YPEL3, a p53-Regulated Gene that Induces Cellular Senescence
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Abstract
Cellular senescence, the limited ability of cultured normal cells to divide, can result from cellular damage triggered through oncogene activation (premature senescence) or the loss of telomeres following successive rounds of DNA replication (replicative senescence). Although both processes require a functional p53 signaling pathway, relevant downstream p53 targets have been difficult to identify. Discovery of senescence activators is important because induction of tumor cell senescence may represent a therapeutic approach for the treatment of cancer. In microarray studies in which p53 was reactivated in MCF7 cells, we discovered that Yippee-like-3 (YPEL3), a member of a recently discovered family of putative zinc finger motif coding genes consisting of YPEL1-5, is a p53-regulated gene. YPEL3 expression induced by DNA damage leads to p53 recruitment to a cis-acting DNA response element located near the human YPEL3 promoter. Physiologic induction of YPEL3 results in a substantial decrease in cell viability associated with an increase in cellular senescence. Through the use of RNAi and H-ras induction of cellular senescence, we show that YPEL3 activates cellular senescence downstream of p53. Consistent with its growth suppressive activity, YPEL3 gene expression is repressed in ovarian tumor samples. One mechanism of YPEL3 downregulation in ovarian tumor cell lines seems to be hypermethylation of a CpG island upstream of the YPEL3 promoter. We believe these findings point to YPEL3 being a novel tumor suppressor, which upon induction triggers a permanent growth arrest in human tumor and normal cells. Cancer Res; 70(9); 3566–75. ©2010 AACR.
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Transcripts for senescence associated genes including YPEL3, IQGAP2, IL15, AXL, PIK3R1, CDK6, PECAM1 and CXCL16 were significantly upregulated in microglia with increasing β-amyloid load.
“Transcripts for senescence associated genes including YPEL3, which encodes a protein downstream of p53 in the senescence pathway induced by DNA damage [36], IQGAP2, IL15, AXL, PIK3R1, CDK6, PECAM1 and CXCL16 were significantly upregulated in microglia with increasing β-amyloid load (Fig. 4c, d) [61].”
From Characterisation of premature cell senescence in Alzheimer's disease using single nuclear transcriptomics (2024) · cites this paper as [36]
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A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477 · see citing works
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,178 · cited 1× · see citing works
“Our data with IMR90 and U2OS cells are also consistent with previous reports showing that the loss of p53 can block H-ras–mediated cellular senescence (18).”
ResultBlinded by the Light: The Growing Complexity of p53
Vousden, K. H., & Prives, C. (2009) · Cell · doi:10.1016/j.cell.2009.04.037 · Cited by 3,163 · see citing works
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Xue, W., Zender, L., Miething, C., Dickins, R. A., Hernando, E., Krizhanovsky, V., Cordon-Cardo, C., & Lowe, S. W. (2007) · Nature · doi:10.1038/nature05529 · Cited by 2,473 · see citing works
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
Campisi, J. (2005) · Cell · doi:10.1016/j.cell.2005.02.003 · Cited by 2,359 · see citing works
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
Narita, M., Nuñez, S., Heard, E., Narita, M., Lin, A. W., Hearn, S. A., Spector, D. L., Hannon, G. J., & Lowe, S. W. (2003) · Cell · doi:10.1016/s0092-8674(03)00401-x · Cited by 2,278 · see citing works
Restoration of p53 function leads to tumour regression in vivo
Ventura, A., Kirsch, D. G., McLaughlin, M. E., Tuveson, D. A., Grimm, J., Lintault, L., Newman, J., Reczek, E. E., Weissleder, R., & Jacks, T. (2007) · Nature · doi:10.1038/nature05541 · Cited by 1,820 · see citing works
p53 Has a Direct Apoptogenic Role at the Mitochondria
Mihara, M., Erster, S. H., Zaika, A. I., Petrenko, O., Chittenden, T. D., Pančoška, P., & Moll, U. M. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00050-9 · Cited by 1,771 · see citing works
Brown, J. P., Wei, W., & Sedivy, J. M. (1997) · Science · doi:10.1126/science.277.5327.831 · Cited by 804 · see citing works
Kortlever, R. M., Higgins, P. J., & Bernards, R. (2006) · Nature Cell Biology · doi:10.1038/ncb1448 · Cited by 637 · cited 1× · see citing works
“In contrast to p21, plasminogen activator inhibitor 1 represents a critical p53-regulated gene in cellular senescence of both murine and human cells (9).”
BackgroundThe p53MH algorithm and its application in detecting p53-responsive genes
Hoh, J., Jin, S. V., Parrado, T., Edington, J., Levine, A. J., & Ott, J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132268899 · Cited by 295 · see citing works
Pantoja, C., & Serrano, M. (1999) · Oncogene · doi:10.1038/sj.onc.1202880 · Cited by 201 · cited 1× · see citing works
“Although it is accepted that cyclindependent kinase inhibitor and p53 target gene p21 is induced as cells undergo senescence, in some cell systems, the loss of p21 leads to senescence bypass (7); yet in other cell systems, p21-null cells can still undergo a ras-mediated senescence (8).”
BackgroundMolecular signature of oncogenic ras-induced senescence
Mason, D. X., Jackson, T. J., & Lin, A. W. (2004) · Oncogene · doi:10.1038/sj.onc.1208172 · Cited by 127 · see citing works
Sbisà, E., Catalano, D., Grillo, G., Licciulli, F., Turi, A., Liuni, S., Pesole, G., Grassi, A., Caratozzolo, M. F., D’Erchia, A. M., et al. (2007) · BMC Bioinformatics · doi:10.1186/1471-2105-8-s1-s20 · Cited by 89 · see citing works
Huang, B., Deo, D. D., Xia, M., & Vassilev, L. T. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0144 · Cited by 72 · see citing works
Hosono, K., Sasaki, T., Minoshima, S., & Shimizu, N. (2004) · Gene · doi:10.1016/j.gene.2004.06.014 · Cited by 67 · see citing works
p53 and Apoptosis: It's Not Just in the Nucleus Anymore
Manfredi, J. J. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00106-0 · Cited by 63 · see citing works
Roxström‐Lindquist, K., & Faye, I. (2001) · Insect Molecular Biology · doi:10.1046/j.1365-2583.2001.00239.x · Cited by 42 · see citing works
Full-length hdmX transcripts decrease following genotoxic stress
Markey, M., & Berberich, S. J. (2008) · Oncogene · doi:10.1038/onc.2008.266 · Cited by 38 · see citing works
Self-citationHeminger, K., Markey, M. P., Mpagi, M. D., & Berberich, S. J. (2009) · Aging · doi:10.18632/aging.100008 · Cited by 23 · see citing works
Self-citationBaker, S. J. (2003) · PubMed · Cited by 21 · see citing works
Flagged first, then by citations
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p53 Dynamics Control Cell Fate
Purvis, J. E., Karhohs, K. W., Mock, C., Batchelor, E., Loewer, A., & Lahav, G. (2012) · Science · doi:10.1126/science.1218351 · Cited by 770 · see citing works
Steelman, L. S., Chappell, W. H., Abrams, S. L., Kempf, C., Long, J. M., Laidler, P. M., Mijatović, S., Maksimović‐Ivanić, D., Stivala, F., Mazzarino, M. C., et al. (2011) · Aging · doi:10.18632/aging.100296 · Cited by 689 · see citing works
Senescence Regulation by the p53 Protein Family
Qian, Y., & Chen, X. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-239-1_3 · Cited by 170 · see citing works
DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control
Chen, X., Chen, J., Gan, S., Guan, H., Zhou, Y., Ouyang, Q., & Shi, J. (2013) · BMC Biology · doi:10.1186/1741-7007-11-73 · Cited by 105 · see citing works
The Premature Senescence in Breast Cancer Treatment Strategy
Milczarek, M. (2020) · Cancers · doi:10.3390/cancers12071815 · Cited by 53 · see citing works
Zhang, J., Wen, X., Ren, X., Li, Y.-Q., Tang, X.-R., Wang, Y., He, Q.-M., Yang, X.-J., Sun, Y. H., Liu, N., et al. (2016) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-016-0384-1 · Cited by 52 · see citing works
Müller, I., Jex, A. R., Kappe, S. H. I., Mikolajczak, S. A., Sattabongkot, J., Patrapuvich, R., Lindner, S. E., Flannery, E. L., Koepfli, C., Ansell, B. R. E., et al. (2019) · International Journal for Parasitology · doi:10.1016/j.ijpara.2019.02.007 · Cited by 52 · see citing works
Fancy, N. N., Smith, A. M., Caramello, A., Tsartsalis, S., Davey, K., Muirhead, R. C. J., McGarry, A., Jenkyns, M. H., Schneegans, E., Chau, V., et al. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02727-9 · Cited by 48 · see citing works
“Transcripts for senescence associated genes including YPEL3, which encodes a protein downstream of p53 in the senescence pathway induced by DNA damage [36], IQGAP2, IL15, AXL, PIK3R1, CDK6, PECAM1 and CXCL16 were significantly upregulated in microglia with increasing β-amyloid load (Fig.”
BackgroundIdentification of a Novel Endoplasmic Reticulum Stress Response Element Regulated by XBP1
Misiewicz, M., Déry, M.-A. C., Foveau, B., Jodoin, J., Ruths, D. A., & LeBlanc, A. C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.457242 · Cited by 49 · see citing works
Lupas, A. N., Zhu, H., & Koryciński, M. (2015) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004023 · Cited by 47 · see citing works
Bogaert, K. A., Perez, E., Rumin, J., Giltay, A., Carone, M., Coosemans, N., Radoux, M., Eppe, G., Levine, R. D., Remacle, F., et al. (2019) · Cells · doi:10.3390/cells8111367 · Cited by 47 · see citing works
Hagen, J., Muniz, V. P., Falls, K. C., Reed, S. M., Taghiyev, A. F., Quelle, F. W., Gourronc, F. A., Klingelhutz, A. J., Major, H. J., Askeland, R. W., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3742 · Cited by 35 · see citing works
Tuttle, R., Miller, K. R., Maiorano, J. N., Termuhlen, P. M., Gao, Y., & Berberich, S. J. (2011) · International Journal of Cancer · doi:10.1002/ijc.26239 · Cited by 34 · see citing works
Self-citationThe druggable schizophrenia genome: from repurposing opportunities to unexplored drug targets
Lago, S. G., & Bahn, S. (2022) · npj Genomic Medicine · doi:10.1038/s41525-022-00290-4 · Cited by 30 · see citing works
Hyperosmolarity induced by high glucose promotes senescence in human glomerular mesangial cells
Avila, M. D. N., Troyano, N., Calleros, L., Griera, M., Rodrı́guez-Puyol, M., Rodrı́guez-Puyol, D., & Ruiz‐Torres, M. P. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.07.006 · Cited by 28 · see citing works
Hasegawa, Y., Kim, J., Ursini, G., Jouroukhin, Y., Zhu, X., Miyahara, Y., Xiong, F., Madireddy, S., Obayashi, M., Lutz, B., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42276-5 · Cited by 28 · see citing works
The protein p17 signaling pathways in cancer
Heese, K. (2013) · Tumor Biology · doi:10.1007/s13277-013-0999-1 · Cited by 25 · see citing works
Current data and future perspectives on DNA methylation in ovarian cancer (Review)
Fu, M., Deng, F., Chen, J., Fu, L., Lei, J., Xu, T., Chen, Y., Zhou, J., Gao, Q., & Ding, H. (2024) · International Journal of Oncology · doi:10.3892/ijo.2024.5650 · Cited by 23 · see citing works
yippee like 3 (ypel3) is a novel gene required for myelinating and perineurial glia development
Blanco-Sánchez, B., Clément, A., Stednitz, S., Kyle, J., Peirce, J. L., McFadden, M., Wegner, J., Phillips, J., Macnamara, E. F., Huang, Y., et al. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008841 · Cited by 21 · see citing works
Yuan, K., Li, Z., Kuang, W., Wang, X., Ji, M., Chen, W., Ding, J., Li, J., Min, W., Sun, C., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30581-4 · Cited by 21 · see citing works
Kamachi, K., Ureshino, H., Watanabe, T., Yoshida, N., Yamamoto, Y., Kurahashi, Y., Fukuda‐Kurahashi, Y., Hayashi, Y., Hirai, H., Yamashita, S., et al. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.11.032 · Cited by 20 · see citing works
Augusto, T. V., Amaral, C., Almeida, C. F., Teixeira, N. A. A., & Correia‐da‐Silva, G. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111426 · Cited by 19 · see citing works
Leone, R., Zuglian, C., Brambilla, R., & Morella, I. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1407865 · Cited by 19 · see citing works
Exploring the effect of nsSNPs in human YPEL3 gene in cellular senescence
Singh, A., Thakur, M. K., Singh, S. K., Sharma, L. K., & Chandra, K. (2020) · Scientific Reports · doi:10.1038/s41598-020-72333-8 · Cited by 19 · see citing works
Senescence-Associated Gene YPEL3 Is Downregulated in Human Colon Tumors
Tuttle, R., Simon, M., Hitch, D. C., Maiorano, J. N., Hellan, M., Ouellette, J. R., Termuhlen, P. M., & Berberich, S. J. (2011) · Annals of Surgical Oncology · doi:10.1245/s10434-011-1558-x · Cited by 18 · see citing works
Self-citationAllele specific expression and methylation in the bumblebee, Bombus terrestris
Lonsdale, Z. N., Lee, K. D., Kiriakidu, M., Amarasinghe, H. E., Nathanael, D., O’Connor, C. J., & Mallon, E. B. (2017) · PeerJ · doi:10.7717/peerj.3798 · Cited by 17 · see citing works
Why YPEL3 represents a novel tumor suppressor
Steven, J. B. (2010) · Frontiers in bioscience · doi:10.2741/3817 · Cited by 16 · see citing works
Han, J.-H., Shin, J., Lee, Y., & Kim, K. S. (2018) · Scientific Reports · doi:10.1038/s41598-018-32633-6 · Cited by 15 · see citing works
Baek, H., Kwon, T.-U., Shin, S., Kwon, Y., & Chun, Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-00051-w · Cited by 15 · see citing works
Wang, L., Zhang, Z., Zhou, X., Wu, J., & Hong, Z. (2022) · Oncology Reports · doi:10.3892/or.2022.8345 · Cited by 14 · see citing works
Shang, S., Li, X., Gao, Y., Guo, S., Sun, D., Zhou, H., Sun, Y., Wang, P., Zhi, H., Bai, J., et al. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.676449 · Cited by 13 · see citing works
Kwon, Y., Lee, H. G., Park, H., Lee, B., Kwon, T.-U., Kwon, Y., & Chun, Y. (2023) · Toxicological Research · doi:10.1007/s43188-023-00208-x · Cited by 13 · see citing works
Yippee like 4 (Ypel4) is essential for normal mouse red blood cell membrane integrity
Mattebo, A., Sen, T., Jassinskaja, M., Pimková, K., González-Albo, I. P., Alattar, A. G., Ramakrishnan, R., Lang, S., Järås, M., Hansson, J., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-95291-1 · Cited by 13 · see citing works
Tan, T. Y., Gordon, C. T., Miller, K. A., Amor, D. J., & Farlie, P. G. (2015) · Developmental Dynamics · doi:10.1002/dvdy.24299 · Cited by 13 · see citing works
Self-citationA novel role for YPEL2 in mediating endothelial cellular senescence via the p53/p21 pathway
Xu, J., Tang, M.-L., Lu, Z.-F., Song, Y., Zhang, K., He, R.-C., Guo, X., Yuan, Y.-Q., Dai, X., & Ma, X. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111803 · Cited by 12 · see citing works
McGrath, M. K., Abolhassani, A., Guy, L., Elshazly, A. M., Barrett, J. T., Mivechi, N. F., Gewirtz, D. A., & Schoenlein, P. V. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1298423 · Cited by 13 · see citing works
Kong, X., Li, Y., & Zhang, X. (2018) · Medical Science Monitor · doi:10.12659/msm.908173 · Cited by 12 · see citing works
Turan, G., Olgun, Ç. E., Ayten, H., Toker, P., Ashyralyyev, A., Savaş, B., Karaca, E., & Muyan, M. (2023) · Protein Science · doi:10.1002/pro.4859 · Cited by 11 · see citing works
Early Suppression of Macrophage Gene Expression by Leishmania braziliensis
Sousa, R., Andrade, V. M., Bair, T., Ettinger, N., Guimarães, L., Andrade, L., Guimarães, L. H., Machado, P. R. L., Carvalho, E. M., Wilson, M. E., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02464 · Cited by 11 · see citing works
Ye, D., Feng, S., Yang, X., Su, Y., Zhang, J., Feng, H., Zhou, M., Zhou, B., Duan, L., Peng, T., et al. (2025) · Science Advances · doi:10.1126/sciadv.adu2958 · Cited by 10 · see citing works
Zhuang, L., Ly, R., Rösl, F., & Niebler, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249533 · Cited by 10 · see citing works
Hasanaj, E., Beaulieu, D., Wang, C., Hu, Q., Bueno, M., Sembrat, J., Pineda, R., Melo-Narváez, M. C., Cárdenes, N., Yanwu, Z., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.21.629928 · Cited by 7 · see citing works
Epigenetics in Ovarian Cancer: A Review of Current Knowledge and Future Perspectives
Dedes, N., Liontos, M., Haidopoulos, D. A., Zagouri, F., Angelou, K., Svarna, A., Michas, A., Aravantinou‐Fatorou, A., Andrikopoulou, Α., & Dimopoulos, M. A. (2025) · Biomedicines · doi:10.3390/biomedicines13112820 · Cited by 7 · see citing works
Ahmadi, Y., Mohammed, T., Abolhasani, S., Hamad, S. A., & Faiq, T. (2025) · Cell Cycle · doi:10.1080/15384101.2025.2599081 · Cited by 6 · see citing works
Frameshift mutations of YPEL3 alter the sensory circuit function in Drosophila
Kim, J. H., Singh, M., Pan, G., Lopez, A., Zito, N., Bosse, B. L., & Ye, B. (2020) · Disease Models & Mechanisms · doi:10.1242/dmm.042390 · Cited by 4 · see citing works
A Narrative Review of the TP53 and Its Product the p53 Protein
Foroutan, B. (2023) · OBM Genetics · doi:10.21926/obm.genet.2303185 · Cited by 5 · see citing works
Upregulation of YPEL3 expression and induction of human breast cancer cell death by microRNAs
Lee, B., Kwon, Y., Shin, S., Kwon, T.-U., Park, H., Lee, H. G., Kwak, J.-H., & Chun, Y. (2024) · Toxicological Research · doi:10.1007/s43188-024-00251-2 · Cited by 4 · see citing works
Okamoto, H., Mizutani, S., Tsukamoto, T., Katsuragawa‐Taminishi, Y., Kawaji‐Kanayama, Y., Mizuhara, K., Muramatsu, A., Isa, R., Fujino, T., Shimura, Y., et al. (2024) · Leukemia · doi:10.1038/s41375-024-02439-9 · Cited by 4 · see citing works
Müller, I., Jex, A. R., Kappe, S. H. I., Mikolajczak, S. A., Sattabongkot, J., Patrapuvich, R., Lindner, S., Flannery, E. L., Koepfli, C., Ansell, B. R. E., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/145250 · Cited by 4 · see citing works
A Narrative Review of the TP53 and Its Product the p53 Protein
Foroutan, B. (2023) · OBM Genetics · doi:10.21926/obm.genet.2302185 · Cited by 8 · see citing works
Chen, L., Yang, H., Wang, J., Zhang, H., Fu, K., Yan, Y., & Liu, Z. (2025) · PLoS Genetics · doi:10.1371/journal.pgen.1011622 · Cited by 2 · see citing works
The role of chimeric FAM72B transcripts generated by intergenic mRNA trans-splicing in breast cancer
Patra, G., Kim, P., Kutzner, A., & Heese, K. (2025) · Functional & Integrative Genomics · doi:10.1007/s10142-025-01734-7 · Cited by 2 · see citing works
SenSet defines cell-type specific senescence signatures in the aged human lung
Hasanaj, E., Beaulieu, D., Wang, C., Hu, Q., Rosas, L., Bueno, M., Sembrat, J., Pineda, R., Melo-Narváez, M. C., Cárdenes, N., et al. (2026) · The EMBO Journal · doi:10.1038/s44318-026-00762-8 · Cited by 10 · see citing works
Naito, S., Kajiwara, T., Karasawa, H., Ono, T., Saito, T., Funayama, R., Nakayama, K., Ohnuma, S., & Unno, M. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150665 · Cited by 2 · see citing works
Nechanitzky, R., Ramachandran, P., Nechanitzky, D., Li, W. Y., Wakeham, A. C., Haight, J., Saunders, M. E., Epelman, S., & Mak, T. W. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01268-8 · Cited by 2 · see citing works
Yang, B. K., Zhu, Y., Li, Y., Gao, Y., Si, H., & Li, Z. (2025) · Frontiers in Veterinary Science · doi:10.3389/fvets.2025.1583605 · Cited by 1 · see citing works
Guan, X., Zhou, Y., Hong, S., Jiang, Y., Xiao, Y., Wang, C., Fu, M., Zhao, H., Chen, S., Fu, Y., et al. (2026) · Clinical Epigenetics · doi:10.1186/s13148-026-02053-9 · Cited by 1 · see citing works
Senescent-like activated naive B cells contribute to progression to clinical rheumatoid arthritis
Wu, X., Zhang, M., Moon, J., Song, E. K., Abrams, J. C., van Dam, L. S., Sharpe, O., Wang, Z., Feser, M. L., Moss, L., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01236-6 · Cited by 4 · see citing works
Hasegawa, Y., Kim, J., Ursini, G., Jouroukhin, Y., Zhu, X., Miyahara, Y., Xiong, F., Madireddy, S., Obayashi, M., Lutz, B., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.24.550212 · Cited by 1 · see citing works
YPEL3 (yippee-like 3 (Drosophila))
Güpür, G., & Muyan, M. (2014) · Atlas of Genetics and Cytogenetics in Oncology and Haematology · doi:10.4267/2042/55376
Exploration of YPEL3 Response to Hormones and Ability to Induce Senescence
Rotsinger, J. E. (2012) · Journal of Bioresource Management
Induction of p53 Dependent Cellular Senescence Through HdmX Inhibition or YPEL3 Expression
Miller, K. L. (2010) · Journal of Bioresource Management
Self-citationA Cytokine Odyssey: From Interleukin-2 Signaling to Cytokine Therapy for Cancer
Tran, E. (2010) · UVic’s Research and Learning Repository (University of Victoria)
LOW TEMPERATURE INTERNAL FRICTION OF URANIUM-0.4 w/o MOLYBDENUM ALLOY
Mima, G., & Hasegawa, M. (1964) · Technology Reports of the Osaka University
Wei, T., Lashanizadegan, R., Liu, L., Singh, M., Mariano, L. G. L., Mathew, D., & Kim, J. H. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.07.647271
Olgun, Ç. E., Duman, G. T., Güpür, G., İzgi, H., Huda, M., Çetin, D., Suludere, Z., Baloğlu, F. K., Çaydaşı, A. K., & Muyan, M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.30.685511
Nguyen, T. H. A., Kim, P., Kutzner, A., & Heese, K. (2025) · Cell Cycle · doi:10.1080/15384101.2025.2602824
Targeting one-carbon metabolic vulnerabilities of metastasis with therapeutic potentialPreprint
Yu, Y., Chen, W. C., & Merlino, G. T. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.07.704548
Development and validation of a 5mC-based prognostic model for lung adenocarcinoma survival
Wu, Y.-F., Jiao, Z.-C., Xue, J., Zheng, X., Huang, Z.-C., Wang, D.-Y., Chen, P.-C., Wang, T., Chen, J., Liang, N.-X., et al. (2026) · Cell Reports Medicine · doi:10.1016/j.xcrm.2026.102727
Olgun, Ç. E., Turan, G., Güpür, G., İzgi, H., Huda, M., Çetin, D., Suludere, Z., Baloğlu, F. K., Çaydaşı, A. K., & Muyan, M. (2026) · Microbial Cell · doi:10.15698/mic2026.06.881
Cheung, N. (2026) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823261468711
Kołat, D., Gałęziewska, J., Buczek, P., Zhao, L.-Y., Kciuk, M., Kałuzińska‐Kołat, Ż., Kozłowska, M., Śliwińska, A., Kontek, R., & Płuciennik, E. (2026) · Cancers · doi:10.3390/cancers18193168
- Authors
- Kelley, K. D., Miller, K. R., Todd, A., Kelley, A. R., Tuttle, R., & Berberich, S. J.
- Affiliations
- Wright State University (US)
- Corresponding author
- Berberich, Steven J.
- Venue
- Cancer Research
- Published
- 2010-04-28
- Volume
- 70
- Issue
- 9
- Pages
- 3566-3575
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- PMC
- PMC2862112
- OpenAlex
- W2017387751
- Cited by
- 73
- References
- 21
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 9 · 2023: 7 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 3
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- CORE Scholar (Wright State University) (submittedVersion)
- Journal of Bioresource Management (submittedVersion, cc-by)
- Funders
- National Cancer Institute (CA-64430, R01CA064430, R29CA064430)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- cellular senescence, p53, tumor suppressor, zinc finger genes, DNA damage response, premature senescence, replicative senescence, H-Ras, CpG island hypermethylation, ovarian neoplasms, MCF-7 cells, growth arrest
- MeSH terms
- Humans, Neoplasms, Gene Expression Regulation, Neoplastic, Tumor Suppressor Protein p53, Cellular Senescence, CpG Islands, DNA Methylation, Tumor Suppressor Proteins, HCT116 Cells, Cell Line, Tumor, Hep G2 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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