Cited by 315Cancer survivorship and careTryptophan and brain disordersCancer-related cognitive impairment studies

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Inflammatory Biomarkers and Fatigue during Radiation Therapy for Breast and Prostate Cancer

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Bower, Julienne E., Ganz, Patricia A., Tao, May Lin, Hu, Wenhua, Belin, Thomas R., Sepah, Saviz, Cole, Steve, Aziz, Najib·2009·Clinical Cancer Research

DOI 10.1158/1078-0432.ccr-08-2584PMC PMC2884979

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Abstract

Purpose: Biomarkers of radiation-induced behavioral symptoms, such as fatigue, have not been identified. Studies linking inflammatory processes to fatigue in cancer survivors led us to test the hypothesis that activation of the proinflammatory cytokine network is associated with fatigue symptoms during radiation therapy for breast and prostate cancer. Experimental Design: Individuals with early-stage breast (n = 28) and prostate cancer (n= 20) completed questionnaires and provided blood samples for determination of serum levels of interleukin 1β (IL-1β) and IL-6 at assessments conducted before, during, and after a course of radiation therapy. Serum markers of proinflammatory cytokine activity, including IL-1 receptor antagonist and C-reactive protein, were examined in a subset of participants. Random coefficient models were used to evaluate the association between changes in cytokine levels and fatigue. Results: As expected, there was a significant increase in fatigue during radiation treatment. Changes in serum levels of inflammatory markers C-reactive protein and IL-1 receptor antagonist were positively associated with increases in fatigue symptoms (Ps < 0.05), although serum levels of IL-1β and IL-6 were not associated with fatigue. These effects remained significant (Ps < 0.05) in analyses controlling for potential biobehavioral confounding factors, including age, body mass index, hormone therapy, depression, and sleep disturbance. Conclusions: Results suggest that activation of the proinflammatory cytokine network and associated increases in downstream biomarkers of proinflammatory cytokine activity are associated with fatigue during radiation therapy for breast and prostate cancer.(Clin Cancer Res 2009;15(17):5534–40)

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Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267
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Cytokine-induced sickness behaviour: mechanisms and implications
Konsman, J. P., Parnet, P., & Dantzer, R. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)02088-9 · Cited by 999
Effects of radiation on normal tissue: consequences and mechanisms
Stone, H. B., Coleman, C. N., Anscher, M. S., & McBride, W. H. (2003) · The Lancet Oncology · doi:10.1016/s1470-2045(03)01191-4 · Cited by 934
Sickness behavior as a new target for drug development
Kent, S., Bluthé, R.-M., Kelley, K. W., & Dantzer, R. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90012-u · Cited by 867
Psychometric properties of the Medical Outcomes Study Sleep measure
Hays, R. D., Martin, S. A., Sesti, A. M., & Spritzer, K. L. (2005) · Sleep Medicine · doi:10.1016/j.sleep.2004.07.006 · Cited by 557
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Measurement of fatigue in cancer patients: development and validation of the Fatigue Symptom Inventory.
Hann, D. M., Jacobsen, P. B., Azzarello, L. M., Martin, S. C., Curran, S. L., Fields, K. K., Greenberg, H., & Lyman, G. H. (1998) · Quality of Life Research · doi:10.1023/a:1024929829627 · Cited by 526
Glucocorticoids, stress, and their adverse neurological effects: relevance to aging
Sapolsky, R. M. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00047-9 · Cited by 507

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Han, T., Felger, J. C., Lee, A., Mister, D., Miller, A. H., & Torres, M. A. (2015) · Psycho-Oncology · doi:10.1002/pon.3831 · Cited by 70
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McGinnis, G. J., Friedman, D. J., Young, K. H., Torres, E. R. S., Thomas, C. R., Gough, M. J., & Raber, J. (2016) · Oncotarget · doi:10.18632/oncotarget.13551 · Cited by 75
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Kaushik, D., Shah, P., Mukherjee, N. Z., Ji, N., Dursun, F., Kumar, A. P., Thompson, I. M., Mansour, A. M., Jha, R., Yang, X., et al. (2021) · Prostate Cancer and Prostatic Diseases · doi:10.1038/s41391-021-00470-w · Cited by 68
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Innominato, P. F., Mormont, M., Rich, T. A., Waterhouse, J. M., Lévi, F., & Bjarnason, G. A. (2009) · Integrative Cancer Therapies · doi:10.1177/1534735409355293 · Cited by 50
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Authors: Bower, J. E., Ganz, P. A., Tao, M. L., Hu, W., Belin, T. R., Sepah, S., Cole, S., & Aziz, N.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Bower, Julienne E.
ORCID: Bower, Julienne E.
Ganz, Patricia A.
Hu, Wenhua
Belin, Thomas R.
Cole, Steve
Aziz, Najib
Venue: Clinical Cancer Research
Publisher: American Association for Cancer Research (AACR)
Published: 2009-08-31
Volume: 15
Issue: 17
Pages: 5534-5540
ISSN: 1078-0432 (ISSN-L)
1557-3265
DOI: 10.1158/1078-0432.ccr-08-2584
PMC: PMC2884979
OpenAlex: W2068185418
Cited by: 315
References: 44
Citations by year: 2026: 10 · 2025: 13 · 2024: 9 · 2023: 21 · 2022: 23 · 2021: 18 · 2020: 26 · 2019: 20 · 2018: 16 · 2017: 18 · 2016: 16 · 2015: 17 · 2014: 21 · 2013: 21 · 2012: 35
FWCI: 10.84
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Clinical Cancer Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Health and Human Services
California Breast Cancer Research Program
National Institutes of Health
National Cancer Institute (K07CA090407, K07-CA90407, R01CA116778)
Topics: Health Sciences › Medicine › Oncology › Cancer survivorship and care
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
Keywords: radiation-induced fatigue, inflammatory markers, inflammatory cytokines, breast cancer, prostate cancer, IL-1β, interleukin-6, C-reactive protein, interleukin-1 receptor antagonist, radiotherapy complications, cancer survivors
MeSH terms: Adult, Aged, Breast Neoplasms, C-Reactive Protein, Fatigue, Female, Humans, Inflammation, Male, Middle Aged, Prostatic Neoplasms, Biomarkers, Interleukin-6, Interleukin-1beta

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Inflammatory Biomarkers and Fatigue during Radiation Therapy for Breast and Prostate Cancer

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