AURKA mRNA expression is an independent predictor of poor prognosis in patients with non-small cell lung cancer
Open accessAbstract
Deregulation of mitotic spindle genes has been reported to contribute to the development and progression of malignant tumours. The aim of the present study was to explore the association between the expression profiles of Aurora kinases (AURKA, AURKB and AURKC), cytoskeleton‑associated protein 5 (CKAP5), discs large‑associated protein 5 (DLGAP5), kinesin‑like protein 11 (KIF11), microtubule nucleation factor (TPX2), monopolar spindle 1 kinase (TTK), and β‑tubulins (TUBB) and (TUBB3) genes and clinicopathological characteristics in human non‑small cell lung carcinoma (NSCLC). Reverse transcription-quantitative polymerase chain reaction‑based RNA gene expression profiles of 132 NSCLC and 44 adjacent wild‑type tissues were generated, and Cox's proportional hazard regression was used to examine associations. With the exception of AURKC, all genes exhibited increased expression in NSCLC tissues. Of the 10 genes examined, only AURKA was significantly associated with prognosis in NSCLC. Multivariate Cox's regression analysis demonstrated that AURKA mRNA expression [hazard ratio (HR), 1.81; 95% confidence interval (CI), 1.16‑2.84; P=0.009], age (HR, 1.03; 95% CI, 1.00‑1.06; P=0.020), pathological tumour stage 2 (HR, 2.43; 95% CI, 1.16‑5.10; P=0.019) and involvement of distal nodes (pathological node stage 2) (HR, 3.14; 95% CI, 1.24‑7.99; P=0.016) were independent predictors of poor prognosis in patients with NSCLC. Poor prognosis of patients with increased AURKA expression suggests that those patients may benefit from surrogate therapy with AURKA inhibitors.
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AURKA expression is a poor prognostic indicator in patients with NSCLC.
“Furthermore, AURKA expression is a poor prognostic indicator in patients with NSCLC151.”
From The current state of the art and future trends in RAS-targeted cancer therapies (2022) · cites this paper as [151]
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Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., Parkin, D. M., Forman, D., & Bray, F. (2015) · International Journal of Cancer · doi:10.1002/ijc.29210 · Cited by 28,766 · see citing works
Purposeful selection of variables in logistic regression
Bursac, Z., Gauss, C. H., Williams, D. K., & Hosmer, D. W. (2008) · Source Code for Biology and Medicine · doi:10.1186/1751-0473-3-17 · Cited by 4,035 · see citing works
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works
Non-small-cell lung cancers: a heterogeneous set of diseases
Chen, Z., Brainson, C. F., Hammerman, P. S., Kim, C. F., & Wong, K. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3775 · Cited by 1,936 · see citing works
Aurora-A — A guardian of poles
Marumoto, T., Zhang, D., & Saya, H. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1526 · Cited by 698 · see citing works
Roles of Aurora Kinases in Mitosis and Tumorigenesis
Fu, J., Bian, M., Jiang, Q., & Zhang, C. (2007) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-06-0208 · Cited by 616 · see citing works
Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53
Katayama, H. G., Sasai, K., Kawai, H., Yuan, Z.-M., Bondaruk, J. E., Suzuki, F., Fujii, S., Arlinghaus, R. B., Czerniak, B. A., & Sen, S. (2003) · Nature Genetics · doi:10.1038/ng1279 · Cited by 586 · see citing works
The LLP risk model: an individual risk prediction model for lung cancer
Cassidy, A., Myles, J. P., van Tongeren, M., Page, R. D., Liloglou, T., Duffy, S. W., & Field, J. K. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6604158 · Cited by 487 · see citing works
Self-citationThe Aurora kinase family in cell division and cancer
Vader, G., & Lens, S. M. A. (2008) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2008.07.003 · Cited by 421 · see citing works
Overexpression and Amplification of Aurora-A in Hepatocellular Carcinoma
Jeng, Y., Peng, S., Lin, C., & Hsu, H. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-1057-03 · Cited by 304 · see citing works
Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment
Jelluma, N., Brenkman, A. B., van den Broek, N. J. F., Cruijsen, C. W. A., van Osch, M. H. J., Lens, S. M. A., Medema, R. H., & Kops, G. J. P. L. (2008) · Cell · doi:10.1016/j.cell.2007.11.046 · Cited by 294 · see citing works
Tang, H., Xiao, G., Behrens, C., Schiller, J. H., Allen, J., Chow, C.-W. B., Suraokar, M. B., Corvalán, A. H., Mao, J., White, M. A., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-2321 · Cited by 282 · see citing works
Tumoral and tissue‐specific expression of the major human β‐tubulin isotypes
Leandro-Garcia, L. J., Leskelä, S., Landa, I., et al. (2010) · Cytoskeleton · doi:10.1002/cm.20436 · Cited by 276 · see citing works
Sato, M., Vaughan, M. B., Girard, L., Peyton, M., Lee, W., Shames, D. S., Ramirez, R. D., Sunaga, N., Gazdar, A. F., Shay, J. W., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2521 · Cited by 260 · see citing works
Mechanisms of Centrosome Separation and Bipolar Spindle Assembly
Tanenbaum, M. E., & Medema, R. H. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.11.011 · Cited by 225 · see citing works
Mitotic checkpoints: from yeast to cancer
Wassmann, K., & Benezra, R. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00161-1 · Cited by 195 · see citing works
Smith, S. L., Bowers, N. L., Betticher, D. C., et al. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602779 · Cited by 155 · see citing works
Aneuploidy: a matter of bad connections
Cimini, D., & Degrassi, F. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.06.008 · Cited by 141 · see citing works
Vischioni, B., Oudejans, J. J., Vos, W., et al. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0301 · Cited by 126 · see citing works
Deregulated Aurora‐B induced tetraploidy promotes tumorigenesis
Nguyen, H. G., Makitalo, M., Yang, D., Chinnappan, D., Hilaire, C. S., & Ravid, K. (2009) · The FASEB Journal · doi:10.1096/fj.09-130963 · Cited by 101 · see citing works
Role of cell cycle regulators in lung carcinogenesis
Eymin, B., & Gazzéri, S. (2010) · Cell Adhesion & Migration · doi:10.4161/cam.4.1.10977 · Cited by 99 · see citing works
The role of clathrin in mitotic spindle organisation
Royle, S. (2012) · Journal of Cell Science · doi:10.1242/jcs.094607 · Cited by 76 · see citing works
Kemp, S. R. M., Nagel, R., van Walsum, M., van der Meulen, I. H., van Beusechem, V. W., Braakhuis, B. J. M., & Brakenhoff, R. H. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-2539 · Cited by 75 · see citing works
A Five-Gene and Corresponding Protein Signature for Stage-I Lung Adenocarcinoma Prognosis
Kadara, H. N., Behrens, C., Yuan, P., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2703 · Cited by 75 · see citing works
Aurora-C kinase supports mitotic progression in the absence of Aurora-B
Slattery, S. D., Mancini, M. A., Brinkley, B. R., et al. (2009) · Cell Cycle · doi:10.4161/cc.8.18.9591 · Cited by 69 · see citing works
Laßmann, S., Shen, Y., Jütting, U., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2775 · Cited by 69 · see citing works
Iacono, M. L., Monica, V., Saviozzi, S., et al. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-100 · Cited by 65 · see citing works
Ogawa, E., Takenaka, K., Katakura, H., et al. (2007) · Annals of Surgical Oncology · doi:10.1245/s10434-007-9653-8 · Cited by 61 · see citing works
Structural and regulatory roles of nonmotor spindle proteins
Manning, A. L., & Compton, D. A. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.11.004 · Cited by 53 · see citing works
Centrosome function in normal and tumor cells
Sankaran, S., & Parvin, J. D. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21003 · Cited by 47 · see citing works
Garrido, G., & Vernos, I. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00088 · Cited by 44 · see citing works
CT screening for lung cancer: Is the evidence strong enough?
Field, J. K., Devaraj, A., Duffy, S. W., et al. (2015) · Lung Cancer · doi:10.1016/j.lungcan.2015.11.003 · Cited by 41 · see citing works
Self-citationGene expression profiling of non-small-cell lung cancer
Lacroix, L., Commo, F., & Soria, J. (2008) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.8.2.167 · Cited by 29 · see citing works
Perumal, D., Singh, S., Yoder, S., Bloom, G. C., & Chellappan, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043589 · Cited by 24 · see citing works
Takeshita, M., Koga, T., Takayama, K., Kouso, H., Nishimura‐Ikeda, Y., Yoshino, I., Maehara, Y., Nakanishi, Y., & Sueishi, K. (2008) · International Journal of Cancer · doi:10.1002/ijc.23673 · Cited by 22 · see citing works
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The current state of the art and future trends in RAS-targeted cancer therapies
Punekar, S. R., Velcheti, V., Neel, B. G., & Wong, K.-K. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00671-9 · Cited by 549 · see citing works
- Authors
- Al-Khafaji, A. S. K., Marcus, M. W., Davies, M. P. A., Risk, J. M., Shaw, R. J., Field, J. K., & Liloglou, T.
- Affiliations
- University of Baghdad (IQ)
- University of Liverpool (GB)
- ORCID
- Venue
- Oncology Letters
- Publisher
- Spandidos Publications
- Published
- 2017-04-07
- Volume
- 13
- Issue
- 6
- Pages
- 4463-4468
- ISSN
- 1792-1074 (ISSN-L)
- 1792-1082
- PMC
- PMC5452881
- OpenAlex
- W2604504944
- Cited by
- 51
- References
- 36
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 9 · 2023: 5 · 2022: 10 · 2021: 6 · 2020: 12 · 2018: 2 · 2017: 1
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Oncology Letters (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Edge Hill University Research Information Repository (Edge Hill University) (submittedVersion)
- Funders
- University of Baghdad
- Roy Castle Lung Cancer Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Health Sciences › Medicine › Oncology › Lung Cancer Research Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
- Keywords
- non-small cell lung cancer, AURKA, prognostic factors, gene expression profiling, TTK, TPX2, KIF11, DLGAP5, CKAP5, beta-tubulin, AURKA inhibitors
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