Cited by 2,542Cancer Genomics and DiagnosticsCancer Cells and MetastasisMicrofluidic and Bio-sensing Technologies

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Tumor Cells Circulate in the Peripheral Blood of All Major Carcinomas but not in Healthy Subjects or Patients With Nonmalignant Diseases

Allard, W. Jeffrey, Matera, Jeri, Miller, M. Craig, Repollet, Madeline, Connelly, Mark C., Rao, Chandra, Tibbe, Arjan G. J., Uhr, Jonathan W., Terstappen, Leon W. M. M.·2004·Clinical Cancer Research

DOI 10.1158/1078-0432.ccr-04-0378

Published version of a preprint

Open this paper in CoChat — free account

Abstract

PURPOSE: The purpose of this study was to determine the accuracy, precision, and linearity of the CellSearch system and evaluate the number of circulating tumor cells (CTCs) per 7.5 mL of blood in healthy subjects, patients with nonmalignant diseases, and patients with a variety of metastatic carcinomas. EXPERIMENTAL DESIGN: The CellSearch system was used to enumerate CTCs in 7.5 mL of blood. Blood samples spiked with cells from tumor cell lines were used to establish analytical accuracy, reproducibility, and linearity. Prevalence of CTCs was determined in blood from 199 patients with nonmalignant diseases, 964 patients with metastatic carcinomas, and 145 healthy donors. RESULTS: Enumeration of spiked tumor cells was linear over the range of 5 to 1,142 cells, with an average recovery of >/=85% at each spike level. Only 1 of the 344 (0.3%) healthy and nonmalignant disease subjects had >/=2 CTCs per 7.5 mL of blood. In 2,183 blood samples from 964 metastatic carcinoma patients, CTCs ranged from 0 to 23,618 CTCs per 7.5 mL (mean, 60 +/- 693 CTCs per 7.5 mL), and 36% (781 of 2,183) of the specimens had >/=2 CTCs. Detection of >/=2 CTCs occurred at the following rates: 57% (107 of 188) of prostate cancers, 37% (489 of 1,316) of breast cancers, 37% (20 of 53) of ovarian cancers, 30% (99 of 333) of colorectal cancers, 20% (34 of 168) of lung cancers, and 26% (32 of 125) of other cancers. CONCLUSIONS: The CellSearch system can be standardized across multiple laboratories and may be used to determine the clinical utility of CTCs. CTCs are extremely rare in healthy subjects and patients with nonmalignant diseases but present in various metastatic carcinomas with a wide range of frequencies.

Integrity signals

Registry

Crossref · 10.1158/1078-0432.ccr-04-0378

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

National Committee for Clinical Laboratory Standards
Bruck, E. (1980) · PEDIATRICS · doi:10.1542/peds.65.1.187 · Cited by 14,736
Statistics for Experimenters
Addelman, S., Box, G. E. P., Hunter, W. G., & Hunter, J. S. (1979) · Technometrics · doi:10.2307/1267766 · Cited by 6,753
Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer
Cristofanilli, M., Budd, G. T., Ellis, M. J., Stopeck, A., Matera, J., Miller, M. C., Reuben, J. M., Doyle, G. V., Allard, W. J., Terstappen, L. W. M. M., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040766 · Cited by 4,602
Detection and characterization of carcinoma cells in the blood
Racila, E. V., Euhus, D., Weiss, A. J., Rao, C., McConnell, J. D., Terstappen, L. W. M. M., & Uhr, J. W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4589 · Cited by 713
Detection and viability of tumor cells in peripheral blood stem cell collections from breast cancer patients using immunocytochemical and clonogenic assay techniques [see comments]
Ross, A., Cooper, B., Lazarus, H. M., Mackay, W., Moss, T., Ciobanu, N., Tallman, M. S., Kennedy, M., Davidson, N., & Sweet, D. (1993) · Blood · doi:10.1182/blood.v82.9.2605.bloodjournal8292605 · Cited by 487
Mobilization of tumor cells and hematopoietic progenitor cells into peripheral blood of patients with solid tumors [see comments]
Brugger, W., Bross, K., Glatt, M., Weber, F., Mertelsmann, R. H., & Kanz, L. (1994) · Blood · doi:10.1182/blood.v83.3.636.636 · Cited by 440
Mobilization of tumor cells and hematopoietic progenitor cells into peripheral blood of patients with solid tumors [see comments]
Brugger, W., Bross, K., Glatt, M., et al. (1994) · Blood · doi:10.1182/blood.v83.3.636.bloodjournal833636 · Cited by 357
Immunohistochemical study of the expression of a Mr 34,000 human epithelium-specific surface glycoprotein in normal and malignant tissues.
Momburg, F., Moldenhauer, G., Hämmerling, G. J., & Möller, P. (1987) · PubMed · Cited by 328
Prevalence, predictive factors, and screening for psychologic distress in patients with newly diagnosed head and neck cancer
Kugaya, A., Akechi, T., Okuyama, T., Nakano, T., Mikami, I., Okamura, H., & Uchitomi, Y. (2000) · Cancer · doi:10.1002/1097-0142(20000615)88:12 · Cited by 309
Standardization of the immunocytochemical detection of cancer cells in BM and blood: I. establishment of objective criteria for the evaluation of immunostained cells
Borgen, E., Naume, B., Nesland, J. M., Kvalheim, G., Beiske, K., Fodstad, Ø., Diel, I., Solomayer, E., Theocharous, P., Coombes, R. C., et al. (1999) · Cytotherapy · doi:10.1080/0032472031000141283 · Cited by 263

Show all 30 references

Research works printed but not linked: 8

Soria JC, Gauthier LR, Raymond E, et al Molecular detection of telomerase positive circulating epithelial cells in metastatic breast cancer patients. Clin Cancer Res 1999;5:971-5.
Fehm T, Sagalowsky A, Clifford E, et al Cytogenetic evidence that circulating epithelial cells in patients with carcinoma are malignant. Clin Cancer Res 2002;8:2073-84.
Kagan M, Howard D, Bendele T, et al A sample preparation and analysis system for identification of circulating tumor cells. J Clin Ligand Assay 2002;25:104-10.
Rao C, Rutner H, Hermann M, Russell T, Terstappen LWMM. Preservation of blood specimens to prevent breakdown of circulating tumor cells. Proc Am Assoc Cancer Res 2002;43:734
Allard WJ, Hayes DF, Repollet MI, et al A cellular preservative improves the specificity and yield of circulating tumor cells in carcinoma patients[abstract A3482]. Proc Am Soc Clin Oncol 2003;22:866
Motulsky H. The confidence interval of counted variables. Intuitive biostatistics 1995p. 245-9. Oxford University Press New York
Miller MC, Gross S, Allard WJ, et al Circulating tumor cells (CTCs) predict survival in patients with metastatic prostate cancer[abstract A5270]. Proc Am Assoc Cancer Res 2004;45:1215
Cristofanilli M, Reuben JM, Fritsche HA, et al Circulating tumor cells (CTCs): a novel prognostic factor for newly diagnosed metastatic breast cancer (MBC)[abstract A1349]. Proc Am Assoc Cancer Res 2003;44:1349

Sorted by citations

Items 201–300 of 1,004

High-Throughput Selection, Enumeration, Electrokinetic Manipulation, and Molecular Profiling of Low-Abundance Circulating Tumor Cells Using a Microfluidic System
Dharmasiri, U., Njoroge, S. K., Witek, M. A., Adebiyi, M. G., Kamande, J. W., Hupert, M. L., Barany, F., & Soper, S. A. (2011) · Analytical Chemistry · doi:10.1021/ac103172y · Cited by 181
Circulating tumor cells predict progression free survival and overall survival in patients with relapsed/recurrent advanced ovarian cancer
Poveda, A. M., Kaye, S. B., Mccormack, R. T., Wang, S., Parekh, T. V., Ricci, D. S., Lebedinsky, C. A., Tercero, J. C., Zintl, P., & Monk, B. J. (2011) · Gynecologic Oncology · doi:10.1016/j.ygyno.2011.05.028 · Cited by 179
Liquid biopsies in lung cancer: The new ambrosia of researchers
Rolfo, C. D., Castiglia, M., Hong, D. S., Alessandro, R., Mertens, I., Baggerman, G., Zwaenepoel, K., Bazo, I. G., Passiglia, F., Carreca, A. P., et al. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.10.001 · Cited by 182
Relationship among circulating tumor cells, CEA and overall survival in patients with metastatic colorectal cancer
Aggarwal, C., Meropol, N. J., Punt, C. J. A., Iannotti, N. O., Saidman, B. H., Sabbath, K. D., Gabrail, N. Y., Picus, J., Morse, M. A., Mitchell, E. P., et al. (2012) · Annals of Oncology · doi:10.1093/annonc/mds336 · Cited by 182
Biomarkers in the Management and Treatment of Men with Metastatic Castration-Resistant Prostate Cancer
Armstrong, A. J., Eisenberger, M. A., Halabi, S., Oudard, S. M., Nanus, D. M., Petrylak, D. P., Sartor, O. A., & Scher, H. I. (2011) · European Urology · doi:10.1016/j.eururo.2011.11.009 · Cited by 183
Filter Characteristics Influencing Circulating Tumor Cell Enrichment from Whole Blood
Coumans, F. A. W., van Dalum, G., Beck, M., & Terstappen, L. W. M. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061770 · Cited by 179
Targeting Continued Androgen Receptor Signaling in Prostate Cancer
Massard, C., & Fizazi, K. S. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2815 · Cited by 177
Enrichment with anti-cytokeratin alone or combined with anti-EpCAM antibodies significantly increases the sensitivity for circulating tumor cell detection in metastatic breast cancer patients
Deng, G. Y., Herrler, M., Burgess, D., Manna, E. A., Krag, D. N., & Burke, J. F. (2008) · Breast Cancer Research · doi:10.1186/bcr2131 · Cited by 179
Design Strategies and Applications of Circulating Cell-Mediated Drug Delivery Systems
Su, Y., Xie, Z., Kim, G. B., Dong, C., & Yang, J. Y. (2015) · ACS Biomaterials Science & Engineering · doi:10.1021/ab500179h · Cited by 180
Size-Based Isolation of Circulating Tumor Cells in Lung Cancer Patients Using a Microcavity Array System
Hosokawa, M., Kenmotsu, H., Koh, Y., Yoshino, T., Yoshikawa, T., Naito, T., Takahashi, T., Murakami, H., Nakamura, Y., Tsuya, A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067466 · Cited by 180
Digitally synthesized beat frequency multiplexing for sub-millisecond fluorescence microscopy
Diebold, E. D., Buckley, B., Gossett, D. R., & Jalali, B. (2013) · Nature Photonics · doi:10.1038/nphoton.2013.245 · Cited by 177
Circulating tumour cell detection: a direct comparison between the CellSearch System, the AdnaTest and CK-19/mammaglobin RT–PCR in patients with metastatic breast cancer
der Auwera, I. V., Peeters, D. J. E., Benoy, I. H., Elst, H., Laere, S. V., Prové, A., Maes, H., Huget, P., van Dam, P. A., Vermeulen, P. B., et al. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6605472 · Cited by 174
Circulating tumour cells and cell-free DNA as tools for managing breast cancer
Mattos‐Arruda, L. D., Cortés, J., Santarpia, L., Vivancos, A. P., Tabernero, J. M., Reis-Filho, J. S., & Seoane, J. (2013) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2013.80 · Cited by 176
Detection of Brain Tumor Cells in the Peripheral Blood by a Telomerase Promoter-Based Assay
MacArthur, K. M., Kao, G. D., Chandrasekaran, S., Alonso‐Basanta, M., Chapman, C. H., Lustig, R. A., Wileyto, E. P., Hahn, S. M., & Dorsey, J. F. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-0813 · Cited by 173
Translational Breast Cancer Research Consortium (TBCRC) 022: A Phase II Trial of Neratinib for Patients With Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer and Brain Metastases
Freedman, R. A., Gelman, R. S., Wefel, J. S., Melisko, M., Hess, K. R., Connolly, R. M., Poznak, C. H. V., Niravath, P. A., Puhalla, S. L., Ibrahim, N. K., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2015.63.0343 · Cited by 172
Biomarker-Driven Early Clinical Trials in Oncology
Tan, D. S. W., THOMAS, G. V., Garrett, M. D., Banerji, U., Bono, J. S. D., Kaye, S. B., & Workman, P. (2009) · The Cancer Journal · doi:10.1097/ppo.0b013e3181bd0445 · Cited by 173
High speed detection of circulating tumor cells
Hsieh, B. R., Marrinucci, D. C., Bethel, K. J., Curry, D. N., Humphrey, M., Krivacic, R. T., Kroener, J. F., Kroener, L. L., Ladányi, A., Lazarus, N. H., et al. (2006) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2005.12.024 · Cited by 172
Materials and microfluidics: enabling the efficient isolation and analysis of circulating tumour cells
Jackson, J. M., Witek, M. A., Kamande, J. W., & Soper, S. A. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00016b · Cited by 172
Monolithic Chip for High-throughput Blood Cell Depletion to Sort Rare Circulating Tumor Cells
Fachin, F., Spuhler, P. S., Martel-Foley, J. M., Jon, F., Barber, T. A., Walsh, J. R., Karabacak, M., Pai, V., Yu, M., Smith, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-11119-x · Cited by 178
Ultrahigh-throughput magnetic sorting of large blood volumes for epitope-agnostic isolation of circulating tumor cells
Mishra, A., Dubash, T. D., Jon, F., Jewett, M. K., Garre, S., Karabacak, M., Rabe, D. C., Mutlu, B. R., Walsh, J. R., Kapur, R., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2006388117 · Cited by 172
Breast cancer stem cells: Multiple capacities in tumor metastasis
Geng, S., Alexandrou, A. T., & Li, J. J. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.03.036 · Cited by 167
Phase I Study of GSK461364, a Specific and Competitive Polo-like Kinase 1 Inhibitor, in Patients with Advanced Solid Malignancies
Olmos, D., Barker, D. S., Sharma, R., Brunetto, A. T., Yap, T. A., Taegtmeyer, A. B., Barriuso, J., Medani, H., Degenhardt, Y., Allred, A. J., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2946 · Cited by 169
Dendrimer‐Mediated Multivalent Binding for the Enhanced Capture of Tumor Cells
Myung, J. H., Gajjar, K. A., Saric, J., Eddington, D., & Hong, S. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201105508 · Cited by 169
Enrichment, detection and clinical significance of circulating tumor cells
Arya, S. K., Lim, B., & Rahman, A. R. A. (2013) · Lab on a Chip · doi:10.1039/c3lc00009e · Cited by 168
Functionalized Conducting Polymer Nanodots for Enhanced Cell Capturing: The Synergistic Effect of Capture Agents and Nanostructures
Sekine, J., Luo, S., Wang, S., Zhu, B., Tseng, H., & Yu, H. (2011) · Advanced Materials · doi:10.1002/adma.201102151 · Cited by 168
Microfluidic technologies for circulating tumor cell isolation
Cho, H., Kim, J., Song, H., Sohn, K. Y., Jeon, M., & Han, K.-H. (2018) · The Analyst · doi:10.1039/c7an01979c · Cited by 167
Circulating tumour cells, their role in metastasis and their clinical utility in lung cancer
O’Flaherty, J. D., Gray, S. G., Richard, D. J., Fennell, D. A., O’Leary, J. J., Blackhall, F. H., & O'Byrne, K. J. (2011) · Lung Cancer · doi:10.1016/j.lungcan.2011.10.018 · Cited by 166
Circulating tumor cells in metastatic breast cancer
Dawood, S. S., Broglio, K. R., Valero, V., Reuben, J., Handy, B. C., Islam, R., Jackson, S. A., Hortobágyi, G. N., Fritsche, H. A., & Cristofanilli, M. (2008) · Cancer · doi:10.1002/cncr.23852 · Cited by 163
Epithelial‐mesenchymal transition in cancer metastasis through the lymphatic system
Karlsson, M. C. I., González, S., Welin, J., & Fuxe, J. (2017) · Molecular Oncology · doi:10.1002/1878-0261.12092 · Cited by 159
Non-small cell lung carcinoma (NSCLC): Implications on molecular pathology and advances in early diagnostics and therapeutics
Padinharayil, H., Varghese, J., John, M. C., Rajanikant, G. K., Wilson, C. M., Al-Yozbaki, M., Renu, K., Dewanjee, S., Sanyal, R., Dey, A., et al. (2022) · Genes & Diseases · doi:10.1016/j.gendis.2022.07.023 · Cited by 172
Expression of epithelial–mesenchymal transition‐inducing transcription factors in primary breast cancer: The effect of neoadjuvant therapy
Mego, M., Mani, S. A., Lee, B.-N., Li, C., Evans, K. W., Cohen, E. N., Gao, H., Jackson, S. A., Giordano, A., Hortobágyi, G. N., et al. (2011) · International Journal of Cancer · doi:10.1002/ijc.26037 · Cited by 161
Acoustofluidic, Label-Free Separation and Simultaneous Concentration of Rare Tumor Cells from White Blood Cells
Antfolk, M., Magnusson, C., Augustsson, P., Lilja, H. G., & Laurell, T. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b02023 · Cited by 161
The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner
Agerbæk, M. Ø., Bang-Christensen, S. R., Yang, M.-H., Clausen, T. M., Pereira, M. A., Sharma, S., Ditlev, S. B., Nielsen, M. A., Choudhary, S., Gustavsson, T., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05793-2 · Cited by 159
Platelets, immune cells and the coagulation cascade; friend or foe of the circulating tumour cell?
Ward, M. P., Kane, L. E., Norris, L., Mohamed, B. M., Kelly, T. E., Bates, M., Clarke, A., Brady, N., Martin, C. M., Brooks, R. D., et al. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01347-1 · Cited by 165
Isolation of Circulating Tumor Cells in Patients with Hepatocellular Carcinoma Using a Novel Cell Separation Strategy
Xu, W. R., Cao, L., Chen, L., Li, J., Zhang, X.-F., Qian, H., Kang, X., Zhang, Y., Liao, J., Shi, L., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-0498 · Cited by 160
Microfluidic Blood Cell Sorting: Now and Beyond
Yu, Z. T. F., Yong, K. M. A., & Fu, J. (2014) · Small · doi:10.1002/smll.201302907 · Cited by 164
Acquisition of Portal Venous Circulating Tumor Cells From Patients With Pancreaticobiliary Cancers by Endoscopic Ultrasound
Catenacci, D. V. T., Chapman, C. G., Xu, P., Koons, A., Konda, V. J. A., Siddiqui, U. D., & Waxman, I. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.08.050 · Cited by 160
Variation of circulating tumor cell levels during treatment of metastatic breast cancer: prognostic and therapeutic implications
Nolè, F., Munzone, E., Zorzino, L., Minchella, I., Salvatici, M., Botteri, E., Medici, M., Verri, E., Adamoli, L., Rotmensz, N., et al. (2007) · Annals of Oncology · doi:10.1093/annonc/mdm558 · Cited by 160
High-recovery visual identification and single-cell retrieval of circulating tumor cells for genomic analysis using a dual-technology platform integrated with automated immunofluorescence staining
Campton, D. E., Ramirez, A. B., Nordberg, J. J., Drovetto, N., Clein, A. C., Varshavskaya, P., Friemel, B. H., Quarre, S., Breman, A. M., Dorschner, M. O., et al. (2015) · BMC Cancer · doi:10.1186/s12885-015-1383-x · Cited by 156
Dynamic liquid biopsy components as predictive and prognostic biomarkers in colorectal cancer
Raza, A., Khan, A. Q., Inchakalody, V. P., Mestiri, S., Yoosuf, Z. S. K. M., Bedhiafi, T., El-Ella, D. M. A., Taib, N., Hydrose, S., Akbar, S., et al. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02318-0 · Cited by 160
An RNA-based signature enables high specificity detection of circulating tumor cells in hepatocellular carcinoma
Kalinich, M., Bhan, I., Kwan, T. T., Miyamoto, D. T., Javaid, S., LiCausi, J. A., Milner, J. D., Hong, X., Goyal, L., Sil, S., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617032114 · Cited by 158
Tumor-Associated Circulating MicroRNAs as Biomarkers of Cancer
Wang, J., Zhang, K.-Y., Liu, S.-M., & Sen, S. (2014) · Molecules · doi:10.3390/molecules19021912 · Cited by 160
Continuous Flow Deformability‐Based Separation of Circulating Tumor Cells Using Microfluidic Ratchets
Park, E. S., Jin, C., Guo, Q., Ang, R. R., Duffy, S. P., Matthews, K., Azad, A., Abdi, H., Todenhöfer, T., Bazov, J., et al. (2016) · Small · doi:10.1002/smll.201503639 · Cited by 151
Nanostructured substrates for isolation of circulating tumor cells
Wang, L., Asghar, W., Demirci, U., & Wan, Y. (2013) · Nano Today · doi:10.1016/j.nantod.2013.07.001 · Cited by 156
Recent advances on multiple tumorigenic cascades involved in prostatic cancer progression and targeting therapies
Mimeault, M., & Batra, S. K. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi229 · Cited by 156
Phosphorylated EGFR and PI3K/Akt signaling kinases are expressed in circulating tumor cells of breast cancer patients
Kallergi, G., Agelaki, S., Kalykaki, A., Stournaras, C., Mavroudis, D., & Georgoulias, V. (2008) · Breast Cancer Research · doi:10.1186/bcr2149 · Cited by 151
Microfluidic-Based Technologies for CTC Isolation: A Review of 10 Years of Intense Efforts towards Liquid Biopsy
Descamps, L., Roy, D. L., & Deman, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23041981 · Cited by 158
Detection of circulating tumor cells in patients with pancreatic cancer: a preliminary result
Kurihara, T., Itoi, T., Sofuni, A., Itokawa, F., Tsuchiya, T., Tsuji, S., Ishii, K., Ikeuchi, N., Tsuchida, A., Kasuya, K., et al. (2008) · Journal of Hepato-Biliary-Pancreatic Surgery · doi:10.1007/s00534-007-1250-5 · Cited by 150
Circulating Tumor Cell Microseparator Based on Lateral Magnetophoresis and Immunomagnetic Nanobeads
Kim, S., Han, S., Park, M.-J., Jeon, C.-W., Joo, Y., Choi, I., & Han, K.-H. (2013) · Analytical Chemistry · doi:10.1021/ac303284u · Cited by 151
Isolation of circulating epithelial and tumor progenitor cells with an invasive phenotype from breast cancer patients
Lu, J. M., Fan, T. M., Zhao, Q., Zeng, W., Zaslavsky, E., Chen, J. J.-W., Frohman, M. A., Golightly, M. G., Madajewicz, S., & Chen, W. (2009) · International Journal of Cancer · doi:10.1002/ijc.24814 · Cited by 149
Phase II trial of Belagenpumatucel-L, a TGF-β2 antisense gene modified allogeneic tumor vaccine in advanced non small cell lung cancer (NSCLC) patients
Nemunaitis, J., Nemunaitis, M., Senzer, N., Snitz, P., Bedell, C., Kumar, P., Pappen, B., Maples, P. B., Shawler, D., & Fakhrai, H. (2009) · Cancer Gene Therapy · doi:10.1038/cgt.2009.15 · Cited by 147
Single-cell sequencing
Nawy, T. (2013) · Nature Methods · doi:10.1038/nmeth.2771 · Cited by 151
Circulating tumor cells: a review of present methods and the need to identify heterogeneous phenotypes.
Millner, L., Linder, M. W., & Valdes, R. (2013) · PubMed · Cited by 148
Uses and Abuses of Tumor Markers in the Diagnosis, Monitoring, and Treatment of Primary and Metastatic Breast Cancer
Henry, N. L., & Hayes, D. F. (2006) · The Oncologist · doi:10.1634/theoncologist.11-6-541 · Cited by 147
High-Throughput Selective Capture of Single Circulating Tumor Cells by Dielectrophoresis at a Wireless Electrode Array
Li, M., & Anand, R. K. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b03288 · Cited by 146
Epithelial Cell Adhesion Molecule: An Anchor to Isolate Clinically Relevant Circulating Tumor Cells
Eslami‐S, Z., Cortés‐Hernández, L. E., & Alix‐Panabières, C. (2020) · Cells · doi:10.3390/cells9081836 · Cited by 146
Cytometric characterization of Circulating Tumor Cells Captured by microfiltration and their correlation to the cellsearch® CTC test
Adams, D. L., Stefansson, S., Haudenschild, C. C., Martin, S. S., Charpentier, M. S., Chumsri, S., Cristofanilli, M., Tang, C., & Alpaugh, R. K. (2014) · Cytometry Part A · doi:10.1002/cyto.a.22613 · Cited by 145
Prospective assessment of the prognostic value of circulating tumor cells and their clusters in patients with advanced-stage breast cancer
Mu, Z., Wang, C., Ye, Z., Austin, L., Civan, J. M., Hyslop, T., Palazzo, J., Jaslow, R. J., Li, B., Myers, R. E., et al. (2015) · Breast Cancer Research and Treatment · doi:10.1007/s10549-015-3636-4 · Cited by 145
The systematic study of circulating tumor cell isolation using lithographic microfilters
Adams, D. L., Zhu, P., Makarova, O. V., Martin, S. S., Charpentier, M. S., Chumsri, S., Li, S., Amstutz, P. T., & Tang, C. (2013) · RSC Advances · doi:10.1039/c3ra46839a · Cited by 144
Clinical value of circulating endothelial cells and circulating tumor cells in metastatic breast cancer patients treated first line with bevacizumab and chemotherapy
Bidard, F., Mathiot, C., Degeorges, A., Étienne-Grimaldi, M.-C., Delva, R., Pivot, X. B., Veyret, C., Bergougnoux, L., de Crémoux, P., Milano, G. A., et al. (2010) · Annals of Oncology · doi:10.1093/annonc/mdq052 · Cited by 145
Clinical and biological significance of circulating tumor cells in cancer
Masuda, T., Hayashi, N., Iguchi, T., Ito, S., Eguchi, H., & Mimori, K. (2016) · Molecular Oncology · doi:10.1016/j.molonc.2016.01.010 · Cited by 149
Circulating Tumor Cells in Peripheral Blood Samples From Patients With Increased Serum Prostate Specific Antigen: Initial Results in Early Prostate Cancer
Davis, J. W., Nakanishi, H., Kumar, V. S., Bhadkamkar, V. A., Mccormack, R. T., Fritsche, H. A., Handy, B. C., Gornet, T. G., & Babaian, R. J. (2008) · The Journal of Urology · doi:10.1016/j.juro.2008.01.102 · Cited by 143
Deformability of Tumor Cells versus Blood Cells
Bagnall, J., Byun, S., Begum, S., Miyamoto, D. T., Hecht, V. C., Maheswaran, S., Stott, S. L., Toner, M., Hynes, R. O., & Manalis, S. R. (2015) · Scientific Reports · doi:10.1038/srep18542 · Cited by 146
Development of Circulating Tumor Cell-Endocrine Therapy Index in Patients with Hormone Receptor–Positive Breast Cancer
Paoletti, C., Muñiz, M. C., Thomas, D. G., Griffith, K. A., Kidwell, K., Tokudome, N., Brown, M. E., Aung, K., Miller, M. C., Blossom, D. L., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-1913 · Cited by 139
Circulating Tumor Cells in Prostate Cancer: From Discovery to Clinical Utility
Pantel, K., Hille, C., & Scher, H. I. (2019) · Clinical Chemistry · doi:10.1373/clinchem.2018.287102 · Cited by 141
Circulating Tumor Cells: Moving Biological Insights into Detection
Chen, L., Bode, A. M., & Dong, Z. (2017) · Theranostics · doi:10.7150/thno.18588 · Cited by 143
Vimentin-positive circulating tumor cells as a biomarker for diagnosis and treatment monitoring in patients with pancreatic cancer
Wei, T., Zhang, X., Zhang, Q., Yang, J., Chen, Q., Wang, J., Li, X., Chen, J., Ma, T., Li, G., et al. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.03.009 · Cited by 138
Improving the yield of circulating tumour cells facilitates molecular characterisation and recognition of discordant HER2 amplification in breast cancer
Flores, L. M., Kindelberger, D. W., Ligon, A. H., Capelletti, M., Fiorentino, M., Loda, M. F., Cibas, E. S., Janne, P. A., & Krop, I. E. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605676 · Cited by 137
Detection of Mutations in EGFR in Circulating Lung-Cancer Cells
Tanoue, L. T. (2010) · Yearbook of Pulmonary Disease · doi:10.1016/s8756-3452(09)79360-0 · Cited by 135
Comparison of two methods for enumerating circulating tumor cells in carcinoma patients
Balić, M., Dandachi, N., Hofmann, G., Samonigg, H., Loibner, H., Obwaller, A., van der Kooi, A., Tibbe, A. G. J., Doyle, G. V., Terstappen, L. W. M. M., et al. (2005) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.20065 · Cited by 135
Circulating Tumor Cells and [18F]Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography for Outcome Prediction in Metastatic Breast Cancer
Giorgi, U. D., Valero, V., ROHREN, E. M., Dawood, S. S., Ueno, N. T., Miller, M. C., Doyle, G. V., Jackson, S. A., Andreopoulou, E., Handy, B. C., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.19.4423 · Cited by 136
Capturing Cancer: Emerging Microfluidic Technologies for the Capture and Characterization of Circulating Tumor Cells
Qian, W., Zhang, Y., & Chen, W. (2015) · Small · doi:10.1002/smll.201403658 · Cited by 135
Detection of Androgen Receptor Mutations in Circulating Tumor Cells in Castration-Resistant Prostate Cancer
Jiang, Y., Palma, J. F., Agus, D. B., Wang, Y., & Gross, M. E. (2010) · Clinical Chemistry · doi:10.1373/clinchem.2010.143297 · Cited by 132
Morphological analysis of circulating tumour cells in patients undergoing surgery for non‐small cell lung carcinoma using the isolation by size of epithelial tumour cell (ISET) method
Hofman, V., Long-Mira, É., Ilié, M., Bonnetaud, C., Vignaud, J.-M., Fléjou, J., Lantuéjoul, S., Piaton, É., Mourad, N., Butori, C., et al. (2011) · Cytopathology · doi:10.1111/j.1365-2303.2010.00835.x · Cited by 132
Promise and limits of the CellSearch platform for evaluating pharmacodynamics in circulating tumor cells
Wang, L., Balasubramanian, P., Chen, A. P., Kummar, S., Evrard, Y. A., & Kinders, R. J. (2016) · Seminars in Oncology · doi:10.1053/j.seminoncol.2016.06.004 · Cited by 132
Liquid biopsy for lung cancer early detection
Santarpía, M., Liguori, A., D’Aveni, A., Karachaliou, N., González‐Cao, M., Daffinà, M. G., Lazzari, C., Altavilla, G., & Rosell, R. (2018) · Journal of Thoracic Disease · doi:10.21037/jtd.2018.03.81 · Cited by 134
The circulating transcriptome as a source of cancer liquid biopsy biomarkers
Solé, C., Arnaiz, E., Manterola, L., Otaegui, D., & Lawrie, C. H. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.01.003 · Cited by 136
Liquid biopsy for cancer screening, patient stratification and monitoring
Brock, G., Castellanos-Rizaldos, E., Hu, L., Coticchia, C. M., & Skog, J. (2018) · Translational Cancer Research · doi:10.21037/4546 · Cited by 130
Diagnostic and prognostic biomarkers in cholangiocarcinoma
Macı́as, R. I. R., Kornek, M., Rodrigues, P. M., Paiva, N. A., Castro, R. E., Urban, S. K., Pereira, S. P., Cadamuro, M., Rupp, C., Loosen, S. H., et al. (2019) · Liver International · doi:10.1111/liv.14090 · Cited by 134
Label-free reflectometric interference microchip biosensor based on nanoporous alumina for detection of circulating tumour cells
Kumeria, T., Kurkuri, M. D., Diener, K. R., Parkinson, L., & Lošić, D. (2012) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2012.02.038 · Cited by 130
Multiple biomarker expression on circulating tumor cells in comparison to tumor tissues from primary and metastatic sites in patients with locally advanced/inflammatory, and stage IV breast cancer, using a novel detection technology
Somlo, G., Lau, S. K., Frankel, P. H., Hsieh, B. R., Liu, X., Yang, L., Krivacic, R. T., & Bruce, R. H. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1508-0 · Cited by 131
Microsystems for the Capture of Low-Abundance Cells
Dharmasiri, U., Witek, M. A., Adams, A. A., & Soper, S. A. (2010) · Annual Review of Analytical Chemistry · doi:10.1146/annurev.anchem.111808.073610 · Cited by 132
Circulating tumor cells and DNA as liquid biopsies
Heitzer, E., Auer, M., Ulz, P., Geigl, J. B., & Speicher, M. R. (2013) · Genome Medicine · doi:10.1186/gm477 · Cited by 130
Use of Naturally Occurring Halloysite Nanotubes for Enhanced Capture of Flowing Cells
Hughes, A. D., & King, M. R. (2010) · Langmuir · doi:10.1021/la101179y · Cited by 128
Circulating tumor cells in precision oncology: clinical applications in liquid biopsy and 3D organoid model
Yang, C. Q., Xia, B.-R., Jin, W., & Lou, G. (2019) · Cancer Cell International · doi:10.1186/s12935-019-1067-8 · Cited by 135
Detection and characterization of invasive circulating tumor cells derived from men with metastatic castration-resistant prostate cancer
Friedlander, T. W., Ngo, V., Dong, H., Premasekharan, G., Weinberg, V., Doty, S., Zhao, Q., Gilbert, E., Ryan, C. J., Chen, W., et al. (2013) · International Journal of Cancer · doi:10.1002/ijc.28561 · Cited by 129
Circulating tumor cells in hepatocellular carcinoma: a pilot study of detection, enumeration, and next-generation sequencing in cases and controls
Kelley, R. K., Magbanua, M. J. M., Butler, T. M., Collisson, E. A., Hwang, J. J., Sidiropoulos, N., Evason, K. J., McWhirter, R. M., Hameed, B., Wayne, E. M., et al. (2015) · BMC Cancer · doi:10.1186/s12885-015-1195-z · Cited by 125
Meta-Analysis of Public Microarray Datasets Reveals Voltage-Gated Calcium Gene Signatures in Clinical Cancer Patients
Wang, C., Lai, M.-D., Phan, N. N., Sun, Z., & Lin, Y.-C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125766 · Cited by 135
Cytopathologic Detection of Circulating Tumor Cells Using the Isolation by Size of Epithelial Tumor Cell Method
Hofman, V., Ilié, M., Bonnetaud, C., Selva, É., Long-Mira, É., Molina, T. J., Vignaud, J.-M., Fléjou, J. F., Lantuéjoul, S., Piaton, É., et al. (2010) · American Journal of Clinical Pathology · doi:10.1309/ajcp9x8ozbeiqvvi · Cited by 125
CTC-Derived Models: A Window into the Seeding Capacity of Circulating Tumor Cells (CTCs)
Tayoun, T., Faugeroux, V., Oulhen, M., Aberlenc, A., Pawlikowska, P., & Farace, F. (2019) · Cells · doi:10.3390/cells8101145 · Cited by 130
Utility of Liquid Biopsy Analysis in Detection of Hepatocellular Carcinoma, Determination of Prognosis, and Disease Monitoring: A Systematic Review
Chen, V. L., Xu, D., Wicha, M. S., Lok, A. S.-F., & Parikh, N. D. (2020) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.04.019 · Cited by 125
Cytomorphology of Circulating Colorectal Tumor Cells: A Small Case Series
Marrinucci, D. C., Bethel, K. J., Lazar, D. C., Fisher, J., Huynh, E., Clark, P., Bruce, R., Nieva, J. J., & Kühn, P. (2010) · Journal of Oncology · doi:10.1155/2010/861341 · Cited by 126
Microfluidic immunocapture of circulating pancreatic cells using parallel EpCAM and MUC1 capture: characterization, optimization and downstream analysis
Thege, F. I., Lannin, T. B., Saha, T. N., Tsai, S. J., Kochman, M. L., Hollingsworth, M. A., Rhim, A. D., & Kirby, B. J. (2014) · Lab on a Chip · doi:10.1039/c4lc00041b · Cited by 130
The measurement and therapeutic implications of circulating tumour cells in breast cancer
Smerage, J. B., & Hayes, D. F. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602871 · Cited by 124
DNA‐Templated Magnetic Nanoparticle‐Quantum Dot Polymers for Ultrasensitive Capture and Detection of Circulating Tumor Cells
Li, Z., Wang, G., Shen, Y., Guo, N., & Ma, N. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201707152 · Cited by 125
Prognostic Significance of Circulating Tumor Cells in Non-Small-Cell Lung Cancer Patients: A Meta-Analysis
Huang, J., Wang, K., Xu, J., Huang, J., & Zhang, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078070 · Cited by 123
Comparative metabolic and lipidomic profiling of human breast cancer cells with different metastatic potentials
Kim, H.-Y., Lee, K., Kim, S., Kwon, Y., Chun, Y., & Choi, H. (2016) · Oncotarget · doi:10.18632/oncotarget.11560 · Cited by 124
Longitudinal enumeration and cluster evaluation of circulating tumor cells improve prognostication for patients with newly diagnosed metastatic breast cancer in a prospective observational trial
Larsson, A.-M., Jansson, S., Bendahl, P., Jørgensen, C. L. T., Loman, N., Graffman, C., Lundgren, L., Aaltonen, K. E., & Rydén, L. (2018) · Breast Cancer Research · doi:10.1186/s13058-018-0976-0 · Cited by 121
Circulating tumor cells in pancreatic cancer patients: Methods of detection and clinical implications
Tjensvoll, K., Nordgård, O., & Smaaland, R. (2013) · International Journal of Cancer · doi:10.1002/ijc.28134 · Cited by 123
Characterization of circulating tumor cells by fluorescence in situ hybridization
Swennenhuis, J. F., Tibbe, A. G. J., Levink, R., Sipkema, R., & Terstappen, L. W. M. M. (2009) · Cytometry Part A · doi:10.1002/cyto.a.20718 · Cited by 122

Authors: Allard, W. J., Matera, J., Miller, M. C., Repollet, M., Connelly, M. C., Rao, C., Tibbe, A. G. J., Uhr, J. W., & Terstappen, L. W. M. M.
Affiliations: 1Immunicon Corporation, Huntingdon Valley, Pennsylvania; and
The University of Texas Southwestern Medical Center (US)
ORCID: Miller, M. Craig
Terstappen, Leon W. M. M.
Venue: Clinical Cancer Research
Publisher: American Association for Cancer Research (AACR)
Published: 2004-10-15
Volume: 10
Issue: 20
Pages: 6897-6904
ISSN: 1078-0432 (ISSN-L)
1557-3265
DOI: 10.1158/1078-0432.ccr-04-0378
OpenAlex: W2116483002
Cited by: 2,542
References: 30
Citations by year: 2026: 66 · 2025: 81 · 2024: 87 · 2023: 135 · 2022: 117 · 2021: 158 · 2020: 169 · 2019: 166 · 2018: 171 · 2017: 193 · 2016: 197 · 2015: 165 · 2014: 177 · 2013: 161 · 2012: 132
FWCI: 7.52
Type: journal article
Language: en
Open access: closed
Locations: Clinical Cancer Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Bio-sensing Technologies
Keywords: circulating tumor cells, CellSearch, metastatic carcinoma, prostate cancer, breast cancer, ovarian cancer, colorectal cancer, lung cancer, liquid biopsy
MeSH terms: Adult, Automation, Biological Assay, Carcinoma, Cytological Techniques, Female, Humans, Male, Middle Aged, Neoplastic Cells, Circulating, Neoplasm Metastasis, Sensitivity and Specificity, Reproducibility of Results, Case-Control Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Tumor Cells Circulate in the Peripheral Blood of All Major Carcinomas but not in Healthy Subjects or Patients With Nonmalignant Diseases

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks