Full-length hdmX transcripts decrease following genotoxic stress
Open accessAbstract
Previous studies have suggested that the mdmX gene is constitutively transcribed, and that MdmX protein activity is instead controlled by cellular localization and DNA damage induced Mdm2-mediated ubiquitination leading to proteasomal degradation. In these studies, we report that the human mdmX (hdmX) mRNA is reproducibly decreased in various human cell lines following treatment with various DNA-damaging agents. Repression of hdmX transcripts is observed in DNA-damaged HCT116 colon cancer cells and in isogenic p53(-/-) cells, suggesting that this effect is p53-independent. Reduction in the amount of hdmX transcript occurs in both human tumor cell lines and primary human diploid fibroblasts, and results in a significant reduction of HdmX protein. Examination of hdmX promoter activity suggests that damage-induced repression of hdmX mRNA is not significantly impacted by transcription initiation. In contrast, changes in hdmX mRNA splicing appear to partly explain the reduction in full-length hdmX mRNA levels in tumor cell lines with the destabilization of full-length hdmX transcripts, potentially through microRNA miR-34a regulation, also impacting transcript levels. Taken together, this study uncovers previously unrecognized cellular mechanisms by which hdmX mRNA levels are kept low following genotoxic stress.
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MDMX mRNA levels are reduced on DNA damage, in part from the action of mir-34a.
“In addition to genotoxin-induced degradation of MDMX, MDMX mRNA levels is also reduced on DNA damage. This results, in part, from the action of mir-34a51.”
From MDM2, MDMX and p53 in oncogenesis and cancer therapy (2013) · cites this paper as [51]
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- Authors
- Markey, M., & Berberich, S. J.
- Affiliations
- Wright State University (US)
- Corresponding author
- Berberich, S J
- ORCID
- Markey, M
- Venue
- Oncogene
- Published
- 2008-08-18
- Volume
- 27
- Issue
- 52
- Pages
- 6657-6666
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- PMC
- PMC2610866
- OpenAlex
- W1988425997
- Cited by
- 38
- References
- 42
- Citations by year
- 2024: 1 · 2023: 1 · 2020: 1 · 2019: 1 · 2017: 4 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 5
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Journal of Bioresource Management (submittedVersion)
- Journal of Bioresource Management (submittedVersion, cc-by)
- Funders
- National Institutes of Health
- National Cancer Institute (R01CA064430, CA66430)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Keywords
- MDMX, genotoxic stress, DNA damage response, mRNA repression, mRNA splicing, miR-34a, p53-independent regulation, HCT116 cells, human diploid fibroblasts, transcriptional regulation, tumor suppressor regulation
- MeSH terms
- Animals, Cell Line, DNA Damage, Humans, Nuclear Proteins, Promoter Regions, Genetic, Proto-Oncogene Proteins, Transcription, Genetic, Down-Regulation, Tumor Suppressor Protein p53, Alternative Splicing, Cell Cycle Proteins, Mice
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