The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Novel Therapeutic Inhibitors of the c-Met Signaling Pathway in Cancer
Abstract
A wide variety of human malignancies exhibit sustained c-Met stimulation, overexpression, or mutation, including carcinomas of the breast, liver, lung, ovary, kidney, and thyroid. Notably, activating mutations in c-Met have been positively identified in patients with a particular hereditary form of papillary renal cancer, directly implicating c-Met in human tumorigenesis. Aberrant signaling of the c-Met signaling pathway due to dysregulation of the c-Met receptor or overexpression of its ligand, hepatocyte growth factor (HGF), has been associated with an aggressive phenotype. Extensive evidence that c-Met signaling is involved in the progression and spread of several cancers and an enhanced understanding of its role in disease have generated considerable interest in c-Met and HGF as major targets in cancer drug development. This has led to the development of a variety of c-Met pathway antagonists with potential clinical applications. The three main approaches of pathway-selective anticancer drug development have included antagonism of ligand/receptor interaction, inhibition of the tyrosine kinase catalytic activity, and blockade of the receptor/effector interaction. Several c-Met antagonists are now under clinical investigation. Preliminary clinical results of several of these agents, including both monoclonal antibodies and small-molecule tyrosine kinase inhibitors, have been encouraging. Several multitargeted therapies have also been under investigation in the clinic and have demonstrated promise, particularly with regard to tyrosine kinase inhibition.
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Cites
MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
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Met, metastasis, motility and more
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Cited by
Molecular targeted therapy for anticancer treatment
Min, H.-Y., & Lee, H.-Y. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00864-3 · Cited by 569
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Induction of MET by Ionizing Radiation and Its Role in Radioresistance and Invasive Growth of Cancer
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Metadata
- Authors
- Eder, J. P., Vande Woude, G. F., Boerner, S. A., & LoRusso, P. M.
- Venue
- Clinical Cancer Research
- Published
- 2009-04-01
- Volume
- 15
- Issue
- 7
- Pages
- 2207-2214
- ISSN
- 1078-0432 (ISSN-L)
- 1557-3265
- OpenAlex
- W2125519805
- Cited by
- 522
- References
- 57
- FWCI
- 38.27
- Type
- journal article
- Language
- en
- Open access
- closed
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