The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Nerve–Cancer Cell Cross-talk: A Novel Promoter of Tumor Progression
Abstract
Recent studies have revealed the essential role played by nerves in tumor progression. Nerves have been shown to infiltrate the tumor microenvironment and actively stimulate cancer cell growth and dissemination. This mechanism involves the release of neurotransmitters, such as catecholamines and acetylcholine, directly into the vicinity of cancer and stromal cells to activate corresponding membrane receptors. Conversely, the secretion of neurotrophic growth factors by cancer cells drives the outgrowth of nerves in solid tumors. This reciprocal interaction between nerves and cancer cells provides new insights into the cellular and molecular bases of tumorigenesis and points to the potential utility of antineurogenic therapies. This review will discuss our evolving understanding of the cross-talk between nerves and cancer cells. Cancer Res; 75(9); 1777–81. ©2015 AACR.
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“More recently, groundbreaking research has revealed that tumors can actively recruit nerves into the TME, which can then directly promote tumor growth—a phenomenon known as “tumor innervation”.319,320”
From Drug repurposing for cancer therapy (2024) · cites this paper as [320]
Citations
Cites
Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
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Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
Initiative, A. P. C. G., Biankin, A. V., Waddell, N., Kassahn, K. S., Gingras, M.-C., Muthuswamy, L. B., Johns, A. L., Miller, D. K., Wilson, P. J., Patch, A.-M., et al. (2012) · Nature · doi:10.1038/nature11547 · Cited by 2,058
Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
Thaker, P. H., Han, L. Y., Kamat, A. A., Arevalo, J. M., Takahashi, R., Lu, C., Jennings, N. B., Armaiz-Pena, G., Bankson, J. A., Ravoori, M., et al. (2006) · Nature Medicine · doi:10.1038/nm1447 · Cited by 1,320
Autonomic nerve development contributes to prostate cancer progression
Magnon, C., Hall, S. J., Lin, J., Xue, X., Gerber, L., Freedland, S. J., & Frenette, P. S. (2013) · Science · doi:10.1126/science.1236361 · Cited by 1,287
The sympathetic nervous system induces a metastatic switch in primary breast cancer
Sloan, E. K., Priceman, S. J., Cox, B. F., Yu, S., Pimentel, M. A., Tangkanangnukul, V., Arevalo, J. M. G., Morizono, K., Karanikolas, B. D. W., Wu, L., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0522 · Cited by 930
NEUROTROPHINS: Mediators and Modulators of Pain
Pezet, S., & McMahon, S. B. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112929 · Cited by 890
Denervation suppresses gastric tumorigenesis
Zhao, C., Hayakawa, Y., Kodama, Y., Muthupalani, S., Westphalen, C. B., Andersen, G. T., Flatberg, A., Johannessen, H., Friedman, R. A., Renz, B. W., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009569 · Cited by 687
Beta Blockers and Breast Cancer Mortality: A Population- Based Study
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Perineural invasion and associated pain in pancreatic cancer
Bapat, A., Hostetter, G. H., Hoff, D. D. V., & Han, H. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3131 · Cited by 502
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Cited by
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The updated landscape of tumor microenvironment and drug repurposing
Jin, M.-Z., & Jin, W.-L. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00280-x · Cited by 1,262
Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa
Dantzer, R. (2018) · Physiological Reviews · doi:10.1152/physrev.00039.2016 · Cited by 1,073
Drug repurposing for cancer therapy
Xia, Y., Sun, M., Huang, H., & Jin, W.-L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01808-1 · Cited by 443
“319,320 These fi ndings have highlighted novel perspectives on tumor – nerve interactions.”
BackgroundTumor microenvironment: barrier or opportunity towards effective cancer therapy
Tiwari, A., Trivedi, R., & Lin, S. (2022) · Journal of Biomedical Science · doi:10.1186/s12929-022-00866-3 · Cited by 399
Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer
Lei, Y., Tang, L., Xie, Y., Xianyu, Y., Zhang, L., Wang, P., Hamada, Y., Jiang, K., Zheng, W., & Jiang, X. (2017) · Nature Communications · doi:10.1038/ncomms15130 · Cited by 340
Metadata
- Authors
- Jobling, P., Pundavela, J., Oliveira, S. M. R., Roselli, S., Walker, M. M., & Hondermarck, H.
- Affiliations
- Hunter Medical Research Institute (AU)
- ORCID
- Venue
- Cancer Research
- Published
- 2015-04-30
- Volume
- 75
- Issue
- 9
- Pages
- 1777-1781
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2128366974
- Cited by
- 272
- References
- 34
- Citations by year
- 2026: 14 · 2025: 22 · 2024: 27 · 2023: 26 · 2022: 28 · 2021: 30 · 2020: 50 · 2019: 30 · 2018: 14 · 2017: 16 · 2016: 10 · 2015: 5
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- NOVA (University of Newcastle Australia) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- tumor microenvironment, tumor progression, neurotrophins, neurotransmitters, catecholamines, acetylcholine, catecholamine receptors, acetylcholine receptor, cancer cell dissemination, tumor stromal cells
- MeSH terms
- Animals, Humans, Neoplasms, Nerve Growth Factors, Neurons, Disease Progression, Tumor Microenvironment, Carcinogenesis
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- The paper
- Jobling, P., Pundavela, J., Oliveira, S. M. R., Roselli, S., Walker, M. M., & Hondermarck, H. (2015). Nerve–Cancer Cell Cross-talk: A Novel Promoter of Tumor Progression. Cancer Research. https://doi.org/10.1158/0008-5472.can-14-3180
