Targeting EphA3 Inhibits Cancer Growth by Disrupting the Tumor Stromal Microenvironment

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

Hanahan, D., & Coussens, L. M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.022 · Cited by 4,632 · see citing works

Nonlinear magic: multiphoton microscopy in the biosciences

Zipfel, W. R., Williams, R. M., & Webb, W. W. (2003) · Nature Biotechnology · doi:10.1038/nbt899 · Cited by 3,911 · see citing works

The Consensus Coding Sequences of Human Breast and Colorectal Cancers

Sjöblom, T., Jones, S., Wood, L. D., Parsons, D. W., Lin, J., Barber, T. D., Mandelker, D. L., Leary, R. J., Ptak, J., Silliman, N., et al. (2006) · Science · doi:10.1126/science.1133427 · Cited by 3,161 · see citing works

Somatic mutations affect key pathways in lung adenocarcinoma

Ding, L., Getz, G., Wheeler, D. A., Mardis, E. R., McLellan, M. D., Cibulskis, K., Sougnez, C., Greulich, H., Muzny, D. M., Morgan, M. B., et al. (2008) · Nature · doi:10.1038/nature07423 · Cited by 2,681 · see citing works

VEGF-targeted therapy: mechanisms of anti-tumour activity

Ellis, L. M., & Hicklin, D. J. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2403 · Cited by 1,673 · see citing works

Mesenchymal Stem Cells: Revisiting History, Concepts, and Assays

Bianco, P., Robey, P. G., & Simmons, P. J. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.03.002 · Cited by 1,625 · see citing works

Eph receptors and ephrins in cancer: bidirectional signalling and beyond

Pasquale, E. B. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2806 · Cited by 1,216 · see citing works

Eph Receptors and Ligands Comprise Two Major Specificity Subclasses and Are Reciprocally Compartmentalized during Embryogenesis

Gale, N. W., Holland, S. J., Valenzuela, D. M., Flenniken, A. M., Pan, L., Ryan, T. E., Henkemeyer, M. J., Strebhardt, K., Hirai, H., Wilkinson, D. G., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80276-7 · Cited by 839 · see citing works

Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow

Morikawa, S., Mabuchi, Y., Kubota, Y., Nagai, Y., Niibe, K., Hiratsu, E., Suzuki, S., Miyauchi-Hara, C., Nagoshi, N., Sunabori, T., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20091046 · Cited by 833 · see citing works

A protocol for isolation and culture of mesenchymal stem cells from mouse compact bone

Zhu, H., Guo, Z., Jiang, X., Li, H., Wang, X.-Y., Yao, H., Zhang, Y., & Mao, N. (2010) · Nature Protocols · doi:10.1038/nprot.2009.238 · Cited by 588 · see citing works

EphB receptor activity suppresses colorectal cancer progression

Batlle, E., Bacani, J. T. C., Begthel, H., Jonkeer, S., Gregorieff, A., van den Born, M., Malats, N., Sancho, E., Boon, E. M. J., Pawson, T. J., et al. (2005) · Nature · doi:10.1038/nature03626 · Cited by 413 · see citing works

Therapeutic targeting of EPH receptors and their ligands

Boyd, A., Bartlett, P. F., & Lackmann, M. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4175 · Cited by 340 · see citing works

Tumor-Host Interactions: A Far-Reaching Relationship

McAllister, S. S., & Weinberg, R. A. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2010.28.4257 · Cited by 326 · see citing works

The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl–Crk pathway

Hooten, N. N., Foos, G. E., Hauser, C. A., & Pasquale, E. B. (2006) · Nature Cell Biology · doi:10.1038/ncb1438 · Cited by 288 · see citing works

EphB–ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells

Cortina, C., Palomo‐Ponce, S., Iglesias, M., Fernández-Masip, J. L., Vivancos, A. P., Whissell, G., Humà, M., Peiró, N., Gallego, L., Jonkheer, S. M., et al. (2007) · Nature Genetics · doi:10.1038/ng.2007.11 · Cited by 269 · see citing works

A conditional feedback loop regulates Ras activity through EphA2

Macrae, M., Neve, R. M., Rodriguez‐Viciana, P., Haqq, C. M., Yeh, J., Chen, C., Gray, J. W., & McCormick, F. P. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.07.005 · Cited by 257 · see citing works

EphA3 Maintains Tumorigenicity and Is a Therapeutic Target in Glioblastoma Multiforme

Day, B. W., Stringer, B. W., Al‐Ejeh, F., Ting, M. J., Wilson, J., Ensbey, K. S., Jamieson, P. R., Bruce, Z. C., Lim, Y. C., Offenhäuser, C., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.01.007 · Cited by 213 · see citing works

Molecular Mechanisms of Cell Segregation and Boundary Formation in Development and TumorigenesisPreprint

Batlle, E., & Batlle, E. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008227 · Cited by 191 · see citing works

Dissociation of EphB2 Signaling Pathways Mediating Progenitor Cell Proliferation and Tumor Suppression

Genander, M., Halford, M. M., Xu, N., Eriksson, M., Yu, Z., Qiu, Z., Martling, A., Greicius, G., Thakar, S., Catchpole, T., et al. (2009) · Cell · doi:10.1016/j.cell.2009.08.048 · Cited by 178 · see citing works

Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling

Lawrenson, I. D., Wimmer-Kleikamp, S. H., Lock, P., Schoenwaelder, S. M., Down, M., Boyd, A., Alewood, P. F., & Lackmann, M. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.5.1059 · Cited by 169 · see citing works

Transcriptional Profiling of Human Cord Blood CD133+ and Cultured Bone Marrow Mesenchymal Stem Cells in Response to Hypoxia

Martin‐Rendon, E., Hale, S. J. M., Ryan, D. J., Baban, D. F., Forde, S. P., Roubelakis, M. G., Sweeney, D., Moukayed, M., Harris, A. L., Davies, K. E., et al. (2006) · Stem Cells · doi:10.1634/stemcells.2006-0398 · Cited by 167 · see citing works

Novel Somatic and Germline Mutations in Cancer Candidate Genes in Glioblastoma, Melanoma, and Pancreatic Carcinoma

Balakrishnan, A., Bleeker, F. E., Lamba, S., Rodolfo, M., Daniotti, M., Scarpa, A., van Tilborg, A. A., Leenstra, S., Zanon, C., & Bardelli, A. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0065 · Cited by 161 · see citing works

Identification of a tumor-specific shared antigen derived from an Eph receptor and presented to CD4 T cells on HLA class II molecules.

Chiari, R., Hames, G., Stroobant, V., Texier, C., Maillère, B., Boon, T., & Coulie, P. G. (2000) · PubMed · Cited by 117 · see citing works

Mosaic Tumor Vessels: Cellular Basis and Ultrastructure of Focal Regions Lacking Endothelial Cell Markers

di Tomaso, E., Capen, D. E., Haskell, A., Hart, J., Logie, J. J., Jain, R. K., McDonald, D. M., Jones, R. C., & Munn, L. L. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4552 · Cited by 115 · see citing works

Segregation of Axial Motor and Sensory Pathways via Heterotypic Trans-Axonal Signaling

Gallarda, B. W., Bonanomi, D., Müller, D., Brown, A. M., Alaynick, W. A., Andrews, S. E., Lemke, G., Pfaff, S. L., & Marquardt, T. (2008) · Science · doi:10.1126/science.1153758 · Cited by 103 · see citing works

The role of bone-marrow-derived cells in tumor growth, metastasis initiation and progression

Gao, D., & Mittal, V. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.06.006 · Cited by 98 · see citing works

Dissecting the EphA3/Ephrin-A5 Interactions Using a Novel Functional Mutagenesis Screen

Smith, F. M., Vearing, C., Lackmann, M., Treutlein, H., Himanen, J. P., Chen, K., Saul, A. J., Nikolov, D. B., & Boyd, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309326200 · Cited by 94 · see citing works

Eph-dependent cell-cell adhesion and segregation in development and cancer

Nievergall, E., Lackmann, M., & Janes, P. W. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0900-6 · Cited by 93 · see citing works

EphB/ephrin-B interactions mediate human MSC attachment, migration and osteochondral differentiation

Arthur, A., Zannettino, A. C. W., Panagopoulos, R. A., Koblar, S. A., Sims, N. A., Stylianou, C., Matsuo, K., & Gronthos, S. (2010) · Bone · doi:10.1016/j.bone.2010.10.180 · Cited by 93 · see citing works

Isolation and characterization of a novel receptor-type protein tyrosine kinase (hek) from a human pre-B cell line.

Boyd, A., Ward, L. D., Wicks, I. P., Simpson, R. J., Salvaris, E. J., Wilks, A. F., Welch, K., Loudovaris, M., Rockman, S. P., & Busmanis, I. A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50725-6 · Cited by 90 · see citing works

Expression of theTyro4/Mek4/Cek4Gene Specifically Marks a Subset of Embryonic Motor Neurons and Their Muscle Targets

Kilpatrick, T. J., Brown, A. M., Lai, C., Gassmann, M., Goulding, M., & Lemke, G. (1996) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1996.0005 · Cited by 84 · see citing works

A critical role for the EphA3 receptor tyrosine kinase in heart development

Stephen, L. J., Fawkes, A. L., Verhoeve, A., Lemke, G., & Brown, A. M. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.08.058 · Cited by 79 · see citing works

Defining Vascular Stem Cells

Lin, C., & Lue, T. F. (2013) · Stem Cells and Development · doi:10.1089/scd.2012.0504 · Cited by 77 · see citing works

Concurrent Binding of Anti-EphA3 Antibody and Ephrin-A5 Amplifies EphA3 Signaling and Downstream Responses: Potential as EphA3-Specific Tumor-Targeting Reagents

Vearing, C., Lee, F.-T., Wimmer-Kleikamp, S. H., Spirkoska, V., To, C., Stylianou, C., Spanevello, M., Brechbiel, M. W., Boyd, A., Scott, A. M., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0758 · Cited by 76 · see citing works

Sall genes regulate region-specific morphogenesis in the mouse limb by modulating Hox activities

Kawakami, Y., Uchiyama, Y., Esteban, C. R., Inenaga, T., Koyano‐Nakagawa, N., Kawakami, H., Martí, M., Kmita, M., Monaghan‐Nichols, P., Nishinakamura, R., et al. (2009) · Development · doi:10.1242/dev.027748 · Cited by 73 · see citing works

Gene Sets Identified with Oncogene Cooperativity Analysis Regulate In Vivo Growth and Survival of Leukemia Stem Cells

Ashton, J. M., Balys, M. M., Neering, S. J., Hassane, D. C., Cowley, G. S., Root, D. E., Miller, P. G., Ebert, B. L., McMurray, H. R., Land, H., et al. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.05.024 · Cited by 68 · see citing works

Cancer Somatic Mutations Disrupt Functions of the EphA3 Receptor Tyrosine Kinase through Multiple Mechanisms

Lisabeth, E. M., Fernandez, C., & Pasquale, E. B. (2012) · Biochemistry · doi:10.1021/bi2014079 · Cited by 67 · see citing works

Clinicopathological significance and prognostic value of EphA3 and CD133 expression in colorectal carcinoma

Xi, H., & Zhao, P. (2011) · Journal of Clinical Pathology · doi:10.1136/jcp.2010.087213 · Cited by 65 · see citing works

An early developmental role for Eph-ephrin interaction during vertebrate gastrulation

Oates, A. C., Lackmann, M., Power, M.-A., Brennan, C. H., Down, L. M., Do, C., Evans, B., Holder, N., & Boyd, A. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00036-2 · Cited by 59 · see citing works

Aberrant expression of EphA3 in gastric carcinoma: correlation with tumor angiogenesis and survival

Xi, H., Wu, X., Wei, B., & Chen, L. (2012) · Journal of Gastroenterology · doi:10.1007/s00535-012-0549-4 · Cited by 55 · see citing works

Ephrins Negatively Regulate Cell Proliferation in the Epidermis and Hair Follicle

Genander, M., Holmberg, J., & Frisén, J. (2010) · Stem Cells · doi:10.1002/stem.442 · Cited by 52 · see citing works

“Eph receptor signalling; dimerisation just isn't enough”

Vearing, C., & Lackmann, M. (2005) · Growth Factors · doi:10.1080/08977190500055869 · Cited by 47 · see citing works

EPHA3 as a novel therapeutic target in the hematological malignancies

Keane, N., Freeman, C. L. L., Swords, R. T., & Giles, F. J. (2012) · Expert Review of Hematology · doi:10.1586/ehm.12.19 · Cited by 26 · see citing works

Analysis of cellular phosphatidylinositol (3,4,5)-trisphosphate levels and distribution using confocal fluorescent microscopy

Palmieri, M., Nowell, C. J., Condron, M. M., Gardiner, J., Holmes, A. B., Desai, J., Burgess, A. W., & Catimel, B. (2010) · Analytical Biochemistry · doi:10.1016/j.ab.2010.06.033 · Cited by 12 · see citing works

An abstract virtual instrument system for high throughput automatic microscopy

Russel, A. B. M., Abramson, D., Bethwaite, B., Dinh, M. N., Enticott, C., Firth, S. D., Garic, S., Harper, I. S., Lackmann, M., Schek, S., et al. (2010) · Procedia Computer Science · doi:10.1016/j.procs.2010.04.058 · Cited by 7 · see citing works

A Phase I Study Of KB004, a Novel Non-Fucosylated humaneered® Antibody, Targeted Against The Receptor Tyrosine Kinase EphA3, In Advanced Hematologic Malignancies

Lancet, J. E., Wei, A. H., Durrant, S., Hertzberg, M., Swords, R. T., Lewis, I. D., Jonas, B. A., Cortes, J. E., Yarranton, G. T., & Walling, J. M. (2013) · Blood · doi:10.1182/blood.v122.21.3838.3838 · Cited by 5 · see citing works

Smart nanoparticles for cancer therapy

Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works

The “less-is-more” in therapeutic antibodies: Afucosylated anti-cancer antibodies with enhanced antibody-dependent cellular cytotoxicity

Pereira, N. A., Chan, K. F., Lin, P. C., & Song, Z. (2018) · mAbs · doi:10.1080/19420862.2018.1466767 · Cited by 336 · see citing works

Bone marrow fibrosis in myelofibrosis: pathogenesis, prognosis and targeted strategies

Zahr, A. A., Salama, M. E., Carreau, N. A., Tremblay, D. A., Verstovšek, S., Mesa, R. A., Hoffman, R., & Mascarenhas, J. O. (2016) · Haematologica · doi:10.3324/haematol.2015.141283 · Cited by 196 · see citing works

Eph receptor signalling: from catalytic to non-catalytic functions

Liang, L., Patel, O., Janes, P. W., Murphy, J. M., & Lucet, I. S. (2019) · Oncogene · doi:10.1038/s41388-019-0931-2 · Cited by 139 · see citing works

Eph receptors and ephrins in cancer progression

Pasquale, E. B. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00634-x · Cited by 137 · see citing works

Combining genomic and network characteristics for extended capability in predicting synergistic drugs for cancer

Sun, Y., Sheng, Z., Ma, C., Tang, K., Zhu, R., Wu, Z., Shen, R., Feng, J. H., Wu, D., Huang, D., et al. (2015) · Nature Communications · doi:10.1038/ncomms9481 · Cited by 134 · see citing works

Nose-to-brain delivery of temozolomide-loaded PLGA nanoparticles functionalized with anti-EPHA3 for glioblastoma targeting

Chu, L., Wang, A., Ni, L., Yan, X., Song, Y., Zhao, M., Sun, K., Mu, H., Liu, S., Wu, Z., et al. (2018) · Drug Delivery · doi:10.1080/10717544.2018.1494226 · Cited by 127 · see citing works

Intranasal Delivery of Temozolomide-Conjugated Gold Nanoparticles Functionalized with Anti-EphA3 for Glioblastoma Targeting

Wang, L., Tang, S., Yu, Y., Lv, Y., Wang, A., Yan, X., Li, N., Sha, C., Sun, K., & Li, Y. (2021) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00911 · Cited by 89 · see citing works

Cancer-associated fibroblasts as therapeutic targets for cancer: advances, challenges, and future prospects

Cao, Z., Quazi, S., Arora, S., Osellame, L. D., Burvenich, I. J. G., Janes, P. W., & Scott, A. M. (2025) · Journal of Biomedical Science · doi:10.1186/s12929-024-01099-2 · Cited by 85 · see citing works

Targeting Eph/ephrin system in cancer therapy

Lodola, A., Giorgio, C., Incerti, M., Zanotti, I., & Tognolini, M. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.07.029 · Cited by 81 · see citing works

EphA3 biology and cancer

Janes, P. W., Slape, C. I., Farnsworth, R. H., Atapattu, L., Scott, A. M., & Vail, M. E. (2014) · Growth Factors · doi:10.3109/08977194.2014.982276 · Cited by 73 · see citing works

Personalized Medicine—Current and Emerging Predictive and Prognostic Biomarkers in Colorectal Cancer

Koulis, C., Yap, R. J., Engel, R. M., Jardé, T., Wilkins, S., Solon, J. G., Shapiro, J. D., Abud, H. E., & McMurrick, P. J. (2020) · Cancers · doi:10.3390/cancers12040812 · Cited by 60 · see citing works

Simultaneous targeting of Eph receptors in glioblastoma

Ferluga, S., Tomé, C. M. L., Herpai, D., D'Agostino, R., & Debinski, W. (2016) · Oncotarget · doi:10.18632/oncotarget.10978 · Cited by 57 · see citing works

Eph Receptors in the Immunosuppressive Tumor Microenvironment

Janes, P. W., Vail, M. E., Ernst, M., & Scott, A. M. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-3047 · Cited by 54 · see citing works

Unliganded EphA3 dimerization promoted by the SAM domain

Singh, D. R., Cao, Q., King, C., Salotto, M., Ahmed, F., Zhou, X., Pasquale, E. B., & Hristova, K. A. (2015) · Biochemical Journal · doi:10.1042/bj20150433 · Cited by 49 · see citing works

EPHA3 regulates the multidrug resistance of small cell lung cancer via the PI3K/BMX/STAT3 signaling pathway

Peng, J., Wang, Q., Liu, H., Ye, M., Wu, X., & Guo, L. (2016) · Tumor Biology · doi:10.1007/s13277-016-5048-4 · Cited by 45 · see citing works

EphA3 Pay-Loaded Antibody Therapeutics for the Treatment of Glioblastoma

Offenhäuser, C., Al‐Ejeh, F., Puttick, S. G., Ensbey, K. S., Bruce, Z. C., Jamieson, P. R., Smith, F. M., Stringer, B. W., Carrington, B., Fuchs, A. V., et al. (2018) · Cancers · doi:10.3390/cancers10120519 · Cited by 42 · see citing works

Therapeutic potential of targeting the Eph/ephrin signaling complex

Saha, N., Tzvetkova‐Robev, D., Mason, E. O., Himanen, J. P., & Nikolov, D. B. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.10.006 · Cited by 39 · see citing works

Eph Receptors in Cancer

Arora, S., Scott, A. M., & Janes, P. W. (2023) · Biomedicines · doi:10.3390/biomedicines11020315 · Cited by 39 · see citing works

EphA3 as a target for antibody immunotherapy in acute lymphoblastic leukemia

Charmsaz, S., Al‐Ejeh, F., Yeadon, T. M., Miller, K. J., Smith, F. M., Stringer, B. W., Moore, A. S., Lee, F.-T., Cooper, L. T., Stylianou, C., et al. (2016) · Leukemia · doi:10.1038/leu.2016.371 · Cited by 37 · see citing works

Antibody Targeting of Eph Receptors in Cancer

Janes, P. W., Vail, M. E., Gan, H. K., & Scott, A. M. (2020) · Pharmaceuticals · doi:10.3390/ph13050088 · Cited by 36 · see citing works

Critical role of EphA3 in cancer and current state of EphA3 drug therapeutics

London, M., & Gallo, E. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05571-8 · Cited by 36 · see citing works

Targeted therapies in hematological malignancies using therapeutic monoclonal antibodies against Eph family receptors

Charmsaz, S., Scott, A. M., & Boyd, A. (2017) · Experimental Hematology · doi:10.1016/j.exphem.2017.07.003 · Cited by 29 · see citing works

The role of Eph/ephrin molecules in stromal–hematopoietic interactions

Nguyen, T. M., Arthur, A., & Gronthos, S. (2015) · International Journal of Hematology · doi:10.1007/s12185-015-1886-x · Cited by 28 · see citing works

Ephs and Ephrins in malignant gliomas

Ferluga, S., & Debinski, W. (2014) · Growth Factors · doi:10.3109/08977194.2014.985787 · Cited by 28 · see citing works

EphA3-targeted chimeric antigen receptor T cells are effective in glioma and generate curative memory T cell responses

Lertsumitkul, L., Iliopoulos, M., Wang, S. S., McArthur, S. J., Ebert, L. M., Davenport, A. J., Endersby, R., Hansford, J. R., Drummond, K. J., Cross, R. S., et al. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-009486 · Cited by 27 · see citing works

The dystroglycan receptor maintains glioma stem cells in the vascular niche

Day, B. W., Lathia, J. D., Bruce, Z. C., D’Souza, R. C. J., Baumgartner, U., Ensbey, K. S., Lim, Y. C., Stringer, B. W., Akgül, S., Offenhäuser, C., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-02069-x · Cited by 27 · see citing works

Hypoxia-Controlled EphA3 Marks a Human Endometrium-Derived Multipotent Mesenchymal Stromal Cell that Supports Vascular Growth

To, C., Farnsworth, R. H., Vail, M. E., Chheang, C., Gargett, C. E., Murone, C., Llerena, C., Major, A. T., Scott, A. M., Janes, P. W., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112106 · Cited by 23 · see citing works

Epha3 acts as proangiogenic factor in multiple myeloma

Caivano, A., Rocca, F. L., Laurenzana, I., Annese, T., Tamma, R., Famigliari, U., Simeon, V., Trino, S., Luca, L. D., Villani, O., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.16100 · Cited by 23 · see citing works

ADAM10-cleaved ephrin-A5 contributes to prostate cancer metastasis

Cai, C., Zhang, M., Liu, L., Zhang, H., Guo, Y. C., Lan, T., Xu, Y., Ma, P., & Li, S. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04893-8 · Cited by 22 · see citing works

EPHA3 enhances macrophage autophagy and apoptosis by disrupting the mTOR signaling pathway in mice with endometriosis

Xu, H., Gao, Y., Shu, Y., Wang, Y., & Shi, Q. (2019) · Bioscience Reports · doi:10.1042/bsr20182274 · Cited by 20 · see citing works

Antibody-drug conjugates: beyond current approvals and potential future strategies

Menon, S., Parakh, S., Scott, A. M., & Gan, H. K. (2022) · Exploration of Targeted Anti-tumor Therapy · doi:10.37349/etat.2022.00082 · Cited by 20 · see citing works

EphA3 CAR T cells are effective against glioblastoma in preclinical models

Martins, J. P., D’Souza, R. C. J., Skarne, N., Lekieffre, L., Horsefield, S., Ranjankumar, M., Li, X. O., Le, T. T., Smith, F., Smith, C., et al. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-009403 · Cited by 18 · see citing works

Dying to communicate: apoptotic functions of Eph/Ephrin proteins

Kandouz, M. (2018) · APOPTOSIS · doi:10.1007/s10495-018-1458-7 · Cited by 16 · see citing works

The Ephrin tyrosine kinase a3 (EphA3) is a novel mediator of RAGE-prompted motility of breast cancer cells

Talia, M., Cirillo, F., Spinelli, A., Zicarelli, A., Scordamaglia, D., Muglia, L., Rosis, S. D., Rigiracciolo, D. C., Filippelli, G., Perrotta, I. D., et al. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02747-5 · Cited by 16 · see citing works

EphA3 targeting reduces in vitro adhesion and invasion and in vivo growth and angiogenesis of multiple myeloma cells

Rocca, F. L., Airoldi, I., Carlo, E. D., Marotta, P., Falco, G., Simeon, V., Laurenzana, I., Trino, S., Luca, L. D., Todoerti, K., et al. (2017) · Cellular Oncology · doi:10.1007/s13402-017-0338-4 · Cited by 17 · see citing works

Low EphA7 Expression Correlated with Lymph Node Metastasis and Poor Prognosis of Patients with Esophageal Squamous Cell Carcinoma

Bai, Y., Zhang, J., Bai, C., Xu, X., Wu, J., Chen, B., Wu, Z., Wang, S., Shen, J., Shen, J., et al. (2015) · ACTA HISTOCHEMICA ET CYTOCHEMICA · doi:10.1267/ahc.14054 · Cited by 17 · see citing works

Ephrin or not? Six tough questions on Eph targeting

Giorgio, C., Zanotti, I., Lodola, A., & Tognolini, M. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1745187 · Cited by 16 · see citing works

EphA3 maintains radioresistance in head and neck cancers through epithelial mesenchymal transition

Kim, S. H., Lee, W. H., Kim, S. W., Je, H. U., Lee, J. C., Chang, H. W., Kim, S. Y., Kim, K., Kim, S. Y., & Han, M. W. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.04.001 · Cited by 16 · see citing works

Nanotechnology Meets the Tumor Microenvironment: Unlocking New Horizons in Cancer Therapy

Yadav, P., Yadav, A. K., & Bhatia, D. D. (2025) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5c01120 · Cited by 16 · see citing works

EphA4‐deleted microenvironment regulates cancer development and leukemoid reaction of the isografted 4T1 murine breast cancer via reduction of an IGF 1 signal

Jing, X., Sonoki, T., Miyajima, M., Sawada, T., Terada, N., Takemura, S., & Sakaguchi, K. (2016) · Cancer Medicine · doi:10.1002/cam4.670 · Cited by 15 · see citing works

Eph/Ephrin-mediated stimulation of human bone marrow mesenchymal stromal cells correlates with changes in cell adherence and increased cell death

Alfaro, D., & Zapata, A. G. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0912-3 · Cited by 15 · see citing works

Inhibition of EphA3 Expression in Tumour Stromal Cells Suppresses Tumour Growth and Progression

Vail, M. E., Farnsworth, R. H., Hii, L. L., Allen, S. M., Arora, S., Anderson, R. L., Dickins, R. A., Orimo, A., Wu, S. Z., Swarbrick, A., et al. (2023) · Cancers · doi:10.3390/cancers15184646 · Cited by 15 · see citing works

A novel prognostic model based on cellular senescence-related gene signature for bladder cancer

Luo, L., Li, F., Gong, B., Xi, P., & Xie, W. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.937951 · Cited by 13 · see citing works

Eph/ephrin Signaling and Biology of Mesenchymal Stromal/Stem Cells

Alfaro, D., Rodríguez-Sosa, M. R., & Zapata, A. G. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020310 · Cited by 13 · see citing works

A high affinity recombinant antibody to the human EphA3 receptor with enhanced ADCC activity

Tomašević, N., Luehrsen, K. R., Baer, M., Palath, V., Martinez, D., Williams, J. C., Yi, C., Sujatha-Bhaskar, S., Lanke, R., Leung, J., et al. (2014) · Growth Factors · doi:10.3109/08977194.2014.984808 · Cited by 13 · see citing works

Loss of EphA3 Protein Expression Is Associated With Advanced TNM Stage in Clear-Cell Renal Cell Carcinoma

Wang, X., Xu, H., Cao, G., Wu, Z., & Wang, J. (2016) · Clinical Genitourinary Cancer · doi:10.1016/j.clgc.2016.07.028 · Cited by 12 · see citing works

Distinctive Structure of the EphA3/Ephrin-A5 Complex Reveals a Dual Mode of Eph Receptor Interaction for Ephrin-A5

Forse, G. J., Uson, M. L., Nasertorabi, F., Kolatkar, A. R., Lamberto, I., Pasquale, E. B., & Kühn, P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127081 · Cited by 12 · see citing works

Androgen receptor induces EPHA3 expression by interacting with transcription factor SP1

Diao, X., Chen, X., Yurui, P., Zhang, Y., Wang, F., Liu, P., Gao, Y., Wang, X., Yang, S., & Lu, S. (2018) · Oncology Reports · doi:10.3892/or.2018.6503 · Cited by 12 · see citing works

Development of an Anti-EphB4 Monoclonal Antibody for Multiple Applications Against Breast Cancers

Nanamiya, R., Suzuki, H., Kaneko, M. K., & Kato, Y. (2023) · Monoclonal Antibodies in Immunodiagnosis and Immunotherapy · doi:10.1089/mab.2023.0015 · Cited by 11 · see citing works

Sam68 Promotes the Progression of Human Breast Cancer through inducing Activation of EphA3

Chen, X., Zhang, L., Yuan, M., Kuang, Z., Zou, Y., Tang, T., Zhang, W., Hu, X., Xia, T., Cao, T., et al. (2019) · Current Cancer Drug Targets · doi:10.2174/1568009619666190718124541 · Cited by 11 · see citing works

The putative tumor suppressor geneEphA3fails to demonstrate a crucial role in murine lung tumorigenesis or morphogenesis

Lahtela, J., Pradhan, B., Närhi, K. M., Hemmes, A., Särkioja, M., Kovanen, P. E., Brown, A. M., & Verschuren, E. W. (2015) · Disease Models & Mechanisms · doi:10.1242/dmm.019257 · Cited by 11 · see citing works

PTP-PEST controls EphA3 activation and ephrin-induced cytoskeletal remodelling

Mansour, M., Nievergall, E., Gegenbauer, K., Llerena, C., Atapattu, L., Hallé, M., Tremblay, M. L., Janes, P. W., & Lackmann, M. (2015) · Journal of Cell Science · doi:10.1242/jcs.174490 · Cited by 11 · see citing works

Eph family co-expression patterns define unique clusters predictive of cancer phenotype

Al‐Ejeh, F., Offenhäuser, C., Lim, Y. C., Stringer, B. W., Day, B. W., & Boyd, A. (2014) · Growth Factors · doi:10.3109/08977194.2014.984807 · Cited by 10 · see citing works

Fresh Noncultured Endothelial Progenitor Cells Improve Neonatal Lung Hyperoxia-Induced Alveolar Injury

Firsova, A. B., Bird, A. D., Abebe, D., Ng, J., Mollard, R., & Cole, T. J. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.17-0093 · Cited by 8 · see citing works

High Tiam1 expression predicts positive lymphatic metastasis and worse survival in patients with malignant solid tumors: a systematic review and meta-analysis

Yang, C., Ma, C., Li, Y., Mo, P., & Yang, Y. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s191571 · Cited by 8 · see citing works

The Hippo effector YAP1/TEAD1 regulates EPHA3 expression to control cell contact and motility

Al‐Mathkour, M. M., Dwead, A. M., Alp, E., Boston, A. M., & Cinar, B. (2022) · Scientific Reports · doi:10.1038/s41598-022-07790-4 · Cited by 6 · see citing works

Overexpression of Ephrin A3 Receptor in Canine Prostatic Carcinoma

Hood, G., Amorim, R. L., Fonseca‐Alves, C. E., & Palmieri, C. (2016) · Journal of Comparative Pathology · doi:10.1016/j.jcpa.2016.01.002 · Cited by 6 · see citing works

Probing phosphorylation events in biological membranes: The transducer function

Wirth, D., Özdemir, E., & Hristova, K. A. (2024) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2024.184362 · Cited by 5 · see citing works

EPH/Ephrin Signaling in Normal Hematopoiesis and Hematologic Malignancies: Deciphering Their Intricate Role and Unraveling Possible New Therapeutic Targets

Stergiou, I. Ε., Papadakos, S. P., Karyda, A., Tsitsilonis, O., Dimopoulos, M. A., & Theocharis, S. E. (2023) · Cancers · doi:10.3390/cancers15153963 · Cited by 5 · see citing works

The Eph Receptor Family

Gaitanos, T. N., Dudanova, I., Σάκκου, Μ., Klein, R., & Paixão, S. (2015) · Springer eBooks · doi:10.1007/978-3-319-11888-8_5 · Cited by 5 · see citing works

Inhibiting Eph kinase activity may not be “Eph”ective for cancer treatment

Herington, A. C., Mertens‐Walker, I., Lisle, J. E., Maharaj, M., & Stephenson, S. (2014) · Growth Factors · doi:10.3109/08977194.2014.985293 · Cited by 5 · see citing works

EPHA2 promotes triple-negative breast cancer progression by suppressing pyroptosis via the AKT/PI3K/mTOR pathway

Huang, X., Na, L., Han, Q., Liu, Q., & Wu, L. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1620122 · Cited by 3 · see citing works

Eph receptor B6 shapes a cold immune microenvironment, inhibiting anti-cancer immunity and immunotherapy response in bladder cancer

Jia, X., Zhang, D., Zhou, C., Yan, Z., Jiang, Z., Xie, L., & Jiang, J. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1175183 · Cited by 3 · see citing works

Development of a specific anti-human EphA3 monoclonal antibody, Ea3Mab-20, for flow cytometry

Satofuka, H., Suzuki, H., Hirose, M., Shinoda, K., Nakamura, T., Tanaka, T., Kaneko, M. K., & Kato, Y. (2025) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2025.102130 · Cited by 2 · see citing works

Eph/ephrin family proteins and therapeutic resistance

Bhatia, S., & Karam, S. D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817868-3.00009-3 · Cited by 2 · see citing works

Glioblastoma Break-in; Try Something New

Bogoyavlenskaya, T. A., Tyagunova, E. E., Kostin, R. K., Захаров, А. С., Vasil’ev, Y. L., & Kytko, O. V. (2021) · International Journal of Cancer Management · doi:10.5812/ijcm.109054 · Cited by 2 · see citing works

Receptor Tyrosine Kinases

Karl, K., Light, T. P., & Hristova, K. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820472-6.00135-3 · Cited by 2 · see citing works

GSCs in the Transdifferentiation Phenomenon: Focus on CAR-T-Based Therapy

Marco, M. D., Giudice, A. L., Cecala, F. C., David, S., Bavisotto, C. C., Campanella, C., Vitale, A. M., & D’Amico, G. (2026) · Cells · doi:10.3390/cells15040363 · Cited by 1 · see citing works

In-silico predictions of deleterious SNPs in human ephrin type-A receptor 3 (EPHA3) gene

Chatterjee, D., Chowdhury, U. F., Shohan, M. U. S., Mohasin, M., & Kabir, Y. (2021) · Informatics in Medicine Unlocked · doi:10.1016/j.imu.2021.100728 · Cited by 1 · see citing works

A pan-cancer analysis of EphA family gene expression and its association with prognosis, tumor microenvironment, and therapeutic targets

Cui, Z., Liu, C., Wang, X., & Xiang, Y.-P. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1378087 · Cited by 1 · see citing works

A disease module detection algorithm for lung adenocarcinoma tumor network with significance of connections and network controllability methodology

Qin, G., Hou, Y.-B., Yu, B., & Liu, X.-Y. (2016) · IEEE International Conference on Bioinformatics and Biomedicine (BIBM) · doi:10.1109/bibm.2016.7822797 · Cited by 1 · see citing works

PTP-PEST: Vías de señalización y su importancia como blanco terapéutico en cáncer

Manzanita-Quintero, K., Lee-Rivera, I., López, E., & López-Colomé, A. M. (2022) · TIP Revista Especializada en Ciencias Químico-Biológicas · doi:10.22201/fesz.23958723e.2022.503 · Cited by 1 · see citing works

Methods | Ligand Binding to Receptor Tyrosine Kinases: Thermodynamic Cycles and Experimental Approaches

Light, T. P., King, C., & Hristova, K. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819460-7.00078-5 · Cited by 1 · see citing works

Ea3Mab-20: A Specific Anti-Human EphA3 Monoclonal Antibody for Flow CytometryPreprint

Satofuka, H., Suzuki, H., Hirose, M., Shinoda, K., Nakamura, T., Tanaka, T., Kaneko, M. K., & Kato, Y. (2025) · Preprints.org · doi:10.20944/preprints202504.0524.v1 · Cited by 1 · see citing works

Pioneer of Eph biology and therapeutics: Martin Lackmann (1956–2014)

Scott, A. M., & Tiganis, T. (2014) · Growth Factors · doi:10.3109/08977194.2014.983226

Erythropoietin-Producing Hepatocellular Receptors A: Ephrin A1, Ephrin A2 and Ephrin A3

Salajegheh, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-28140-7_14

Cell-extrinsic effects in T cell acute lymphoblastic pre-leukemia stem cells mediated by EphA3Preprint

Zamora, A. C. P., Ranasinghe, H., Lisle, J. E., Huang, S., Wadlow, R., Scott, A. M., Boyd, A., & Slape, C. I. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.14.297127

The Mechanisms and Overcoming Strategies of the Radioresistance in Head and Neck Cancer

Han, M. W. (2023) · Korean Journal of Otorhinolaryngology - Head and Neck Surgery · doi:10.3342/kjorl-hns.2022.01102

The EphA3 Antibody Enhances CD47 Antibody-Mediated Phagocytosis by Repolarizing M2-Like Tumor-Associated Macrophages in a Preclinical Model of Recurrent Head and Neck Cancer

Kim, S. H., Kim, J. W., Kim, M. S., Cha, H. J., Kim, S. W., & Han, M. W. (2026) · OncoTargets and Therapy · doi:10.2147/ott.s595937

A Phase I and Biodistribution Study of Ifabotuzumab, a Humanized Agonistic EphA3-Targeted Antibody, in Patients with Recurrent Glioblastoma

Gan, H. K., Cher, L., Inglis, P.-L., Lwin, Z., Gunjur, A., Balasubramanian, A., Schmidt, A. L., Wichmann, C. W., Guo, N., Lee, S. T., et al. (2026) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-25-3608

Association between human genomes and mycobacterial genomes contributes to severity and transmissibility of pulmonary tuberculosis

Tantivitayakul, P., Kunhapan, P., Boonbangyang, M., Chaichoompu, K., Wilantho, A., Sawaengdee, W., Ruangchai, W., Thawornwattana, Y., Yanai, H., Wattanapokayakit, S., et al. (2026) · iScience · doi:10.1016/j.isci.2026.117699

Establishment and characterization of LNCaP-TR-BoM, a bone metastasis-derived prostate cancer cell line with an intermediate AR-attenuated phenotypePreprint

Chao, A., & Lü, X. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.03.756361

BindingDB Entry 50003224: Targeting Eph/ephrin system in cancer therapy.

BindingDB (2020) · UC San Diego · doi:10.7270/q29026gx

Inhibition of EphA3 Expression in Tumour Stromal Cells Suppresses Tumour Growth and Progression

Vail, M. E., Farnsworth, R. H., Hii, L. L., Allen, S. M., Arora, S., Anderson, R. L., Dickins, R. A., Orimo, A., Wu, S. Z., Swarbrick, A., et al. (2023) · Cancers · doi:10.3390/cancers15184646 · Cited by 15 · see citing works

EphA3 biology and cancer

Janes, P. W., Slape, C. I., Farnsworth, R. H., Atapattu, L., Scott, A. M., & Vail, M. E. (2014) · Growth Factors · doi:10.3109/08977194.2014.982276 · Cited by 73 · see citing works

Critical role of EphA3 in cancer and current state of EphA3 drug therapeutics

London, M., & Gallo, E. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05571-8 · Cited by 36 · see citing works

EphA2 Receptor Tyrosine Kinase as a Promising Target for Cancer Therapeutics

Ireton, R. C., & Chen, J. (2005) · Current Cancer Drug Targets · doi:10.2174/1568009053765780 · Cited by 178 · see citing works

Concurrent Binding of Anti-EphA3 Antibody and Ephrin-A5 Amplifies EphA3 Signaling and Downstream Responses: Potential as EphA3-Specific Tumor-Targeting Reagents

Vearing, C., Lee, F.-T., Wimmer-Kleikamp, S. H., Spirkoska, V., To, C., Stylianou, C., Spanevello, M., Brechbiel, M. W., Boyd, A., Scott, A. M., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0758 · Cited by 76 · see citing works