Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma
Open accessAbstract
Loss of function of the von Hippel-Lindau (VHL) tumor suppressor gene is a hallmark of clear cell renal cell carcinoma (ccRCC). The importance of heterogeneity in the loss of this tumor suppressor has been under reported. To study the impact of intratumoral VHL heterogeneity observed in human ccRCC, we engineered VHL gene deletion in four RCC models, including a new primary tumor cell line derived from an aggressive metastatic case. The VHL gene-deleted (VHL-KO) cells underwent epithelial-to-mesenchymal transition (EMT) and exhibited increased motility but diminished proliferation and tumorigenicity compared to the parental VHL-expressing (VHL + ) cells. Renal tumors with either VHL + or VHL-KO cells alone exhibit minimal metastatic potential. Combined tumors displayed rampant lung metastases, highlighting a novel cooperative metastatic mechanism. The poorly proliferative VHL-KO cells stimulated the proliferation, EMT, and motility of neighboring VHL + cells. Periostin (POSTN), a soluble protein overexpressed and secreted by VHL non-expressing (VHL − ) cells, promoted metastasis by enhancing the motility of VHL-WT cells and facilitating tumor cell vascular escape. Genetic deletion or antibody blockade of POSTN dramatically suppressed lung metastases in our preclinical models. This work supports a new strategy to halt the progression of ccRCC by disrupting the critical metastatic crosstalk between heterogeneous cell populations within a tumor.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Loss-of-function mutations in VHL impair proteasomal degradation of hydroxylated HIF α subunits and result in constitutive HIF activation despite normoxia.
“A clear causal link between HIF dysregulation and tumorigenesis is illustrated by loss of function mutations in von Hippel–Lindau (VHL), which impair proteasomal degradation of hydroxylated HIF α subunits and result in constitutive HIF activation despite normoxia [[222], [223], [224], [225]].”
From HIF inhibition: Current strategies and clinical challenges (2026) · cites this paper as [224]
The Introduction (page unavailable) says VHL targets HIF-α for oxygen-dependent degradation and links VHL inactivation to constitutive HIF-pathway activation. It does not explicitly describe proteasomal degradation or state that activation persists under normoxia; proline hydroxylation appears in the titles of works it cites, rather than in its own explanation. (LLM, conf=0.82)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
Jemal, A., Bray, F., Ferlay, J., Ward, E., & Forman, D. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 54,708 · see citing works
Integrated analysis of multimodal single-cell data
Hao, Y., Hao, S., Andersen-Nissen, E., Mauck, W. M., Zheng, S., Butler, A., Lee, M. J., Wilk, A. J., Darby, C., Zagar, M., et al. (2020) · doi:10.1101/2020.10.12.335331 · Cited by 15,508 · see citing works
Salmon provides fast and bias-aware quantification of transcript expression
Patro, R., Duggal, G., Love, M. I., Irizarry, R. A., & Kingsford, C. (2017) · Nature Methods · doi:10.1038/nmeth.4197 · Cited by 12,700 · see citing works
A framework for variation discovery and genotyping using next-generation DNA sequencing data
DePristo, M. A., Banks, E., Poplin, R. E., Garimella, K. V., Maguire, J., Hartl, C., Philippakis, A., del Angel, G., Rivas, M. A., Hanna, M., et al. (2011) · Nature Genetics · doi:10.1038/ng.806 · Cited by 11,216 · see citing works
The basics of epithelial-mesenchymal transition
Kalluri, R., & Weinberg, R. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39104 · Cited by 10,196 · see citing works
UMAP: Uniform Manifold Approximation and Projection
McInnes, L., Healy, J., Saul, N., & Großberger, L. (2018) · Journal of Open Source Software · doi:10.21105/joss.00861 · Cited by 9,826 · see citing works
The Ensembl Variant Effect Predictor
McLaren, W., Gil, L., Hunt, S. E., Riat, H. S., Ritchie, G. R. S., Thormann, A., Flicek, P., & Cunningham, F. (2016) · Genome Biology · doi:10.1186/s13059-016-0974-4 · Cited by 8,099 · see citing works
Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing
Gerlinger, M., Rowan, A. J., Horswell, S., Larkin, J., Endesfelder, D., Gronroos, E., Martinez, P., Matthews, N., Stewart, A., Tarpey, P., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1113205 · Cited by 7,774 · see citing works
Massively parallel digital transcriptional profiling of single cells
Zheng, G. X. Y., Terry, J. M., Belgrader, P., Ryvkin, P., Bent, Z. W., Wilson, R., Ziraldo, S. B., Wheeler, T. D., McDermott, G. P., Zhu, J., et al. (2017) · Nature Communications · doi:10.1038/ncomms14049 · Cited by 7,353 · see citing works
Nowell, P. C. (1976) · Science · doi:10.1126/science.959840 · Cited by 6,471 · see citing works
Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535 · see citing works
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
Cibulskis, K., Lawrence, M. S., Carter, S. L., Sivachenko, A., Jaffe, D. B., Sougnez, C. L., Gabriel, S., Meyerson, M. M., Lander, E. S., & Getz, G. A. (2013) · Nature Biotechnology · doi:10.1038/nbt.2514 · Cited by 4,838 · see citing works
Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients
Locatelli, F., Fishbane, S. N., Block, G. A., & Macdougall, I. C. (2017) · American Journal of Nephrology · doi:10.1159/000455166 · Cited by 4,834 · see citing works
Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735 · see citing works
Fast gene set enrichment analysisPreprint
Korotkevich, G., Sukhov, V., Budin, N., Shpak, B., Artyomov, M. N., & Sergushichev, A. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/060012 · Cited by 3,742 · see citing works
Comprehensive molecular characterization of clear cell renal cell carcinoma
The Cancer Genome Atlas Research Network (2013) · Nature · doi:10.1038/nature12222 · Cited by 3,485 · see citing works
Pembrolizumab plus axitinib versus sunitinib for advanced renal-cell carcinoma
Rini, B. I., Plimack, E. R., Stus, V., Gafanov, R., Hawkins, R., Nosov, D., Pouliot, F., Alekseev, B., Soulières, D., Melichar, B., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1816714 · Cited by 3,403 · see citing works
On the Dependency of Cellular Protein Levels on mRNA Abundance
Liu, Y., Beyer, A., & Aebersold, R. (2016) · Cell · doi:10.1016/j.cell.2016.03.014 · Cited by 3,221 · see citing works
Finak, G., McDavid, A., Yajima, M., Deng, J., Gersuk, V., Shalek, A. K., Slichter, C. K., Miller, H. W., McElrath, M. J., Prlic, M., et al. (2015) · Genome Biology · doi:10.1186/s13059-015-0844-5 · Cited by 3,159 · see citing works
Identification of the von Hippel-Lindau Disease Tumor Suppressor Gene
Latif, F., Tory, K., Gnarra, J. R., Yao, M., Duh, F.-M. C., Orcutt, M. L., Stackhouse, T. M., Kuzmin, I., Modi, W. S., Geil, L., et al. (1993) · Science · doi:10.1126/science.8493574 · Cited by 2,971 · see citing works
Genes that mediate breast cancer metastasis to lung
Minn, A. J., Gupta, G. P., Siegel, P. M., Bos, P. D., Shu, W., Giri, D. D., Viale, A., Olshen, A. B., Gerald, W. L., & Massagué, J. (2005) · Nature · doi:10.1038/nature03799 · Cited by 2,922 · see citing works
A multigenic program mediating breast cancer metastasis to bone
Kang, Y., Siegel, P. M., Shu, W., Drobnjak, M., Käkönen, S.-M., Cordon‐Cardo, C., Guise, T. A., & Massagué, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00132-6 · Cited by 2,562 · see citing works
Giard, D. J., Aaronson, S. A., Todaro, G. J., Arnstein, P., Kersey, J. H., Dosik, H., & Parks, W. P. (1973) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/51.5.1417 · Cited by 2,293 · see citing works
CNVkit: Genome-Wide Copy Number Detection and Visualization from Targeted DNA Sequencing
Talevich, E., Shain, A. H., Botton, T., & Bastian, B. C. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004873 · Cited by 2,057 · see citing works
Zheng, X., Carstens, J. L., Kim, J., Scheible, M., Kaye, J. A., Sugimoto, H., Wu, C.-C., LeBleu, V. S., & Kalluri, R. (2015) · Nature · doi:10.1038/nature16064 · Cited by 2,018 · see citing works
Fischer, K. R., Durrans, A., Lee, S., Sheng, J., Li, F., Wong, S. T. C., Choi, H., El Rayes, T., Ryu, S., Troeger, J., et al. (2015) · Nature · doi:10.1038/nature15748 · Cited by 1,791 · see citing works
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
Keith, B., Johnson, R. S., & Simon, M. C. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3183 · Cited by 1,693 · see citing works
Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy
Semenza, G. L. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.01.005 · Cited by 1,514 · see citing works
Hoadley, K. A., Yau, C. S. F., Wolf, D. M., Cherniack, A. D., Tamborero, D., Ng, S., Leiserson, M. D. M., Niu, B., McLellan, M. D., Uzunangelov, V., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.049 · Cited by 1,500 · see citing works
Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation
Hu, C.-J., Wang, L.-Y., Chodosh, L. A., Keith, B., & Simon, M. C. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.24.9361-9374.2003 · Cited by 1,386 · see citing works
Interactions between cancer stem cells and their niche govern metastatic colonization
Malanchi, I., Santamaria-Martínez, A., Susanto, E., Peng, H., Lehr, H.-A., Delaloye, J.-F., & Huelsken, J. (2012) · Nature · doi:10.1038/nature10694 · Cited by 1,339 · see citing works
Integrated molecular analysis of clear-cell renal cell carcinoma
Sato, Y., Yoshizato, T., Shiraishi, Y., Maekawa, S., Okuno, Y., Kamura, T., Shimamura, T., Sato‐Otsubo, A., Nagae, G., Suzuki, H., et al. (2013) · Nature Genetics · doi:10.1038/ng.2699 · Cited by 1,223 · see citing works
Systematic pan-cancer analysis of tumour purity
Aran, D., Sirota, M., & Butte, A. J. (2015) · Nature Communications · doi:10.1038/ncomms9971 · Cited by 1,206 · see citing works
Raval, R. R., Lau, K. W., Tran, M. G. B., Sowter, H. M., Mandriota, S. J., Li, J.-L., Pugh, C. W., Maxwell, P. H., Harris, A. L., & Ratcliffe, P. J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.13.5675-5686.2005 · Cited by 940 · see citing works
Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal
Turajlic, S., Xu, H., Litchfield, K., Rowan, A., Chambers, T., Lopez, J. I., Nicol, D. L., O’Brien, T., Larkin, J., Horswell, S. D., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.057 · Cited by 831 · see citing works
Self-citationVHL, the story of a tumour suppressor gene
Gossage, L., Eisen, T. G., & Maher, E. R. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3844 · Cited by 777 · see citing works
An accurate and robust imputation method scImpute for single-cell RNA-seq data
Li, W. V., & Li, J. J. (2018) · Nature Communications · doi:10.1038/s41467-018-03405-7 · Cited by 682 · see citing works
Takeshita, S., Kikuno, R. F., Tezuka, K., & Amann, E. P. (1993) · Biochemical Journal · doi:10.1042/bj2940271 · Cited by 665 · see citing works
Distribution of metastatic sites in renal cell carcinoma: a population-based analysis
Bianchi, M., Sun, M., Claudio Jeldres, A., Shariat, S. F., Trinh, Q., Briganti, A., Tian, Z., Schmitges, J., Graefen, M., Perrotte, P., et al. (2011) · Annals of Oncology · doi:10.1093/annonc/mdr362 · Cited by 656 · see citing works
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
Thomas, G. V., Tran, C., Mellinghoff, I. K., Welsbie, D. S., Chan, E., Fueger, B., Czernin, J., & Sawyers, C. L. (2006) · Nature Medicine · doi:10.1038/nm1337 · Cited by 604 · see citing works
Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis
Strilić, B., Yang, L., Albarrán-Juárez, J., Wachsmuth, L., Han, K., Müller, U., Pasparakis, M., & Offermanns, S. (2016) · Nature · doi:10.1038/nature19076 · Cited by 523 · see citing works
Self-citationHIF activation identifies early lesions in VHL kidneys
Mandriota, S. J., Turner, K. J., Davies, D. R., Murray, P. G., Morgan, N. V., Sowter, H. M., Wykoff, C. C., Maher, E. R., Harris, A. L., Ratcliffe, P. J., et al. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00071-5 · Cited by 483 · see citing works
Pericyte–fibroblast transition promotes tumor growth and metastasis
Hosaka, K., Yang, Y., Seki, T., Fischer, C., Dubey, O., Fredlund, E., Hartman, J., Religa, P., Morikawa, H., Ishii, Y., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1608384113 · Cited by 418 · see citing works
Foster, K., Prowse, A. H., van den Berg, A., Fleming, S., Hulsbeek, M. M. F., Crossey, P. A., Richards, F. M., Cairns, P., Affara, N. A., Ferguson-Smith, M. A., et al. (1994) · Human Molecular Genetics · doi:10.1093/hmg/3.12.2169 · Cited by 373 · see citing works
Rankin, E. B., Tomaszewski, J. E., & Haase, V. H. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3241 · Cited by 356 · see citing works
Periostin expression and epithelial-mesenchymal transition in cancer: a review and an update
Morra, L., & Moch, H. (2011) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-011-1151-5 · Cited by 257 · see citing works
The chick embryo chorioallantoic membrane as a model for tumor biology
Ribatti, D. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.06.010 · Cited by 237 · see citing works
Whaley, J. M., Naglich, J. G., Gelbert, L. M., Hsia, Y. E., Lamiell, J. M., Green, J. S., Collins, D. L., Neumann, H. P. H., Laidlaw, J., & Li, F. P. (1994) · PubMed Central · Cited by 232 · see citing works
Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer
Vanharanta, S., Shu, W., Brenet, F., Hakimi, A. A., Heguy, A., Viale, A., Reuter, V. E., Hsieh, J. J.-D., Scandura, J. M., & Massagué, J. (2013) · Nature Medicine · doi:10.1038/nm.3029 · Cited by 215 · see citing works
Accessing key steps of human tumor progression in vivo by using an avian embryo model
Hagedorn, M., Javerzat, S., Gilgès, D., Meyre, A., de Lafarge, B., Eichmann, A., & Bikfalvi, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408622102 · Cited by 189 · see citing works
Yang, Y., Andersson, P., Hosaka, K., Zhang, Y., Cao, R., Iwamoto, H., Yang, X., Nakamura, M., Wang, J., Zhuang, R., et al. (2016) · Nature Communications · doi:10.1038/ncomms11385 · Cited by 185 · see citing works
Self-citationHypoxia-Inducible Factor 1α in Clear Cell Renal Cell Carcinoma
Klatte, T., Seligson, D. B., Riggs, S. B., Leppert, J. T., Berkman, M. K., Kleid, M. D., Yu, H., Kabbinavar, F. F., Pantuck, A. J., & Belldegrun, A. S. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0411 · Cited by 181 · see citing works
Maher, E. R., Yates, J. R. W., & Ferguson-Smith, M. A. (1990) · Journal of Medical Genetics · doi:10.1136/jmg.27.5.311 · Cited by 177 · see citing works
Young, A. C., Craven, R. A., Cohen, D. R., Taylor, C., Booth, C., Harnden, P., Cairns, D. A., Astuti, D., Gregory, W. M., Maher, E. R., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-2131 · Cited by 174 · see citing works
Neelakantan, D., Zhou, H., Oliphant, M. U. J., Zhang, X., Simon, L. M., Henke, D., Shaw, C. A., Wu, M.-F., Hilsenbeck, S. G., White, L. D., et al. (2017) · Nature Communications · doi:10.1038/ncomms15773 · Cited by 168 · see citing works
VHL gene mutations in renal cell carcinoma: Role as a biomarker of disease outcome and drug efficacy
Cowey, C. L., & Rathmell, W. K. (2009) · Current Oncology Reports · doi:10.1007/s11912-009-0015-5 · Cited by 163 · see citing works
Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer
Cejas, P., Xie, Y., Font‐Tello, A., Lim, K., Syamala, S., Qiu, X., Tewari, A. K., Shah, N., Nguyen, H. M., Patel, R. A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26042-z · Cited by 163 · see citing works
pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation
Frew, I. J., Thoma, C. R., Georgiev, S., Minola, A., Hitz, M., Montani, M., Moch, H., & Krek, W. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.96 · Cited by 156 · see citing works
Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice
Albers, J., Rajski, M., Schönenberger, D., Harlander, S., Schraml, P., von Teichman, A., Georgiev, S., Wild, P. J., Moch, H., Krek, W., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201202231 · Cited by 149 · see citing works
Novel Mechanism of Macrophage-Mediated Metastasis Revealed in a Zebrafish Model of Tumor Development
Wang, J., Cao, Z., Zhang, X., Nakamura, M., Sun, M., Hartman, J., Harris, R. A., Sun, Y., & Cao, Y. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-2819 · Cited by 131 · see citing works
msigdbr: MSigDB Gene Sets for Multiple Organisms in a Tidy Data Format
Dolgalev, I. (2018) · doi:10.32614/cran.package.msigdbr · Cited by 120 · see citing works
Michaylira, C. Z., Wong, G. S., Miller, C. G., Gutierrez, C. M., Nakagawa, H., Hammond, R., Klein-Szanto, A. J., Lee, J.-S., Kim, S. B., Herlyn, M., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0704 · Cited by 117 · see citing works
Rechsteiner, M., von Teichman, A., Nowicka, A., Sulser, T., Schraml, P., & Moch, H. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-0757 · Cited by 105 · see citing works
Fu, L., Wang, G., Shevchuk, M. M., Nanus, D. M., & Gudas, L. J. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-1745 · Cited by 97 · see citing works
Pantuck, A. J., An, J., Liu, H., & Rettig, M. B. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2211 · Cited by 95 · see citing works
Dahinden, C., Ingold, B., Wild, P. J., Boysen, G., Luu, V.-D., Montani, M., Kristiansen, G., Sulser, T., Bühlmann, P., Moch, H., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0260 · Cited by 91 · see citing works
Razorenova, O. V., Finger, E. C., Colavitti, R., Chernikova, S. B., Boiko, A. D., Chan, C. K. F., Krieg, A. J., Bedogni, B., LaGory, E. L., Weissman, I. L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011777108 · Cited by 88 · see citing works
Brady, N. J., Bagadion, A. M., Singh, R., Conteduca, V., Emmenis, L. V., Arceci, E., Pakula, H., Carelli, R., Khani, F., Bakht, M. K., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23780-y · Cited by 82 · see citing works
Untangling the web of intratumour heterogeneity
Li, Z., Seehawer, M., & Polyák, K. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00969-x · Cited by 81 · see citing works
Sinha, R., Winer, A., Chevinsky, M. S., Jakubowski, C. D., Chen, Y., Dong, Y., Tickoo, S. K., Reuter, V. E., Russo, P., Coleman, J., et al. (2017) · Nature Communications · doi:10.1038/ncomms15165 · Cited by 80 · see citing works
Neutralizing Monoclonal Antibody to Periostin Inhibits Ovarian Tumor Growth and Metastasis
Zhu, M., Saxton, R. E., Ramos, L., Chang, D. D., Karlan, B. Y., Gasson, J. C., & Slamon, D. J. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0046 · Cited by 74 · see citing works
CRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma
Schokrpur, S., Hu, J., Moughon, D. L., Liu, P., Lin, L. C., Hermann, K. J., Mangul, S., Guan, W., Pellegrini, M. A., Xu, H., et al. (2016) · Scientific Reports · doi:10.1038/srep29032 · Cited by 67 · see citing works
Self-citationrMATS-DVR: rMATS discovery of differential variants in RNA
Wang, J., Pan, Y., Shen, S., Lin, L., & Xing, Y. (2017) · Bioinformatics · doi:10.1093/bioinformatics/btx128 · Cited by 64 · see citing works
Nakazawa, Y., Taniyama, Y., Sanada, F., Morishita, R., Nakamori, S., Morimoto, K., Yeung, K. T., & Yang, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-22340-7 · Cited by 60 · see citing works
Brion, C., Lutz, S., & Albert, F. W. (2020) · eLife · doi:10.7554/elife.60645 · Cited by 49 · see citing works
Fu, L., Wang, G., Shevchuk, M. M., Nanus, D. M., & Gudas, L. J. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3983 · Cited by 45 · see citing works
Hu, J., Ishihara, M., Chin, A. I., & Wu, L. (2019) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbz018 · Cited by 45 · see citing works
Self-citationHsu, T. (2011) · Oncogene · doi:10.1038/onc.2011.442 · Cited by 44 · see citing works
Hu, J., Schokrpur, S., Archang, M., Hermann, K., Sharrow, A. C., Khanna, P., Novak, J., Signoretti, S., Bhatt, R. S., Knudsen, B. S., et al. (2018) · Molecular Therapy - Methods & Clinical Development · doi:10.1016/j.omtm.2018.02.009 · Cited by 37 · see citing works
Self-citationField, S., Uyttenhove, C., Stroobant, V., Chéou, P., Donckers, D., Coutelier, J., Simpson, P. T., Cummings, M. C., Saunus, J. M., Reid, L., et al. (2015) · International Journal of Cancer · doi:10.1002/ijc.29946 · Cited by 33 · see citing works
Self-citationSharrow, A. C., Ishihara, M., Hu, J., Kim, I. H., & Wu, L. (2020) · Journal of Visualized Experiments · doi:10.3791/60651 · Cited by 12 · see citing works
Self-citationIshihara, M., Hu, J., Zhang, X., Choi, Y., Wong, A., Cano-Ruiz, C., Zhao, R., Tan, P., Tso, J. L., & Wu, L. (2020) · Journal of Visualized Experiments · doi:10.3791/60314 · Cited by 8 · see citing works
Self-citationCombined mutation of Vhl and Trp53 causes renal cysts and tumours in mice
Albers, J., Rajski, M., Schönenberger, D., Harlander, S., Schraml, P., von Teichman, A., Georgiev, S., Wild, P. J., Moch, H., Krek, W., et al. (2013) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-77889 · Cited by 6 · see citing works
Advances in Urologic Oncology: Results Progress From Successful Interdisciplinary Research
Bajorin, D. F., Motzer, R. J., & Bosl, G. J. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.09.6602 · Cited by 3 · see citing works
Flagged first, then by citations
1 of the 86 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [73]Cancer Genome Atlas Research Network Comprehensive molecular characterization of clear cell renal cell carcinoma Nature 2013 499 43 49 10.1038/nature12222 23792563 PMC3771322 · DOI · Paper page
Cited by
Sorted by citations
Recruitment of FBXO22 for targeted degradation of NSD2
Nie, Y., Tabor, J. R., Li, J., Kutera, M., St‐Germain, J. R., Hanley, R. P., Wolf, E., Paulаkonis, E., Kenney, T. M. G., Duan, S., et al. (2024) · Nature Chemical Biology · doi:10.1038/s41589-024-01660-y · Cited by 70 · see citing works
Wolf, M. M., Madden, M. Z., Arner, E. N., Bader, J. E., Ye, X., Vlach, L. M., Tigue, M. L., Landis, M. D., Jonker, P. B., Hatem, Z., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci173934 · Cited by 32 · see citing works
Theranostic Lipid Nanoparticles for Renal Cell Carcinoma
Mao, X., Wang, G., Wang, Z., Duan, C., Wu, X., & Xu, H. (2023) · Advanced Materials · doi:10.1002/adma.202306246 · Cited by 27 · see citing works
Self-citationXu, X., Li, H., Tong, B., Zhang, W., Wang, X., Wang, Y., Tian, G., Xu, Z., & Zhang, G. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400204 · Cited by 26 · see citing works
Genomic Profiling and Molecular Characterization of Clear Cell Renal Cell Carcinoma
Pezzicoli, G., Ciciriello, F., Musci, V., Salonne, F., Ragno, A., & Rizzo, M. (2023) · Current Oncology · doi:10.3390/curroncol30100670 · Cited by 23 · see citing works
Exploiting E3 ligases for lung cancer therapy: The promise of DCAF-PROTACs
Hussain, M. S., Eltaib, L., Rana, A. J., Maqbool, M., Ashique, S., Alanazi, M. N., Khan, Y., & Agrawal, M. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.156001 · Cited by 22 · see citing works
Multimodal targeting of metastatic renal cell carcinoma via CD70-directed allogeneic CAR-NKT cells
Li, Y.-R., Hu, J., Li, Z., Zhu, E., Chen, Y., Halladay, T., Shen, X., Fang, Y., Zhu, Y., Lyu, Z., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102321 · Cited by 21 · see citing works
Self-citationCD70-targeted cancer theranostics: Progress and challenges
Wei, W., Grünwald, V., & Herrmann, K. (2025) · Med · doi:10.1016/j.medj.2025.100671 · Cited by 18 · see citing works
Mohammadipoor, N., Naiebi, R., Mazhari, S. A., Amooei, F., Owrang, M., Dastghaib, S., Shams, M., Maleki, M. H., & Dastghaib, S. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09355-2 · Cited by 14 · see citing works
Zhu, J., Shen, K., Su, Q., Yao, G., & Chen, X. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1662464 · Cited by 13 · see citing works
Zhou, J., Wei, Z., Zheng, Y., Xie, H., Cao, W., Cai, X.-Y., Huang, J., & Wu, X. (2023) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.2312 · Cited by 13 · see citing works
Self-citationExosomes from Von Hippel-Lindau-Null Cancer Cells Promote Metastasis in Renal Cell Carcinoma
Flora, K., Ishihara, M., Zhang, Z., Bowen, E. S., Wu, A., Ayoub, T., Huang, J., Cano-Ruiz, C., Jackson, M., Reghu, K., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417307 · Cited by 13 · see citing works
Self-citationDiscovery and Characterization of a Novel Cereblon-Recruiting PRC1 Bridged PROTAC Degrader
Kabir, M., Qin, L., Luo, K., Xiong, Y., Sidi, R. A., Park, K., & Jin, J. J. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c00538 · Cited by 13 · see citing works
Histone deacetylases and their inhibitors in kidney diseases
Zheng, Y., Zhang, T., Hao, P.-H., Yang, N., & Du, Y. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.04.026 · Cited by 13 · see citing works
The Role of the PAX Genes in Renal Cell Carcinoma
Li, L., Hossain, S. M., & Eccles, M. R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126730 · Cited by 11 · see citing works
Biomarkers in advanced renal cell carcinoma: current practice and future directions
Wong, V., Goodstein, T. A., Bravo, G. L., Srinivasan, R., & Singer, E. A. (2025) · Current Opinion in Oncology · doi:10.1097/cco.0000000000001138 · Cited by 12 · see citing works
VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway
Jiao, M., Hu, M., Pan, D., Liu, X., Bao, X., Kim, J., Li, F., & Li, C. (2024) · iScience · doi:10.1016/j.isci.2024.110285 · Cited by 10 · see citing works
Lou, L., Peng, K., Ouyang, S., Ding, W., Mo, J., Yan, J., Gong, X., Liu, G., Lu, J., Yue, P., et al. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03266-7 · Cited by 10 · see citing works
Delgado‐Bellido, D., Chacón-Barrado, A., Olmedo-Pelayo, J., Perez, C. J., Gilabert-Prieto, P., Díaz‐Martín, J., García-Díaz, Á., Oliver, F. J., & de Álava, E. (2025) · Cell Death and Differentiation · doi:10.1038/s41418-025-01469-9 · Cited by 10 · see citing works
Pal, J., Riester, M., Ganner, A., Ghosh, A., Dhamija, S., Mookherjee, D., Voss, C., Frew, I. J., Kotsis, F., Neumann‐Haefelin, E., et al. (2025) · Science Advances · doi:10.1126/sciadv.adr6375 · Cited by 8 · see citing works
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Kim, D., Nam, H. J., & Baek, S. H. (2025) · Molecular Oncology · doi:10.1002/1878-0261.70033 · Cited by 9 · see citing works
Shi, Y., Zhang, J., Li, J., He, J., Wu, S., Yu, M., Yang, D., & Ju, L. (2024) · Cancer Science · doi:10.1111/cas.16237 · Cited by 7 · see citing works
Xie, Z., Peng, S., Wang, J., Huang, Y., Zhou, X., Zhang, G., Jiang, H., Zhong, K., Feng, L., & Chen, N. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1602898 · Cited by 6 · see citing works
Jin, Y., Ide, H., Nagata, M., Kobayashi, T., Lu, J., Ikehata, Y., Shimizu, F., Lü, Y., & Horie, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1641383 · Cited by 6 · see citing works
Periostin: A matricellular protein with a multifaceted role in tumorigenesis (Review)
Xian, Y., & Wang, L. (2025) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2025.5670 · Cited by 7 · see citing works
Che, X., Tian, X., Wang, Z., Zhu, S., Ye, S., Wang, Y., Chen, Y., Huang, Y., Anwaier, A., Yao, P., et al. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03546-4 · Cited by 6 · see citing works
Ma, C., Feng, B., Yan, L., Yu, Z., Liu, Y., Cui, J. F., Li, R., Huang, X., Wu, B., Luo, Z., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-25109-x · Cited by 5 · see citing works
Mitochondrial respiratory complex II is altered in renal carcinoma
Miklovicova, S., Volpini, L., Sanovec, O., Monaco, F., Vanova, K. H., Novák, J., Boukalová, Š., Zobalová, R., Klézl, P., Tomasetti, M., et al. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167556 · Cited by 5 · see citing works
Gu, J., Ruan, J., Guo, C., Li, Z., Fu, H., Xie, Y., Xie, H., Gong, X., & Shi, H. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.118317 · Cited by 4 · see citing works
Chen, Y., Zeng, B., Xiang, M., Han, X. T., Zhang, X., Chen, H. H., Zhao, Q., Liu, D., Li, X., Li, J., et al. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117086 · Cited by 4 · see citing works
Self-citationHuang, J., Wang, X., Ge, S., Lü, X., & Sun, C. (2024) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-024-00825-y · Cited by 4 · see citing works
Self-citationTian, Q., Tang, W., & Cao, X. (2025) · Clinical & Translational Oncology · doi:10.1007/s12094-025-03954-6 · Cited by 4 · see citing works
CDCP1-targeting ADC outperforms standard therapies in Ras-mutant pancreatic cancer
Um, Y. J., Noh, H.-D., Cho, J. G., Ko, H., Wi, T. M., Kim, J.-O., & Park, S. G. (2025) · Molecular Therapy Oncology · doi:10.1016/j.omton.2025.201024 · Cited by 3 · see citing works
Meng, L., Zhang, H., Qiu, Y., Zhu, X., Ji, X., Wang, B., Zhang, G., Xue, Y., & Wang, C. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1727099 · Cited by 3 · see citing works
Pan-cancer proteogenomic interrogation of the ubiquitin-proteasome system
González-Robles, T. J., Khan, M., Sastourne-Haletou, P., Triola, M., Zhou, H., Kito, Y., Kaisari, S., Fenyö, D., Róna, G., Soto‐Feliciano, Y. M., et al. (2026) · Cell Death and Differentiation · doi:10.1038/s41418-026-01787-6 · Cited by 3 · see citing works
Apolipoprotein L1 is a tumor suppressor in clear cell renal cell carcinoma metastasis
Le, L. N.-H., Choi, C.-W., Han, J., Kim, E.-B., Trinh, V. N., Kim, Y., & Ryu, S. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1371934 · Cited by 3 · see citing works
Maharati, A., Taghehchian, N., Taghavinia, F., Golshan, A., Aarabi, A., Abbaszadegan, M. R., & Moghbeli, M. (2024) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2024.101843 · Cited by 3 · see citing works
HIF inhibition: Current strategies and clinical challenges
Więch-Walów, A., Bartoszewska, S., Barton, A., Czechowicz, P., Dudzik, J., Wielockx, B., Collawn, J. F., & Bartoszewski, R. (2026) · Redox biology · doi:10.1016/j.redox.2026.104220 · Cited by 3 · see citing works
Sgobba, M. N., Musio, B., Pastrana, C. I., Todisco, S., Schlosserová, N., Mastropirro, F., Favia, M., Radesco, A., Duarte, I. F., Grassi, A., et al. (2025) · Molecules · doi:10.3390/molecules30040821 · Cited by 2 · see citing works
Decoding the genetic puzzle: Mutations in key driver genes of pancreatic neuroendocrine tumors
Jiang, H., Zhang, W., Xu, X., Yu, X., & Ji, S. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189305 · Cited by 2 · see citing works
Ferroptosis in renal cell carcinoma: integrative multi-omics insights and therapeutic perspectives
Wang, X., Li, J., Zhang, Y., Huang, R., Zhang, P., & Hu, H. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000004583 · Cited by 2 · see citing works
Self-citationRole of LONP1 in human diseases: molecular mechanisms and therapeutic potential
Li, M., Wang, A., Tang, C., Qiao, Y., Zhang, W., & Wu, Y. (2026) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-026-00858-3 · Cited by 2 · see citing works
Targeting urological cancers with CAR-T cell therapy: current landscape and future directions
Chen, K., Wang, Y., Zhang, P., He, Y., Wusiman, D., Yoo, K. H., Lin, L., Hu, Q., Wu, W., Wu, L., et al. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07737-7 · Cited by 2 · see citing works
Self-citationDevelopment of prognostic signatures and risk index related to lipid metabolism in ccRCC
Chen, W., Zhao, Z., Zhou, H., Dong, S., Li, X., Hu, S. C., Zhong, S., & Chen, K. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1378095 · Cited by 2 · see citing works
Kumar, S. S., Khandekar, N., Dani, K., Bhatt, S. R., Duddalwar, V. A., & D'souza, A. (2024) · Oncology · doi:10.1159/000541370 · Cited by 4 · see citing works
Tsai, Y., & Kuo, C. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46100671 · Cited by 2 · see citing works
Marshall, M. R., Lajara, S. B., Quiroga‐Garza, G. M., Korentzelos, D. K., Mohebnasab, M., & Khader, S. N. (2024) · Journal of the American Society of Cytopathology · doi:10.1016/j.jasc.2024.11.002 · Cited by 2 · see citing works
VHL L169P Variant Does Not Alter Cellular Hypoxia Tension in Clear Cell Renal Cell Carcinoma
Hu, J., Smith, D., & Wu, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814075 · Cited by 2 · see citing works
Self-citationLiu, G., Liu, Q., Zhao, J., Luo, R., Wan, Y., & Luo, Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312929 · Cited by 1 · see citing works
DDX24 inhibits clear cell renal cell carcinoma progression by directly regulating AKR1B10
Li, Z., Li, X., Yang, M., Pei, X., Que, T., Xian, J., & Jin, H. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111804 · Cited by 1 · see citing works
Extracellular vesicles as biomarkers in cancer diagnosis and prognosis
Silvestrini, M. M. A., Magalhães-Gama, F., & Teixeira‐Carvalho, A. (2025) · Current topics in membranes · doi:10.1016/bs.ctm.2025.07.002 · Cited by 1 · see citing works
Yao, J.-T., Hu, P.-C., Li, X., Xu, J., Wang, K., Ye, S., Meng, X.-Y., Chen, H., Liang, Y., & Ma, Q. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101991 · Cited by 1 · see citing works
Zhong, Z., 杨安卿, Wang, J., Tian, Y., Ma, B., & Liu, X. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.153305 · Cited by 1 · see citing works
Sun, Y., Cheng, Q., Zhou, Q., Xu, Y., Wang, G., Xu, C., Wang, W., Cai, S., & Chen, W. (2026) · Clinical and Experimental Medicine · doi:10.1007/s10238-025-01885-8 · Cited by 1 · see citing works
Mitochondrial changes in clear cell renal cell carcinoma: mechanisms and potential targets
Yang, J., Pan, X., Luo, X., Zheng, X., & Wang, J. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.153354 · Cited by 1 · see citing works
HIF2 drives PTHrP-mediated cancer cachexia
Yan, J., Wang, W., & Wei, G. (2026) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2026.01.004 · Cited by 1 · see citing works
Hu, S., Zhang, X., Xin, H., Guo, M., Xiao, Y., Chang, Z., Luo, Q., Li, Y., & Zhu, C. (2024) · Cancer Reports · doi:10.1002/cnr2.70010 · Cited by 1 · see citing works
Waleron, M. M., Kallor, A. A., Pałkowski, A., Daghir‐Wojtkowiak, E., Borole, P., Kocikowski, M., Połom, K., Marino, F., Monterde, B., Mastromattei, M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.08.651510 · Cited by 1 · see citing works
HIF-1α/LAPTM5/STAT1 axis promotes the malignant progression of clear cell renal cell carcinomaPreprint
Li, Y.-L., Zhang, M.-M., Zhang, Z., Cheng, J., Xu, W.-Y., Yan, K.-Y., Liu, Y.-H., Zhang, H.-Q., & Zhang, C. (2023) · Research Square · doi:10.21203/rs.3.rs-3300556/v1
Chatterjee, S., Paul, N., Das, A., Bank, S., Bankura, B., Sarkar, K., Saha, S., Malakar, S., Choudhury, S., Ghosh, S., et al. (2025) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2024.12.266
VH032 suppresses glioma proliferation by inhibiting the VHL/HIF-1α/VEGF pathway
Zhang, Y. Q., Zhu, X., Gu, J., Wang, P., Wen, Y.-J., Hou, S., Yang, J.-Y., & Gu, J.-H. (2025) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2025.102254
Self-citationAbramov, P., Mazur, A., Starshin, A., Zhenilo, S. V., & Prokhortchouk, E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110629
Ythdc1‐p300‐Klf5 Complex‐Mediated Golgi Dysfunction Promotes Aortic Aneurysm
Wang, W., Song, Z., Bu, S., Liu, Y., Li, Q., Zhang, W., Sun, X., Zhang, X., Xiao, Y., Bo, D., et al. (2025) · Advanced Science · doi:10.1002/advs.202512116
Immune Landscape and Application of Immune Checkpoint Inhibitors in Clear Cell Renal Cell Carcinoma
An, Y., & Luo, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262411986
Li, Z., Ruan, S., Yu, Y., Xiang, H., & Mi, W. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1732056
BPX-Net: biomarker-preserved explainable networks for disease diagnosis and prognosis
Wang, J., Chen, S., Wen, R., Ying, H., Xu, W., Yin, L., Deng, X., Han, C., Zhu, Q., Zhang, B., et al. (2026) · BioData Mining · doi:10.1186/s13040-026-00537-1
Zhang, C., Zeng, H., Liu, X., Lai, G., Li, K., Fu, H., Xie, B., & Zhong, X. (2026) · The EPMA Journal · doi:10.1007/s13167-026-00445-8
Chi, Y., Wang, H., Zou, Q., Sun, F., Hu, C., Liu, C. L., Li, Q., Yang, B., Wu, J., & Li, Y. (2026) · Scientific Reports · doi:10.1038/s41598-026-46515-9
Xu, J., Ni, C., Qin, L., Wang, P., & Xu, J. (2026) · Clinical & Translational Oncology · doi:10.1007/s12094-026-04330-8
Chen, Y., Wang, Y., Ning, X., & Xu, J. (2026) · Scientific Reports · doi:10.1038/s41598-026-46158-w
Single-cell foundation models reveal context-sensitive cancer programmes under subtype shiftPreprint
Wallace, J., Youssef, G., & Han, N. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.28.721114
Kasperczak, F., Pawłowska-Kasperczak, K., Szuścik, A., Zysnarska, M., Rajwa, P., Yanagisawa, T., Zattoni, F., & Kasperczak, M. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27115054
Feng, B., Yu, Z., Cui, J., Lei, Y., Wang, X., Chen, Y., Lu, S., Liu, Y., 吴百明, Long, W., et al. (2026) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2026.110734
Cheng, L., Wang, X., Huang, X., Liang, Q., Gan, W., Gao, J., & Guo, H. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08593-1
Dual loss of VHL and RASSF1A enhances tumorigenicity in clear cell renal cancer
Donninger, H., Ferrill, R., Hobbing, K., Vos, M., & Clark, G. J. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1884868
Wang, Y., Wang, L., Deng, J., Tian, Z., Liang, Z., & Zhang, H. (2026) · Experimental Cell Research · doi:10.1016/j.yexcr.2026.115150
Luo, R., Li, S., Wang, H., Zhang, Z., Li, L., & Shang, P. (2026) · Genes and Immunity · doi:10.1038/s41435-026-00407-0
Mutha, D., Vedula, C. P., Bhagavatula, S., Grinstaff, M. W., Wong, W. W., Lu, D., Ganem, N. J., & Flynn, R. L. (2026) · Pharmaceutical Research · doi:10.1007/s11095-026-04174-5
Seront, E., Lhommel, R., Maanen, A. G. V., Pasoglou, V., Gizzi, M., Grisay, G., & TOMBAL, B. F. (2026) · BMJ Open · doi:10.1136/bmjopen-2026-119297
Kerckhofs, A., Dautricourt, S., van Kempen, L. C. L. T., Wachter, S. D., & Ramadhan, A. (2026) · Case Reports in Urology · doi:10.1155/criu/5538985
Mátrai, Á. A., Barkóczi, A., Kovács, P. B., Vinh, H. Q. T., Varga, Á., Fazekas, L. Á., Képes, Z., Trencsényi, G., Szabó, J., Nagy, T., et al. (2026) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2026.107682
Zhang, Y., Wang, S., Zhao, Z., Yuan, T., Zhu, C., & Zhong, L. (2026) · Biomedicines · doi:10.3390/biomedicines14102334
Self-citationAdvances in the management of renal cell carcinoma
Lewis, A. R., Lyon, T. D., Gupta, S., Zakharia, Y., Leibovich, B. C., & Costello, B. A. (2026) · BMJ · doi:10.1136/bmj-2026-100785
- Authors
- Hu, J., Tan, P., Ishihara, M., Bayley, N. A., Schokrpur, S., Reynoso, J. G., Zhang, Y., Lim, R. J., Dumitras, C., Yang, L., Dubinett, S. M., Jat, P. S., Van Snick, J., Huang, J., Chin, A. I., Prins, R. M., Graeber, T. G., Xu, H., & Wu, L.
- Affiliations
- University of California, Los Angeles (US)
- West China Hospital of Sichuan University (CN)
- University of California San Diego (US)
- Zhongnan Hospital of Wuhan University (CN)
- MRC Prion Unit (GB)
- Duke University (US)
- Corresponding author
- Xu, Hua
- Wu, Lily
- ORCID
- Venue
- Signal Transduction and Targeted Therapy
- Published
- 2023-04-17
- Volume
- 8
- Issue
- 1
- Pages
- 155-155
- ISSN
- 2059-3635 (ISSN-L)
- PMC
- PMC10110583
- OpenAlex
- W4366171201
- Cited by
- 85
- References
- 86
- Citations by year
- 2026: 27 · 2025: 33 · 2024: 19 · 2023: 6
- FWCI
- 15.66
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Signal Transduction and Targeted Therapy (publishedVersion, cc-by)
- Research Square (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion, cc-by)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Tobacco-Related Disease Research Program (27IR-0016)
- Cancer Research Coordinating Committee (CRC15-380768)
- National Institutes of Health (W81XWH, UL1TR001881)
- National Cancer Institute (R21CA216770, P50CA211015, T32CA067754, P30CA016042)
- National Center for Advancing Translational Sciences
- Jonsson Comprehensive Cancer Center (P30 CA016042, UL1TR001881, 27IR-0016, W81XWH-20-1-0918)
- Clinical and Translational Science Institute, University of California, Los Angeles (UL1 TR001881)
- Congressionally Directed Medical Research Programs (W81XWH-20-1-0918, P30CA016042)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Renal cell carcinoma treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- von Hippel-Lindau tumor suppressor, clear cell renal cell carcinoma, intratumoral heterogeneity, metastasis, epithelial-mesenchymal transition, periostin, lung metastasis, tumor cell motility, tumor cell proliferation
- MeSH terms
- Carcinoma, Renal Cell, Humans, Kidney Neoplasms, Lung Neoplasms, Genes, Tumor Suppressor, Von Hippel-Lindau Tumor Suppressor Protein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
