The DOI matches its Crossref record; 74 of the 77 references it cites were found in a registry or an index.
Marine natural products as anticancer drugs
Abstract
The chemical and biological diversity of the marine environment is immeasurable and therefore is an extraordinary resource for the discovery of new anticancer drugs. Recent technological and methodologic advances in structure elucidation, organic synthesis, and biological assay have resulted in the isolation and clinical evaluation of various novel anticancer agents. These compounds range in structural class from simple linear peptides, such as dolastatin 10, to complex macrocyclic polyethers, such as halichondrin B; equally as diverse are the molecular modes of action by which these molecules impart their biological activity. This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs.
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“On the other hand, neovastat stops the binding of VEGF to its receptor [227,229].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [229]
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Sponge-Associated Microorganisms: Evolution, Ecology, and Biotechnological Potential
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Marine Natural Products: A Source of Novel Anticancer Drugs
Khalifa, S. A. M., Elias, N., Farag, M. A., Chen, L., Saeed, A., Hegazy, M.-E. F., Moustafa, M. S., Abd El-Wahed, A., Al-Mousawi, S. M., Musharraf, S. G., et al. (2019) · Marine Drugs · doi:10.3390/md17090491 · Cited by 555
Metadata
- Authors
- Simmons, T. L., Andrianasolo, E., McPhail, K., Flatt, P., & Gerwick, W. H.
- Affiliations
- Oregon State University (US)
- Venue
- Molecular Cancer Therapeutics
- Published
- 2005-02-01
- Volume
- 4
- Issue
- 2
- Pages
- 333-342
- ISSN
- 1535-7163 (ISSN-L)
- 1538-8514
- OpenAlex
- W2169637929
- Cited by
- 597
- References
- 77
- Citations by year
- 2026: 10 · 2025: 6 · 2024: 13 · 2023: 21 · 2022: 15 · 2021: 31 · 2020: 36 · 2019: 37 · 2018: 25 · 2017: 32 · 2016: 32 · 2015: 40 · 2014: 40 · 2013: 40 · 2012: 42
- FWCI
- 21.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Cancer Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
- Physical Sciences › Chemistry › Organic Chemistry › Isoquinoline Alkaloid Synthesis
- Keywords
- marine natural products, anticancer agents, dolastatin 10, halichondrin B, macrocyclic polyethers, marine peptides, structure elucidation, organic synthesis, clinical evaluation, mechanism of action
- MeSH terms
- Trabectedin, Polyether Polyketides, Animals, Antineoplastic Agents, Biological Products, Dioxoles, Ethers, Cyclic, Humans, Isoquinolines, Oceans and Seas, Tyrosine, Macrolides, Tetrahydroisoquinolines, Depsipeptides
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