The DOI matches its Crossref record; 76 of the 77 references it cites were found in a registry or an index.
Current and Emerging Therapies in Metastatic Pancreatic Cancer
Published version of a preprint
Abstract
Targeted therapies and immunotherapy have changed the face of multiple solid malignancies, including metastatic melanoma and lung cancer, but no such therapies exist for pancreatic ductal adenocarcinoma (PDAC) despite the knowledge of key mutations and an increasing understanding of the tumor microenvironment. Until now, most clinical studies have not been biomarker driven in this highly immunosuppressive and heterogeneous cancer. Ongoing basic and translational studies are better classifying the disease in hopes of identifying critical pathways that distinguish the unique PDAC subtypes, which will lead to personalized therapies. In this review, we discuss the current treatment options for metastatic pancreatic cancer and highlight current ongoing clinical trials, which aim to target the stroma and the immune microenvironment either alone or in combination with standard chemotherapy. Identifying biomarkers and key resistance pathways and targeting these pathways in a personalized manner in combination with chemotherapy are likely to yield a more immediate and durable clinical benefit.
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“most chemotherapeutic and immunotherapeutic agents that have proven efficacy in other malignancies have limited efficacy in PDAC”
From Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes (2019) · cites this paper as Manji et al., 2017
Citations
Cites
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Cited by
Sorted by citations
Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes
Riquelme, E., Zhang, Y., Zhang, L., Montiel, M., Zoltan, M., Dong, W., Quesada, P., Sahin, I., Chandra, V., San Lucas, A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.07.008 · Cited by 1,577
“This represents a significant unmet need, as most chemotherapeutic and immunotherapeutic agents that have proven efficacy in other malignancies have limited efficacy in PDAC (Garrido-Laguna and Hidalgo, 2015; Manji et al., 2017).”
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Non-coding RNAs in GI cancers: from cancer hallmarks to clinical utility
Dragomir, M. P., Kopetz, S., Ajani, J. A., & Călin, G. A. (2020) · Gut · doi:10.1136/gutjnl-2019-318279 · Cited by 211
Metadata
- Authors
- Manji, G. A., Olive, K. P., Saenger, Y. M., & Oberstein, P.
- Affiliations
- NewYork–Presbyterian Hospital (US)
- Columbia University Irving Medical Center (US)
- Corresponding author
- Manji, Gulam Abbas
- Venue
- Clinical Cancer Research
- Published
- 2017-04-01
- Volume
- 23
- Issue
- 7
- Pages
- 1670-1678
- ISSN
- 1078-0432 (ISSN-L)
- 1557-3265
- OpenAlex
- W2605366445
- Cited by
- 145
- References
- 77
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 9 · 2023: 19 · 2022: 19 · 2021: 12 · 2020: 26 · 2019: 23 · 2018: 12 · 2017: 13
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Peptidase Inhibition and Analysis
- Keywords
- metastatic pancreatic cancer, pancreatic ductal adenocarcinoma, targeted therapy, immunotherapy, tumor microenvironment, biomarkers, drug resistance, personalized treatment, combination chemotherapy, clinical trials
- MeSH terms
- Adenocarcinoma, Antineoplastic Combined Chemotherapy Protocols, Clinical Trials as Topic, Humans, Immunotherapy, Neoplasm Metastasis, Neoplasms, Second Primary, Carcinoma, Pancreatic Ductal, Precision Medicine, Tumor Microenvironment
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