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Human papillomavirus E7 enhances hypoxia-inducible factor 1-mediated transcription by inhibiting binding of histone deacetylases

Bodily, Jason M., Mehta, Kavi P.M., Laimins, Laimonis A.·2011·Cancer Research
DOI 10.1158/0008-5472.can-10-2626PMC PMC3077548

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Abstract

Infection by human papillomaviruses (HPV) leads to the formation of benign lesions, warts, and in some cases, cervical cancer. The formation of these lesions is dependent upon increased expression of proangiogenic factors. Angiogenesis is linked to tissue hypoxia through the activity of the oxygen-sensitive hypoxia-inducible factor 1α (HIF-1α). Our studies indicate that the HPV E7 protein enhances HIF-1 transcriptional activity whereas E6 functions to counteract the repressive effects of p53. Both high- and low-risk HPV E7 proteins were found to bind to HIF-1α through a domain located in the N-terminus. Importantly, the ability of E7 to enhance HIF-1 activity mapped to the C-terminus and correlated with the displacement of the histone deacetylases HDAC1, HDAC4, and HDAC7 from HIF-1α by E7. Our findings describe a novel role of the E7 oncoprotein in activating the function of a key transcription factor mediating hypoxic responses by blocking the binding of HDACs. Cancer Res; 71(3); 1187–95. ©2010 AACR.

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Metadata

Authors
Bodily, J. M., Mehta, K. P. M., & Laimins, L. A.
Affiliations
Authors' Affiliation: Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois
Venue
Cancer Research
Publisher
American Association for Cancer Research (AACR)
Published
2011-02-01
Volume
71
Issue
3
Pages
1187-1195
ISSN
  • 0008-5472
  • 1538-7445
DOI
10.1158/0008-5472.can-10-2626
PMC
PMC3077548
Cited by
147
References
3
Language
en

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CoChat. (2026). Citation check: Human papillomavirus E7 enhances hypoxia-inducible factor 1-mediated transcription by inhibiting binding of histone deacetylases. https://app.cochat.ai/papers/10.1158/0008-5472.can-10-2626
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Bodily, J. M., Mehta, K. P. M., & Laimins, L. A. (2011). Human papillomavirus E7 enhances hypoxia-inducible factor 1-mediated transcription by inhibiting binding of histone deacetylases. Cancer Research. https://doi.org/10.1158/0008-5472.can-10-2626