Association between 8-oxo-7,8-dihydro-2′-deoxyguanosine Excretion and Risk of Postmenopausal Breast Cancer: Nested Case–Control Study
Abstract
Background: Oxidative stress may be important in carcinogenesis and a possible risk factor for breast cancer. The urinary excretion of oxidatively generated biomolecules, such as 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG), represents biomarkers of oxidative stress, reflecting the rate of global damage to DNA in steady state. Methods: In a nested case–control design, we examined associations between urinary excretion of 8-oxodG and risk of breast cancer in a population-based cohort of 24,697 postmenopausal women aged 50 to 64 years with 3 to 7 years follow-up. The accruing cases of breast cancer were matched to controls by age at diagnosis, baseline age, and hormone replacement therapy (HRT). Spot urine samples collected at entry was analyzed for 8-oxodG by high-performance liquid chromatography with electrochemical detection. Incidence rate ratio (IRR; 95% confidence intervals) based on 336 matched pairs with all information was estimated per unit increase in 8-oxodG divided by creatinine for all and estrogen receptor (ER) positive and negative breast cancers. Results: There was a borderline significant positive association between 8-oxodG and risk of all breast cancer (IRR: 1.08; 1.00–1.17 per unit increase in nmol/mmol creatinine). This association was significant with respect to the risk of ER-positive cancer (IRR: 1.11; 1.01–1.23) and among women not using HRT (IRR: 1.11; 0.97–1.26) or with low dietary iron intake (IRR: 1.10; 1.06–1.37 per unit increase) for all breast cancer. Conclusions: We observed positive association between 8-oxodG excretion and risk of especially ER-positive breast cancer. Impact: Our results suggest that oxidative stress with damage to DNA is important for the development of breast cancer. Cancer Epidemiol Biomarkers Prev; 22(7); 1289–96. ©2013 AACR.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Severe oxidation of DNA is a precursor for the risk of some cancers, in particular, breast and lung cancers.
“Severe oxidation of DNA is a precursor for the risk of some cancers, in particular, breast and lung cancers (Loft et al. 2013).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Loft et al. 2013
Cites
Kasai, H. (1997) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(97)00035-5 · Cited by 1,140 · see citing works
Dose-Response and Trend Analysis in Epidemiology
Greenland, S. (1995) · Epidemiology · doi:10.1097/00001648-199507000-00005 · Cited by 1,086 · see citing works
Loft, S., Vistisen, K., Ewertz, M., Tjønneland, A., Overvad, K., & Poulsen, H. E. (1992) · Carcinogenesis · doi:10.1093/carcin/13.12.2241 · Cited by 643 · see citing works
Self-citationTjønneland, A. M., Olsen, A., Boll, K., Stripp, C., Christensen, J., Engholm, G., & Overvad, K. (2007) · Scandinavian Journal of Public Health · doi:10.1080/14034940601047986 · Cited by 595 · see citing works
Self-citationOxidation of the Guanine Nucleotide Pool Underlies Cell Death by Bactericidal Antibiotics
Foti, J. J., Devadoss, B., Winkler, J. A., Collins, J. J., & Walker, G. C. (2012) · Science · doi:10.1126/science.1219192 · Cited by 500 · see citing works
The Human OGG1 Gene: Structure, Functions, and Its Implication in the Process of Carcinogenesis
Boiteux, S., & Radicella, J. P. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1773 · Cited by 478 · see citing works
Pilger, A., & Rüdiger, H. W. (2006) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-006-0106-7 · Cited by 341 · see citing works
Aburatani, H., Hippo, Y., Ishida, T., Takashima, R., Matsuba, C., Kodama, T., Takao, M., Yasui, A., Yamamoto, K., & Asano, M. (1997) · PubMed · Cited by 333 · see citing works
Oxidative Damage to DNA and Lipids as Biomarkers of Exposure to Air Pollution
Möller, P., & Loft, S. H. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0901725 · Cited by 249 · see citing works
Self-citationAcute hypoxia and hypoxic exercise induce DNA strand breaks and oxidative DNA damage in humans
Möller, P., Loft, S. H., Lundby, C., & Olsen, N. V. (2001) · The FASEB Journal · doi:10.1096/fj.00-0703com · Cited by 239 · see citing works
Self-citationMatsui, A., Ikeda, T., Enomoto, K., Hosoda, K., Nakashima, H., Omae, K., Watanabe, M., Hibi, T., & Kitajima, M. (2000) · Cancer Letters · doi:10.1016/s0304-3835(99)00424-3 · Cited by 232 · see citing works
Prognostic and aetiological relevance of 8-hydroxyguanosine in human breast carcinogenesis
Musarrat, J., Arezina-Wilson, J., & Wani, A. A. (1996) · European Journal of Cancer · doi:10.1016/0959-8049(96)00031-7 · Cited by 232 · see citing works
Measurement and Meaning of Oxidatively Modified DNA Lesions in Urine
Cooke, M. S., Oliński, R., & Loft, S. H. (2008) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-0751 · Cited by 222 · see citing works
Self-citationEstrogen-induced reactive oxygen species-mediated signalings contribute to breast cancer
Okoh, V. O., Deoraj, A., & Roy, D. (2010) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2010.10.005 · Cited by 186 · see citing works
Mass spectrometry based metabolomic approaches in urinary biomarker study of women's cancers
Woo, H. M., Kim, K. M., Choi, M. H., Jung, B. H., Lee, J., Kong, G., Nam, S. J., Kim, S., Bai, S. W., & Chung, B. C. (2008) · Clinica Chimica Acta · doi:10.1016/j.cca.2008.10.014 · Cited by 182 · see citing works
Prospective study of 8-oxo-7,8-dihydro-2′-deoxyguanosine excretion and the risk of lung cancer
Loft, S. H., Svoboda, P., Kasai, H., Tjønneland, A. M., Vogel, U. B., Möller, P., Overvad, K., & Raaschou‐Nielsen, O. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi313 · Cited by 166 · see citing works
Self-citationMarkers of oxidative damage to DNA: Antioxidants and molecular damage
Loft, S. H., & Poulsen, H. E. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)00124-x · Cited by 165 · see citing works
Self-citationBarregård, L., Möller, P., Henriksen, T., Mistry, V., Koppen, G., Rössner, P., Šrám, R. J., Weimann, A., Poulsen, H. E., Nataf, R., et al. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4714 · Cited by 159 · see citing works
Self-citationTelomere Length, Oxidative Damage, Antioxidants and Breast Cancer Risk
Shen, J., Gammon, M. D., Terry, M. B., Wang, Q., Bradshaw, P., Teitelbaum, S. L., Neugut, A. I., & Santella, R. M. (2009) · International Journal of Cancer · doi:10.1002/ijc.24105 · Cited by 159 · see citing works
Dietary antioxidants and beneficial effect on oxidatively damaged DNA
Möller, P., & Loft, S. H. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.04.001 · Cited by 146 · see citing works
Self-citationEvans, M. D., Oliński, R., Loft, S. H., & Cooke, M. S. (2009) · The FASEB Journal · doi:10.1096/fj.09-147124 · Cited by 145 · see citing works
Self-citationMøller, P., Vogel, U. B., Pedersen, A. T., Dragsted, L. O., Sandström, B., & Loft, S. H. (2003) · PubMed · Cited by 134 · see citing works
Self-citationPriemé, H., Loft, S., Klarlund, M., Grønbæk, K., Tønnesen, P., & Poulsen, H. E. (1998) · Carcinogenesis · doi:10.1093/carcin/19.2.347 · Cited by 117 · see citing works
Self-citationPorkkala-Sarataho, E., Salonen, J. T., Nyyssönen, K., Kaikkonen, J., Salonen, R. M., Ristonmaa, U., Diczfalusy, U., Brigelius‐Flohé, R., Loft, S. H., & Poulsen, H. E. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.9.2087 · Cited by 109 · see citing works
Self-citationDoes iron have a role in breast cancer?
Huang, X. (2008) · The Lancet Oncology · doi:10.1016/s1470-2045(08)70200-6 · Cited by 108 · see citing works
Rössner, P., Gammon, M. D., Terry, M. B., Agrawal, M., Zhang, F. F., Teitelbaum, S. L., Eng, S. M., Gaudet, M. M., Neugut, A. I., & Santella, R. M. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0554 · Cited by 107 · see citing works
Synowiec, E., Stefanska, J., Morawiec, Z., Błasiak, J., & Woźniak, K. (2008) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2008.09.014 · Cited by 97 · see citing works
Hormone replacement therapy in relation to breast carcinoma incidence rate ratios
Tjønneland, A. M., Christensen, J., Thomsen, B. L., et al. (2004) · Cancer · doi:10.1002/cncr.20250 · Cited by 86 · see citing works
Self-citationDanish Breast Cancer Cooperative Group--DBCG.
Fischerman, K., & Ht, M. (1977) · PubMed · Cited by 83 · see citing works
Oxidative DNA Damage and Human Cancer: Need for Cohort Studies
Loft, S. H., & Möller, P. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1021 · Cited by 82 · see citing works
Self-citationAccumulation of oxidatively induced clustered DNA lesions in human tumor tissues
Nowsheen, S., Wukovich, R. L., Aziz, K., Kalogerinis, P. T., Richardson, C., Panayiotidis, M. I., Bonner, W. M., Sedelnikova, O. A., & Georgakilas, A. G. (2008) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2008.09.010 · Cited by 82 · see citing works
Occupational and lifestyle factors and urinary 8‐hydroxydeoxyguanosine
Irie, M., Tamae, K., Iwamoto‐Tanaka, N., & Kasai, H. (2005) · Cancer Science · doi:10.1111/j.1349-7006.2005.00083.x · Cited by 79 · see citing works
Li, D., Zhang, W., Zhu, J., Chang, P., Şahin, A. A., Singletary, E. S., Bondy, M. L., Hazra, T. K., MITRA, S. P., Lau, S. S., et al. (2001) · Molecular Carcinogenesis · doi:10.1002/mc.1056 · Cited by 77 · see citing works
Estimation of oxidative DNA damage in man from urinary excretion of repair products.
Loft, S. H., & Poulsen, H. E. (1998) · Acta Biochimica Polonica · doi:10.18388/abp.1998_4328 · Cited by 77 · see citing works
Self-citationAntioxidant vitamins and cancer risk: is oxidative damage to DNA a relevant biomarker?
Loft, S. H., Möller, P., Cooke, M. S., Różalski, R., & Oliński, R. (2008) · European Journal of Nutrition · doi:10.1007/s00394-008-2004-0 · Cited by 76 · see citing works
Self-citationUrinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) and genetic polymorphisms in breast cancer patients
Kuo, H., Chou, S.-Y., Hu, T.-W., Wu, F.-Y., & Chen, D.-J. (2007) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2007.04.009 · Cited by 74 · see citing works
Methods to detect DNA damage by free radicals: relation to exercise
Poulsen, H. E., Weimann, A., & Loft, S. H. (1999) · Proceedings of The Nutrition Society · doi:10.1017/s0029665199001329 · Cited by 70 · see citing works
Self-citationLoft, S. H., Svoboda, P., Kawai, K., Kasai, H., Sørensen, M., Tjønneland, A. M., Vogel, U. B., Möller, P., Overvad, K., & Raaschou‐Nielsen, O. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.439 · Cited by 69 · see citing works
Self-citationThompson, H. J., Heimendinger, J., Diker, A., O'Neill, C., Haegele, A. D., Meinecke, B., Wolfe, P., SEDLACEK, S. M., Zhu, Z., & Jiang, W. (2006) · Journal of Nutrition · doi:10.1093/jn/136.8.2207 · Cited by 67 · see citing works
OGG1 expression and OGG1 Ser326Cys polymorphism and risk of lung cancer in a prospective study
Hatt, L., Loft, S. H., Risom, L., Möller, P., Sørensen, M., Raaschou‐Nielsen, O., Overvad, K., Tjønneland, A. M., & Vogel, U. B. (2007) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2007.11.002 · Cited by 63 · see citing works
Self-citationDietary Iron and Heme Iron Intake and Risk of Breast Cancer: A Prospective Cohort Study
Kabat, G. C., Miller, A. B., Jain, M. G., et al. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-0086 · Cited by 61 · see citing works
Evaluation of urinary nucleosides in breast cancer patients before and after tumor removal
Cho, S.-H., Choi, M. H., Lee, W., et al. (2009) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2008.12.026 · Cited by 60 · see citing works
Lee, K., Shu, X., Gao, Y.-T., Ji, B., Yang, G., Blair, A. E., Rothman, N., Zheng, W., Chow, W., & Kang, D. (2010) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-09-1098 · Cited by 51 · see citing works
Wang, Z., Chandrasena, E. R., Yuan, Y., Peng, K.-W., van Breemen, R. B., Thatcher, G. R. J., & Bolton, J. L. (2010) · Chemical Research in Toxicology · doi:10.1021/tx1001282 · Cited by 47 · see citing works
Urinary Hydroxyestrogens and Breast Cancer Risk among Postmenopausal Women: A Prospective Study
Wellejus, A., Olsen, A., Tjønneland, A. M., Thomsen, B. L., Overvad, K., & Loft, S. H. (2005) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-04-0934 · Cited by 46 · see citing works
Self-citationDanish Breast Cancer Cooperative Group (DBCG) Structure and results of the organization
Fischerman, K., & Mouridsen, H. T. (1988) · Acta Oncologica · doi:10.3109/02841868809091756 · Cited by 38 · see citing works
Kabat, G. C., Cross, A. J., Park, Y., Schatzkin, A. G., Hollenbeck, A. R., Rohan, T. E., & Sinha, R. R. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29753 · Cited by 38 · see citing works
Dziaman, T., Huzarski, T., Gackowski, D., et al. (2009) · International Journal of Cancer · doi:10.1002/ijc.24600 · Cited by 37 · see citing works
Receptor‐mediated ethinylestradiol‐induced oxidative DNA damage in rat testicular cells
Wellejus, A., & Loft, S. H. (2002) · The FASEB Journal · doi:10.1096/fj.01-0385com · Cited by 36 · see citing works
Self-citationFotouhi, A., Skiöld, S., Manesh, S. S., Osterman-Golkar, S. M., Wójcik, A., Jenssen, D., Harms‐Ringdahl, M., & Haghdoost, S. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.07.005 · Cited by 16 · see citing works
HPLC-ECD, HPLC-MS/MS (Urinary Biomarkers)
Poulsen, H. E., Loft, S. H., Jensen, B. R., et al. (2002) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789812775733_0013 · Cited by 7 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works
- Authors
- Loft, S., Olsen, A., Møller, P., Poulsen, H. E., & Tjønneland, A.
- Affiliations
- University of Copenhagen (DK)
- Authors' Affiliations: 1Department of Public Health, Section of Enviromental Health, Faculty of Health and Medical Sciences, University of Copenhagen; 2Institute of Cancer Epidemiology, The Danish Cancer Society; 3Department of Clinical Pharmacology, Bispebjerg Hospital and Laboratory of Clinical Pharmacology, Q7642, Rigshospitalet, University of Copenhagen, Denmark
- Venue
- Cancer Epidemiology, Biomarkers & Prevention
- Published
- 2013-07-01
- Volume
- 22
- Issue
- 7
- Pages
- 1289-1296
- ISSN
- 1055-9965 (ISSN-L)
- 1538-7755
- OpenAlex
- W2130091539
- Cited by
- 72
- References
- 51
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 4 · 2023: 7 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 11 · 2016: 7 · 2015: 7 · 2014: 8 · 2013: 1
- FWCI
- 5.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Epidemiology Biomarkers & Prevention (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Keywords
- 8-oxo-7,8-dihydro-2'-deoxyguanosine, oxidative stress, postmenopausal breast cancer, urinary biomarkers, DNA damage, estrogen receptor-positive breast cancer, hormone replacement therapy, iron intake, biomarkers of carcinogenesis
- MeSH terms
- 8-Hydroxy-2'-Deoxyguanosine, Breast Neoplasms, Denmark, Deoxyguanosine, Diet, DNA Damage, Female, Follow-Up Studies, Humans, Middle Aged, Prospective Studies, Receptors, Estrogen, Risk Factors, Biomarkers, Tumor, Cohort Studies, Case-Control Studies, Postmenopause, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
