The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions
Open accessAbstract
Runx2, a bone-specific transcriptional regulator, is abnormally expressed in highly metastatic prostate cancer cells. Here, we identified the functional activities of Runx2 in facilitating tumor growth and osteolysis. Our studies show that negligible Runx2 is found in normal prostate epithelial and non-metastatic LNCaP prostate cancer cells. In the intra-tibial metastasis model, high Runx2 levels are associated with development of large tumors, increased expression of metastasis-related genes (MMP9, MMP13, VEGF, Osteopontin) and secreted bone-resorbing factors (PTHrP, IL8) promoting osteolytic disease. Runx2 siRNA treatment of PC3 cells decreased cell migration and invasion through Matrigel in vitro, and in vivo shRunx2 expression in PC3 cells blocked their ability to survive in the bone microenvironment. Mechanisms of Runx2 function were identified in co-culture studies showing that PC3 cells promote osteoclastogenesis and inhibit osteoblast activity. The clinical significance of these findings is supported by human tissue microarray studies of prostate tumors at stages of cancer progression, in which Runx2 is expressed in both adenocarcinomas and metastatic tumors. Together these findings indicate that Runx2 is a key regulator of events associated with prostate cancer metastatic bone disease.
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Cites
New functions for the matrix metalloproteinases in cancer progression
Egeblad, M., & Werb, Z. (2002) · Nature Reviews Cancer · doi:10.1038/nrc745 · Cited by 6,108
Metastasis to bone: causes, consequences and therapeutic opportunities
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Basic Mechanisms Responsible for Osteolytic and Osteoblastic Bone Metastases
Guise, T. A., Mohammad, K. S., Clines, G., Stebbins, E. G., Wong, D. H., Higgins, L. S., Vessella, R., Corey, E., Padalecki, S., Suva, L., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1007 · Cited by 539
Self-citationThe runx genes: gain or loss of function in cancer
Blyth, K., Cameron, E. R., & Neil, J. C. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1607 · Cited by 455
Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals
Shao, J.-S., Cheng, S.-L., Pingsterhaus, J. M., Charlton-Kachigian, N., Loewy, A. P., & Towler, D. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200524140 · Cited by 452
Molecular Biology of Bone Metastasis
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Self-citationPratap, J., Javed, A., Languino, L. R., van Wijnen, A. J., Stein, J. L., Stein, G. S., & Lian, J. B. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.19.8581-8591.2005 · Cited by 312
Self-citationCell growth regulatory role of Runx2 during proliferative expansion of preosteoblasts.
Pratap, J., Galindo, M. A., Zaidi, S. K., Vradii, D., Bhat, B. M., Robinson, J. A., Choi, J. Y., Komori, T., Stein, J. L., Lian, J. B., et al. (2003) · PubMed · Cited by 300
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Cited by
Zhang, Y., Xie, R.-L., Croce, C. M., Stein, J. L., Lian, J. B., van Wijnen, A. J., & Stein, G. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018493108 · Cited by 423
Self-citationThe RUNX family: developmental regulators in cancer
Ito, Y., Bae, S.-C., & Chuang, L. S. H. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3877 · Cited by 399
Long non-coding RNA NEAT1 promotes bone metastasis of prostate cancer through N6-methyladenosine
Wen, S., Wei, Y., Zen, C., Xiong, W., Niu, Y., & Zhao, Y. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01293-4 · Cited by 259
Ma, Y., Gao, J., & Guo, H. (2022) · Journal of Oncology · doi:10.1155/2022/8719542 · Cited by 16
Metadata
- Authors
- Akech, J., Wixted, J. J., Bedard, K., van der Deen, M., Hussain, S., Guise, T. A., van Wijnen, A. J., Stein, J. L., Languino, L. R., Altieri, D. C., Pratap, J., Keller, E., Stein, G. S., & Lian, J. B.
- Venue
- Oncogene
- Published
- 2009-11-16
- Volume
- 29
- Issue
- 6
- Pages
- 811-821
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2019998985
- Cited by
- 295
- References
- 45
- FWCI
- 13.47
- Type
- journal article
- Language
- en
- Open access
- green
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- Akech, J., Wixted, J. J., Bedard, K., van der Deen, M., Hussain, S., Guise, T. A., van Wijnen, A. J., Stein, J. L., Languino, L. R., Altieri, D. C., Pratap, J., Keller, E., Stein, G. S., & Lian, J. B. (2010). Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions. Oncogene. https://doi.org/10.1038/onc.2009.389
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