Immune Exclusion-Wnt/CTNNB1 Class Predicts Resistance to Immunotherapies in HCC
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Next-generation sequencing has provided information on actionable targets and biomarkers of response in oncology. In hepatocellular carcinoma (HCC), Wnt/CTNNB1 mutations characterize the immune-excluded class (cold tumors) and might represent the biomarkers predicting resistance to immune checkpoint inhibitors. Large-scale validation of these data is needed to customize immunotherapy in advanced HCC. See related article by Harding et al., p. 2116
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Patients with non-inflamed hepatocellular carcinomas tend to have a low likelihood of benefiting from immunotherapies.
“Patients with HCCs classified as non-inflamed tend to have a low likelihood of benefiting from immunotherapies72,83.”
From Adjuvant and neoadjuvant immunotherapies in hepatocellular carcinoma (2024) · cites this paper as [83]
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Cites
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Self-citationA New Era of Systemic Therapy for Hepatocellular Carcinoma with Regorafenib and Lenvatinib
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Self-citationIdentification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features
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Trial Design and Endpoints in Hepatocellular Carcinoma: AASLD Consensus Conference
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Self-citationAdjuvant and neoadjuvant immunotherapies in hepatocellular carcinoma
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Self-citationWNT/β-Catenin Signaling Pathway Regulating T Cell-Inflammation in the Tumor Microenvironment
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- Authors
- Pinyol, R., Sia, D., & Llovet, J. M.
- Affiliations
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Tisch Cancer Institute (US)
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Corresponding author
- Llovet, Josep M.
- Venue
- Clinical Cancer Research
- Published
- 2019-04-01
- Volume
- 25
- Issue
- 7
- Pages
- 2021-2023
- ISSN
- 1078-0432 (ISSN-L)
- 1557-3265
- PMC
- PMC6445700
- OpenAlex
- W2911120667
- Cited by
- 249
- References
- 9
- Citations by year
- 2026: 32 · 2025: 27 · 2024: 41 · 2023: 32 · 2022: 42 · 2021: 41 · 2020: 22 · 2019: 12
- FWCI
- 12.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (acceptedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, other-oa)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, public-domain)
- Funders
- NCI (P30-CA196521)
- U.S. Department of Defense (CA150272P3)
- Horizon 2020 (667273-2)
- EIT (18053)
- CRUK AECC AIRC (C9380/A26813)
- NIH (SAF2016-76390)
- Generalitat de Catalunya AGAUR (SGR-1358)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Keywords
- hepatocellular carcinoma, immune exclusion, cold tumors, CTNNB1, immune checkpoint inhibitors, immunotherapy resistance, predictive biomarkers, tumor immune microenvironment
- MeSH terms
- Adult, Carcinoma, Hepatocellular, Humans, Immunotherapy, Liver Neoplasms, beta Catenin
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