The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
SOX4 Induces Epithelial–Mesenchymal Transition and Contributes to Breast Cancer Progression
Abstract
Epithelial–mesenchymal transition (EMT) is a developmental program, which is associated with breast cancer progression and metastasis. Here, we report that ectopic overexpression of SOX4 in immortalized human mammary epithelial cells is sufficient for acquisition of mesenchymal traits, enhanced cell migration, and invasion, along with epithelial stem cell properties defined by the presence of a CD44high/CD24low cell subpopulation. SOX4 positively regulated expression of known EMT inducers, also activating the TGF-β pathway to contribute to EMT. SOX4 itself was induced by TGF-β in mammary epithelial cells and was required for TGF-β–induced EMT. Murine xenograft experiments showed that SOX4 cooperated with oncogenic Ras to promote tumorigenesis in vivo. Finally, in clinical specimens of human breast cancer, we found that SOX4 was abnormally overexpressed and correlated with the triple-negative breast cancer subtype (ER−/PR−/HER2−). Our findings define an important function for SOX4 in the progression of breast cancer by orchestrating EMT, and they implicate this gene product as a marker of poor prognosis in this disease. Cancer Res; 72(17); 4597–608. ©2012 AACR.
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Cites
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The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
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In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells
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Cited by
Guidelines and definitions for research on epithelial-mesenchymal transition
Yang, J., Antin, P., Berx, G., Blanpain, C., Brabletz, T., Bronner, M., Campbell, K., Cano, A., Casanova, J., Christofori, G., et al. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0237-9 · Cited by 2,226
The biology and role of CD44 in cancer progression: Therapeutic implications
Chen, C., Zhao, S., Karnad, A., & Freeman, J. W. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0605-5 · Cited by 1,245
TGF-β signaling and epithelial–mesenchymal transition in cancer progression
Katsuno, Y., Lamouille, S., & Derynck, R. (2013) · Current Opinion in Oncology · doi:10.1097/cco.0b013e32835b6371 · Cited by 786
Tiwari, N., Tiwari, V. K., Waldmeier, L., Balwierz, P. J., Arnold, P., Pachkov, M., Meyer-Schaller, N., Schübeler, D., van Nimwegen, E., & Christofori, G. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.04.020 · Cited by 484
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Self-citation
Metadata
- Authors
- Zhang, J., Liang, Q., Lei, Y., Yao, M., Li, L., Gao, X., Feng, J., Zhang, Y., Gao, H., Liu, D.-X., Lu, J., & Huang, B.
- Venue
- Cancer Research
- Published
- 2012-08-30
- Volume
- 72
- Issue
- 17
- Pages
- 4597-4608
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2167246201
- Cited by
- 264
- References
- 48
- FWCI
- 9.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhang, J., Liang, Q., Lei, Y., Yao, M., Li, L., Gao, X., Feng, J., Zhang, Y., Gao, H., Liu, D.-X., Lu, J., & Huang, B. (2012). SOX4 Induces Epithelial–Mesenchymal Transition and Contributes to Breast Cancer Progression. Cancer Research. https://doi.org/10.1158/0008-5472.can-12-1045
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