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Basic Mechanisms Responsible for Osteolytic and Osteoblastic Bone Metastases
Open accessAbstract
Certain solid tumors metastasize to bone and cause osteolysis and abnormal new bone formation. The respective phenotypes of dysregulated bone destruction and bone formation represent two ends of a spectrum, and most patients will have evidence of both. The mechanisms responsible for tumor growth in bone are complex and involve tumor stimulation of the osteoclast and the osteoblast as well as the response of the bone microenvironment. Furthermore, factors that increase bone resorption, independent of tumor, such as sex steroid deficiency, may contribute to this vicious cycle of tumor growth in bone. This article discusses mechanisms and therapeutic implications of osteolytic and osteoblastic bone metastases.
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Citations
Cited by
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Sims, N. A., & Gooi, J. H. (2008) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2008.07.016 · Cited by 513
Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling
Crane, J. L., & Cao, X. (2014) · Journal of Clinical Investigation · doi:10.1172/jci70050 · Cited by 448
Akech, J., Wixted, J. J., Bedard, K., van der Deen, M., Hussain, S., Guise, T. A., van Wijnen, A. J., Stein, J. L., Languino, L. R., Altieri, D. C., et al. (2010) · Oncogene · doi:10.1038/onc.2009.389 · Cited by 295
Self-citationRegulation of TNF-Induced Osteoclast Differentiation
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“Imbalance of bone remodeling (increased OC bone resorption and/or decreased OB bone formation) results in bone loss, contributing to common diseases affecting adult bone, including osteoporosis [1–3], rheumatoid arthritis (RA), [4,5], bone metastatic cancer [6,7], aseptic loosening of arthroplasty [8], and periodontit…”
Background
Metadata
- Authors
- Guise, T. A., Mohammad, K. S., Clines, G., Stebbins, E. G., Wong, D. H., Higgins, L. S., Vessella, R., Corey, E., Padalecki, S., Suva, L., & Chirgwin, J. M.
- Venue
- Clinical Cancer Research
- Published
- 2006-10-15
- Volume
- 12
- Issue
- 20
- Pages
- 6213s-6216s
- ISSN
- 1078-0432 (ISSN-L)
- 1557-3265
- OpenAlex
- W2130687125
- Cited by
- 539
- References
- 0
- FWCI
- 9.45
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Basic Mechanisms Responsible for Osteolytic and Osteoblastic Bone Metastases. https://app.cochat.ai/papers/10.1158/1078-0432.ccr-06-1007
- The paper
- Guise, T. A., Mohammad, K. S., Clines, G., Stebbins, E. G., Wong, D. H., Higgins, L. S., Vessella, R., Corey, E., Padalecki, S., Suva, L., & Chirgwin, J. M. (2006). Basic Mechanisms Responsible for Osteolytic and Osteoblastic Bone Metastases. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.ccr-06-1007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
