Spano, C., Tagliazzucchi, M., Barti-Juhasz, H., Scarabelli, L., Bambi, F., Frassoldati, A., Rossi, G., Casali, C., Morandi, U., Horwitz, E. M., Paolucci, P., Conte, P., & Dominici, M.
Venue
Cancer Research
Publisher
American Association for Cancer Research (AACR)
Published
2010-04-28
Volume
70
Issue
9
Pages
3718-3729
ISSN
  • 0008-5472 (ISSN-L)
  • 1538-7445
DOI
10.1158/0008-5472.can-09-1865
OpenAlex
W2132067615
Cited by
245
References
11
FWCI
11.01
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Adipose-Derived Mesenchymal Stem Cells as Stable Source of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Delivery for Cancer Therapy. https://app.cochat.ai/papers/10.1158/0008-5472.can-09-1865
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Grisendi, G., Bussolari, R., Cafarelli, L., Petak, I., Rasini, V., Veronesi, E., De Santis, G., Spano, C., Tagliazzucchi, M., Barti-Juhasz, H., Scarabelli, L., Bambi, F., Frassoldati, A., Rossi, G., Casali, C., Morandi, U., Horwitz, E. M., Paolucci, P., Conte, P., & Dominici, M. (2010). Adipose-Derived Mesenchymal Stem Cells as Stable Source of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Delivery for Cancer Therapy. Cancer Research. https://doi.org/10.1158/0008-5472.can-09-1865

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.