The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
A strategy for cancer prevention: Stimulation of the Nrf2-ARE signaling pathway
Open accessAbstract
Many genes, with products involved in the protection of cells against carcinogens, oxidants, and other toxic chemicals, are under the transcriptional control of a simple DNA regulatory element [i.e., the antioxidant response element (ARE)]. One or more functional AREs have been confirmed or are believed to exist in the upstream region of many anticarcinogenic/antioxidant genes and have been shown to mediate the coordinate transcriptional up-regulation of these genes by many chemical agents [i.e., the ARE-mediated inducers]. There is strong evidence that increased expression of ARE-regulated genes inhibits cancer development. The signaling system leading to ARE activation has been partly elucidated, and nuclear factor erythroid 2–related factor 2 (Nrf2) has been identified as the key transcriptional factor that serves to transmit the inducer signal to ARE. It is now known that nuclear factor erythroid 2–related factor 2, which is normally sequestered in the cytoplasm by Kelch-like ECH-associated protein 1, dissociates from Kelch-like ECH-associated protein 1 on exposure to ARE-mediated inducers, translocates to the nucleus, complexes with other nuclear factors, and binds to ARE. Rapid and simple assays have been devised to identify chemical agents that can stimulate this signaling pathway. Moreover, many ARE-mediated inducers have been identified, and several of them have shown promising cancer preventive activity.
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Nrf2–Keap1 defines a physiologically important stress response mechanism
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Stress-activated cap’n’collar transcription factors in aging and human disease
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Emerging Role of Nrf2 in Protecting Against Hepatic and Gastrointestinal Disease
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Metadata
- Authors
- Zhang, Y., & Gordon, G. B.
- Venue
- Molecular Cancer Therapeutics
- Published
- 2004-07-01
- Volume
- 3
- Issue
- 7
- Pages
- 885-893
- ISSN
- 1535-7163 (ISSN-L)
- 1538-8514
- OpenAlex
- W2168599730
- Cited by
- 226
- References
- 9
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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