Effect of epidermal growth factor receptor tyrosine kinase domain mutations on the outcome of patients with non-small cell lung cancer treated with epidermal growth factor receptor tyrosine kinase inhibitors

Jänne, Pasi A.; Johnson, Bruce E.

doi:10.1158/1078-0432.ccr-06-0555

Cited by 147Lung Cancer Treatments and MutationsHER2/EGFR in Cancer ResearchLung Cancer Diagnosis and Treatment

Effect of epidermal growth factor receptor tyrosine kinase domain mutations on the outcome of patients with non-small cell lung cancer treated with epidermal growth factor receptor tyrosine kinase inhibitors

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Jänne, Pasi A., Johnson, Bruce E.·2006·Clinical Cancer Research

DOI 10.1158/1078-0432.ccr-06-0555

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Abstract

Somatic mutations in the epidermal growth factor receptor (EGFR) have been identified in patients with advanced non-small cell lung cancer who achieve dramatic clinical and radiographic response to the EGFR tyrosine kinase inhibitors (TKI) gefitinib and erlotinib. These mutations in EGFR are found more frequently in patients with adenocarcinomas, nonsmokers, patients of Asian ethnicity, and in females: the same populations that are the most likely to have a clinical response when treated with EGFR TKIs. Retrospective studies comparing the outcomes of patients with and without EGFR mutations treated with EGFR TKIs show a significant clinical benefit of EGFR TKIs in patients with EGFR mutations. These findings suggest that for patients with advanced non-small cell lung cancer bearing EGFR mutations, treatment with an EGFR TKI should be incorporated as at least part of their initial therapy. These approaches are being studied in ongoing clinical trials and will spur the development of additional technology for EGFR mutation detection.

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Exon 19 deletions, L858R, G719X, and L861Q are 1st generation EGFR-TKI sensitizing mutations.
“The exon 19 deletions, L858R, G719X, and L861Q mutations are 1st generation EGFR-TKIs, gefitinib and erlotinib, sensitizing mutations.”
From In vitro modeling to determine mutation specificity of EGFR tyrosine kinase inhibitors against clinically relevant EGFR mutants in non-small-cell lung cancer (2015) · cites this paper as [14]

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Authors: Jänne, P. A., & Johnson, B. E.
Affiliations: Authors' Affiliation: Lowe Center for Thoracic Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute and Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
Brigham and Women's Hospital (US)
ORCID: Johnson, Bruce E.
Venue: Clinical Cancer Research
Publisher: American Association for Cancer Research (AACR)
Published: 2006-07-15
Volume: 12
Issue: 14
Pages: 4416s-4420s
ISSN: 1078-0432 (ISSN-L)
1557-3265
DOI: 10.1158/1078-0432.ccr-06-0555
OpenAlex: W2165187741
Cited by: 147
References: 39
Citations by year: 2026: 3 · 2025: 5 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 5 · 2019: 4 · 2018: 7 · 2017: 10 · 2016: 7 · 2015: 9 · 2014: 5 · 2013: 6 · 2012: 4
FWCI: 2.56
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Clinical Cancer Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
Keywords: epidermal growth factor receptor, EGFR tyrosine kinase inhibitors, non-small cell lung cancer, EGFR mutation, gefitinib, erlotinib, adenocarcinoma, treatment response, EGFR mutation testing, predictive biomarkers
MeSH terms: Carcinoma, Non-Small-Cell Lung, Humans, Lung Neoplasms, Mutation, Treatment Outcome, Protein Structure, Tertiary, Protein Kinase Inhibitors, ErbB Receptors

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Effect of epidermal growth factor receptor tyrosine kinase domain mutations on the outcome of patients with non-small cell lung cancer treated with epidermal growth factor receptor tyrosine kinase inhibitors

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