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Cited by 66Smoking Behavior and CessationPharmacogenetics and Drug MetabolismGenetic Associations and Epidemiology

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Association of COMT Val108/158Met Genotype with Smoking Cessation in a Nicotine Replacement Therapy Randomized Trial

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Johnstone, Elaine C., Elliot, Katherine M., David, Sean P., Murphy, Michael F.G., Walton, Robert T., Munafò, Marcus R.·2007·Cancer Epidemiology, Biomarkers & Prevention
DOI 10.1158/1055-9965.epi-06-0936PMC PMC2031911
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Abstract

We investigated the association of catechol O-methyltransferase (COMT) genotype with abstinence following a smoking cessation attempt among a large cohort of smokers who attempted to quit using either the nicotine transdermal patch or placebo and were followed up over an 8-year period following their initial cessation attempt. In addition, we examined the possible moderating influence of sex on any association. The genotype × treatment interaction effect at 12-week follow-up indicated a greater benefit of active nicotine replacement treatment compared with placebo on likelihood of abstinence in the COMT Met/Met genotype group (33% versus 12%), in comparison to the Met/Val + Val/Val group (22% versus 16%). Our results indicate that COMT genotype may moderate the effect of active transdermal nicotine patch compared with placebo, with reduced relative benefit of nicotine replacement therapy in individuals with Met/Val or Val/Val genotype. Our data follow an emerging pattern of results suggesting that genetic variation in the dopamine pathway may provide a future basis for tailored smoking cessation therapies, but indicate that different genes influencing various components of this pathway may have different effects on response to smoking cessation pharmacotherapy. (Cancer Epidemiol Biomarkers Prev 2007;16(6):1065–9)

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  1. WHO. WHO framework convention on tobacco control. Geneva: WHO Press; 2003.

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Metadata

Authors
Johnstone, E. C., Elliot, K. M., David, S. P., Murphy, M. F. G., Walton, R. T., & Munafò, M. R.
Affiliations
  • 1Department of Clinical Pharmacology and
  • Brown University (US)
  • University of Oxford (GB)
  • Medical Research Council (GB)
  • 5Department of Experimental Psychology, University of Bristol, Bristol, United Kingdom
ORCID
Venue
Cancer Epidemiology, Biomarkers & Prevention
Publisher
American Association for Cancer Research (AACR)
Published
2007-06-01
Volume
16
Issue
6
Pages
1065-1069
ISSN
  • 1055-9965 (ISSN-L)
  • 1538-7755
DOI
10.1158/1055-9965.epi-06-0936
PMC
PMC2031911
OpenAlex
W2050054512
Cited by
66
References
43
Citations by year
2024: 5 · 2023: 2 · 2022: 1 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 8 · 2012: 3
FWCI
5.37
Type
journal article
Language
en
Open access
Locations
  • Cancer Epidemiology Biomarkers & Prevention (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Explore Bristol Research (submittedVersion)
Funders
National Institute on Drug Abuse (K08DA014276)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
catechol-O-methyltransferase, COMT Val158Met polymorphism, smoking cessation, nicotine replacement therapy, nicotine patch, abstinence, genetic moderation, dopaminergic pathways, sex differences, pharmacogenetics
MeSH terms
Administration, Cutaneous, Adult, Catechol O-Methyltransferase, Double-Blind Method, Female, Genotype, Humans, Male, Nicotine, Polymorphism, Genetic, Sex Factors, Tobacco Use Disorder, Polymerase Chain Reaction, Smoking Cessation, Treatment Outcome, Nicotinic Agonists

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CoChat. (2026). Citation check: Association of COMT Val108/158Met Genotype with Smoking Cessation in a Nicotine Replacement Therapy Randomized Trial. https://app.cochat.ai/papers/10.1158/1055-9965.epi-06-0936
The paper
Johnstone, E. C., Elliot, K. M., David, S. P., Murphy, M. F. G., Walton, R. T., & Munafò, M. R. (2007). Association of COMT Val108/158Met Genotype with Smoking Cessation in a Nicotine Replacement Therapy Randomized Trial. Cancer Epidemiology, Biomarkers & Prevention. https://doi.org/10.1158/1055-9965.epi-06-0936