The biobehavioral and neuroimmune impact of low-dose ionizing radiation
Open accessAbstract
In the clinical setting, repeated exposures (10-30) to low-doses of ionizing radiation (≤200 cGy), as seen in radiotherapy for cancer, causes fatigue. Almost nothing is known, however, about the fatigue inducing effects of a single exposure to environmental low-dose ionizing radiation that might occur during high-altitude commercial air flight, a nuclear reactor accident or a solar particle event (SPE). To investigate the short-term impact of low-dose ionizing radiation on mouse biobehaviors and neuroimmunity, male CD-1 mice were whole body irradiated with 50 cGy or 200 cGy of gamma or proton radiation. Gamma radiation was found to reduce spontaneous locomotor activity by 35% and 36%, respectively, 6 h post irradiation. In contrast, the motivated behavior of social exploration was un-impacted by gamma radiation. Examination of pro-inflammatory cytokine gene transcripts in the brain demonstrated that gamma radiation increased hippocampal TNF-α expression as early as 4 h post-irradiation. This was coupled to subsequent increases in IL-1RA (8 and 12 h post irradiation) in the cortex and hippocampus and reductions in activity-regulated cytoskeleton-associated protein (Arc) (24 h post irradiation) in the cortex. Finally, restraint stress was a significant modulator of the neuroimmune response to radiation blocking the ability of 200 cGy gamma radiation from impairing locomotor activity and altering the brain-based inflammatory response to irradiation. Taken together, these findings indicate that low-dose ionizing radiation rapidly activates the neuroimmune system potentially causing early onset fatigue-like symptoms in mice.
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Exposure to low-dose rate SPE-like proton radiation leads to an increase in fatigue in a mouse model.
“Using a mouse model, studies suggest that exposure to low-dose rate SPE-like proton radiation leads to an increase in fatigue [71,72].”
From Space Radiation: The number one risk to astronaut health beyond low earth orbit (2014) · cites this paper as [71]
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IDENTIFICATION OF GENES EXPRESSED IN LOW-DOSE-RATE γ-IRRADIATED MOUSE WHOLE BRAIN
Bong, J. J., Kang, Y. M., Choi, S. J., Kim, D.-K., Lee, K., & Kim, H. S. (2013) · Journal of Radiation Protection and Research · doi:10.14407/jrp.2013.38.4.166
Extracellular adenosine as a novel neuroimmune modulator
Chiu, G. S. (2014) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Сгибнева, Викторовна, С. Н., Маслов, Maslov, N., Насонова, Александровна, Н. Н., Спицин, & Spitsin, V. V. (2013) · Journal of New Medical Technologies · doi:10.12737/2745
Joesting, J. J. (2013) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Water Maze Strategies used by Mice Exposed to Radiation and Pomegranate Juice
Lorenzo, P. V. (2017) · The Scholars Repository - LLU (Loma Linda University)
- Authors
- York, J. M., Blevins, N. A., Meling, D. D., Peterlin, M. B., Gridley, D. S., Cengel, K. A., & Freund, G. G.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- University of Pennsylvania (US)
- Loma Linda University (US)
- Corresponding author
- Freund, Gregory G.
- Venue
- Brain Behavior and Immunity
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 26
- Issue
- 2
- Pages
- 218-227
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC3264777
- OpenAlex
- W2059580306
- Cited by
- 53
- References
- 53
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 1 · 2015: 2 · 2014: 6 · 2013: 8 · 2012: 5
- FWCI
- 4.64
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (AA019357, RC1AA019357)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK064862, DK 064862)
- National Institute of Neurological Disorders and Stroke (R01NS058525, NS058525)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Keywords
- low-dose radiation, neuroimmunity, radiation-induced fatigue, locomotor activity, social exploration, TNF-α, interleukin-1 receptor antagonist, Arc, restraint stress, gamma radiation, proton radiation, solar energetic particle events, nuclear reactor accidents
- MeSH terms
- Animals, Cerebral Cortex, Cytoskeletal Proteins, Dose-Response Relationship, Radiation, Exploratory Behavior, Fatigue, Gamma Rays, Hippocampus, Male, Motor Activity, Nerve Tissue Proteins, Radiation, Ionizing, Restraint, Physical, Time Factors, Tumor Necrosis Factor-alpha, Whole-Body Irradiation, Neuroimmunomodulation, Mice, Interleukin 1 Receptor Antagonist Protein
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