Cited by 999Tryptophan and brain disordersNeuroinflammation and Neurodegeneration MechanismsStress Responses and Cortisol

Cytokine-induced sickness behaviour: mechanisms and implications

Konsman, Jan Pieter, Parnet, Patricia, Dantzer, Robert·2002·Trends in Neurosciences

Abstract

Sickness behaviour represents the expression of the adaptive reorganization of the priorities of the host during an infectious episode. This process is triggered by pro-inflammatory cytokines produced by peripheral phagocytic cells in contact with invading micro-organisms. The peripheral immune message is relayed to the brain via a fast neural pathway and a slower humoral pathway, resulting in the expression of pro-inflammatory cytokines in macrophage-like cells and microglia in the brain. The cellular and molecular components of this previously unsuspected system are being progressively identified. These advances are opening new avenues for understanding brain disorders, including depression.

Integrity signals

Registry

Crossref · 10.1016/s0166-2236(00)02088-9

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4 of 4 references verified0 citation errors · 0 not checkable

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  • Cytokines reduce levels of serotonin and possibly other related neurotransmitters by decreasing the availability of tryptophan.

    “cytokines have been found to reduce levels of serotonin and possibly other related neurotransmitters by decreasing the availability of its serotonin precursor, an essential amino acid called tryptophan”

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Authors
Konsman, J. P., Parnet, P., & Dantzer, R.
Affiliations
Inserm (FR)
Corresponding author
Dantzer, Robert
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2002-03
Volume
25
Issue
3
Pages
154-159
ISSN
0166-2236 (ISSN-L)
OpenAlex
W2120987567
Cited by
999
References
4
Citations by year
2026: 18 · 2025: 23 · 2024: 28 · 2023: 38 · 2022: 49 · 2021: 40 · 2020: 36 · 2019: 53 · 2018: 35 · 2017: 45 · 2016: 35 · 2015: 34 · 2014: 40 · 2013: 61 · 2012: 44
FWCI
5.68
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
sickness behavior, inflammatory cytokines, neuroimmune interactions, microglia, macrophages, peripheral immune activation, infection, depression, neuroinflammation, brain disorders
MeSH terms
Animals, Anorexia, Brain, Communicable Diseases, Depression, Humans, Immune System, Sick Role, Signal Transduction, Cytokines, Visceral Afferents

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