The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Long Noncoding RNA, Polycomb, and the Ghosts Haunting INK4b-ARF-INK4a Expression
Open accessAbstract
Polycomb group proteins (PcG) function as transcriptional repressors of gene expression. The important role of PcG in mediating repression of the INK4b-ARF-INK4a locus, by directly binding to the long noncoding RNA (lncRNA) transcript antisense noncoding RNA in the INK4 locus (ANRIL), was recently shown. INK4b-ARF-INK4a encodes 3 tumor-suppressor proteins, p15INK4b, p14ARF, and p16INK4a, and its transcription is a key requirement for replicative or oncogene-induced senescence and constitutes an important barrier for tumor growth. ANRIL gene is transcribed in the antisense orientation of the INK4b-ARF-INK4a gene cluster, and different single-nucleotide polymorphisms are associated with increased susceptibility to several diseases. Although lncRNA-mediated regulation of INK4b-ARF-INK4a gene is not restricted to ANRIL, both polycomb repressive complex-1 (PRC1) and -2 (PRC2) interact with ANRIL to form heterochromatin surrounding the INK4b-ARF-INK4a locus, leading to its repression. This mechanism would provide an increased advantage for bypassing senescence, sustaining the requirements for the proliferation of stem and/or progenitor cell populations or inappropriately leading to oncogenesis through the aberrant saturation of the INK4b-ARF-INK4a locus by PcG complexes. In this review, we summarize recent findings on the underlying epigenetic mechanisms that link PcG function with ANRIL, which impose gene silencing to control cellular homeostasis as well as cancer development. Cancer Res; 71(16); 5365–9. ©2011 AACR.
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1 retracted
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RetractedLong non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
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Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
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Role of histone H2A ubiquitination in Polycomb silencing
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Polycomb silencing mechanisms and the management of genomic programmes
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Implications of Genetic and Epigenetic Alterations of CDKN2A (p16 INK4a ) in Cancer
Zhao, R., Choi, B. Y., Lee, M.-H., Bode, A. M., & Dong, Z. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.04.017 · Cited by 425
Xu, M., Chen, X., Lin, K., Zeng, K., Liu, X., Pan, B., Xu, X., Xu, T., Hu, X., Sun, L., et al. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0894-x · Cited by 298
Metadata
- Authors
- Aguilo, F., Zhou, M.-M., & Walsh, M. J.
- Venue
- Cancer Research
- Published
- 2011-08-11
- Volume
- 71
- Issue
- 16
- Pages
- 5365-5369
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2084639301
- Cited by
- 255
- References
- 30
- FWCI
- 5.89
- Type
- journal article
- Language
- en
- Open access
- green
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