The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Overexpression and Amplification of Aurora-A in Hepatocellular Carcinoma
Abstract
Purpose: Aurora-A/STK15/BTAK, a centrosome-associated serine/threonine kinase, has been shown to induce chromosomal instability, leading to aneuploidy and cell transformation. The purpose of this study was to investigate the expression and amplification of Aurora-A in hepatocellular carcinoma (HCC). Experimental Design: Aurora-A mRNA levels were measured in 224 HCCs and 199 paired nontumorous liver tissues by reverse transcription-PCR. Aurora-A mRNA and protein levels of 8 were also measured by reverse transcription-PCR and Western blot hybridization in 8 liver cancer cell lines. Amplification of Aurora-A was determined by Southern blot hybridization in 99 cases. Results: Aurora-A was overexpressed in 137 of 224 (61%) HCCs and all 8 of the cell lines. Overexpression of Aurora-A was associated with high-grade (grade II-IV), and high-stage (stage IIIB-IV) tumors, p53 mutation, infrequent β-catenin mutation, and poor outcome. Aurora-A overexpression and p53 mutation acted synergistically toward poor prognosis. Amplification of Aurora-A was detected only in 3 HCCs. Conclusion: The results show that Aurora-A is overexpressed frequently in HCC, and correlated with high grade and high stage, indicating that overexpression of Aurora-A plays a role in the development and progression of HCC.
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Cites
Genetic instabilities in human cancers
Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1998) · Nature · doi:10.1038/25292 · Cited by 4,168
Carroll, P. E., Okuda, M., Horn, H. F., Biddinger, P., Stambrook, P. J., Gleich, L. L., Li, Y.-Q., Tarapore, P., & Fukasawa, K. (1999) · Oncogene · doi:10.1038/sj.onc.1202515 · Cited by 279
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Menyhárt, O., Nagy, Á., & Győrffy, B. (2018) · Royal Society Open Science · doi:10.1098/rsos.181006 · Cited by 507
AURKA is one of the downstream targets of MAPK1/ERK2 in pancreatic cancer
Furukawa, T., Kanai, N., Shiwaku, H. O., Soga, N., Uehara, A., & Horii, A. (2006) · Oncogene · doi:10.1038/sj.onc.1209494 · Cited by 135
Al-Khafaji, A. S. K., Marcus, M. W., Davies, M. P. A., Risk, J. M., Shaw, R. J., Field, J. K., & Liloglou, T. (2017) · Oncology Letters · doi:10.3892/ol.2017.6012 · Cited by 51
Post-transcriptional control drives Aurora kinase A expression in human cancers
Cacioppo, R., Rad, D., Pagani, G., Gandellini, P., & Lindon, C. (2024) · PLOS ONE · doi:10.1371/journal.pone.0310625 · Cited by 3
Metadata
- Authors
- Jeng, Y.-M., Peng, S.-Y., Lin, C.-Y., & Hsu, H.-C.
- Venue
- Clinical Cancer Research
- Published
- 2004-03-15
- Volume
- 10
- Issue
- 6
- Pages
- 2065-2071
- ISSN
- 1078-0432 (ISSN-L)
- 1557-3265
- OpenAlex
- W2134064448
- Cited by
- 304
- References
- 2
- FWCI
- 6.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jeng, Y.-M., Peng, S.-Y., Lin, C.-Y., & Hsu, H.-C. (2004). Overexpression and Amplification of Aurora-A in Hepatocellular Carcinoma. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.ccr-1057-03
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