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Tumor-Infiltrating Macrophages Are Associated with Metastasis Suppression in High-Grade Osteosarcoma: A Rationale for Treatment with Macrophage Activating Agents
Published version of a preprint
Abstract
Purpose: High-grade osteosarcoma is a malignant primary bone tumor with a peak incidence in adolescence. Overall survival (OS) of patients with resectable metastatic disease is approximately 20%. The exact mechanisms of development of metastases in osteosarcoma remain unclear. Most studies focus on tumor cells, but it is increasingly evident that stroma plays an important role in tumorigenesis and metastasis. We investigated the development of metastasis by studying tumor cells and their stromal context. Experimental Design: To identify gene signatures playing a role in metastasis, we carried out genome-wide gene expression profiling on prechemotherapy biopsies of patients who did (n = 34) and patients who did not (n = 19) develop metastases within 5 years. Immunohistochemistry (IHC) was performed on pretreatment biopsies from 2 additional cohorts (n = 63 and n = 16) and corresponding postchemotherapy resections and metastases. Results: A total of 118/132 differentially expressed genes were upregulated in patients without metastases. Remarkably, almost half of these upregulated genes had immunological functions, particularly related to macrophages. Macrophage-associated genes were expressed by infiltrating cells and not by osteosarcoma cells. Tumor-associated macrophages (TAM) were quantified with IHC and associated with significantly better overall survival (OS) in the additional patient cohorts. Osteosarcoma samples contained both M1- (CD14/HLA-DRα positive) and M2-type TAMs (CD14/CD163 positive and association with angiogenesis). Conclusions: In contrast to most other tumor types, TAMs are associated with reduced metastasis and improved survival in high-grade osteosarcoma. This study provides a biological rationale for the adjuvant treatment of high-grade osteosarcoma patients with macrophage activating agents, such as muramyl tripeptide. Clin Cancer Res; 17(8); 2110–9. ©2011 AACR.
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“However, in primary OS, heterogenous TAMs displaying an intermediate phenotype between M1 and M2 have been associated with anti-metastatic effects [4,5].”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [5]
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Cites
Bioconductor: open software development for computational biology and bioinformatics
Gentleman, R. C., Carey, V. J., Bates, D. M., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge, Y., Gentry, J., et al. (2004) · Genome biology · doi:10.1186/gb-2004-5-10-r80 · Cited by 12,082
Smyth, G. K. (2004) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1027 · Cited by 11,829
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
Macrophage Diversity Enhances Tumor Progression and Metastasis
Qian, B., & Pollard, J. W. (2010) · Cell · doi:10.1016/j.cell.2010.03.014 · Cited by 5,349
Bielack, S. S., Kempf-Bielack, B., Delling, G., Exner, G. U., Flege, S., Helmke, K., Kotz, R., Salzer-Kuntschik, M., Werner, M., Winkelmann, W., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.20.3.776 · Cited by 2,393
Bielack, S., Kempf-Bielack, B., Delling, G., Exner, G. U., Flege, S., Helmke, K., Kotz, R., Salzer-Kuntschik, M., Werner, M., Winkelmann, W., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.20.3.776 · Cited by 2,391
Martinez, F. O., Gordon, S., Locati, M., & Mantovani, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.10.7303 · Cited by 2,125
lumi : a pipeline for processing Illumina microarray
Du, P., Kibbe, W. A., & Lin, S. M. (2008) · Bioinformatics · doi:10.1093/bioinformatics/btn224 · Cited by 2,028
How dying cells alert the immune system to danger
Kono, H., & Rock, K. L. (2008) · Nature Reviews Immunology · doi:10.1038/nri2215 · Cited by 1,737
Immunological aspects of cancer chemotherapy
Zitvogel, L., Apetoh, L., Ghiringhelli, F., & Kroemer, G. (2008) · Nature Reviews Immunology · doi:10.1038/nri2216 · Cited by 1,712
Research works printed but not linked: 2
- Raymond, 2002, Conventional osteosarcoma, 264
- 2005, R: a language and environment for statistical computing, reference index version 2.9.0.
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Items 201–300 of 504
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Song, Y., Xu, Y., Deng, C., Zhu, X., Fu, J., Chen, H., Lu, J., Xu, H., Song, G., Tang, Q., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.623762 · Cited by 26
Immunotherapy in Pediatric Solid Tumors—A Systematic Review
Marayati, R., Quinn, C. H., & Beierle, E. A. (2019) · Cancers · doi:10.3390/cancers11122022 · Cited by 27
Role of microRNAs in the crosstalk between osteosarcoma cells and the tumour microenvironment
Lei, Y. H., Junxin, C., Huang, Y., Xiaoguang, L., & Yu, B.-S. (2020) · Journal of bone oncology · doi:10.1016/j.jbo.2020.100322 · Cited by 25
Huang, H., Tan, M., Li, Z., Yan, G., Li, K., Lu, D., Cui, X., He, S., Lei, D., Zhu, B., et al. (2021) · OncoTargets and Therapy · doi:10.2147/ott.s295063 · Cited by 25
Yang, J., Zhang, J., Na, S., Wang, Z., Li, H., Su, Y., Ji, L., Tang, X., Yang, J., & Lu, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.994034 · Cited by 25
Current Landscape of Immunotherapy for Advanced Sarcoma
Albarrán, V., Villamayor, M. L., Pozas, J., Chamorro, J., Rosero, D. I., Román, M. S., Guerrero, P., de Aguado, P. P., Calvo, J. C., de Quevedo, C. G., et al. (2023) · Cancers · doi:10.3390/cancers15082287 · Cited by 25
Yu, Y., Zhang, H., Ren, T., Huang, Y., Liang, X., Wang, W., Niu, J., Han, Y., & Guo, W. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15687 · Cited by 25
Li, G.-Q., Wang, Y.-K., Zhou, H., Jin, L.-G., Wang, C.-Y., Albahde, M., Wu, Y., Li, H.-Y., Zhang, W.-K., Li, B.-H., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.630355 · Cited by 24
Focus on Hypoxia-Related Pathways in Pediatric Osteosarcomas and Their Druggability
Pierrevelcin, M., Fuchs, Q., Lhermitte, B., Messé, M., Guérin, É., Weingertner, N., Martin, S., Lelong-Rebel, I. H., Nazon, C., Dontenwill, M., et al. (2020) · Cells · doi:10.3390/cells9091998 · Cited by 28
Magnetic resonance imaging of tumor-associated-macrophages (TAMs) with a nanoparticle contrast agent
Zhou, J., Meli, V. S., Chen, E. Y., Kapre, R., Nagalla, R. R., Xiao, W., Borowsky, A. D., Lam, K. S., Liu, W. F., & Louie, A. Y. (2022) · RSC Advances · doi:10.1039/d1ra08061j · Cited by 24
Li, D.-K., & Wang, G. (2022) · Pharmaceutical Biology · doi:10.1080/13880209.2022.2109688 · Cited by 24
Pierrevelcin, M., Flacher, V., Mueller, C. G., Vauchelles, R., Guérin, É., Lhermitte, B., Pencreach, E., Reisch, A., Muller, Q., Doumard, L., et al. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202200195 · Cited by 25
Biomaterials‐Boosted Immunotherapy for Osteosarcoma
Sun, C., Li, S., & Ding, J. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400864 · Cited by 25
Costa, S. A., Rodrigues, J., Vieira, C., Dias, S., Viegas, J. S. R., Castro, F., Sarmento, B. F. C. C., & Pereira, C. L. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.10.068 · Cited by 24
Tumor microenvironment in osteosarcoma: From cellular mechanism to clinical therapy
Yu, Y., Li, K., Peng, Y., Zhang, Z., Pu, F., Shao, Z., & Wu, W. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101569 · Cited by 26
Bisphosphonates in common pediatric and adult bone sarcomas
Heymann, M., Lézot, F., & Heymann, D. (2020) · Bone · doi:10.1016/j.bone.2020.115523 · Cited by 23
Fowler, D. W., Copier, J. P., Dalgleish, A. G., & Bodman‐Smith, M. D. (2017) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-017-2011-1 · Cited by 23
Yang, Q., Su, Y., Wang, W., Wang, N., Yao, Z., & Zhang, X. (2020) · Cancer Management and Research · doi:10.2147/cmar.s251814 · Cited by 23
Osteosarcoma immune microenvironment: cellular struggle and novel therapeutic insights
Zhang, Y., Jiang, S., Lv, J., Feng, W., Yu, Y., & Zhao, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1584450 · Cited by 22
Barøy, T., Chilamakuri, C. S. R., Lorenz, S., Sun, J., Bruland, Ø. S., Myklebost, O., & Meza‐Zepeda, L. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163859 · Cited by 22
Self-citationFour genes relevant to pathological grade and prognosis in ovarian cancer
Pan, X., Chen, Y., & Gao, S. (2020) · Cancer Biomarkers · doi:10.3233/cbm-191162 · Cited by 22
Gilchrist, A. (2020) · Handbook of experimental pharmacology · doi:10.1007/164_2020_349 · Cited by 22
Recent advances in understanding osteosarcoma and emerging therapies
Gaspar, N., Costa, M. E. M. D., Fromigué, O., Droit, R., Berlanga, P., & Marchais, A. (2020) · Faculty Reviews · doi:10.12703/r/9-18 · Cited by 22
Li, F., Tang, H., Luo, X., Li, X., Luo, K., Liu, S., Liang, J., Liao, S., Zhong, C., Zhan, X., et al. (2023) · Cancer Science · doi:10.1111/cas.15821 · Cited by 22
Sun, W. Y., Ma, X., Shen, J., Yin, F., Wang, C., & Cai, Z. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2657 · Cited by 21
Cross-Species Gene Expression Analysis Reveals Gene Modules Implicated in Human Osteosarcoma
Jin, Z., Liu, S., Zhu, P., Tang, M., Wang, Y., Tian, Y., Li, D., Zhu, X., Yan, D., & Zhu, Z. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00697 · Cited by 21
Prognostic Signature of Osteosarcoma Based on 14 Autophagy-Related Genes
Wei, Q., Yan, Q., Lv, M., Song, D., Wang, X., & Tian, K. (2021) · Pathology & Oncology Research · doi:10.3389/pore.2021.1609782 · Cited by 22
Martínez-Vélez, N., Laspidea, V., Zalacain, M., Labiano, S., García-Moure, M., Puigdelloses, M., Marrodan, L., Gonzalez-Huarriz, M., Herrador, G., de la Nava, D., et al. (2021) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-21-0565 · Cited by 21
Jiang, J., Qu, H., Zhan, X., Liu, D., Liang, T., Chen, L., Huang, S., Sun, X., Chen, J., Chen, T., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-28739-1 · Cited by 21
A support vector machine classifier for the prediction of osteosarcoma metastasis with high accuracy
He, Y., Ma, J., & Ye, X. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3126 · Cited by 21
Hypoxia-immune-related microenvironment prognostic signature for osteosarcoma
Zhang, W., Lyu, P., Andreev, D., Jia, Y., Zhang, F., & Bözec, A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.974851 · Cited by 20
Anoikis patterns exhibit distinct prognostic and immune landscapes in Osteosarcoma
Zhang, Z., Zhu, Z., Fu, J., Liu, X., Mi, Z., Tao, H., & Fan, H. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109684 · Cited by 20
Zhou, H., Jia, W., Lu, L., & Han, R. (2023) · Cancers · doi:10.3390/cancers15030824 · Cited by 21
Is carcinoma a mesenchymal disease? The role of the stromal microenvironment in carcinogenesis
Hemmings, C. (2013) · Pathology · doi:10.1097/pat.0b013e328360b600 · Cited by 20
Tumor‐targeted and immune‐targeted monoclonal antibodies: Going from passive to active immunotherapy
Marabelle, A., & Gray, J. C. (2015) · Pediatric Blood & Cancer · doi:10.1002/pbc.25508 · Cited by 20
Zhang, Y., Zhao, H., Wu, X., Jiang, D., Huang, L., & Li, L. (2019) · Journal of Cancer · doi:10.7150/jca.28480 · Cited by 21
Baron, M., Drohat, P., Crawford, B., Hornicek, F. J., Best, T. M., & Kouroupis, D. (2023) · Bioengineering · doi:10.3390/bioengineering10101187 · Cited by 19
Xu, R., Zhu, S., Zhang, W., Xu, H., Tu, C., Wang, H., Wang, L., He, N., Liu, T., Guo, X., et al. (2025) · Advanced Science · doi:10.1002/advs.202500632 · Cited by 19
Multi-omics analysis of tumor mutation burden combined with immune infiltrates in melanoma
Jiang, F., Wu, C., Wang, M., Wei, K., Zhou, G., & Wang, J. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.10.030 · Cited by 19
Lin, Z., He, Y., Wu, Z., Yuan, Y., Li, X., & Luo, W. (2023) · Scientific Reports · doi:10.1038/s41598-023-42053-w · Cited by 19
Sorenson, L., Fu, Y., Hood, T., Warren, S. E., & McEachron, T. A. (2019) · OncoImmunology · doi:10.1080/2162402x.2019.1629779 · Cited by 20
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Martino, V. D., Rossi, M., Battafarano, G., Pepe, J., Minisola, S., & Fattore, A. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212586 · Cited by 19
Osteosarcoma exocytosis of soluble LGALS3BP mediates macrophages toward a tumoricidal phenotype
Li, J., Zhao, C., Li, Y., Wen, J., Wang, S., Wang, D., Dong, H., Wang, D., Zhao, Y., Wang, X., et al. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.12.023 · Cited by 19
Intact interferon signaling in peripheral blood leukocytes of high-grade osteosarcoma patients
Buddingh, E. P., Ruslan, S. E. N., Berghuis, D., Gelderblom, H. A. J., Anninga, J., Hogendoorn, P. C. W., Egeler, R. M., Schilham, M. W., & Lankester, A. C. (2012) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-012-1232-6 · Cited by 19
Self-citationDutour, A., Pasello, M., Farrow, L., Amer, M. H., Entz‐Werlé, N., Nathrath, M., Scotlandi, K., Mittnacht, S., & Gomez‐Brouchet, A. (2025) · Cancer and Metastasis Reviews · doi:10.1007/s10555-025-10257-3 · Cited by 21
CDKL3 promotes osteosarcoma progression by activating Akt/PKB
He, A., Ma, L., Huang, Y., Zhang, H., Duan, W., Li, Z., Teng, F., Yuan, J., Wu, H., Liu, L., et al. (2020) · Life Science Alliance · doi:10.26508/lsa.202000648 · Cited by 19
Ablative and Immunostimulatory Effects of Histotripsy Ablation in a Murine Osteosarcoma Model
Hay, A. N., Imran, K. M., Hendricks-Wenger, A., Gannon, J. M., Sereno, J., Simon, A., López, V. A. Q., Coutermarsh‐Ott, S. L., Vlaisavljevich, E., Allen, I. C., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11102737 · Cited by 18
The tumor microenvironment of metastatic osteosarcoma in the human and canine lung
McGee, L. E., Pereira, J. D. S., McEachron, T. A., Mazcko, C. N., LeBlanc, A. K., & Beck, J. A. (2025) · Communications Biology · doi:10.1038/s42003-025-07992-2 · Cited by 18
Tsuda, Y., Tsoi, K. M., Stevenson, J. D., Parry, M., Fujiwara, T., Sumathi, V. P., & Jeys, L. M. (2020) · Clinical Orthopaedics and Related Research · doi:10.1097/corr.0000000000001079 · Cited by 18
Effect of tumor-associated macrophages on lncRNA PURPL/miR-363/PDZD2 axis in osteosarcoma cells
He, F., Ding, G., Jiang, W., Fan, X.-L., & Zhu, L. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00700-z · Cited by 18
Ferrena, A., Wang, J., Zhang, R., Karadal-Ferrena, B., Al-Hardan, W., Singh, S., Borjihan, H., Schwartz, E. L., Zhao, H., Oktay, M. H., et al. (2023) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-23-0173 · Cited by 18
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Lee, L. H., Lin, F., Pope, J., & Wagner, L. M. (2016) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0000000000000717 · Cited by 17
Chen, W., Liao, Y., Yao, H., Zou, Y., Ji, F., Zhang, J., Guo, Z., Tu, J., Chen, J., Huo, Z., et al. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-011091 · Cited by 17
Franceschini, N., Gaeta, R., Krimpenfort, P., Bruijn, I. H. B., Kruisselbrink, A. B., Szuhai, K., Palubeckaitė, I., Cleton-Jansen, A., & Bovée, J. V. M. G. (2021) · Laboratory Investigation · doi:10.1038/s41374-021-00709-z · Cited by 16
Self-citationBarnes, D., Dutton, P., Bruland, Ø. S., Gelderblom, H. A. J., Faleti, A., Bühnemann, C., van Maldegem, A. M., Johnson, H., Poulton, L., Love, S., et al. (2022) · BMC Cancer · doi:10.1186/s12885-022-09697-9 · Cited by 16
Self-citationBiodegradable photothermal thermosensitive hydrogels treat osteosarcoma by reprogramming macrophages
Luo, G., Xu, Z., Zhong, H., Shao, H., Liao, H., Liu, N., Jiang, X., Zhang, Y., & Ji, X. (2023) · Biomaterials Science · doi:10.1039/d2bm01900k · Cited by 16
Zhang, Y., Gan, W., Ru, N., Xue, Z., Chen, W., Chen, Z., Wang, H., & Zheng, X. (2023) · Journal of bone oncology · doi:10.1016/j.jbo.2023.100481 · Cited by 16
Costa, M. E. M. D., Daudigeos‐Dubus, E., Gomez‐Brouchet, A., Bawa, O., Rouffiac, V., Serra, M., Scotlandi, K., Santos, C., Geoerger, B., & Gaspar, N. (2018) · Cancer Medicine · doi:10.1002/cam4.1346 · Cited by 16
Self-citationPratt, H. G., Justin, E. M., & Lindsey, B. A. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-43085-6_6 · Cited by 16
Hexokinase 2 is a transcriptional target and a positive modulator of AHR signalling
Watzky, M., Huard, S., Juricek, L., Dairou, J., Chauvet, C., Coumoul, X., Letessier, A., & Miotto, B. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac360 · Cited by 16
Putative Multifunctional Signature of Lung Metastases in Dedifferentiated Chondrosarcoma
Malchenko, S., Seftor, E. A., Nikolsky, Y., Hasegawa, S. L., Kuo, S.-M., Stevens, J. W., Poyarkov, S., Nikolskaya, T., Kucaba, T. A., Wang, M., et al. (2012) · Sarcoma · doi:10.1155/2012/820254 · Cited by 16
PD-L1 Expression in Carcinosarcomas of the Gynecologic Tract: A Potentially Actionable Biomarker
Pinto, A., Mackrides, N., & Nadji, M. (2016) · Applied immunohistochemistry & molecular morphology · doi:10.1097/pai.0000000000000457 · Cited by 16
Xiao, K.-W., Liu, Z., Zeng, Z., Yan, F., Xiao, L., Li, J.-L., & Cai, L. (2021) · Journal of Oncology · doi:10.1155/2021/9967954 · Cited by 15
Wang, Z., Wu, H., Chen, Y., Chen, H., Yuan, W., & Wang, X. (2021) · Journal of Oncology · doi:10.1155/2021/4836292 · Cited by 15
Zheng, D., Wei, Z., & Guo, W. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.849789 · Cited by 15
Clinicopathological correlation of tumor-associated macrophages in Ewing sarcoma
Handl, M., Hermanová, M., Hotárková, S., Jarkovský, J., Múdrý, P., Shatokhina, T., Vesela, M., Štěrba, J., & Zambo, I. S. (2017) · Biomedical Papers · doi:10.5507/bp.2017.049 · Cited by 15
Wang, X., Xia, G., Xiao, S., Wu, S. J., Zhang, L., Huang, J., Zhang, W., & Cao, X. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1024915 · Cited by 14
Ma, Z., Wang, Y., Zhang, X., Ding, S., Fan, J., Li, T. X., Xiao, X., & Li, J. (2025) · Tissue and Cell · doi:10.1016/j.tice.2025.102745 · Cited by 14
Cui, L., Zhao, S., Teng, H., Yang, B., Liu, Q., & Qin, A. (2025) · npj Precision Oncology · doi:10.1038/s41698-024-00794-5 · Cited by 14
Huang, T., Chen, Y., Zhao, Q., Wu, X., Li, H., Luo, X., Su, Y., Zhang, S., Liu, P., & Tang, N. (2025) · Research · doi:10.34133/research.0708 · Cited by 14
Advance of nano anticancer therapies targeted on tumor-associated macrophages
Wang, M., Zhao, J., Xiong, H., Lu, H., Jiang, H., & Wang, X. (2021) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2021.214126 · Cited by 14
Du, X., Zhang, Q., Wang, S., Chen, X., & Wang, Y. (2021) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24214 · Cited by 14
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Liu, X., Wang, Z., Liu, M., Zhi, F., Wang, P., Liu, X., Yu, S., Liu, B., & Jiang, Y. (2022) · Journal of Oncology · doi:10.1155/2022/4656661 · Cited by 14
Su, Z., Wang, C., Pan, R., Li, H., Chen, J., Tan, J., Tian, X., Lin, T., & Shen, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1028263 · Cited by 14
Identification of key genes in osteosarcoma by meta‑analysis of gene expression microarray
Sun, J., Xu, H., Qi, M., Zhang, C., & Shi, J. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10543 · Cited by 15
From biology to personalized medicine: Recent knowledge in osteosarcoma
Mohr, A., Costa, M. E. M. D., Fromigué, O., Audinot, B., Balde, T., Droit, R., Abbou, S. D., Khneisser, P., Berlanga, P., Pérez, E., et al. (2024) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2024.104941 · Cited by 13
Pan, F., Pan, R., Hu, R., Zhang, H., Lei, S., Zhang, L., Zhou, C., Zeng, Z., Tian, X., & Xie, Q. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18395 · Cited by 14
Dong, B., Wang, B., Fan, M., Zhang, J., & Zhao, Z. (2024) · Aging · doi:10.18632/aging.205863 · Cited by 13
Ellerman, D. A. (2024) · BioDrugs · doi:10.1007/s40259-024-00691-0 · Cited by 13
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Shrestha, P., Shrestha, R., Zhou, Y. L., Zielinski, R. J., Priebe, W., & Kleinerman, E. S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1608375 · Cited by 13
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Hattinger, C. M., Salaroglio, I. C., Fantoni, L., Godel, M., Casotti, C., Kopecka, J., Scotlandi, K., Ibrahim, T., Riganti, C., & Serra, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24010799 · Cited by 14
Self-citationYang, Q., Lai, Q., Wang, Y., Wang, Y., Yao, Z., & Zhang, X. (2020) · Neoplasma · doi:10.4149/neo_2020_200617n639 · Cited by 13
Griffin, K. H., Mizenko, R. R., Arun, V., Carney, R. P., & Leach, J. K. (2024) · Advanced Biology · doi:10.1002/adbi.202300577 · Cited by 12
Machine learning survival prediction using tumor lipid metabolism genes for osteosarcoma
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Pathania, A. S. (2024) · Cancers · doi:10.3390/cancers16122201 · Cited by 16
CD103+ cDC1 Dendritic Cell Vaccine Therapy for Osteosarcoma Lung Metastases
Yang, Y., Zhou, Y., Wang, J., Zhou, Y. L., Watowich, S. S., & Kleinerman, E. S. (2024) · Cancers · doi:10.3390/cancers16193251 · Cited by 12
Tokumura, K., Fukasawa, K., Ichikawa, J., Sadamori, K., Hiraiwa, M., & Hinoi, E. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07903-7 · Cited by 12
Yan, B., Liu, Q., Liu, G., Huang, X., Zhu, G., Gao, L., & Xu, Y. (2020) · RSC Advances · doi:10.1039/c9ra07332a · Cited by 12
RetractedHuang, X., Maguire, O. A. B., Walker, J. M., Jiang, C. S., Carroll, T. S., Luo, J., Tonorezos, E. S., Friedman, D. N., & Cohen, P. (2021) · JCI Insight · doi:10.1172/jci.insight.153586 · Cited by 12
Тодосенко, Н. М., Yurova, K. A., Хазиахматова, О. Г., Malashchenko, V. V., Хлусов, И. А., & Litvinova, L. S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14102181 · Cited by 12
The analysis of the pyroptosis-related genes and hub gene TP63 ceRNA axis in osteosarcoma
Han, J., Hu, Y., Ding, S., Liu, S., & Wang, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.974916 · Cited by 12
Li, Y., Li, M., Wei, R., & Wu, J. (2020) · Journal of Immunology Research · doi:10.1155/2020/9374240 · Cited by 12
Zhang, L., Jiang, H., & Ma, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1548527 · Cited by 11
Immunotherapeutic Strategies in the Management of Osteosarcoma
Supra, R., & Agrawal, D. K. (2023) · Journal of Orthopaedics and Sports Medicine · doi:10.26502/josm.511500076 · Cited by 11
Tatsuno, R., Komohara, Y., Pan, C., Kawasaki, T., Enomoto, A., Jubashi, T., Kono, H., Wako, M., Ashizawa, T., Haro, H., et al. (2024) · Cancers · doi:10.3390/cancers16162801 · Cited by 10
YKL ‐40 protein in osteosarcoma tumor tissue
Thorn, A., Daugaard, S., Christensen, L. H., Christensen, I. J., & Petersen, M. M. (2016) · Apmis · doi:10.1111/apm.12524 · Cited by 11
Dailey, D. D., Hess, A. M., Bouma, G. J., & Duval, D. L. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.637622 · Cited by 11
NTRK fusions are extremely rare in bone tumours
Lam, S. W., Bruijn, I. H. B., van Wezel, T., Cleven, A. H. G., Hogendoorn, P. C. W., Cleton-Jansen, A., & Bovée, J. V. M. G. (2021) · Histopathology · doi:10.1111/his.14432 · Cited by 12
Self-citationBrulin, B., Nolan, J., Marangon, T., Kovacevic, M., Chatelais, M., Meheust, P., Abadie, J., Nail, L. L., Rosset, P., Brennan, M. Á., et al. (2021) · Cancers · doi:10.3390/cancers13194890 · Cited by 11
Metadata
- Authors
- Buddingh, E. P., Kuijjer, M. L., Duim, R. A. J., Bürger, H., Agelopoulos, K., Myklebost, O., Serra, M., Mertens, F., Hogendoorn, P. C. W., Lankester, A. C., & Cleton-Jansen, A.-M.
- Affiliations
- Oslo University Hospital (NO)
- Authors' Affiliations: 1Department of Pediatrics; 2Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands; 3Institute of Pathology; 4Department of Medicine, Hematology and Oncology, University of Münster, Münster, Germany; 5Department of Tumor Biology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway; 6Laboratory of Experimental Oncology Research, Istituto Ortopedico Rizzoli, Bologna, Italy; and 7Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
- Corresponding author
- Cleton-Jansen, Anne-Marie
- ORCID
- Venue
- Clinical Cancer Research
- Published
- 2011-04-14
- Volume
- 17
- Issue
- 8
- Pages
- 2110-2119
- ISSN
- 1078-0432 (ISSN-L)
- 1557-3265
- OpenAlex
- W2106409672
- Cited by
- 508
- References
- 45
- Citations by year
- 2026: 27 · 2025: 45 · 2024: 48 · 2023: 63 · 2022: 47 · 2021: 54 · 2020: 50 · 2019: 24 · 2018: 20 · 2017: 36 · 2016: 24 · 2015: 17 · 2014: 15 · 2013: 13 · 2012: 18
- FWCI
- 7.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- high-grade osteosarcoma, tumor-infiltrating macrophages, metastasis suppression, tumor-associated macrophages, tumor stroma, gene expression profiling, overall survival, muramyl tripeptide, adjuvant therapy, CD14, CD163, angiogenesis
- MeSH terms
- Bone Neoplasms, Humans, Immunohistochemistry, Macrophages, Neoplasm Metastasis, Prognosis, Osteosarcoma, Time Factors, Cohort Studies, Gene Expression Regulation, Neoplastic, Reverse Transcriptase Polymerase Chain Reaction, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Cell Line, Tumor
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