Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

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Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

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Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

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Trastuzumab plus Adjuvant Chemotherapy for Operable HER2-Positive Breast Cancer

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Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

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Trastuzumab-Induced Hepatotoxicity: A Case Report

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Lapatinib plus Capecitabine for HER2-Positive Advanced Breast Cancer

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Adjuvant Trastuzumab in HER2-Positive Breast Cancer

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Design and Evaluation of Engineered Extracellular Vesicle (EV)-Based Targeting for EGFR-Overexpressing Tumor Cells Using Monobody Display

Komuro, H., Aminova, S., Lauro, K., Woldring, D., & Harada, M. (2022) · Bioengineering · doi:10.3390/bioengineering9020056 · Cited by 23

Engineering exosomes for mRNA delivery: a review

Yao, T. S., Dong, X., Wang, X., Liu, X., Fu, L., & Li, L. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.144662 · Cited by 23

Nonviral targeted mRNA delivery: principles, progresses, and challenges

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Divinylpyrimidine reagents generate antibody–drug conjugates with excellent in vivo efficacy and tolerability

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Extracellular vesicles as a novel approach for breast cancer therapeutics

Lee, Y., Graham, P., & Li, Y. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.216036 · Cited by 19

Biomimetic exosome harnessing exosomal lipidomics and functional proteins for PEDF-pDNA delivery in high altitude pulmonary edema intervention

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DNA‐Programmed Stem Cell Niches via Orthogonal Extracellular Vesicle–Cell Communications

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Mesenchymal growth hormone receptor deficiency leads to failure of alveolar progenitor cell function and severe pulmonary fibrosis

Xie, T., Kulur, V., Liu, N., Deng, N., Wang, Y., Rowan, S. C., Yao, C., Huang, G., Liu, X., Taghavifar, F., et al. (2021) · Science Advances · doi:10.1126/sciadv.abg6005 · Cited by 19

Applications of mRNA Delivery in Cancer Immunotherapy

Pan, X., Zhang, Y.-W.-Q., Dai, C., Zhang, J., Zhang, M., & Chen, X. X. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s500520 · Cited by 19

Ultrasound-directed enzyme-prodrug therapy (UDEPT) using self-immolative doxorubicin derivatives

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Lactadherin: From a Well-Known Breast Tumor Marker to a Possible Player in Extracellular Vesicle-Mediated Cancer Progression

Durán-Jara, E., Vera-Tobar, T., & Lobos-González, L. D. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073855 · Cited by 14

Cell-Derived Vesicles for mRNA Delivery

Li, Z., Liu, Z., Wu, J., & Li, B. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14122699 · Cited by 16

Optimal delivery strategies for nanoparticle-mediated mRNA delivery

Li, X., Guo, X., Hu, M., Cai, R., & Chen, C. (2023) · Journal of Materials Chemistry B · doi:10.1039/d2tb02455a · Cited by 16

mRNA delivery systems 2.0: Engineering extrahepatic delivery for non-vaccine therapeutics

Dalabehera, M., Ghosh, A., Mohanty, S., Chellappan, D. K., Chaudhari, S., Ale, Y., Poonia, N., Subudhi, R. N., Khanna, M., & Lim, H. G. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102584 · Cited by 22

Mesenchymal Stem Cell-Derived Extracellular Vesicles: Hype or Hope for Skeletal Muscle Anti-Frailty

Mahindran, E., Zaman, W. S. W. K., Noordin, K. B. A. A., Tan, Y.-F., & Nordin, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097833 · Cited by 16

Smart delivery vehicles for cancer: categories, unique roles and therapeutic strategies

Zeng, Y., Gao, Y., He, L., Ge, W., Wang, X., Ma, T., & Xie, X.-Y. (2024) · Nanoscale Advances · doi:10.1039/d4na00285g · Cited by 16

A Meta-analysis on the Effectiveness of Extracellular Vesicles as Nanosystems for Targeted Delivery of Anticancer Drugs

Muhammad, S. A., Mohammed, J. S., & Rabiu, S. (2023) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00878 · Cited by 14

Exosome: The “Off-the-Shelf” Cellular Nanocomponent as a Potential Pathogenic Agent, a Disease Biomarker, and Neurotherapeutics

Ghosh, S., & Ghosh, S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.878058 · Cited by 13

Harnessing exosomes as a platform for drug delivery in breast cancer: A systematic review for in vivo and in vitro studies

Gharavi, A. T., Irian, S., Niknejad, A., Parang, K., & Salimi, M. (2024) · Molecular Therapy Oncology · doi:10.1016/j.omton.2024.200800 · Cited by 13

Engineering of Surface Proteins in Extracellular Vesicles for Tissue-Specific Targeting

Vogt, S., Stadlmayr, G., Grillari, J., Rüker, F., & Wozniak‐Knopp, G. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.83537 · Cited by 13

Repurposing 18F-FMISO as a PET tracer for translational imaging of nitroreductase-based gene directed enzyme prodrug therapy

Ponce, G. R. D. G., de Jalón, E. G., Stigen, E., Lund, K. B., Popa, M. L., Davidson, B., Safont, M. M., Rygh, C. B., Espedal, H., Barrett, T. M., et al. (2021) · Theranostics · doi:10.7150/thno.55092 · Cited by 13

PlexinA1 (PLXNA1) as a novel scaffold protein for the engineering of extracellular vesicles

Zhao, H., Li, Z., Liu, D., Zhang, J., You, Z., Shao, Y., Li, H., Yang, H. J., Liu, X., wang, M., et al. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.70012 · Cited by 12

The Role of Extracellular Vesicles in the Treatment of Prostate Cancer

Hu, C., Chen, Q., Wu, T., Du, X., Dong, Y., Peng, Z., Xue, W., Sunkara, V., Cho, Y., & Dong, L. (2024) · Small · doi:10.1002/smll.202311071 · Cited by 11

Leveraging the intratumoral microbiota to treat human cancer: are engineered exosomes an effective strategy?

Qiu, J., Jiang, Y., Ye, N., Jin, G., Shi, H., & Qian, D. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05531-x · Cited by 13

Engineering Hybrid Extracellular Vesicles for Functional mRNA Delivery

Louro, A. F., Gomes, I., Lu, C., Alfonzo‐Méndez, M. A., Dekker, N., Khan, M., & Lázaro‐Ibáñez, E. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202509636 · Cited by 11

Deciphering the biological fate of mRNA-LNP-based biologics: A perspective from tissue to intracellular distribution

Xu, X., Cui, L., Zhang, Y., & Gu, J. (2026) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.11.023 · Cited by 13

Engineered exosomes: a potential therapeutic strategy for septic cardiomyopathy

Mao, L., Liu, S., Chen, Y., Huang, H., Ding, F., & Deng, L. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1399738 · Cited by 11

An extracellular vesicle delivery platform based on the PTTG1IP protein

Perez, C. M., Liang, X., Gupta, D., Haughton, E. R., Conceição, M., Mäger, I., Andaloussi, S. E., Wood, M. J. A., & Roberts, T. C. (2024) · Extracellular Vesicle · doi:10.1016/j.vesic.2024.100054 · Cited by 11

Targeted macrophage mannose receptor (CD206)-specific protein delivery via engineered extracellular vesicles

Ovchinnikova, L. A., Tanygina, D. Y., Dzhelad, S. S., Evtushenko, E. G., Bagrov, D. V., Gabibov, A. G., & Lomakin, Y. A. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e40940 · Cited by 14

Exosome-based approaches in cancer along with unlocking new insights into regeneration of cancer-prone tissues

Safaei, M., Rajabi, S.-S., Tirgar, M., Namdar, N., Dalfardi, M., Mohammadifar, F., Goodarzi, A., Farmani, A. R., Ramezani, V., & Abpeikar, Z. (2025) · Regenerative Therapy · doi:10.1016/j.reth.2025.03.005 · Cited by 10

Extracellular vesicle-based targeted RNA therapies against cancer

Wang, Z., Xing, H., Huang, Y., & Lu, M. (2025) · Extracellular Vesicle · doi:10.1016/j.vesic.2025.100083 · Cited by 10

Drug target therapy and emerging clinical relevance of exosomes in meningeal tumors

Sharma, S., Rana, R., Prakash, P., & Ganguly, N. K. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04715-1 · Cited by 10

Radiolabeled HER2-Directed Exosomes Exhibit Improved Cell Targeting and Specificity

Ghavami, M., Vraka, C., Hubert, V., Schachner, H., Bamminger, K., Hacker, M., Kain, R., & Moghadam, M. F. (2021) · Nanomedicine · doi:10.2217/nnm-2020-0408 · Cited by 8

Role of Exosomes in Breast Cancer Management: Evidence-Based Review

Al-Humaidi, R. B., Fayed, B. E., Sharif, S. I., Noreddin, A. M., & Soliman, S. S. M. (2021) · Current Cancer Drug Targets · doi:10.2174/1568009621666210601115707 · Cited by 8

Strategies to functionalize extracellular vesicles against HER2 for anticancer activity

Gurrieri, E., & D’Agostino, V. (2022) · Extracellular Vesicles and Circulating Nucleic Acids · doi:10.20517/evcna.2022.07 · Cited by 8

Minicircles for a two-step blood biomarker and PET imaging early cancer detection strategy

Robinson, E. R., Gowrishankar, G., D’Souza, A. L., Kheirolomoom, A., Haywood, T., Hori, S. S., Chuang, H., Zeng, Y., Tumbale, S. K., Aalipour, A., et al. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.05.026 · Cited by 8

Versatile tethering system to control cell-specific targeting of bioengineered extracellular vesicles

Bui, S., Lainé, J., Chevé, M., Vassilopoulos, S., & Lavieu, G. (2025) · Scientific Reports · doi:10.1038/s41598-025-04576-2 · Cited by 6

Latest developments in advanced exosome engineering for optimized site-specific drug delivery by modulating exosome functionalities in breast cancer

Dawn, B., Talom, A., Jirpu, T., & Ghosh, A. (2025) · Discover Pharmaceutical Sciences · doi:10.1007/s44395-025-00023-3 · Cited by 6

DNAJB6-Containing Extracellular Vesicles as Chaperone Delivery Systems: A Proteomic Analysis

Joshi, B. S., Romeu, H. G., Aliyandi, A., de Vries, M. P., & Zuhorn, I. S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14112485 · Cited by 6

Deciphering the Functional Status of Breast Cancers through the Analysis of Their Extracellular Vesicles

Carrasco, A. G. M., Otake, A. H., Macedo-da-Silva, J., Santiago, V. F., Palmisano, G., Andrade, L. N. D. S., & Chammas, R. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241613022 · Cited by 6

Extracellular vesicles in cancer: golden goose or Trojan horse

Han, T., Hao, Q., Chao, T., Sun, Q., Chen, Y., Gao, B., Guan, L., Ren, W., & Zhou, X. Y. (2024) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjae025 · Cited by 8

Exosomes with IR780 and Lenvatinib loaded on GPC3 single-chain scFv antibodies for targeted hyperthermia and chemotherapy in hepatocellular carcinoma therapy.

Huang, S., Xiong, M., Liu, J., Wang, J., Han, X., Chen, Z., Xie, P., Zhou, Z., Liu, C., Li, H., et al. (2023) · PubMed Central · Cited by 5

Therapeutic potential of extracellular vesicle-polyphenol nanoplatform in regenerative medicine

Ma, M., Wu, Q., Wang, T., Ma, Y., Le, F., Wang, Y., Jiang, L., Gu, Z., & Hao, Z. (2025) · Nano Materials Science · doi:10.1016/j.nanoms.2025.05.008 · Cited by 5

Engineered extracellular vesicles as imaging biomarkers and therapeutic applications for urological diseases

Ling, L., Liang, S., Cai, M., Ge, J., Tan, H., Wang, C.-B., & Xu, B. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101646 · Cited by 4

Exploiting Exosomes for Cancer Diagnosis and Treatment

Kugeratski, F. G., & Kalluri, R. (2023) · Current cancer research · doi:10.1007/978-3-031-22903-9_3 · Cited by 4

Engineered retrovirus-like nanocarriers for messenger RNA delivery into neuronsPreprint

Gu, W., Luozhong, S., Cai, S., Londhe, K., Elkasri, N., Hawkins, R. D., Yuan, Z., Greene, K. S., Cruz, M., Chang, Y.-W., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.07.518870 · Cited by 4

Customised extracellular vesicle therapeutics for neurological conditions

Johnston, E. L., Weber, J. F., Sango, X., Nisbet, I. T., & Haylock, D. N. (2025) · Health Nanotechnology · doi:10.1186/s44301-025-00007-3 · Cited by 4

Precision Engineering of Extracellular Vesicles as Programmable Carriers for mRNA Therapeutics

Yoon, H., Lee, G., Jo, J., Koo, J., Kim, E., Choi, H. J., Jung, S., Shin, Y., Oh, K. T., & Lim, C. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s595161 · Cited by 3

Exosomes as a window of opportunity in hepatocellular carcinoma: Insights from diagnostic to targeted drug delivery

Gupta, S., Deb, A., Mazumder, P. B., & Shekhawat, G. S. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106259 · Cited by 3

Extracellular vesicles engineered to directly target encephalomyocarditis virus ameliorates multi-organ viremia in a lethal infection model

Yue, J., Yang, Y., Idris, A., Jin, W., Zhang, Y., Chen, Y., Li, X., Li, H., Li, S., Wen, Y., et al. (2025) · Veterinary Microbiology · doi:10.1016/j.vetmic.2025.110448 · Cited by 3

Dimeric Human β-Defensin 3 as a Universal Platform for Intracellular Delivery of Nucleic Acid Cargos

Kim, H. Y., Jang, J.-E., & Ahn, D. (2018) · ACS Applied Bio Materials · doi:10.1021/acsabm.8b00024 · Cited by 3

Targeted Delivery of mGluR5 Agonists via Engineered hucMSC-Derived EVs to Enhance Macrophage Function and Mitigate Glutamate-Induced Toxicity

Khushi, K., Kumar, A., Jadhav, K., Gupta, A., & Verma, R. K. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.5c00646 · Cited by 2

Strategies to Improve the Stability and Translation of Therapeutic mRNAs

Gao, B., He, S., & Sun, Q. (2026) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-100724-084241 · Cited by 3

Unlocking the potential of mRNA nanomedicines for comprehensive fibrosis therapy

Yang, Y., Li, C., Xiong, W., Li, C., & Xiao, J. (2026) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2026.102917 · Cited by 2

Engineered Extracellular Vesicles: Advancing Cancer Therapy Through Precision Nanomedicine

Ma, S., Niu, Y., Sui, S., Xu, W., Kong, L., Wu, X., Wu, J., Gao, Y., & Yan, T. (2026) · BIO Integration · doi:10.15212/bioi-2025-0208 · Cited by 2

Breast cancer immunotherapy using scFv antibody-based approaches, a systematic review

Heidarnejad, K., Faraji, S. N., Mahfoozi, S., Ghasemi, Z., Dashti, F. S., Asadi, M., & Ramezani, A. (2024) · Human Immunology · doi:10.1016/j.humimm.2024.111090 · Cited by 2

mRNA vaccine delivery strategies for cancer therapy

Zhang, H., Zhang, H., Xu, B., & Liu, H. (2024) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/tb-2024-0670 · Cited by 2

mRNA-based vaccines and therapies - a revolutionary approach for conquering fast-spreading infections and other clinical applications: a review

Pan, M., Cao, W., Zhai, J., Zheng, C., Xu, Y., & Zhang, P. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.143134 · Cited by 2

Engineering HEK293T cell line by lentivirus to produce miR34a-loaded exosomes

Sarkami, S. A., Molavipordanjani, S., Abediankenari, S., Akhtari, J., Gill, P., Ghalehnoei, H., & Khodashenas, S. (2023) · Molecular Biology Reports · doi:10.1007/s11033-023-08754-1 · Cited by 2

An EVolving approach to directed enzyme prodrug therapy for cancer

Jay, S. M. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat1642 · Cited by 1

Biomimetic Nucleic Acid Drug Delivery Systems for Relieving Tumor Immunosuppressive Microenvironment

Yan, W., Cao, Y., Yin, Q., & Li, Y. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16081028 · Cited by 1

New Advances in Stem Cell–Derived Extracellular Vesicle Functionalization Technology

Tomasini, S., Centomo, M. L., Neveux, I., & Panella, R. (2025) · Stem cells in clinical applications · doi:10.1007/978-3-031-90698-5_6 · Cited by 1

Hit the bull's eye: Engineered extracellular vesicles for targeted therapy

Cai, Y., Zhang, H., Fan, X., Fu, H., Li, H., Fu, X., Wang, X., Yuan, C., Lin, K., & Zhuang, Y. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.04.035 · Cited by 1

Medical Use of mRNA-Based Directed Gene Delivery

Matin, A., & Forterre, A. V. (2022) · RNA technologies · doi:10.1007/978-3-031-08415-7_5 · Cited by 1

Advances in mRNA Delivery and Clinical Applications

Hu, B., Hussain, A., Liu, Q. L., Weng, Y., & Huang, Y. (2022) · RNA technologies · doi:10.1007/978-3-031-08415-7_13 · Cited by 1

基于纳米技术的mRNA递送系统的研究进展

Wang, Y., Zhang, M., Li, G., Hou, T., Li, Z., Chen, S., Wang, D., & Jiang, W. (2024) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/tb-2023-1077 · Cited by 2

Extracellular Vesicles in Regenerative Medicines

Shah, H., Chakraborty, D., Shetty, A., Gopalakrishnan, A. V., Renji, A., Mukherjee, A. G., Wanjari, U. R., Murali, R., & Kannampuzha, S. (2024) · Springer eBooks · doi:10.1007/978-981-97-6270-5_17 · Cited by 1

Conjugated biomimetic nanohybrids as smart drug delivery systems

Jadhav, M., Jain, N. K., Prasad, R., & Srivastava, R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821352-0.00002-2

Decreased miR- 31 Suppress Cell Migration and Proliferation By Targeting Syncytin-1 in Pancreatic CarcinomaPreprint

Yang, J., Luo, J., Wang, F., Cheng, Z., Han, X., Liu, C., & Wang, Z. (2020) · doi:10.21203/rs.3.rs-27017/v1

Review: Single Chain Fragment Variable sebagai Pemandu Diagnosis dan Terapi Bertarget Human Epidermal Growth Factor Receptor 2 Kanker Payudara

Priskila, M., & Febrina, E. (2023) · Jurnal Sains Farmasi & Klinis · doi:10.25077/jsfk.10.2.155-161.2023

Technologies for the Surface Functionalization of Extracellular Vesicles

Han, G., Geng, M., & Yin, H. (2024) · Springer eBooks · doi:10.1007/978-981-99-8365-0_11

Clinical Applications of Exosomes

Huang, C. F. (2025) · Springer eBooks · doi:10.1007/978-981-96-1261-1_23

Construction and Efficacy Evaluation of Fluorouracil-Loading Hepatocellular Carcinoma-Targeted Exosomes

饶, 立. (2025) · Hans Journal of Biomedicine · doi:10.12677/hjbm.2025.154079

Exosomes facilitate mRNA and siRNA delivery using cationic liposomes 2X3-DOPE to rat heart mesenchymal cells in vitro

Dovbysh, O. V., Vysochinskaya, V. V., Gavrilova, N. V., Docshin, P. M., Nikitina, E. G., Klochev, A. S., Elpaeva, E. A., Dobrovolskaya, O. A., Shmendel, E. V., Maslov, M. A., et al. (2025) · Medical academic journal · doi:10.17816/maj641910 · Cited by 1

The updated role of exosomes in cancer diagnosis and therapy

Huang, X., Huang, Y., Wei, X., & Xu, Y. (2026) · Discover Oncology · doi:10.1007/s12672-026-05193-9

Exosomes Next-Generation Approaches in Breast Cancer: Nano Drug Delivery to AI-Based Prediction

Shah, T. M. (2026) · Journal of Drug Delivery and Therapeutics · doi:10.22270/jddt.v16i7.7891 · Cited by 1

Small molecules as delivery tools for enzymes employed in enzyme-prodrug therapy

Qoura, L. A., & Pokrovsky, V. S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-44185-1.00014-8

Engineered exosomes for breast cancer immunotherapy: Emerging strategies and translational potential

Orooji, N., Ghasemian-Irani, M., Salari, N., Eskandari, T., Shams, M., Razavi, F. T., & Haghmorad, D. (2026) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2026.102822

A review of exosomes as nanomedicine for antimicrobial delivery and combating antimicrobial resistance

Choonara, Y. E., Mnqiwu, K., Chougule, M. B., Kashikar, R., Aggarwal, A., Mosharraf, M., Salem, A. K., Dusane, A., Janardhanam, L. S. L., Sachdeva, M. S., et al. (2026) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2026.127492

Engineering extracellular vesicles for inflammatory bowel disease and colitis-associated colorectal cancer: from therapeutic innovation to clinical translation

Huang, M., Yuan, J., Muro, P., Jin, T., Mao, F., & Zhu, W. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1933602

Engineered extracellular vesicles as next-generation platforms for mRNA therapeutics delivery

Xiao, Y., Tong, X., Wang, Z., Zhang, Y., Liu, S., Tian, M., Chen, Y., Gan, L., Yang, X., & Yong, T. (2026) · Biomaterials Science · doi:10.1039/d6bm00986g

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