The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Epithelial versus Mesenchymal Phenotype Determines In vitro Sensitivity and Predicts Clinical Activity of Erlotinib in Lung Cancer Patients
Abstract
Significant improvements in the outcome of non-small cell lung carcinoma (NSCLC) have been reported in patients treated with the epidermal growth factor receptor (EGFR) inhibitor, erlotinib. To discover biomarkers for the enrichment of patients who might benefit from treatment, a pharmacogenomic approach was used to identify gene signatures that may predict erlotinib activity using in vitro model systems. Erlotinib sensitivity in a panel of 42 NSCLC cell lines was determined by EGFR-mediated proliferative potential, EGFR mutations, and/or EGFR gene amplification, thus supporting an underlying biological mechanism of receptor activation. A strong multigene signature indicative of an epithelial to mesenchymal transition (EMT) was identified as a determinant of insensitivity to erlotinib through both supervised and unsupervised gene expression approaches. This observation was further supported by expression analysis of classic EMT marker proteins, including E-cadherin and vimentin. To investigate the clinical relevance of these findings, we examined expression of the epithelial marker E-cadherin by immunohistochemistry on primary tumor samples from subjects enrolled in a randomized NSCLC clinical trial in which erlotinib in combination with chemotherapy previously failed to show clinical activity. The majority (75%) of the 87 subjects tested showed strong E-cadherin staining and exhibited a significantly longer time to progression (hazard ratio, 0.37; log rank P=0.0028) and a nonsignificant trend toward longer survival with erlotinib plus chemotherapy treatment versus chemotherapy alone. These data support a potential role for EMT as a determinant of EGFR activity in NSCLC tumor cells and E-cadherin expression as a novel biomarker predicting clinical activity of the EGFR inhibitor erlotinib in NSCLC patients.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In the Tarceva Responses in conjunction with Paclitaxel and Carboplatin (TRIBUTE) trial,38 among patients receiving erlotinib and chemotherapy, time to progression was longer for those with E-cadherin-positive staining.39”
From Mechanisms of resistance to EGFR-targeted drugs: lung cancer (2016) · cites this paper as [39]
Citations
Cites
Cluster analysis and display of genome-wide expression patterns
Eisen, M. B., Spellman, P. T., Brown, P. O., & Botstein, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14863 · Cited by 16,184
Lynch, T. J., Bell, D. W., Sordella, R., Gurubhagavatula, S., Okimoto, R. A., Brannigan, B. W., Harris, P. L., Haserlat, S. M., Supko, J. G., Haluska, F. G., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040938 · Cited by 11,486
EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
Paez, J. G., Jänne, P. A., Lee, J. C., Tracy, S., Greulich, H., Gabriel, S., Herman, P., Kaye, F. J., Lindeman, N., Boggon, T. J., et al. (2004) · Science · doi:10.1126/science.1099314 · Cited by 9,368
Untangling the ErbB signalling network
Yarden, Y., & Sliwkowski, M. X. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35052073 · Cited by 6,974
Tissue microarrays for high-throughput molecular profiling of tumor specimens
Kononen, J., Bubendorf, L., Kallionimeni, A., Barlund, M. T., Schraml, P., Leighton, S. B., Torhorst, J. K. H., Mihatsch, M. J., Sauter, G., & Kallionimeni, O.-P. (1998) · Nature Medicine · doi:10.1038/nm0798-844 · Cited by 4,101
EGFR Mutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib
Kobayashi, S., Boggon, T. J., Dayaram, T., Jänne, P. A., Kocher, O., Meyerson, M., Johnson, B. E., Eck, M. J., Tenen, D. G., & Halmos, B. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa044238 · Cited by 3,964
Pao, W., Miller, V. A., Politi, K. A., Riely, G. J., Somwar, R., Zakowski, M. F., Kris, M. G., & Varmus, H. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020073 · Cited by 3,527
ERBB receptors and cancer: the complexity of targeted inhibitors
Hynes, N. E., & Lane, H. A. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1609 · Cited by 3,379
Epidermal growth factor-related peptides and their receptors in human malignancies
Salomon, D. S., Brandt, R., Ciardiello, F., & Normanno, N. (1995) · Critical Reviews in Oncology/Hematology · doi:10.1016/1040-8428(94)00144-i · Cited by 2,695
Gefitinib-Sensitizing EGFR Mutations in Lung Cancer Activate Anti-Apoptotic Pathways
Sordella, R., Bell, D. W., Haber, D. A., & Settleman, J. E. (2004) · Science · doi:10.1126/science.1101637 · Cited by 1,605
Cited by
Sorted by citations
Items 301–400 of 497
Inhibition by erlotinib of primary lung adenocarcinoma at an early stage in male mice
Zerbe, L. K., Dwyer‐Nield, L. D., Fritz, J. M., Redente, E. F., Shroyer, R. J., Conklin, E., Kane, S., Tucker, C., Eckhardt, S. G., Gustafson, D. L., et al. (2007) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-007-0644-z · Cited by 36
Planck, M., Edlund, K., Botling, J., Micke, P., Isaksson, S., & Staaf, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078614 · Cited by 36
Epidermal growth factor receptor mutations and susceptibility to targeted therapy in lung cancer
AHMED, S. M., & Salgia, R. (2006) · Respirology · doi:10.1111/j.1440-1843.2006.00887.x · Cited by 36
Ogunwobi, O. O., & Liu, C. (2011) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2011.11.007 · Cited by 36
Smith, D. L., Acquaviva, J., Sequeira, M., Jimenez, J.-P., Zhang, C., Sang, J., Bates, R. C., & Proia, D. A. (2014) · Targeted Oncology · doi:10.1007/s11523-014-0329-6 · Cited by 35
Onion, D., Argent, R. H., Reece-Smith, A. M., Craze, M. L., Pineda, R. G., Clarke, P. A., Ratan, H. L., Parsons, S. L., Lobo, D. N., Duffy, J. P., et al. (2016) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0598 · Cited by 35
Re-evaluating the role of epithelial-mesenchymal-transition in cancer progression
Sulaiman, A., Zemin, Y., & Wang, L. (2017) · Journal of Biomedical Research · doi:10.7555/jbr.31.20160124 · Cited by 36
N-cadherin expression is a potential survival mechanism of gefitinib-resistant lung cancer cells.
Yamauchi, M., Yoshino, I., Yamaguchi, R., Shimamura, T., Nagasaki, M., Imoto, S., Niida, A., Koizumi, F., Kohno, T., Yokota, J., et al. (2011) · Europe PMC (PubMed Central) · Cited by 35
Lung Cancer Genomic Signatures
Agulló-Ortuño, M. T., López‐Ríos, F., & Paz-Ares, L. G. (2010) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e3181f1900e · Cited by 33
TGFβ1 rapidly activates Src through a non-canonical redox signaling mechanism
Zhang, H., Davies, K. J. A., & Forman, H. J. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.01.001 · Cited by 33
Huang, D., Su, L., Peng, X.-H., Zhang, H., Khuri, F. R., Shin, D. M., & Chen, Z. (2009) · Nanotechnology · doi:10.1088/0957-4484/20/22/225102 · Cited by 33
Fleming, I. N., Hogben, M., Frame, S., McClue, S. J., & Green, S. R. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4633 · Cited by 33
Zhao, B.-X., Wang, J., Song, B., WEI, H., Lv, W., TIAN, L.-M., Li, M., & Lv, S. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.3058 · Cited by 32
Haque, I., Kawsar, H. I., Motes, H. C., Sharma, M., Banerjee, S., Banerjee, S. K., Godwin, A. K., & Huang, C. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239307 · Cited by 32
Kobayashi, M., Miki, Y., Ebina, M., Abe, K., Mori, K., Narumi, S., Suzuki, T., Sato, I., Maemondo, M., Endo, C., et al. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.422 · Cited by 32
Predicting response to epidermal growth factor receptor-targeted therapy in colorectal cancer
Adams, R., & Maughan, T. (2007) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.7.4.503 · Cited by 32
Jang, W., Choi, B., Song, S.-H., Lee, N., Kim, D. J., Lee, S., & Jeong, C. (2017) · Oncotarget · doi:10.18632/oncotarget.21572 · Cited by 29
Demuth, C., Madsen, A. T., Weber, B., Wu, L., Meldgaard, P., & Sørensen, B. S. (2018) · BMC Cancer · doi:10.1186/s12885-018-4108-0 · Cited by 31
Systematic Analysis of Drug Vulnerabilities Conferred by Tumor Suppressor Loss
Ding, H., Zhao, J., Zhang, Y. L., Yu, J., Liu, M., Li, X., Xu, L., Lin, M., Liu, C., He, Z., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.043 · Cited by 28
Association of Divergent Carcinoembryonic Antigen Patterns and Lung Cancer Progression
Kuo, Y., Zheng, M., Huang, M.-F., Miao, C., Yang, L., Huang, T.-W., & Chou, Y. (2020) · Scientific Reports · doi:10.1038/s41598-020-59031-1 · Cited by 31
Tamura, D., Arao, T., Nagai, T., Kaneda, H., Aomatsu, K., Fujita, Y., MATSUMOTO, K. Y., Velasco, M. A. D., Kato, H., Hayashi, H., et al. (2013) · Cancer Medicine · doi:10.1002/cam4.68 · Cited by 31
Nolan-Stevaux, O., Truitt, M. C., Pahler, J., Olson, P., Guinto, C., Lee, D. C., & Hanahan, D. (2010) · Genes & Cancer · doi:10.1177/1947601909358722 · Cited by 31
Mizutani, H., Okano, T., Minegishi, Y., Matsuda, K., Sudoh, J., Kitamura, K., Noro, R., Soeno, C., Yoshimura, A., Seike, M., et al. (2010) · Oncology Letters · doi:10.3892/ol.2010.190 · Cited by 33
Boeckx, C., Blockx, L., de Beeck, K. O., Limame, R., Camp, G. V., Peeters, M., Vermorken, J. B., Specenier, P. M., Wouters, A., Baay, M. F. D., et al. (2015) · Europe PMC (PubMed Central) · Cited by 30
Snail Is a Critical Mediator of Invadosome Formation and Joint Degradation in Arthritis
Lauzier, A., Lavoie, R. R., Charbonneau, M., Gouin-Boisvert, B., Harper, K., & Dubois, C. M. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.10.021 · Cited by 29
Li, M., Zheng, C., Xu, H., He, W., Ruan, Y., Jian-yong, M., Zheng, J., Ye, C., & Li, W. (2017) · PubMed Central · Cited by 29
Hyperglycemia as a mechanism of pancreatic cancer metastasis
Li, W. (2011) · Frontiers in bioscience · doi:10.2741/4017 · Cited by 29
Argast, G. M., Mercado, P., Mulford, I. J., O’Connor, M., Keane, D. M., Shaaban, S. A., Epstein, D. M., Pachter, J. A., & Kan, J. L. C. (2010) · Cells Tissues Organs · doi:10.1159/000320179 · Cited by 28
Molecular Pathology of Lung Cancer
Solis, L. M., & Wistuba, I. I. (2012) · Springer eBooks · doi:10.1007/978-1-4419-0787-5_14 · Cited by 27
MicroRNAs as the critical regulators of tyrosine kinase inhibitors resistance in lung tumor cells
Maharati, A., Zangouei, A. S., Khalili‐Tanha, G., & Moghbeli, M. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-022-00840-4 · Cited by 28
Odin (ANKS1A) Modulates EGF Receptor Recycling and Stability
Tong, J., Sydorskyy, Y., St-Germain, J. R., Taylor, P., Tsao, M. S., & Moran, M. F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064817 · Cited by 25
Yoshioka, M., Ohashi, S., Ida, T., Nakai, Y., Kikuchi, O., Amanuma, Y., Matsubara, J., Yamada, A., Miyamoto, S., Natsuizaka, M., et al. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-017-0572-7 · Cited by 27
Targeting the growth factors and angiogenesis pathways: Small molecules in solid tumors
Berz, D., & Wanebo, H. J. (2011) · Journal of Surgical Oncology · doi:10.1002/jso.21776 · Cited by 26
Basu, D., Bewley, A. F., Sperry, S. M., Montone, K. T., Gimotty, P. A., Räsänen, K., Facompre, N. D., Weinstein, G. S., Nakagawa, H., Diehl, J. A., et al. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-1210 · Cited by 26
Han, R., Jia, Y., Li, X., Zhao, C., Zhao, S., Liu, S., Liu, Y., Chen, D., Zhang, Q., Liu, X., et al. (2021) · Translational Lung Cancer Research · doi:10.21037/tlcr-20-1153 · Cited by 27
Wilsbacher, J. L., Zhang, Q., Tucker, L. A., Hubbard, R. D., Sheppard, G. S., BaMaung, N. Y., Fidanze, S. D., Wang, G. T., Hu, X., Davidsen, S. K., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708360200 · Cited by 26
Kitahara, H., Hirai, M., Kato, K., Bou–Gharios, G., Nakamura, H., & Kawashiri, S. (2016) · Oncology Reports · doi:10.3892/or.2016.5189 · Cited by 26
RAF1-MEK1-ERK/AKT axis may confer NSCLC cell lines resistance to erlotinib.
Xu, Z., Hang, J., Hu, J., & Gao, B. (2013) · Europe PMC (PubMed Central) · Cited by 25
Chung, B. M. (2014) · World Journal of Clinical Oncology · doi:10.5306/wjco.v5.i5.806 · Cited by 25
Tan, J., Guo, W., Yang, S., Han, D., & Li, H. (2021) · Translational Lung Cancer Research · doi:10.21037/tlcr-20-1298 · Cited by 25
The importance of matrix metalloproteinase-3 in respiratory disorders
Yamashita, C. M., Radisky, D. C., Aschner, Y., & Downey, G. P. (2014) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.2014.909288 · Cited by 26
Epithelial–mesenchymal transition in pulmonary carcinosarcoma: case report and literature review
Thomas, V. T., Hinson, S., & Konduri, K. (2011) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758834011421949 · Cited by 25
Ulivi, P. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17071186 · Cited by 24
Ecological responses and remediation ability of water fern (Azolla japonica) to water pollution
Song, U., Park, H., & Lee, E. J. (2012) · Journal of Plant Biology · doi:10.1007/s12374-012-0010-5 · Cited by 24
Planck, M., Isaksson, S., Veerla, S., & Staaf, J. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-0928 · Cited by 24
Discovery of 3-Aminopyrazole Derivatives as New Potent and Orally Bioavailable AXL Inhibitors
Chan, S., Zhang, Y., Wang, J., Yu, Q., Xia, P., Zou, J., Zhou, L., Tan, L., Duan, Y., Zhou, Y., et al. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01346 · Cited by 23
Kim, B., Sohn, E. J., Jung, J. H., SHIN, E. A., You, O. H., IM, J., & Kim, S. (2013) · Oncology Reports · doi:10.3892/or.2013.2801 · Cited by 23
Park, K., Moon, Y. W., Raffeld, M. A., Lee, K. H., Wang, Y., & Giaccone, G. (2017) · Lung Cancer · doi:10.1016/j.lungcan.2017.12.010 · Cited by 23
Upregulation of EphB3 in gastric cancer with acquired resistance to a FGFR inhibitor
Lee, S., Na, Y. J., Jeong, Y. A., Kim, J. L., Oh, S. C., & Lee, D.-H. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.07.008 · Cited by 23
Poly(ADP-ribose) polymerase-1 regulates vimentin expression in lung cancer cells
Chu, S., Xu, H., Ferro, T. J., & Rivera, P. X. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00197.2007 · Cited by 24
Hashimoto, M., Kobayashi, T., Tashiro, H., Arihiro, K., Kikuchi, A., & Ohdan, H. (2016) · International Journal of Cancer · doi:10.1002/ijc.30118 · Cited by 22
Augustin, A., Lamerz, J., Meistermann, H., Golling, S., Scheiblich, S., Hermann, J. C., Duchâteau-Nguyen, G., Tzouros, M., Avila, D. W., Langen, H., et al. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-0880 · Cited by 21
Resistance to targeted cancer drugs through hepatocyte growth factor signaling
Heynen, G. J. J. E., Fonfara, A., & Bernards, R. (2014) · Cell Cycle · doi:10.4161/15384101.2014.988033 · Cited by 21
Li, J., Ao, J., Li, K., Zhang, J., Li, Y., Zhang, L., Wei, Y., Gong, D., Gao, J., Tan, W., et al. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.328 · Cited by 21
Novel insights into the molecular origins and treatment of lung cancer
Webb, J. D., & Simon, M. C. (2010) · Cell Cycle · doi:10.4161/cc.9.20.13588 · Cited by 21
Current Challenges and Future Directions
Matthews, D., & Gerritsen, M. E. (2010) · Wiley eBooks · doi:10.1002/9780470555293.ch11 · Cited by 21
Wang, L., Wang, Y., Han, N., Wang, X., & Ruan, M. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112424 · Cited by 20
Wang, S., Rong, R., Yang, D. M., Fujimoto, J., Bishop, J. A., Yan, S. X., Cai, L., Behrens, C., Berry, L. D., Wilhelm, C., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci160330 · Cited by 22
Hattori, S., Kikuchi, E., Kosaka, T., Miyazaki, Y. J., Tanaka, N., Miyajima, A., Mikami, S., & Oya, M. (2015) · Annals of Surgical Oncology · doi:10.1245/s10434-015-4848-x · Cited by 20
Wu, Y., Fu, Y., Zheng, L., Lin, G., Ma, J., Lou, J.-S., Zhu, H., He, Q., & Yang, B. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.08.039 · Cited by 20
Genetic Clonality as the Hallmark Driving Evolution of Non-Small Cell Lung Cancer
Nicoś, M., & Krawczyk, P. A. (2022) · Cancers · doi:10.3390/cancers14071813 · Cited by 21
Haley, J. D., Haughney, E., Ullman, E., Bean, J. M., Haley, J. D., & Fink, M. Y. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00344 · Cited by 19
Erlotinib in the first-line treatment of non-small-cell lung cancer
D’Arcangelo, M., & Cappuzzo, F. (2013) · Expert Review of Anticancer Therapy · doi:10.1586/era.13.23 · Cited by 19
Xu, Y., & Lü, S. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2678 · Cited by 18
Murgu, S. D., & Colt, H. G. (2013) · Clinical Lung Cancer · doi:10.1016/j.cllc.2013.04.002 · Cited by 17
Hu, X., Wu, L., Weng, X., Lin, N., & Zhang, C. (2018) · Oncology Letters · doi:10.3892/ol.2018.8956 · Cited by 17
Deng, Q., Cai‐Cun, Z. H. O. U., & Su, C. (2009) · Respirology · doi:10.1111/j.1440-1843.2009.01496.x · Cited by 17
From the bench to the bed: individualizing treatment in non-small-cell lung cancer
Santarpía, M., Altavilla, G., Salazar, F., Tarón, M., & Rosell, R. (2006) · Clinical & Translational Oncology · doi:10.1007/s12094-006-0161-2 · Cited by 17
Chong, G. O., Park, J. Y., Han, H. S., Cho, J., Kim, M.-G., Choi, Y., Yeo, J. Y., Lee, Y. H., Hong, D. G., & Park, J. Y. (2021) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2021.07.009 · Cited by 16
Zhou, J., Zhang, X., Xue, S., Dai, M., Wang, Y., Xia, P., Chen, J., Wang, X., Shen, Y., Qin, H., et al. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01403-w · Cited by 16
Larsson, A. H., Lehn, S., Wangefjord, S., Karnevi, E., Kuteeva, E., Sundström, M., Nodin, B., Uhlén, M., Eberhard, J., Birgisson, H., et al. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0882-0 · Cited by 16
silva, J. D., Jouida, A., Ancel, J., Dalstein, V., Routhier, J., Delépine, G., Cutrona, J., Jonquet, A., Dewolf, M., Birembaut, P. L., et al. (2020) · The Journal of Pathology · doi:10.1002/path.5439 · Cited by 16
Epithelial–Mesenchymal Transition in Mouse Mammary Tumorigenesis
Radaelli, E., Damonte, P., & Cardiff, R. D. (2009) · Future Oncology · doi:10.2217/fon.09.93 · Cited by 15
Complex Role of Histone Deacetylase Inhibitors in the Treatment of Non–Small-Cell Lung Cancer
Neal, J. W., & Sequist, L. V. D. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.41.0860 · Cited by 15
Hülsmann, H., Rolff, J., Bender, C., Jarahian, M., Korf, U., Herwig, R., Fröhlich, H., Thomas, M., Merk, J., Fichtner, I., et al. (2014) · Lung Cancer · doi:10.1016/j.lungcan.2014.09.001 · Cited by 16
Chen, B., Xiao, F., Li, B., Xie, B., Zhou, J., Zheng, J., & Zhang, W. (2013) · Cancer Investigation · doi:10.3109/07357907.2013.820315 · Cited by 15
Molecular mechanisms of therapy resistance in solid tumors: chasing “moving” targets
Tafe, L. J. (2017) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-017-2101-7 · Cited by 14
Wang, D., Haley, J. D., & Thompson, P. A. (2017) · BMC Cancer · doi:10.1186/s12885-017-3832-1 · Cited by 14
He, L. C., Liu, K., Wang, X., Chen, H., Zhou, J., Wu, X., Liu, T., Yang, Y., Yang, X., Cui, D., et al. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.05.003 · Cited by 14
4-Hydroxynonenal activates Src through a non-canonical pathway that involves EGFR/PTP1B
Zhang, H.-Q., & Forman, H. (2015) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2015.08.025 · Cited by 13
Rivera, G. A., & Wakelee, H. A. (2016) · Cancer treatment and research · doi:10.1007/978-3-319-40389-2_9 · Cited by 14
Wu, C., Zhu, X.-X., Dai, Q., Chu, Z., Yang, S., & Dong, Z. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2808192 · Cited by 13
Gottschling, S., Herpel, E., Eberhardt, W., Heigener, D. F., Fischer, J. R., Köhne, C., Kortsik, C., Kuhnt, T., Muley, T., Meister, M. A., et al. (2012) · Lung Cancer · doi:10.1016/j.lungcan.2012.03.003 · Cited by 14
[Epithelial-mesenchymal transition and tumor metastasis].
Zhao, R., Wu, Z., & Zhou, Q. (2011) · Europe PMC (PubMed Central) · doi:10.3779/j.issn.1009-3419.2011.07.11 · Cited by 13
Proto, C., Russo, G. L., Corrao, G., Ganzinelli, M., Facchinetti, F., Minari, R., Tiseo, M., & Garassino, M. C. (2017) · Tumori Journal · doi:10.5301/tj.5000663 · Cited by 14
Ito, K., Nishio, M., Kato, M., Murakami, H., Aoyagi, Y., Ohe, Y., Okayama, T., Hashimoto, A., Ohsawa, H., Tanaka, G., et al. (2019) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-18-0645 · Cited by 12
Xin, H., Yang, J. H., & Nguyen, D. M. (2013) · PubMed · Cited by 11
Fidler, M. J., Frankenberger, C. A., Seto, R., Lobato, G. C., Fhied, C. L., Sayidine, S., Basu, S., Pool, M. D., Karmali, R., Batus, M., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.17510 · Cited by 10
Zheng, M., Lin, Y., Kuo, Y., Lin, Y., Kuo, M.-H., Huang, T.-W., Shieh, Y., Huang, Y., & Chou, Y. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-00910-z · Cited by 10
Li, H., Da, L., Fan, W., Long, X.-H., & Zhang, X. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3150 · Cited by 10
Bruun, J., Eide, P. W., Bergsland, C. H., Brück, O. E., Svindland, A., Arjama, M., Välimäki, K. E., Bjørnslett, M., Guren, M. G., Kallioniemi, O., et al. (2021) · Molecular Oncology · doi:10.1002/1878-0261.13159 · Cited by 10
Targeted agents in non-small cell lung cancer therapy: What is there on the horizon?
Villaflor, V. M., & Salgia, R. (2013) · Journal of Carcinogenesis · doi:10.4103/1477-3163.109253 · Cited by 10
Erlotinib has tumor inhibitory effect in human retinoblastoma cells
Shao, Y., Yao, Y., Zong, R., Quyang, L., He, H., Zhou, Q., & Pei, C.-G. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.11.054 · Cited by 10
Decoupling of Nrf2 Expression Promotes Mesenchymal State Maintenance in Non-Small Cell Lung Cancer
Haley, J. D., Ruiz, C. F., Montal, E. D., Wang, D., Haley, J. D., & Girnun, G. D. (2019) · Cancers · doi:10.3390/cancers11101488 · Cited by 10
RB1, Cancer Lineage Plasticity, and Therapeutic Resistance
Zhang, L., & Goodrich, D. W. (2022) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-070120-092840 · Cited by 10
Alghamian, Y., Soukkarieh, C., Abbady, A. Q., & Murad, H. (2022) · Scientific Reports · doi:10.1038/s41598-022-11634-6 · Cited by 9
Dazio, G., Epistolio, S., Frattini, M., & Saletti, P. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11247523 · Cited by 10
Novel Molecular Challenges in Targeting Anaplastic Lymphoma Kinase in ALK-Expressing Human Cancers
Alshareef, A. (2017) · Cancers · doi:10.3390/cancers9110148 · Cited by 10
Wang, J., Wei, H., Zhao, B.-X., Li, M., Lv, W., Lv, L., Song, B., & Lv, S. (2014) · Journal of Molecular Histology · doi:10.1007/s10735-014-9583-2 · Cited by 9
Walser, T. C., Yanagawa, J., Garon, E. B., Lee, J. M., & Dubinett, S. M. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-524-8_2 · Cited by 9
Metadata
- Authors
- Yauch, R. L., Januario, T., Eberhard, D. A., Cavet, G., Zhu, W., Fu, L., Pham, T. Q., Soriano, R., Stinson, J., Seshagiri, S., Modrusan, Z., Lin, C.-Y., O'Neill, V., & Amler, L. C.
- Affiliations
- Genentech (US)
- 5BioOncology, Genentech, Inc., South San Francisco, California
- Venue
- Clinical Cancer Research
- Published
- 2005-12-15
- Volume
- 11
- Issue
- 24
- Pages
- 8686-8698
- ISSN
- 1078-0432 (ISSN-L)
- 1557-3265
- OpenAlex
- W2111599976
- Cited by
- 495
- References
- 45
- Citations by year
- 2026: 4 · 2025: 6 · 2023: 12 · 2022: 7 · 2021: 15 · 2020: 15 · 2019: 15 · 2018: 21 · 2017: 41 · 2016: 29 · 2015: 27 · 2014: 35 · 2013: 50 · 2012: 36
- FWCI
- 21.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Food and Drug Administration
- Division of Materials Research
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
- Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- erlotinib, non-small cell lung cancer, epithelial-mesenchymal transition, E-cadherin, EGFR inhibitors, predictive biomarkers, pharmacogenomics, EGFR mutation, EGFR amplification, vimentin, time to progression, combination chemotherapy
- MeSH terms
- Erlotinib Hydrochloride, Antineoplastic Agents, Carcinoma, Non-Small-Cell Lung, Epithelium, Gene Amplification, Humans, Immunohistochemistry, Lung Neoplasms, Mesoderm, Mutation, Pharmacogenetics, Phenotype, Quinazolines, Biomarkers, Tumor, Vimentin, Cadherins, Treatment Outcome, Drug Resistance, Neoplasm, Oligonucleotide Array Sequence Analysis, Cell Line, Tumor, Protein Kinase Inhibitors, Cell Proliferation, Genes, Neoplasm, ErbB Receptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review