Evaluation of circulating tumor cells and circulating tumor DNA in non-small cell lung cancer: association with clinical endpoints in a phase II clinical trial of pertuzumab and erlotinib

Erlotinib in Previously Treated Non–Small-Cell Lung Cancer

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Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer

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MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling

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Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors

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Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases

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Circulating Tumor Cells Predict Survival Benefit from Treatment in Metastatic Castration-Resistant Prostate Cancer

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Relationship of Circulating Tumor Cells to Tumor Response, Progression-Free Survival, and Overall Survival in Patients With Metastatic Colorectal Cancer

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Measurement of clinical and subclinical tumour response using [18F]-fluorodeoxyglucose and positron emission tomography: review and 1999 EORTC recommendations

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Detection of Mutations in EGFR in Circulating Lung-Cancer Cells

Maheswaran, S., Sequist, L. V., Nagrath, S., Ulkus, L., Brannigan, B., Collura, C. V., Inserra, E., Diederichs, S., Iafrate, A. J., Bell, D. W., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0800668 · Cited by 1,617

Mutations in the Epidermal Growth Factor Receptor and in KRAS Are Predictive and Prognostic Indicators in Patients With Non–Small-Cell Lung Cancer Treated With Chemotherapy Alone and in Combination With Erlotinib

Eberhard, D. A., Johnson, B. E., Amler, L. C., Goddard, A. D., Heldens, S., Herbst, R. S., Ince, W. L., Janne, P. A., Januario, T., Johnson, D. H., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.02.857 · Cited by 1,453

Liquid biopsy: creating opportunities in brain space

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Advances in Circulating Tumor DNA Analysis

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A fully automated assay to detect the expression of pan-cytokeratins and of EML4-ALK fusion protein in circulating tumour cells (CTCs) predicts outcome of non-small cell lung cancer (NSCLC) patients

Rossi, E. M. C., Aieta, M., Tartarone, A., Pezzuto, A., Facchinetti, A., Santini, D., Ulivi, P., Ludovini, V., Possidente, L., Fiduccia, P., et al. (2021) · Translational Lung Cancer Research · doi:10.21037/tlcr-20-855 · Cited by 27

Soluble Biomarkers with Prognostic and Predictive Value in Advanced Non-Small Cell Lung Cancer Treated with Immunotherapy

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ERK Signal Suppression and Sensitivity to CH5183284/Debio 1347, a Selective FGFR Inhibitor

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Feasibility of Cell-Free Circulating Tumor DNA Testing for Lung Cancer

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An improved CTC isolation scheme for pairing with downstream genomics: Demonstrating clinical utility in metastatic prostate, lung and pancreatic cancer

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Use of circulating tumor cells in prospective clinical trials for NSCLC patients – standardization of the pre-analytical conditions

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Application of an improved magnetic immunosorbent in an Ephesia chip designed for circulating tumor cell capture

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Epithelial-mesenchymal transition and GALC expression of circulating tumor cells indicate metastasis and poor prognosis in non-small cell lung cancer

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Development and clinical validation of a microfluidic-based platform for CTC enrichment and downstream molecular analysis

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A lab-on-a-disc platform enables serial monitoring of individual CTCs associated with tumor progression during EGFR-targeted therapy for patients with NSCLC

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Liquid biopsy in colorectal cancer

Najafi, S., Majidpoor, J., & Mortezaee, K. (2023) · Clinica Chimica Acta · doi:10.1016/j.cca.2023.117674 · Cited by 27

Possible applications of circulating tumor cells in patients with non small cell lung cancer

Tartarone, A., Rossi, E. M. C., Lerose, R., Mambella, G., Calderone, G., Zamarchi, R., & Aieta, M. (2016) · Lung Cancer · doi:10.1016/j.lungcan.2016.05.027 · Cited by 25

Prognostic role of circulating tumor cells in patients with EGFR‐mutated or ALK‐rearranged non‐small cell lung cancer

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Clinical Utility of Circulating Tumour Cell Detection in Non-Small-Cell Lung Cancer

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Dynamic Monitoring and Predictive Value of Circulating Tumor Cells in EGFR-Mutated Advanced Non–Small-Cell Lung Cancer Patients Treated With First-Line EGFR Tyrosine Kinase Inhibitors

Jiang, T., Zhao, J., Zhao, C., Li, X., Shen, J., Zhou, J., Ren, S., Su, C., Zhou, C., & O'Brien, M. E. R. (2018) · Clinical Lung Cancer · doi:10.1016/j.cllc.2018.11.014 · Cited by 24

Potential of Circulating Tumor Cells as Blood-Based Biomarkers in Cancer Liquid Biopsy

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Erythrocyte-derived vesicles for circulating tumor cell capture and specific tumor imaging

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Isolation and Analysis of Tumor Cell Subpopulations Using Biomimetic Immuno‐Fluorescent Magnetic Multifunctional Nanoprobes

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Tri‐modal liquid biopsy: Combinational analysis of circulating tumor cells, exosomes, and cell‐free DNA using machine learning algorithm

Bu, J., Lee, T. H., Poellmann, M. J., Rawding, P. A., Jeong, W., Hong, R. S., Hyun, S. H., Eun, H. S., & Hong, S. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.499 · Cited by 23

Survivin mRNA-circulating tumor cells predict treatment efficacy of chemotherapy and survival for advanced non-small cell lung cancer patients

Du, Y., Li, J., Zhu, W., Wu, Y. R., Tang, X.-P., Wang, Y., & Hu, Y. (2014) · Tumor Biology · doi:10.1007/s13277-013-1592-3 · Cited by 23

Critical issues in the clinical application of liquid biopsy in non-small cell lung cancer

Manicone, M., Poggiana, C., Facchinetti, A., & Zamarchi, R. (2017) · Journal of Thoracic Disease · doi:10.21037/jtd.2017.07.28 · Cited by 23

The diagnostic value of circulating tumor cells and ctDNA for gene mutations in lung cancer

Lyu, M., Zhou, J. H., Kang, N., & Ying, B. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s195342 · Cited by 25

Applications of liquid biopsy in lung cancer-diagnosis, prognosis prediction, and disease monitoring.

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Circulating Tumour Cells (CTCs) in NSCLC: From Prognosis to Therapy Design

Kejík, Z., Kaplánek, R., Dytrych, P., Masařík, M., Veselá, K., Abramenko, N., Hoskovec, D., Vašáková, M., Králová, J., Pavel Martasek, E., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111879 · Cited by 23

Effect of Osimertinib on CTCs and ctDNA in EGFR Mutant Non-Small Cell Lung Cancer Patients: The Prognostic Relevance of Liquid Biopsy

Kallergi, G., Kontopodis, E., Ntzifa, A., Jordana‐Ariza, N., Karachaliou, N., Pantazaka, E., Charalambous, H., Psyrri, A. K., Tsaroucha, E. G., Boukovinas, I., et al. (2022) · Cancers · doi:10.3390/cancers14061574 · Cited by 22

Inertia based microfluidic capture and characterisation of circulating tumour cells for the diagnosis of lung cancer

Chudasama, D. Y., Freydin, M., Freidin, M. B., Leung, M., Montero, Á., Rice, A. J., Nicholson, A. G., Karteris, E., Anikin, V., & Lim, E. K. S. (2016) · Annals of Translational Medicine · doi:10.21037/atm.2016.12.28 · Cited by 22

Circulating Tumor Cells as Cancer Biomarkers in the Clinic

Chinen, L. T. D., Abdallah, E. A., Braun, A. C., Flores, B. C. T., Corassa, M. P., Sanches, S. M., & Fanelli, M. F. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55947-6_1 · Cited by 23

Characteristics of circulating tumor cells in organ metastases, prognosis, and T lymphocyte mediated immune response

Sun, W., Xu, Z., Lian, P., Gao, B., & Hu, J. (2017) · OncoTargets and Therapy · doi:10.2147/ott.s130087 · Cited by 21

Advanced NSCLC Patients With EGFR T790M Harboring TP53 R273C or KRAS G12V Cannot Benefit From Osimertinib Based on a Clinical Multicentre Study by Tissue and Liquid Biopsy

Fu, Y., Wang, A., Zhou, J., Feng, W., Shi, M., Xu, X., Zhao, H., Cai, L., Feng, J., Lv, X., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.621992 · Cited by 21

Greatly isolated heterogeneous circulating tumor cells using hybrid engineered cell membrane-camouflaged magnetic nanoparticles

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Circulating free mitochondrial DNA concentration and its association with erlotinib treatment in patients with adenocarcinoma of the lung

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Correlation between epidermal growth factor receptor tyrosine kinase inhibitor efficacy and circulating tumor cell levels in patients with advanced non-small cell lung cancer

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Ethanol-dispersed and antibody-conjugated polymer nanofibers for the selective capture and 3-dimensional culture of EpCAM-positive cells

Yoon, J., Yoon, H.-S., Shin, Y., Kim, S.-H., Ju, Y., Kim, J., & Chung, S. H. (2017) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2017.02.015 · Cited by 20

Association of circulating tumour cells with early relapse and 18F-fluorodeoxyglucose positron emission tomography uptake in resected non-small-cell lung cancers†

Bayarri-Lara, C. I., de Miguel‐Pérez, D., de Guevara, A. C. L., Fernández, A. R., Puche, J. L. G., Ramos, A. S.-P., Zafra, J. R., Ospina, C. F. G., Delgado‐Rodríguez, M., Ruíz, M. E., et al. (2017) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezx049 · Cited by 20

Detection of somatic variants and EGFR mutations in cell-free DNA from non-small cell lung cancer patients by ultra-deep sequencing using the ion ampliseq cancer hotspot panel and droplet digital polymerase chain reaction

Sung, J. S., Chong, H., Kwon, N., Kim, H. M., Lee, J. W., Kim, B., Lee, S. B., Park, C. W., Choi, J. Y., Chang, W. J., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.22456 · Cited by 20

Liquid Biopsy in Solid Malignancy

Scarlotta, M., Şimşek, C., & Kim, A. K. (2019) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2018.0237 · Cited by 22

Opportunities of circulating tumor DNA in lung cancer

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The Use of Three-Dimensional DNA Fluorescent In Situ Hybridization (3D DNA FISH) for the Detection of Anaplastic Lymphoma Kinase (ALK) in Non-Small Cell Lung Cancer (NSCLC) Circulating Tumor Cells

Kulasinghe, A., Lim, Y., Kapeleris, J., Warkiani, M. E., O'Byrne, K. J., & Punyadeera, C. (2020) · Cells · doi:10.3390/cells9061465 · Cited by 20

CK-coated magnetic-based beads as a tool to isolate circulating tumor cells (CTCs) in human tumors.

Mayo, C., Ortega, F. G., Giménez-Capitán, A. A., Molina‐Vila, M. Á., Serrano, M. J., Viteri, S., Costa, C., Gascó, A., Bertrán-Alamillo, J., Karachaliou, N., et al. (2013) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2218-6751.2013.02.06 · Cited by 20

Assessment of the Efficacy and Clinical Utility of Different Circulating Tumor Cell (CTC) Detection Assays in Patients with Chemotherapy-Naïve Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

Papadaki, M. A., Messaritakis, I., Fiste, O., Souglakos, J., Politaki, E., Kotsakis, A. P., Georgoulias, V., Mavroudis, D., & Agelaki, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020925 · Cited by 19

Relevance of Circulating Tumor Cells as Predictive Markers for Cancer Incidence and Relapse

Chelakkot, C., Yang, H., & Shin, Y. K. (2022) · Pharmaceuticals · doi:10.3390/ph15010075 · Cited by 19

New insights in non-small-cell lung cancer: circulating tumor cells and cell-free DNA

Duréndez-Saéz, E., Azkárate, A., Meri-Abad, M., Fariñas, S. C., Aguilar-Gallardo, C., Blasco, A., Lewintre, E. J., & Camps, C. (2017) · Journal of Thoracic Disease · doi:10.21037/jtd.2017.06.112 · Cited by 19

Isolation of Breast cancer CTCs with multitargeted buoyant immunomicrobubbles

Wang, G., Benasutti, H., Jones, J. F., Shi, G., Benchimol, M. J., Pingle, S. C., Kesari, S., Yeh, Y., Hsieh, L.-E., Liu, Y., et al. (2017) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2017.10.060 · Cited by 19

The potential of monitoring treatment response in non-small cell lung cancer using circulating tumour cells

Gallo, M., Luca, A. D., Frezzetti, D., Passaro, V., Maiello, M. R., & Normanno, N. (2019) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2019.1640606 · Cited by 19

Detection and application of circulating tumor cell and circulating tumor DNA in the non-small cell lung cancer.

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Measurement and immunophenotyping of pleural fluid EpCAM-positive cells and clusters for the management of non-small cell lung cancer patients

Thompson, J. C., Fan, R., Black, T. A., Yu, G. H., Savitch, S. L., Chien, A. L., Yee, S. S., Sen, M., Hwang, W., Katz, S. I., et al. (2018) · Lung Cancer · doi:10.1016/j.lungcan.2018.11.020 · Cited by 19

Molecular analysis of cell-free circulating DNA for the diagnosis of somatic mutations associated with resistance to tyrosine kinase inhibitors in non-small-cell lung cancer

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The prognostic role of circulating tumor cells in lung cancer

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Personalized Treatment Through Detection and Monitoring of Genetic Aberrations in Single Circulating Tumor Cells

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Circulating Tumor Cells in Patients with Lung Cancer: Developments and Applications for Precision Medicine

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Performance comparison of commercial kits for isolating and detecting circulating tumor DNA

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Circulating tumor cells as lung cancer biomarkers.

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EGFR plasma mutation in prediction models for resistance with EGFR TKI and survival of non‐small cell lung cancer

Phan, T. T., Tran, B., Nguyen, S. T., Ho, T. T., Nguyen, H. T., Le-Thuong, V., & Le, A. T. (2019) · Clinical and Translational Medicine · doi:10.1186/s40169-019-0219-8 · Cited by 17

Detection of EGFR Mutations in Plasma Cell-Free Tumor DNA of TKI-Treated Advanced-NSCLC Patients by Three Methodologies: Scorpion-ARMS, PNAClamp, and Digital PCR

Siggillino, A., Ulivi, P., Pasini, L., Reda, M. S., Chiadini, E., Tofanetti, F. R., Baglivo, S., Metro, G., Crinò, L., Delmonte, A., et al. (2020) · Diagnostics · doi:10.3390/diagnostics10121062 · Cited by 18

Analysis of Cell-Free DNA to Assess Risk of Tumoremia Following Endoscopic Ultrasound Fine-Needle Aspiration of Pancreatic Adenocarcinomas

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Circulating Tumor DNA Is a Variant of Liquid Biopsy with Predictive and Prognostic Clinical Value in Breast Cancer Patients

Zavarykina, T. M., Lomskova, P., Валерьевна, П. И., Khokhlova, S. V., Stenina, M. B., & Sukhikh, G. T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242317073 · Cited by 16

Prognostic value of cytokeratin-7 mRNA expression in peripheral whole blood of advanced lung adenocarcinoma patients

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Clinical Applications of Circulating Tumor Cells in Pharmacotherapy: Challenges and Perspectives

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Correlation Between Circulating Tumor DNA Levels and Response to Tyrosine Kinase Inhibitors (TKI) Treatment in Non-Small Cell Lung Cancer

Wei, Z., Wang, W., Shu, Z., Zhou, X., & Zhang, Y. (2017) · Medical Science Monitor · doi:10.12659/msm.902265 · Cited by 16

The applications of liquid biopsy in resistance surveillance of anaplastic lymphoma kinase inhibitor

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The value of radial endobronchial ultrasound-guided bronchial brushing in peripheral non-squamous non-small cell lung cancer

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Interrelationships of Circulating Tumor Cells with Metastasis and Thrombosis: Role of MicroRNAs

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Circulating Tumor DNA for Mutation Detection and Identification of Mechanisms of Resistance in Non-Small Cell Lung Cancer

Yeung, K. T., More, S., Woodward, B. D., Velculescu, V. E., & Husain, H. (2017) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-017-0260-5 · Cited by 16

Analyzing epidermal growth factor receptor mutation status changes in advanced non‐small‐cell lung cancer at different sampling time‐points of blood within one day

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Molecular detection and prognostic value of epithelial markers mRNA expression in peripheral blood of advanced non-small cell lung cancer patients

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Routine clinical use of circulating tumor cells for diagnosis of mutations and chromosomal rearrangements in non-small cell lung cancer—ready for prime-time?

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Liquid Biopsy Analysis as a Tool for TKI-Based Treatment in Non-Small Cell Lung Cancer

Buszka, K., Ntzifa, A., Owecka, B., Kamińska, P., Kolecka-Bednarczyk, A., Zabel, M., Nowicki, M. O., Lianidou, E. S., & Budna, J. (2022) · Cells · doi:10.3390/cells11182871 · Cited by 15

Novel Molecular Tumor Cell Markers in Regional Lymph Nodes and Blood Samples from Patients Undergoing Surgery for Non-Small Cell Lung Cancer

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