Telomere Length, Oxidative Damage, Antioxidants and Breast Cancer Risk
Open accessAbstract
Telomeres play a critical role in maintaining the integrity and stability of the genome, and are susceptible to oxidative damage after telomere shortening to a critical length. In the present study, we explored the role of white blood cell DNA telomere length on breast cancer risk, and examined whether urinary 15‐F 2‐isoprostanes (15‐F 2t‐IsoP) and 8‐oxo‐7,8‐dihydrodeoxyguanosine (8‐oxodG) or dietary antioxidant intake modified the relationship between telomere length and breast cancer risk. A population‐based case–control study—the Long Island Breast Cancer Study Project—was conducted among 1,067 cases and 1,110 controls. Telomere length was assessed by quantitative PCR. Overall, the mean levels of telomere length (T/S ratio), 15‐F 2t‐IsoP and 8‐oxodG were not significantly different between cases and controls. Among premenopausal women only, carrying shorter telomeres (Q3 and Q4), as compared with the longest (Q1), was associated with significantly increased breast cancer risk. Age‐adjusted OR and 95% CI were 1.71 (1.10–2.67) and 1.61 (1.05–2.45). The 5‐F 2t‐IsoP and 8‐oxodG biomarkers did not modify the telomere–breast cancer association. A moderate increase in breast cancer risk was observed among women with the shortest telomeres (Q4) and lower dietary and supplemental intake of β‐carotene, vitamin C or E intake [OR (95% CI) = 1.48 (1.08–2.03), 1.39 (1.01–1.92) and 1.57 (1.14–2.18), respectively], although the trend test exhibited statistical significance only within the lower vitamin E intake subgroup (ptrend = 0.01). These results provided the strongest evidence to date that breast cancer risk may be affected by telomere length among premenopausal women or women with low dietary intake of antioxidants or antioxidant supplements. © 2008 Wiley‐Liss, Inc.
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Higher consumption of antioxidants such as vitamin E is able to reduce ROS levels, leading to decreased telomere shortening, decelerating cellular senescence, and potentially decreasing the risk of disease development.
“It has been recently observed that a higher consumption of antioxidants such as vitamin E is able to reduce ROS levels, leading to decreased telomere shortening, decelerating the cellular senescence, and potentially decreasing the risk of disease development [132,133].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [132]
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- Authors
- Shen, J., Gammon, M. D., Terry, M. B., Wang, Q., Bradshaw, P., Teitelbaum, S. L., Neugut, A. I., & Santella, R. M.
- Affiliations
- Columbia University (US)
- University of North Carolina at Chapel Hill (US)
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Shen, Jing
- ORCID
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2009-01-27
- Volume
- 124
- Issue
- 7
- Pages
- 1637-1643
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- PMC
- PMC2727686
- OpenAlex
- W2041443490
- Cited by
- 159
- References
- 68
- Citations by year
- 2026: 1 · 2024: 10 · 2023: 9 · 2022: 10 · 2021: 11 · 2020: 12 · 2019: 8 · 2018: 9 · 2017: 16 · 2016: 7 · 2015: 10 · 2014: 7 · 2013: 10 · 2012: 10
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Cancer (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- Breast Cancer Research Foundation
- National Cancer Institute (U01 CA/ES66572, R03CA125768)
- National Institute of Environmental Health Sciences (P30ES10126), P30-ES09089, P30ES010126, P30ES009089)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Keywords
- telomere length, breast cancer risk, oxidative DNA damage, dietary antioxidants, beta-carotene, vitamin C, vitamin E, white blood cell DNA, premenopausal women, Long Island Breast Cancer Study Project
- MeSH terms
- 8-Hydroxy-2'-Deoxyguanosine, Antioxidants, Breast Neoplasms, Deoxyguanosine, Female, Humans, Risk Factors, Biomarkers, Tumor, Case-Control Studies, Polymerase Chain Reaction, Telomere, Premenopause, Oxidative Stress, Isoprostanes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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