Gerwick, William H.

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

Wang, M., Carver, J. J., Phelan, V. V., Sanchez, L. M., Garg, N., Peng, Y., Nguyen, D. D., Watrous, J., Kapono, C. A., Luzzatto-Knaan, T., et al. (2016) · Nature Biotechnology

Metabolomics and Mass Spectrometry StudiesMass Spectrometry Techniques and Applications

Cited by 4,629

Systematic classification of unknown metabolites using high-resolution fragmentation mass spectra

Dührkop, K., Nothias, L.-F., Fleischauer, M., Reher, R., Ludwig, M., Hoffmann, M. A., Petras, D., Gerwick, W. H., Rousu, J., Dorrestein, P. C., et al. (2021) · Nature Biotechnology

Metabolomics and Mass Spectrometry StudiesMass Spectrometry Techniques and Applications

Cited by 860

Marine natural products as anticancer drugs

Simmons, T. L., Andrianasolo, E., McPhail, K., Flatt, P., & Gerwick, W. H. (2005) · Molecular Cancer Therapeutics

Marine Sponges and Natural ProductsMicrobial Natural Products and Biosynthesis

Cited by 597

NPClassifier: A Deep Neural Network-Based Structural Classification Tool for Natural Products

Kim, H. W., Wang, M., Leber, C. A., Nothias, L.-F., Reher, R., Kang, K. B., van der Hooft, J. J. J., Dorrestein, P. C., Gerwick, W. H., & Cottrell, G. W. (2021) · Journal of Natural Products

Computational Drug Discovery MethodsMicrobial Natural Products and Biosynthesis

Cited by 551

The structure of scytonemin, an ultraviolet sunscreen pigment from the sheaths of cyanobacteria

Proteau, P. J., Gerwick, W. H., Garcia-Pichel, F., & Castenholz, R. (1993) · Experientia

Microbial Metabolism and ApplicationsSkin Protection and Aging

Cited by 392

Structure of curacin A, a novel antimitotic, antiproliferative and brine shrimp toxic natural product from the marine cyanobacterium Lyngbya majuscula

Gerwick, W. H., Proteau, P. J., Nagle, D. G., Hamel, E., Blokhin, A., & Slate, D. L. (1994) · The Journal of Organic Chemistry

Microbial Natural Products and BiosynthesisMarine Sponges and Natural Products

Cited by 365

Marine Natural Products as Novel Antioxidant Prototypes

Takamatsu, S., Hodges, T. W., Rajbhandari, I., Gerwick, W. H., Hamann, M. T., & Nagle, D. G. (2003) · Journal of Natural Products

Marine Sponges and Natural ProductsSeaweed-derived Bioactive Compounds

Cited by 278

Coibamide A, a Potent Antiproliferative Cyclic Depsipeptide from the Panamanian Marine Cyanobacterium Leptolyngbya sp.

Medina, R. A., Goeger, D. E., Hills, P., Mooberry, S. L., Huang, N., Romero, L. I., Ortega-Barría, E., Gerwick, W. H., & McPhail, K. L. (2008) · Journal of the American Chemical Society

Microbial Natural Products and BiosynthesisMarine Sponges and Natural Products

Cited by 231

Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly

Marquez, B. L., Watts, K. S., Yokochi, A., Roberts, M. A., Verdier-Pinard, P., Jimenez, J. I., Hamel, E., Scheuer, P. J., & Gerwick, W. H. (2002) · Journal of Natural Products

Microbial Natural Products and BiosynthesisMarine Sponges and Natural Products

Cited by 181

Scytonemin-a marine natural product inhibitor of kinases key in hyperproliferative inflammatory diseases

Stevenson, C. S., Capper, E. A., Roshak, A. K., Marquez, B., Grace, K., Gerwick, W. H., Jacobs, R. S., & Marshall, L. A. (2002) · Inflammation Research

Bioactive natural compoundsProtein Kinase Regulation and GTPase Signaling

Cited by 172

Ichthyotoxic and cytotoxic metabolites of the tropical brown alga Stypopodium zonale (Lamouroux) Papenfuss

Gerwick, W. H., & Fenical, W. (1981) · The Journal of Organic Chemistry

Seaweed-derived Bioactive CompoundsMarine Sponges and Natural Products

Cited by 142

Exploiting Adaptive Laboratory Evolution of Streptomyces clavuligerus for Antibiotic Discovery and Overproduction

Charusanti, P., Fong, N. L., Nagarajan, H., Pereira, A. R., Li, H. J., Abate, E. A., Su, Y., Gerwick, W. H., & Palsson, B. O. (2012) · PLoS ONE

Microbial Natural Products and BiosynthesisEvolution and Genetic Dynamics

Cited by 93

Assessment of Anabaena sp. Strain PCC 7120 as a Heterologous Expression Host for Cyanobacterial Natural Products: Production of Lyngbyatoxin A

Videau, P., Wells, K. N., Singh, A. J., Gerwick, W. H., & Philmus, B. (2016) · ACS Synthetic Biology

Microbial Natural Products and BiosynthesisMicrobial Metabolic Engineering and Bioproduction

Cited by 66

Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi Cruzain

Boudreau, P. D., Miller, B. W., McCall, L.-I., Almaliti, J., Reher, R., Hirata, K., Le, T., Siqueira-Neto, J. L., Hook, V., & Gerwick, W. H. (2019) · Journal of Medicinal Chemistry

Protease and Inhibitor MechanismsTrypanosoma species research and implications

Cited by 57

Native metabolomics identifies the rivulariapeptolide family of protease inhibitors

Reher, R., Aron, A. T., Fajtová, P., Stincone, P., Wagner, B., Pérez-Lorente, A. I., Liu, C., Shalom, I. Y. B., Bittremieux, W., Wang, M., et al. (2022) · Nature Communications

Microbial Natural Products and BiosynthesisMetabolomics and Mass Spectrometry Studies

Cited by 53

NPOmix: a machine learning classifier to connect mass spectrometry fragmentation data to biosynthetic gene clusters

Leão, T. F., Wang, M., da Silva, R., Gurevich, A., Bauermeister, A., Gomes, P. W. P., Brejnrod, A., Glukhov, E., Aron, A. T., Louwen, J. J. R., et al. (2021) · PNAS Nexus

Microbial Natural Products and BiosynthesisMetabolomics and Mass Spectrometry Studies

Cited by 32

Isolation of Polycavernoside D from a Marine Cyanobacterium

Navarro, G., Cummings, M. E., Lee, J., Moss, N., Glukhov, E., Valeriote, F. A., Gerwick, L., & Gerwick, W. H. (2015) · Environmental Science & Technology Letters

Marine Toxins and Detection MethodsMicrobial Natural Products and Biosynthesis

Cited by 31